INK4d-Deficient Mice Are Fertile Despite Testicular Atrophy

REFERENCES

• Alevizopoulos, K., Vlach, J., Hennecke, S., and Amati, B.. 1997. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16:5322–5333
   PubMedGoogle Scholar
• Blain, S. W., Montalvo, E., and Massague, J.. 1997. Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J. Biol. Chem. 272:25863–25872
   PubMed Web of Science ®Google Scholar
• Brotherton, D. H., Dhanaraj, V., Wick, S., Brizuela, L., Domaille, P. J., Volyanik, E., Xu, X., Parisini, E., Smith, B. O., Archer, S. J., Serrano, M., Brenner, S. L., Blundell, T. L., and Laue, E. D.. 1998. Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature 395:244–250
   PubMed Web of Science ®Google Scholar
• Caviness, V. S.Jr., Takahashi, T., and Nowakowski, R. S.. 1995. Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci. 18:379–383
   PubMed Web of Science ®Google Scholar
• Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M., and Sherr, C. J.. 1999. The p21Cip1 and p27Kip1 CDK “inhibitors” are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571–1583
   PubMed Web of Science ®Google Scholar
• Chenn, A., and McConnell, S. K.. 1995. Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell 82:631–642
   PubMed Web of Science ®Google Scholar
• Dyson, N.. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245–2262
   PubMed Web of Science ®Google Scholar
• Fero, M. L., Rivkin, M., Tasch, M., Porter, P., Carow, C. E., Firpo, E., Polyak, K., Tsai, L.-H., Broudy, V., Perlmutter, R. M., Kaushansky, K., and Roberts, J. M.. 1996. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-deficient mice. Cell 85:733–744
   PubMed Web of Science ®Google Scholar
• Franklin, D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., and Xiong, Y.. 1998. CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 12:2899–2911
   PubMed Web of Science ®Google Scholar
• Freeman, R. S., Johnson, E. M.Jr.. 1994. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12:343–355
   PubMed Web of Science ®Google Scholar
• Hannon, G. J., and Beach, D.. 1994. p15INK4B is a potential effector of TGFβ-induced cell cycle arrest. Nature 371:257–261
   PubMed Web of Science ®Google Scholar
• Hirai, H., Roussel, M. F., Kato, J., Ashmun, R. A., and Sherr, C. J.. 1995. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15:2672–2681
   PubMed Web of Science ®Google Scholar
• Hu, N., Gutsmann, A., Herbert, D. C., Bradley, A., Lee, W.-H., and Lee, E. Y.-H. P.. 1994. Heterozygous Rb-1D20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9:1021–1027
   PubMedGoogle Scholar
• Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., and Weinberg, R. A.. 1992. Effects of an Rb mutation in the mouse. Nature 359:295–300
   PubMed Web of Science ®Google Scholar
• Jacks, T., and Weinberg, R. A.. 1996. Cell-cycle control and its watchman. Nature 381:643–644
   PubMed Web of Science ®Google Scholar
• Jiang, H., Chou, H. S., and Zhu, L.. 1998. Requirement of cyclin E-cdk2 inhibition in p16INK4a-mediated growth suppression. Mol. Cell. Biol. 18:5284–5290
   PubMedGoogle Scholar
• Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., and Sherr, C. J.. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91:649–659
   PubMed Web of Science ®Google Scholar
• Kang, M. J., Kim, M. K., Terhune, A., Park, J. K., Kim, Y. H., and Koh, G. Y.. 1997. Cytoplasmic localization of cyclin D3 in seminiferous tubules during testicular development. Exp. Cell Res. 234:27–36
   PubMed Web of Science ®Google Scholar
• Kiyokawa, H., Kineman, R. D., Manova-Todorova, K. O., Soares, V. C., Hoffman, E. S., Ono, M., Khanam, D., Hayday, A. C., Frohman, L. A., and Koff, A.. 1996. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 85:721–732
