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Cell Growth and Development

Dominant Active Alleles of RIM101(PRR2) Bypass the pH Restriction on Filamentation of Candida albicans

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Pages 4635-4647 | Received 29 Nov 1999, Accepted 11 Apr 2000, Published online: 28 Mar 2023

REFERENCES

  • Auger, P., and Joly, J.. 1977. Factors influencing germ tube production in Candida albicans. Mycopathologia 61:183–186
  • Boecke, J. P., LaCroute, F., and Fink, G. R.. 1984. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5′-fluoro-orotic acid resistance. Mol. Gen. Genet. 197:345–346
  • Brown, A. J. P., and Gow, N. A. R.. 1999. Regulatory network controlling Candida albicans morphogenesis. Trends Microbiol. 7:333–338
  • Buffo, J., Herman, M. A., and Soll, D. R.. 1984. A characterization of pH-regulated dimorphism in Candida albicans. Mycopathologia 85:21–30
  • Caddick, M. X., Brownlee, A. G., Arst, H. N.Jr.. 1986. Regulation of gene expression by pH of the growth medium in Aspergillus nidulans. Mol. Gen. Genet. 203:346–353
  • Davis, D., Wilson, R. B., and Mitchell, A. P.. 2000. RIM101-dependent and -independent pathways govern pH responses in Candida albicans. Mol. Cell. Biol. 20:971–978
  • De Bernardis, F., Mühlschlegel, F. A., Cassone, A., and Fonzi, W. A.. 1998. The pH of the host niche controls gene expression in and virulence of Candida albicans. Infect. Immun. 66:3317–3325
  • Do Carmo-Sousa, L.. Distribution of yeasts in nature The yeasts Alt, R., and Harrison, J. S. 1:79–105 Academic Press, London, U.K
  • Espeso, E. A., Roncal, T., Díez, E., Rainbow, L., Bignell, E., Álvaro, J., Suárez, T., Denison, S. H., Tilburn, J., Arst, H. N.Jr., and Peñalva, M. A.. 2000. 1969. On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction. EMBO J. 19:719–728
  • Evans, E. G., Odds, F. C., Richardson, M. D., and Holland, K. T.. 1974. Optimum conditions for initiation of filamentation in Candida albicans. Can. J. Microbiol. 21:338–342
  • Fonzi, W. A.. 1999. PHR1 and PHR2 of Candida albicans encode putative glycosidases required for proper cross-linking of β-1,3- and β-1,6-glucans. J. Bacteriol. 181:7070–7079
  • Fonzi, W. A., and Irwin, M. Y.. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717–728
  • Fridkin, S. K., and Jarvis, W. R.. 1996. Epidemiology of nosocomial fungal infections. Clin. Microbiol. Rev. 9:499–511
  • Gietz, D., Jean, A. S., Woods, R. A., and Schiestl, R. H.. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20: 1425
  • Gillum, A. M., Tsay, E. Y. H., and Kirsch, D. R.. 1984. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of Saccharomyces cerevisiae ura3 and E. coli pyrF mutations. Mol. Gen. Genet. 198:179–182
  • Heinz, W. J., Kurzai O., Brackhage A. A., Fonzi W. A., Korting H. C., Frosch M., and Mühlschlegel F. A.. Molecular responses to changes in the environmental pH are conserved between the fungal pathogens Candida dubliniensis and Candida albicans. Int. J. Med. Microbiol., in press.
  • Lambert, M., Blanchin-Roland, S., Le Louedec, F., Lépingle, A., and Gaillardin, C.. 1997. Genetic analysis of regulatory mutants affecting synthesis of extracellular proteinases in the yeast Yarrowia lipolytica: identification of a RIM101/pacC homolog. Mol. Cell. Biol. 17:3966–3976
  • Lee, K. L., Buckley, H. R., and Campell, C. C.. 1975. An amino acid liquid synthetic medium for development of mycelial and yeast forms of Candida albicans. Sabouraudia 13:148–153
  • Li, W., and Mitchell, A. P.. 1997. Proteolytic activation of Rimp1p, a positive regulator of yeast sporulation and invasive growth. Genetics 145:63–73
