55
Views
203
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL

, , , &
Pages 205-212 | Received 04 Jun 1999, Accepted 27 Sep 1999, Published online: 28 Mar 2023

REFERENCES

  • Ashkenazi, A., and Dixit, V. M.. 1999. Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol. 11:255–260
  • Ashkenazi, A., and Dixit, V. M.. 1998. Death receptors: signaling and modulation. Science 281:1305–1308
  • Baeuerle, P. A., and Baltimore, D.. 1996. NF-kappa B: ten years after. Cell 87:13–20
  • Basu, S., Rosenzweig, K. R., Youmell, M., and Price, B. D.. 1998. The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage. Biochem. Biophys. Res. Commun. 247:79–83
  • Bates, S., and Vousden, K. H.. 1999. Mechanisms of p53-mediated apoptosis. Cell. Mol. Life Sci. 55:28–37
  • Fanger, G. R., Johnson, N. L., and Johnson, G. L.. 1997. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16:4961–4972
  • French, L. E., and Tschopp, J.. 1999. The TRAIL to selective tumor death. Nat. Med. 5:146–147
  • Fuchs, S. Y., Adler, V., Pincus, M. R., and Ronai, Z.. 1998. MEKK1/JNK signaling stabilizes and activates p53. Proc. Natl. Acad. Sci. USA 95:10541–10546
  • Gibson, S., Widmann, C., and Johnson, G. L.. 1999. Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. J. Biol. Chem. 274:10916–10922
  • Golstein, P.. 1997. Cell death: TRAIL and its receptors. Curr. Biol. 7:R750–R753
  • Griffith, T. S., and Lynch, D. H.. 1998. TRAIL: a molecule with multiple receptors and control mechanisms. Curr. Opin. Immunol. 10:559–563
  • Gura, T.. 1997. How TRAIL kills cancer cells, but not normal cells. Science 277: 768
  • Jarpe, M. B., Widmann, C., Knall, C., Schlesinger, T. K., Gibson, S., Yujiri, T., Fanger, G. R., Gelfand, E. W., and Johnson, G. L.. 1998. Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death. Oncogene 17:1475–1482
  • Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., and Green, D. R.. 1998. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Mol. Cell 1:543–551
  • Keane, M. M., Ettenberg, S. A., Nau, M. M., Russell, E. K., and Lipkowitz, S.. 1999. Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. Cancer Res. 59:734–741
  • Le-Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F. X., Green, D. R., and Karin, M.. 1999. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell. Biol. 19:751–763
  • Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X.. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479–489
  • Lin, K. I., DiDonato, J. A., Hoffmann, A., Hardwick, J. M., and Ratan, R. R.. 1998. Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. J. Cell Biol. 141:1479–1487
  • Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., and Ashkenazi, A.. 1997. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 7:1003–1006
  • Mo, Y. Y., and Beck, W. T.. 1999. DNA damage signals induction of fas ligand in tumor cells. Mol. Pharmacol. 55:216–222
  • Nemoto, S., DiDonato, J. A., and Lin, A.. 1998. Coordinate regulation of I-κB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase. Mol. Cell. Biol. 18:7336–7343
  • Pan, G., Ni, J., Wei, Y. F., Yu, G., Gentz, R., and Dixit, V. M.. 1997. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277:815–818
  • Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., and Dixit, V. M.. 1997. The receptor for the cytotoxic ligand TRAIL. Science 276:111–113
  • Potmesil, M., Hsiang, Y. H., Liu, L. F., Bank, B., Grossberg, H., Kirschenbaum, S., Forlenza, T. J., Penziner, A., Kanganis, D., Forlenzar, T. J. et al. 1988. Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res. 48:3537–3543
  • Schneider, P., Bodmer, J. L., Thome, M., Hofmann, K., Holler, N., and Tschopp, J.. 1997. Characterization of two receptors for TRAIL. FEBS Lett. 416:329–334
  • Schneider, P., Thome, M., Burns, K., Bodmer, J. L., Hofmann, K., Kataoka, T., Holler, N., and Tschopp, J.. 1997. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity 7:831–836
  • Schulze-Osthoff, K., Ferrari, D., Los, M., Wesselborg, S., and Peter, M. E.. 1998. Apoptosis signaling by death receptors. Eur. J. Biochem. 254:439–459
  • Screaton, G. R., Mongkolsapaya, J., Xu, X. N., Cowper, A. E., McMichael, A. J., and Bell, J. I.. 1997. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. Curr. Biol. 7:693–696
  • Sheikh, M. S., Burns, T. F., Huang, Y., Wu, G. S., Amundson, S., Brooks, K. S., Fornace, A. J.Jr., and el-Deiry, W. S.. 1998. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res. 58:1593–1598
  • Walczak, H., Degli-Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., Goodwin, R. G., and Rauch, C. T.. 1997. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16:5386–5397
  • Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., Smith, C., Smolak, P., Goodwin, R. G., Rauch, C. T., Schuh, J. C., and Lynch, D. H.. 1999. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. 5:157–163
  • Wang, C. Y., Cusack, J. C.Jr., Liu, R., Baldwin, A. S.Jr.. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med. 5:412–417
  • Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., Baldwin, A. S.Jr.. 1998. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680–1683
  • Widmann, C., Gerwins, P., Johnson, N. L., Jarpe, M. B., and Johnson, G. L.. 1998. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol. Cell. Biol. 18:2416–2429
  • Yeh, W. C., Pompa, J. L., McCurrach, M. E., Shu, H. B., Elia, A. J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W. S., Lowe, S. W., Goeddel, D. V., and Mak, T. W.. 1998. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279:1954–1958
  • Zou, H., Li, Y., Liu, X., and Wang, X.. 1999. An APAF-1.Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274:11549–11556

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.