1
Views
16
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Scanning Mutagenesis of Mcm1: Residues Required for DNA Binding, DNA Bending, and Transcriptional Activation by a MADS-Box Protein

, , &
Pages 1-11 | Received 11 Jun 1999, Accepted 23 Sep 1999, Published online: 28 Mar 2023

REFERENCES

  • Acton, T. B., Zhong, H., and Vershon, A. K.. 1997. DNA-binding specificity of Mcm1: operator mutations that alter DNA bending and transcriptional activities by a MADS box protein. Mol. Cell. Biol. 17:1881–1889
  • Affolter, M., Montagne, J., Walldorf, U., Groppe, J., Kolter, U., LaRosa, M., and Gehring, W. J.. 1994. The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development. Development 120:743–753
  • Boeke, J. D., Trueheart, J., Natsoulis, G., and Fink, G. R.. 1987. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 154:164–175
  • Bruhn, L., and Sprague, G. F. J.. 1994. MCM1 point mutants deficient in expression of α-specific genes: residues important for interaction with α1. Mol. Cell. Biol. 14:2534–2544
  • Dubois, E., and Messenguy, F.. 1997. Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to different nitrogen signals: role of Gln3p, ArgRp-Mcm1p, and Ume6p. Mol. Gen. Genet. 253:568–580
  • Ebright, R. H.. 1991. Identification of amino acid-base pair contacts by genetic methods. Methods Enzymol. 208:620–640
  • Gehring, W. J., Qian, Y. Q., Billeter, M., Furukubo-Tokunaga, K., Schier, A. F., Otting, G., and Wuthrich, K.. 1994. Homeodomain-DNA recognition. Cell 78:211–223
  • Gustafson, T. A., Taylor, A., and Kedes, L.. 1989. DNA bending is induced by a transcription factor that interacts with the human c-fos and alpha-actin promoters. Proc. Natl. Acad. Sci. USA 86:2162–2166
  • Huang, H., Mizukami, Y., Hu, Y., and Ma, H.. 1993. Isolation and characterization of the binding sequences for the product of the Arabidopsis floral homeotic gene Agamous. Nucleic Acids Res. 21:1089–1095
  • Jarvis, E. E., Clark, K. L., and Sprague, G. F.. 1989. The yeast transcription activator PRTF, a homolog of the mammalian serum response factor, is encoded by the MCM1 gene. Genes Dev. 3:936–945
  • Keleher, C. A., Goutte, C., and Johnson, A. D.. 1988. The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein. Cell 53:927–936
  • Kuo, M. H., Nadeau, E. T., and Grayhack, E. J.. 1997. Multiple phosphorylated forms of the Saccharomyces cerevisiae Mcm1 protein include an isoform induced in response to high salt concentrations. Mol. Cell. Biol. 17:819–832
  • Lilly, B., Galewsky, S., Firulli, A. B., Schulz, R. A., and Olson, E. N.. 1994. D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis. Proc. Natl. Acad. Sci. USA 91:5662–5666
  • Mead, J., Zhong, H., Acton, T. B., and Vershon, A. K.. 1996. The yeast α2 and Mcm1 proteins interact through a region similar to a motif found in homeodomain proteins of higher eukaryotes. Mol. Cell. Biol. 16:2135–2143
  • Mohun, T. J., Chambers, A. E., Towers, N., and Taylor, M. V.. 1991. Expression of genes encoding the transcription factor SRF during early development of Xenopus laevis: identification of a CArG box-binding activity as SRF. EMBO J. 10:933–940
  • Norman, C., Runswick, M., Pollock, R., and Treisman, R.. 1988. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell 55:989–1003
  • Ogata, R. T., and Gilbert, W.. 1977. Contacts between the lac repressor and thymines in the lac operator. Proc. Natl. Acad. Sci. USA 74:4973–4976
  • Passmore, S., Maine, G. T., Elble, R., Christ, C., and Tye, B.-K.. 1988. Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MATα cells. J. Mol. Biol. 204:593–606
  • Pellegrini, L., Tan, S., and Richmond, T. J.. 1995. Structure of serum response factor core bound to DNA. Nature 376:490–498
  • Reichmann, J. L., Wang, M., and Meyerowitz, E. M.. 1996. DNA-binding properties of Arabidopsis MADS domain homeotic proteins APETALA1, APETALA3, PISTILLATA and AGAMAOUS. Nucleic Acids Res. 24:3134–3141
  • Sharrocks, A. D., and Shore, P.. 1995. DNA bending in the ternary nucleoprotein complex at the c-fos promoter. Nucleic Acids Res. 23:2442–2449
  • Smith, D. L., Desai, A. B., and Johnson, A. D.. 1995. DNA bending by the a1 and α2 homeodomain proteins from yeast. Nucleic Acids Res. 23:1239–1243
  • Sommer, H., Beltran, J.-P., Huijser, P., Pape, H., Lonig, W.-E., Saedler, H., and Schwarz-Sommer, Z.. 1990. Deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum majus: the protein shows homology to transcription factors. EMBO J. 9:605–613
  • Tan, S., and Richmond, T. J.. 1998. Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex. Nature 391:660–666
  • Tan, S., and Richmond, T. J.. 1990. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 62:367–377
  • Thompson, J. F., and Landy, A.. 1988. Empirical estimation of protein-induced DNA-bending angles: applications to site-specific recombination complexes. Nucleic Acids Res. 16:9687–9705
  • Treisman, R.. 1986. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 46:567–574
  • Trobner, W., Ramirez, L., Motte, P., Hue, H., Huijser, P., Lonnig, W.-E., Saedler, H., Sommer, H., and Schwarz-Sommer, Z.. 1992. GLOBOSA: a homeotic gene which interacts with DEFICIENS in the control of Antirrhinum floral organogensis. EMBO J. 11:4693–4704
  • West, A. G., and Sharrocks, A. D.. 1999. MADS-box transcription factors adopt alternative mechanisms for bending DNA. J. Mol. Biol. 286:1311–23
  • West, A. G., Shore, P., and Sharrocks, A. D.. 1997. DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bending. Mol. Cell. Biol. 17:2876–2887
  • Wynne, J., and Treisman, R.. 1992. SRF and MCM1 have related but distinct DNA binding specificities. Nucleic Acids Res. 20:3297–3303
  • Yanofsky, M. F., Ma, H., Bowman, J. L., Drews, G. N., Feldmann, K. A., and Meyerowitz, E. M.. 1990. The protein encoded by the Arabidopsis homeotic gene agamous resembles transcriptional factors. Nature 346:35–39
  • Zhong, H., and Vershon, A. K.. 1997. The yeast homeodomain protein Matα2 shows extended DNA-binding specificity in complex with Mcm1. J. Biol. Chem. 272:8402–8409

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.