  • Liu, H., Köhler, J., and Fink, G. R.. 1994. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266:1723–1726
  • Lo, H. J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., and Fink, G. R.. 1997. Nonfilamentous Candida albicans mutants are avirulent. Cell 90:939–949
  • Mouyna, I., Fontaine M., Vai M., Monod M., Fonzi W. A., Diaquin M., Popolo L., Hartland R. P., and Latgé J. P.. 2000. GPI-anchored glucanosyltransferases play an active role in the biosynthesis of the fungal cell wall. J. Biol. Chem., in press.
  • Mühlschlegel, F. A., and Fonzi, W. A.. 1997. PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression. Mol. Cell. Biol. 17:5960–5967
  • Odds, F. C.. 1988. Candida and candidosis. Baillière Tindall, London, United Kingdom
  • Orejas, M., Espeso, E. A., Tilburn, J., Sarkar, S., Arst, H. N.Jr., and Peñalva, M. A.. 1995. Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety. Genes Dev. 9:1622–1632
  • Porta, A., Ramon, A. M., and Fonzi, W. A.. 1999. PRR1, the homolog of the Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicans. J. Bacteriol. 181:7516–7523
  • Ramon, A. M., Porta, A., and Fonzi, W. A.. 1999. Effect of environmental pH on morphological development of Candida albicans is mediated via the PacC-related transcription factor encoded by PRR2. J. Bacteriol. 181:7524–7530
  • Riggle, P. J., Andrutis, K. A., Chen, X., Tzipori, S. R., and Kumamoto, C. A.. 1999. Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture. Infect. Immun. 67:3649–3652
  • Saporito-Irwin, S. M., Birse, C. E., Sypherd, P. S., and Fonzi, W. A.. 1995. PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis. Mol. Cell. Biol. 15:601–613
  • Schorling, S. R., Korting H. C., Frosch M., and Mühlschlegel F. A.. The role of Candida dubliniensis in oral candidiasis in human immunodeficiency virus-infected individuals. Crit. Rev. Microbiol., in press.
  • Sentandreu, M., Elorza, M. V., Sentandreu, R., and Fonzi, W. A.. 1998. Cloning and characterization of PRA1, a gene encoding a novel pH-regulated antigen of Candida albicans. J. Bacteriol. 180:282–289
  • Sharkey, L. L., McNemar, M. D., Saporito-Irwin, S. M., Sypherd, P. S., and Fonzi, W. A.. 1999. HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J. Bacteriol. 181:5273–5279
  • Sherman, F., Fink, G. R., and Hicks, J. B.. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y
  • Sonneborn, A., Bockmühl, D. P., and Ernst, J. F.. 1999. Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator. Infect. Immun. 67:5514–5517
  • Sonneborn, A., Bockmühl, D. P., Gerads, M., Kurpanek, K., Sanglard, D., and Ernst, J.. 2000. Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans. Mol. Microbiol. 35:386–396
  • Staab, J. F., Bradway, S. D., Fidel, P. L., and Sundstrom, P.. 1999. Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283:1535–1538
  • Stoldt, V. R., Sonneborn, A., Leuker, C., and Ernst, J. F.. 1997. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J. 16:1982–1991
  • Su, S. S. Y., and Mitchell, A. P.. 1993. Molecular characterization of the yeast meiotic regulatory gene RIM1. Nucleic Acids Res. 21:3789–3797
  • Tilburn, J., Sarkar, S., Widdick, D. A., Espeso, E. A., Orejas, M., Mungroo, J., Peñalva, M. A., Arst, H. N.Jr.. 1995. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline expressed genes by ambient pH. EMBO J. 14:779–790
  • Wilson, R. B., Davis, D., and Mitchell, A. P.. 1999. Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol. 181:1868–1874

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