21
Views
38
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Genetic Analysis of Mouse Embryonic Stem Cells Bearing Msh3 and Msh2 Single and Compound Mutations

, &
Pages 149-157 | Received 20 Apr 1999, Accepted 10 Sep 1999, Published online: 28 Mar 2023

REFERENCES

  • Aaltonen, L. A., Peltomaki, P., Leach, F., Sistonen, P., Pylkkanen, S. M., Mecklin, J.-P., Jarvinen, H., Powell, S., Jen, J., Hamilton, S. R., Petersen, G. M., Kinzler, K. W., Vogelstein, B., and de la Chapelle, A.. 1993. Clues to the pathogenesis of familial colorectal cancer. Science 260:812–816
  • Abuin, A., and Bradley, A.. 1996. Recycling selectable markers in mouse embryonic stem cells. Mol. Cell. Biol. 16:1851–1856
  • Barrett, W. L., First, M. R., Aron, B. S., and Penn, I.. 1993. Clinical course of malignancies in renal transplant recipients. Cancer 72:2186–2189
  • Bhattacharyya, N. P., Ganesh, A., Phear, G., Richards, B., Skandalis, A., and Meuth, M.. 1995. Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum. Mol. Genet. 4:2057–2064
  • Bhattacharyya, N. P., Skandalis, A., Ganesh, A., Groden, J., and Meuth, M.. 1994. Mutator phenotypes in human colorectal carcinoma cell lines. Proc. Natl. Acad. Sci. USA 91:6319–6323
  • de Wind, N., Dekker, M., Bern, A., Radman, M., and te Reile, H.. 1995. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyper recombination, and predisposition to cancer. Cell 82:321–330
  • Dosch, J., Christmann, M., and Kaina, B.. 1998. Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents. Carcinogenesis 19:567–573
  • Drexler, H. G., MacLeod, R. A., Borkhardt, A., and Janssen, J. W.. 1995. Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines. Leukemia 9:480–500
  • Drummond, J. T., Genschel, J., Wolf, E., and Modrich, P.. 1997. DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc. Natl. Acad. Sci. USA 94:10144–10149
  • Farber, R. A., Petes, T. D., Dominska, M., Hudgens, S. S., and Liskay, R. M.. 1994. Instability of simple sequence repeats in a mammalian cell line. Hum. Mol. Genet. 3:253–256
  • Fink, D., Aebi, S., and Howell, S. B.. 1998. The role of DNA mismatch repair in drug resistance. Clin. Cancer Res. 4:1–6
  • Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N., Jenkins, N., Garber, J., Kane, M., and Kolodner, R.. 1993. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027–1038
  • Genschel, J., Littman, S. J., Drummond, J. T., and Modrich, P.. 1998. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J. Biol. Chem. 273:19895–19901
  • Huang, J., Papadopoulos, N., McKinley, A. J., Farrington, S. M., Curtis, L. J., Wyllie, A., Zheng, S., Willson, K. V., Markowitz, S. D., Morin, P., Kinzler, K. W., Vogelstein, B., and Dunlop, M. G.. 1996. APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. USA 93:9049–9054
  • Kolodner, R.. 1996. Biochemistry and genetics of eucaryotic mismatch repair. Genes Dev. 10:1433–1442
  • Kolodner, R. D., and Alani, E.. 1994. Mismatch repair and cancer susceptibility. Curr. Opin. Biotechnol. 5:585–594
  • Lawler, S., Candia, A. F., Ebner, R., Shum, L., Lopez, A. R., Wright, C. V., and Derynck, R.. 1994. The murine type II TGF-beta receptor has a coincident expression and binding preference for TGF-beta 1. Development 120:165–175
  • Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., Peltomaki, R. et al. 1993. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215–1225
  • Lennard, L., Thomas, S., Harrington, C. I., and Maddocks, J. L.. 1985. Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells. Br. J. Dermatol. 113:723–729
  • Luria, S. E., and Delbruck, M.. 1943. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491–511
  • Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, K. V.. 1995. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268:1336–1338
  • Marra, G., Iaccarano, I., Lettieri, T., Roscilli, G., Delmastro, P., and Jiricny, J.. 1998. Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc. Natl. Acad. Sci. USA 95:8568–8573
  • McMahon, A., and Bradley, A.. 1990. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62:1073–1085
