11
Views
94
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Involvement of p21Waf1/Cip1 in Protein Kinase C Alpha-Induced Cell Cycle Progression

&
Pages 4580-4590 | Received 14 Feb 2000, Accepted 15 Mar 2000, Published online: 28 Mar 2023

REFERENCES

  • Ahmad, S., Mineta, T., Martuza, R. L., and Glazer, R. I.. 1994. Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. Neurosurgery 35:904–909
  • Arita, Y., Buffolino, P., and Coppock, D. L.. 1998. Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity. Exp. Cell Res. 242:381–390
  • Baltuch, G. H., Shenouda, G., Langleben, A., and Villemure, J. H.. 1993. High dose tamoxifen in the treatment of recurrent high-grade glioma: a report of clinical stabilization and tumor regression. Can. J. Neurol. Sci. 20:168–170
  • Baltuch, G. H., Dooley, N. P., Couldwell, W. T., and Yong, V. W.. 1993. Staurosporine differentially inhibits glioma versus non-glioma cell lines. J. Neurooncol. 16:141–147
  • Baltuch, G. H., Dooley, N. P., Villemure, J.-G., and Yong, V. W.. 1995. Protein kinase C and growth regulation of malignant gliomas. Can. J. Neurol. Sci. 22:264–271
  • Begemann, M., Kashimawo, S. A., Choi, Y. J. A. et al. 1996. Inhibition of the growth of glioblastomas by CPG41251, an inhibitor of protein kinase C, and by phorbol ester tumor promoter. Clin. Cancer Res. 2:1017–1030
  • Burns, K. L., Ueki, K., Jhung, S. L., Koh, J., and Louis, D. N.. 1998. Molecular genetics correlates of p16, CDK4, and Rb immunochemistry in glioblastomas. J. Neuropathol. Exp. Neurol. 57:122–130
  • Cheng, M., Olivier, P., Dielh, J. A., Fero, M., Roussel, M. F., Roberts, J. M., and Sherr, C. J.. 1999. The p21(Cip1) and p27(Kip1) CDK ‘inhibitors’ are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571–1583
  • Costello, J. F., Plass, C., Arap, W., Chapman, V. M., Held, W. A., Berger, M. S., Huang, H. J. S., and Cavenee, W. K.. 1997. Cyclin dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 57:1250–1254
  • Couldwell, W. T., Antel, J. P., and Yong, V. W.. 1992. Protein kinase C activity correlates with the growth rate of malignant gliomas. II. Effect of glioma mitogens and modulators of PKC. Neurosurgery 31:717–724
  • Couldwell, W. T., Hinton, D. R., Surnock, A. A., DeGiorgio, C. M., Weiner, L. P., Apuzzo, M. L. J., Masri, L., and Weiss, M. H.. 1996. Treatment of recurrent malignant gliomas with chronic oral high dose tamoxifen. Clin. Cancer Res. 2:619–622
  • Dean, N., McKay, R., Miraglia, L., Howard, R., Cooper, S., Giddings, J., Nicklin, P., Meister, L., Ziel, R., Geiger, T., Muller, M., and Fabbro, D.. 1996. Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C alpha expression. Cancer Res. 56:3499–3507
  • Delphin, C., and Baudier, J.. 1994. The protein kinase C activator, phorbol ester, cooperates with wild type p53 species in ras transformed embryo fibroblasts growth arrest. J. Biol. Chem. 269:29579–29587
  • Dirks, P. B., Hubbard, S. L., Murakami, M., and Rutka, J. T.. 1997. Cyclin and cyclin-dependent kinase expression in human astrocytoma cell lines. J. Neuropathol. Exp. Neurol. 56:291–300
  • Estanyol, J. M., Jaumont, M., Casanovas, O., Rodriguez-Vilarrupla, A., Agell, N., and Bachs, O.. 1999. The protein SET regulates the inhibitory effect of p21/Cip1 on cyclin-E-cyclin dependent kinase-2 activity. J. Biol. Chem. 274:33161–33165
  • Fishman, D. D., Segal, S., and Livneh, E.. 1998. The role of protein kinase C in G1 and G2/M phases of the cell cycle. Int. J. Oncol. 12:181–186
  • Frey, M. R., Saxon, M. L., Zhao, X., Rollins, A., Evans, S. S., and Black, J. D.. 1997. Protein kinase C mediated cell cycle arrest involves induction of p21Waf1/Cip1 and p27Kip1 and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells. J. Biol. Chem. 272:9424–9435
  • Funk, J. O., Waga, S., Harry, J. B., Espling, E., Stillman, B., and Galloway, D. A.. 1997. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:2090–2100
  • Hamada, K., Takuwa, N., Zhou, W., Kumada, M., and Takuwa, Y.. 1993. Protein kinase C inhibits the CAK-CDK2 cyclin dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts. Biochim. Biophys. Acta 1310:149–156
  • Hass, R., Gunji, H., Hirano, M., Weichselbaum, R., and Kufe, D.. 1993. Phorbol ester induced monocytic differentiation is associated with G2 delay and down regulation of cdc25 expression. Cell Growth Differ. 4:159–166
  • He, J., Olson, J. J., and James, C. D.. 1995. Lack of p16INK4 or retinoblastoma protein (Rb), or amplification associated overexpression of CDK4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res. 55:4833–4836
  • Herman, J. G., Jen, J., Merlo, A., and Baylin, S. B.. 1996. Hypermethylation associated inactivation indicates a tumor suppressor role for p15/INK4b1. Cancer Res. 56:722–727
  • Hiyama, H., Iavarone, A., and Reeves, S. A.. 1998. Regulation of the CDK inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F. Oncogene 16:1513–1523
  • Jaken, S.. 1996. Protein kinase C isozymes and substrates. Curr. Opin. Cell Biol. 8:168–173
  • Jones, D. L., Alani, R. M., and Munger, K.. 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11:2101–2111
