DNA Binding Site Selection of Dimeric and Tetrameric Stat5 Proteins Reveals a Large Repertoire of Divergent Tetrameric Stat5a Binding Sites

REFERENCES

• Azam, M., Erdjument-Bromage, H., Kreider, B. L., Xia, M., Quelle, F., Basu, R., Saris, C., Tempst, P., Ihle, J. N., and Schindler, C.. 1995. Interleukin-3 signals through multiple isoforms of Stat5. EMBO J. 14:1402–1411
   PubMed Web of Science ®Google Scholar
• Baldwin, A. S. J.. Methylation interference assay for analysis of DNA-protein interactions Current protocols in molecular biology Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. 2:12.3.1–12.3.4 Greene Publishing Associates/Wiley-Interscience, New York, N.Y
   Google Scholar
• Beadling, C., Ng, J., Babbage, J. W., and Cantrell, D. A.. 1996. 1987. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15:101–112
   Google Scholar
• Becker, S., Groner, B., and Muller, C. W.. 1998. Three-dimensional structure of the Stat3β homodimer bound to DNA. Nature 394:145–151
   PubMed Web of Science ®Google Scholar
• Bergad, P. L., Shih, H.-M., Towle, H. C., Schwarzenberg, S. J., and Berry, S. A.. 1995. Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites. J. Biol. Chem. 270:24903–24910
   PubMed Web of Science ®Google Scholar
• Boucheron, C., Dumon, S., Santos, S. C. R., Moriggl, R., Hennighausen, L., Gisselbrecht, S., and Gouilleux, F.. 1998. A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities. J. Biol. Chem. 273:33936–33941
   PubMed Web of Science ®Google Scholar
• Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J. E.Jr., and Kuriyan, J.. 1998. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93:827–839
   PubMed Web of Science ®Google Scholar
• Darnell, J. E.Jr.. 1997. STATs and gene regulation. Science 277:1630–1635
   PubMed Web of Science ®Google Scholar
• Decker, T., Kovarik, P., and Meinke, A.. 1997. GAS elements: A few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17:121–134
   PubMed Web of Science ®Google Scholar
• Grillot, D. A. M., González-García, M., Ekhterae, D., Duan, L., Inohara, N., Otha, S., Seldin, M. F., and Núñez, G.. 1997. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J. Immunol. 158:4750–4757
   PubMed Web of Science ®Google Scholar
• Horvath, C. M., Wen, Z., Darnell, J. E.Jr.. 1995. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:984–994
   PubMed Web of Science ®Google Scholar
• Hou, J., Schindler, U., Henzel, W. J., Wong, S. C., McKnight. 1995. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321–329
   PubMed Web of Science ®Google Scholar
• Ihle, J. N.. 1996. STATs: signal transducers and activators of transcription. Cell 84:331–334
   PubMed Web of Science ®Google Scholar
• Imada, K., Bloom, E. T., Nakajima, H., Horvath-Arcidiacono, J. A., Udy, G. B., Davey, H., and Leonard, W. J.. 1998. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188:2067–2074
   PubMed Web of Science ®Google Scholar
• John, S., Vinkemeier, U., Soldaini, E., Darnell, J. E.Jr., and Leonard, W. J.. 1999. The significance of tetramerization in promoter recruitment by Stat5. Mol. Cell. Biol. 19:1910–1918
   PubMed Web of Science ®Google Scholar
• Laskowski, R. A., Macarthur, M. W., Moss, D. S., and Thornton, J. M.. 1993. PROCHECK—a program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 26:283–291
   Web of Science ®Google Scholar
• Leonard, W. J., and O'Shea, J. J.. 1998. Jaks and STATs: Biological implications. Annu. Rev. Immunol. 16:293–322
   PubMed Web of Science ®Google Scholar
• Levitt, M., Hirshberg, M., Sharon, R., and Daggett, V.. 1995. Potential-energy function and parameters for simulations of the molecular-dynamics of proteins and nucleic-acids in solution. Comput. Phys. Commun. 91:215–231
   Web of Science ®Google Scholar
• Lin, J.-X., Mietz, J., Modi, W. S., John, S., and Leonard, W. J.. 1996. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J. Biol. Chem. 271:10738–10744
   PubMedGoogle Scholar
• Liu, X., Robinson, G. W., Gouilleux, F., Groner, B., and Hennighausen, L.. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 92:8831–8835
   PubMedGoogle Scholar
• Liu, X., Robinson, G. W., Wagner, K. U., Garrett, L., Wynshaw-Boris, A., and Hennighausen, L.. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 9:2266–2278
   Google Scholar