   PubMed Web of Science ®Google Scholar
• Kranenburg, O., van der Eb, A. J., and Zantema, A.. 1996. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15:46–54
   PubMed Web of Science ®Google Scholar
• LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E.. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847–862
   PubMed Web of Science ®Google Scholar
• Lee, M.-H., Nikolic, M., Bapista, C. A., Lai, E., Tsai, L.-H., and Massagué, J.. 1996. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. Proc. Natl. Acad. Sci. USA 93:3259–3263
   PubMed Web of Science ®Google Scholar
• Lukas, J., Herzinger, T., Hansen, K., Moroni, M. C., Resnitzky, D., Helin, K., Reed, S. I., and Bartek, J.. 1997. Cyclin E-induced S phase without activation of the Rb/E2F pathway. Genes Dev. 11:1479–1492
   PubMed Web of Science ®Google Scholar
• McConnell, B. B., Gregory, F. J., Stott, F. J., Hara, E., and Peters, G.. 1999. Induced expression of p16INK4a inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol. Cell. Biol. 19:1981–1989
   PubMed Web of Science ®Google Scholar
• Mitra, J., Dai, C. Y., Somasundaram, K., El-Deiry, W., Satamoorthy, K., Herlyn, M., and Enders, G. H.. 1999. Induction of p21WAF1/Cip1 and inhibition of Cdk2 mediated by the tumor suppressor p16INK4a. Mol. Cell. Biol. 19:3916–3928
   PubMed Web of Science ®Google Scholar
• Morse, L., Chen, D., Franklin, D., Xiong, Y., and Chen-Kiang, S.. 1997. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18 (INK4c) and IL-6. Immunity 6:47–56
   PubMedGoogle Scholar
• Naito, M., and DiGiovanni, J.. Genetic background and development of skin tumors p. 187–212. In Conti, C. J., Slaga, T. J., and Klein-Szanto, A. J. P. Carcinogenesis, vol. III. Skin tumors: experimental and clinical aspects. Raven Press, New York, N.Y
   Google Scholar
• Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., and Loh, D. Y.. 1996. 1989. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707–720
   PubMed Web of Science ®Google Scholar
• Oberdick, J., Wallace, J. D., Lewin, A., and Smeyne, R. J.. 1994. Transgenic expression to monitor dynamic organization of neuronal development: use of Escherichia coli LacZ gene product, β-galactosidase. Methods Neurosci. 5:54–62
   Google Scholar
• O'Farrell, A.-M., Parry D. A., Zindy F., Roussel M. F., Lees E., Moore K. W. and Mui A. L.-F.. Inhibition of proliferation by IL-10 is mediated by Stat3-dependent induction ofp19INK4d. J. Immunol., in press.
   Google Scholar
• Parry, D. A., Mahony, D., Wills, K., and Lees, E.. 1999. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell. Biol. 19:1775–1783
   PubMed Web of Science ®Google Scholar
• Pavletich, N. P.. 1999. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J. Mol. Biol. 287:821–828
   PubMed Web of Science ®Google Scholar
• Quelle, D. E., Zindy, F., Ashmun, R. A., and Sherr, C. J.. 1995. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993–1000
   PubMed Web of Science ®Google Scholar
• Rane, S. G., Dubus, P., Mettus, R. V., Galbreath, E. J., Boden, G., Reddy, E. P., and Barbacid, M.. 1999. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat. Genet. 22:44–52
   PubMed Web of Science ®Google Scholar
• Reiners, J. J.Jr., Nesnow, S., and Slaga, T. J.. 1984. Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion. Carcinogenesis 5:301–307
   PubMed Web of Science ®Google Scholar
• Reynisdóttir, I., and Massagué, J.. 1997. The subcellular locations of p15INK4b and p27Kip1 coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 11:492–503
   PubMed Web of Science ®Google Scholar