  • Jung, J. M., Bruner, J. M., Ruan, S., Langford, L. A., Kyritsis, A. P., Kobayashi, T., Levin, V. A., and Zhang, W.. 1995b. Increased levels of p21/Waf1/Cip1 in human brain tumors. Oncogene 11:2021–2028
  • Kazanietz, M. G., Areces, L. B., Bahador, A., Mischak, H., Goodnight, J., Mushinski, J. F., and Blumberg, P. M.. 1993. Characterization of ligand and substrate specificity for the calcium-dependent and calcium independent protein kinase C isozymes. Mol. Pharmacol. 44:298–307
  • Korkolopoulou, P., Kouzelis, K., Christodoulou, P., Papanikolaou, A., and Thomas-Tsagli, E.. 1998. Expression of retinoblastoma gene product and p21/Waf1/Cip1 protein in gliomas: correlations with proliferation markers, p53 expression and survival. Acta Neuropathol. 95:617–624
  • Kosaka, C., Sasaguri, T., Ishida, A., and Ogata, J.. 1996. Cell cycle arrest in G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells. Am. J. Physiol. 270:C170–C178
  • LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E.. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847–862
  • Li, S., MacLachlan, T. K., De Luca, A., Claudio, P. P., Condorelli, G., and Giordano, A.. 1995. The cdc-2 related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Res. 55:3992–3995
  • Livneh, E., Shimon, T., Bechor, E., Doki, Y., Schieren, I., and Weinstein, I. B.. 1996. Linking protein kinase C to the cell cycle: ectopic expression of PKC eta in NIH-3T3 cells alters the expression of cyclins and CDK inhibitors and induces adipogenesis. Oncogene 12:1545–1555
  • Livneh, E., and Fishman, D. D.. 1997. Linking protein kinase C to cell cycle control. Eur. J. Biochem. 248:1–9
  • Macleod, K. F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B., and Jacks, T.. 1995. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9:935–944
  • Mann, D. J., Higgins, T., Jones, N. C., and Rozengurt, E.. 1997. Differential control of cyclins D1 and D3 and the CDK inhibitor p27/Kip1 by diverse signaling pathways in Swiss 3T3 cells. Oncogene 14:1759–1766
  • Mantel, C., Luo, Z., Canfield, J., Braun, S., Deng, C., and Broxmeyer, H. E.. 1996. Involvement of p21Cip1 and p27Kip1 in the molecular mechanisms of Steel Factor induced proliferative synergy in vitro and of p21Cip1 in the maintenance of stem/progenitor cells in vivo. Blood 88:3710–3719
  • Mastronardi, L., Puzzilli, F., Couldwell, W. T., Farah, J. O., and Lunardi, P.. 1998. Tamoxifen and carboplatin combinational treatment of high-grade gliomas. J. Neurooncol. 38:59–68
  • Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J., and Kato, J.-Y.. 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14:2066–2076
  • Mellor, H., and Parker, P. J.. 1998. The extended protein kinase C superfamily. Biochem. J. 332:281–292
  • Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E., and Givol, D.. 1994. Induction of WAF1/CIP1 by a p53 independent pathway. Cancer Res. 54:3391–3395
  • Newton, A. C.. 1997. Regulation of protein kinase C. Curr. Opin. Cell Biol. 9:161–167
  • Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., Massague, J., Crabtree, G. R., and Roberts, J. M.. 1994. Interleukin-2 mediated elimination of the p27Kip1 cyclin dependent kinase inhibitor prevented by rapamycin. Nature 372:570–573
  • Pollack, I. F., and Kawecki, S.. 1997. The effect of Calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J. Neurooncol. 31:255–266
  • Ryves, W. J., Evans, A. T., Olivier, A. R., Parker, P. J., and Evans, F. J.. 1991. Activation of the PKC isotypes alpha, beta 1, gamma, delta, and epsilon by phorbol esters of different biological activities. FEBS Lett. 288:5–9
  • Sioud, M., and Sorensen, D. R.. 1998. A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth. Nat. Biotechnol. 16:556–561
  • Sonoda, Y., Yoshimoto, T., and Sekiya, T.. 1995. Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. Oncogene 11:2145–2149
  • Srivenugopal, K. S., and Ali-Osman, F.. 1996. Deletions and rearrangements inactivate the p16/INK4 gene in human glioma cells. Oncogene 12:2029–2034
  • Thompson, L. J., and Fields, A. P.. 1996. Beta2 protein kinase C is required for the G2/M transition of cell cycle. J. Biol. Chem. 271:15045–15053
  • Yazaki, T., Ahmad, S., Chablavi, A., Zylber-Katz, E., Dean, N. M., Rabkin, S. D., Martuza, R. L., and Glazer, R. I.. 1996. Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide. Mol. Pharmacol. 50:236–242
  • Yong, V. W., Dooley, N. P., and Noble, P. G.. 1994. Protein kinase C in cultured adult human oligodendrocytes: a potential role for isoform alpha as a mediator of process outgrowth. J. Neurosci. Res. 39:83–96
  • Zeng, Y.-X., and El-Deiry, W. S.. 1996. Regulation of p21/Waf1/Cip1 expression by p53 independent mechanisms. Oncogene 12:1557–1564
  • Zezula, J., Sexl, V., Hutter, C., Karel, A., Schutz, W., and Freissmuth, M.. 1997. The cyclin-dependent kinase inhibitor p21cip1 mediates the growth inhibitory effect of phorbol esters in human venous endothelial cells. J. Biol. Chem. 272:29967–29974
  • Zhang, H., Hannon, G. H., and Beach, D.. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750–1758

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.