• Meeker, T. C., Loeb, J., Ayres, M., and Sellers, W.. 1990. The human Pim-1 gene is selectively transcribed in different hemato-lymphoid cell lines in spite of a G+C-rich housekeeping promoter. Mol. Cell. Biol. 10:1680–1688
   PubMedGoogle Scholar
• Meyer, W. K.-H., Reichenbach, P., Schindler, U., Soldaini, E., and Nabholz, M.. 1997. Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor α gene transcription. J. Biol. Chem. 272:31821–31828
   PubMedGoogle Scholar
• Mohamadi, F., Richards, N. G. J., Guida, W. C., Liskamp, R., Lipton, M., Caufield, C., Chang, G., Hendrickson, T., and Still, W. C.. 1990. MacroModel-An integrated software system for modeling organic and bioorganic molecules using molecular mechanics. J. Comput. Chem. 11:440–450
   Web of Science ®Google Scholar
• Moriggl, R., Topham, D. J., Teglund, S., Sexl, V., McKay, C., Wang, D., Hoffmeyer, A., van Deursen, J., Sangster, M. Y., Bunting, K. D., Grosveld, G. C., and Ihle, J. N.. 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249–259
   PubMedGoogle Scholar
• Mui, A. L., Wakao, H., O'Farrell, A. M., Harada, N., and Miyajima, A.. 1995. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologues. EMBO J. 14:1166–1175
   PubMed Web of Science ®Google Scholar
• Nakajima, H., Liu, X. W., Wynshaw-Boris, A., Rosenthal, L. A., Imada, K., Finbloom, D. S., Hennighausen, L., and Leonard, W. J.. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691–701
   PubMed Web of Science ®Google Scholar
• Needleman, S. B., and Wunsch, C. D.. 1970. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48:443–453
   PubMed Web of Science ®Google Scholar
• Pollock, R., and Treisman, R.. 1990. A sensitive method for the determination of protein-DNA binding specificities. Nucleic Acids Res. 18:6197–6204
   PubMed Web of Science ®Google Scholar
• Schindler, U., Wu, P., Rothe, M., Brasseur, M., and McKnight, S. L.. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689–697
   PubMed Web of Science ®Google Scholar
• Silva, C. M., and Lu, H.. 1996. Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. Mol. Endocrinol. 10:508–518
   PubMedGoogle Scholar
• Socolovsky, M., Fallon, A. E., Wang, S., Brugnara, C., and Lodish, H. F.. 1999. Fetal anemia and apoptosis of red cell progenitors in Stat5a−/−5b−/− mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 98:181–191
   PubMed Web of Science ®Google Scholar
• Teglund, S., McKay, C., Schuetz, E., van Dursen, J. M., Stravopodis, D., Wang, D., Brown, M., Bodner, S., Grosveld, G., and Ihle, J. N.. 1998. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841–850
   PubMed Web of Science ®Google Scholar
• Tijan, R., and Maniatis, T.. 1994. Transcriptional activation: a complex puzzle with few easy pieces. Cell 77:5–8
   PubMedGoogle Scholar
• Udy, G. B., Towers, R. P., Snell, R. G., Wilkins, R. J., Park, S.-H., Ram, P. A., Waxman, D. J., and Davey, H. W.. 1997. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 94:7239–7244
   PubMed Web of Science ®Google Scholar
• Verdier, F., Rabionet, R., Gouilleux, F., Beisenherz-Huss, C., Varlet, P., Muller, O., Mayeux, P., Lacombe, C., Gisselbrecht, S., and Chretien, S.. 1998. A sequence of the CIS promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B. Mol. Cell. Biol. 18:5852–5860
   PubMed Web of Science ®Google Scholar
• Vinkemeier, U., Cohen, S. L., Moarefi, I., Chait, B. T., Kuriyan, J., Darnell, J. E.Jr.. 1996. DNA binding of in vitro activated Stat1a, Stat1b and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 15:5616–5626
   PubMed Web of Science ®Google Scholar
• Vinkemeier, U., Moarefi, I., Darnell, J. E.Jr., and Kuriyan, J.. 1998. Structure of the amino-terminal protein interaction domain of Stat4. Science 279:1048–1052
   PubMed Web of Science ®Google Scholar
• Weiner, S. J., Kollman, P. A., Nguyen, D. T., and Case, D. A.. 1986. An all-atom force field for stimulation of protein and nucleic acids. J. Comput. Chem. 7:230–252
   PubMed Web of Science ®Google Scholar
• Xu, X., Sun, Y.-L., and Hoey, T.. 1996. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273:794–797
   PubMed Web of Science ®Google Scholar
• Ye, S.-K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I. L., Honjo, T., and Ikuta, K.. 1999. Induction of germline transcription in the TCRγ locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity 11:213–223
   PubMedGoogle Scholar