• Reynisdóttir, I., Polyak, K., Iavarone, A., and Massagué, J.. 1995. Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9:1831–1845
   PubMed Web of Science ®Google Scholar
• Rhee, K., and Wolgemuth, D. J.. 1995. Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation. Dev. Dyn. 204:406–420
   PubMed Web of Science ®Google Scholar
• Roberts, J. M.. 1999. Evolving ideas about cyclins. Cell 98:129–132
   PubMed Web of Science ®Google Scholar
• Roussel, M. F.. 1999. The INK4 family of cell cycle inhibitors in cancer. Oncogene 18:5311–5317
   PubMed Web of Science ®Google Scholar
• Ruas, M., and Peters, G.. 1998. The p16INK4a/CDKN2A tumor suppressor and its relatives. BBA Rev. Cancer 1378:F115–F177
   PubMed Web of Science ®Google Scholar
• Russo, A. A., Tong, L., Lee, J.-O., Jeffrey, P. D., and Pavletich, N. P.. 1998. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395:237–243
   PubMed Web of Science ®Google Scholar
• Serrano, M., Hannon, G. J., and Beach, D.. 1993. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704–707
   PubMed Web of Science ®Google Scholar
• Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., and DePinho, R. A.. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85:27–37
   PubMed Web of Science ®Google Scholar
• Sherr, C., and Roberts, J. M.. 1999. Positive and negative regulation by CDK inhibitors. Genes Dev. 13:1501–1512
   PubMed Web of Science ®Google Scholar
• Sherr, C. J.. 1993. Mammalian G1 cyclins. Cell 73:1059–1065
   PubMed Web of Science ®Google Scholar
• Sherr, C. J., and Roberts, J. M.. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149–1163
   PubMed Web of Science ®Google Scholar
• Soos, T. J., Kiyokawa, H., Yan, J. S., Rubin, M. S., Giordano, A., DeBlasio, A., Bottega, S., Wong, B., Mendelsohn, J., and Koff, A.. 1996. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ. 7:135–146
   PubMedGoogle Scholar
• Takahashi, T., Nowakowshi, R. S., and Caviness, V. S.. 1995. The cell cycle of the pseudostratified venticular epithelium of the embryonic murine cerebral wall. J. Neurosci. 15:6046–6057
   PubMed Web of Science ®Google Scholar
• Weinberg, R. A.. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323–330
   PubMed Web of Science ®Google Scholar
• Whitlock, C. A., and Witte, O. N.. 1987. Long-term culture of murine bone marrow precursors of B lymphocytes. Methods Enzymol. 150:275–286
   PubMedGoogle Scholar
• Zhang, H., Hannon, G. J., and Beach, D.. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750–1758
   PubMed Web of Science ®Google Scholar
• Zhang, P., Wong, C., DePinho, R., Harper, J. W., and Elledge, S. J.. 1998. Cooperation between the Cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development. Genes Dev. 12:3162–3167
   PubMed Web of Science ®Google Scholar
• Zhang, P., Wong, C., Liu, D., Finegold, M., Harper, J. W., and Elledge, S. J.. 1999. p21Cip1 and p57Kip2 control muscle differentiation at the myogenin step. Genes Dev. 13:213–224
   PubMed Web of Science ®Google Scholar
• Zindy, F., Cunningham J. J., Sherr C. J., Jogal S., Smeyne R. J., and Roussel M. F.. Postnatal neuronal proliferation in mice lacking INK4a and KIP1 inhibitors of cyclin-dependent kinases. Proc. Natl. Acad. Sci. USA, in press.
   Google Scholar
• Zindy, F., Quelle, D. E., Roussel, M. F., and Sherr, C. J.. 1997. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15:203–211
   PubMedGoogle Scholar
• Zindy, F., Soares, H., Herzog, K.-H., Morgan, J., Sherr, C. J., and Roussel, M. F.. 1997. Expression of INK4 inhibitors in cyclin D-dependent kinases during mouse brain development. Cell Growth Differ. 8:1139–1150
   PubMedGoogle Scholar