  • Orth, K., Hung, J., Gazdar, A., Bowcodk, A., Mathis, J. M., and Sambrook, J.. 1994. Genetic instability in human ovarian cancer cell lines. Proc. Natl. Acad. Sci. USA 91:9495–9499
  • Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J. J., and Jiricny, J.. 1995. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science 268:1912–1914
  • Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Willson, J. K. V., Kinzler, K. W., Jiricny, J., and Vogelstein, B.. 1995. Mutations of GTBP in genetically unstable cells. Science 268:1915–1917
  • Parsons, R., Myeroff, L. L., Liu, B., Willson, J. K., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B.. 1995. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res. 55:5548–5550
  • Peltomaki, P., Lothe, R. A., Aaltonen, L. A., Pylkkanen, L., Nystrom-Lahti, M., Seruca, R., David, L., Holm, R., Ryberg, D., Haugen, A., Brogger, A., Borresen, A.-L., and de la Chapelle, A.. 1993. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res. 53:5853–5855
  • Petit, M. A., Dimpfl, J., Radman, M., and Echols, H.. 1991. Control of large chromosomal duplications in Escherichia coli by the mismatch repair system. Genetics 129:327–332
  • Ramirez-Solis, R., Liu, P., and Bradley, A.. 1995. Chromosome engineering in mice. Nature 378:720–724
  • Ramirez-Solis, R., Davis, A. C., and Bradley, A.. 1993. Gene targeting in mouse embryonic stem cells. Methods Enzymol. 225:855–877
  • Ramirez-Solis, R., Rivera-Perez, J., Wallace, J. D., Wims, M., Zheng, H., and Bradley, A.. 1992. Genomic DNA microextraction: a method to screen numerous samples. Anal. Biochem. 201:331–335
  • Rampino, N., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J. C., and Perucho, M.. 1997. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275:967–969
  • Rayssiguier, C., Thaler, D. S., and Radman, M.. 1989. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342:396–401
  • Reitmair, A. H., Redston, M., Cai, J. C., Chuang, T. C., Bjerknes, M., Cheng, H., Hay, K., Gallinger, S., Bapat, B., and Mak, T. W.. 1996. Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res. 56:3842–3849
  • Reitmair, A. H., Schmits, R., Ewel, A., Bapat, B., Redston, M., Mitri, A., Waterhouse, P., Mittrucker, H.-W., Wakeham, A., Liu, B., Thomason, A., Griesser, H., Gallinger, S., Ballhausen, W. G., Fishel, R., and Mak, T. W.. 1995. Msh2 deficient mice are viable and susceptible to lymphoid tumors. Nat. Genet. 11:64–70
  • Risinger, J. I., Umar, A., Boyd, J., Berchuck, A., Kunkel, T. A., and Barrett, J. C.. 1996. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet. 14:102–105
  • Sambrook, J., Fritsch, E. F., and Maniatis, T.. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y
  • Selva, E. M., Maderazo, A. B., and Lahue, R. S.. 1989. 1997. Differential effects of the mismatch repair genes MSH2 and MSH3 on homeologous recombination in Saccharomyces cerevisiae. Mol. Gen. Genet. 257:71–82
  • Selva, E. M., New, L., Crouse, G. F., and Lahue, R. S.. 1995. Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae. Genetics 139:1175–1188
  • Strand, M., Prolla, T. A., Liskay, R. M., and Petes, T. D.. 1993. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365:274–276
  • Swann, P. F., Waters, T. R., Moulton, D. C., Xu, Y.-Z., Zheng, Q., Edwards, M., and Mace, R.. 1996. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science 273:1109–1111
  • Thibodeau, S. N., Bren, G., and Schaid, D.. 1993. Microsatellite instability in cancer of the proximal colon. Science 260:816–819
  • Umar, A., Risinger, J. I., Glaab, W. E., Tindall, K. R., Barrett, J. C., and Kunkel, T. A.. 1998. Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics 148:1637–1646
  • Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L. E., Yang, J., Liang, J., Zborowska, E., Markowitz, S., Willson, J. K. et al. 1995. Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-prone colon carcinoma cells. J. Biol. Chem. 270:22044–22049
  • Waters, T. R., and Swann, P. F.. 1997. Cytotoxic mechanism of 6-thioguanine: hMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine. Biochemistry 36:2501–2506

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.