68
Views
132
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2

, , , , , , , & show all
Pages 6913-6922 | Received 22 Feb 2000, Accepted 30 May 2000, Published online: 28 Mar 2023

REFERENCES

  • Artavanis-Tsakonas, S., Rand, M. D., and Lake, R. J.. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770–776
  • Bettenhausen, B., Hrabe de Angelis, M., Simon, D., Guenet, J. L., and Gossler, A.. 1995. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121:2407–2418
  • Bigas, A., Martin, D. I., and Milner, L. A.. 1998. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol. Cell. Biol. 18:2324–2333
  • Blaumueller, C. M., Qi, H., Zagouras, P., and Artavanis-Tsakonas, S.. 1997. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90:281–291
  • Cohen, B., Bashirullah, A., Dagnino, L., Campbell, C., Fisher, W. W., Leow, C. C., Whiting, E., Ryan, D., Zinyk, D., Boulianne, G., Hui, C. C., Gallie, B., Phillips, R. A., Lipshitz, H. D., and Egan, S. E.. 1997. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat. Genet. 16:283–288
  • Conlon, R. A., Reaume, A. G., and Rossant, J.. 1995. Notch1 is required for the coordinate segmentation of somites. Development 121:1533–1545
  • De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R.. 1999. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518–522
  • Dunwoodie, S. L., Henrique, D., Harrison, S. M., and Beddington, R. S.. 1997. Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 124:3065–3076
  • Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., and Sklar, J.. 1991. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649–661
  • Felli, M. P., Maroder, M., Mitsiadis, T. A., Campese, A. F., Bellavia, D., Vacca, A., Mann, R. S., Frati, L., Lendahl, U., Gulino, A., and Screpanti, I.. 1999. Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int. Immunol. 11:1017–1025
  • Fleming, R. J., Gu, Y., and Hukriede, N. A.. 1997. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124:2973–2981
  • Fleming, R. J., Scottgale, T. N., Diederich, R. J., and Artavanis-Tsakonas, S.. 1990. The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4:2188–2201
  • Fortini, M. E., Rebay, I., Caron, L. A., and Artavanis-Tsakonas, S.. 1993. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365:555–557
  • Greenwald, I.. 1998. LIN-12/Notch signaling: lessons from worms and flies. Genes Dev. 12:1751–1762
  • Gu, Y., Hukriede, N. A., and Fleming, R. J.. 1995. Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121:855–865
  • Hamada, Y., Kadokawa, Y., Okabe, M., Ikawa, M., Coleman, J. R., and Tsujimoto, Y.. 1999. Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development 126:3415–3424
  • Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., and Ish-Horowicz, D.. 1995. Expression of a Delta homologue in prospective neurons in the chick. Nature 375:787–790
  • Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R., and Israel, A.. 1995. Signalling downstream of activated mammalian Notch. Nature 377:355–358
  • Jarriault, S., Le, B. O., Hirsinger, E., Pourquie, O., Logeat, F., Strong, C. F., Brou, C., Seidah, N. G., and Isra, I. A.. 1998. Delta-1 activation notch-1 signaling results in HES-1 transactivation. Mol. Cell. Biol. 18:7423–7431
  • Jen, W. C., Wettstein, D., Turner, D., Chitnis, A., and Kintner, C.. 1997. The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos. Development 124:1169–1178
  • Jiang, R., Lan, Y., Chapman, H. D., Shawber, C., Norton, C. R., Serreze, D. V., Weinmaster, G., and Gridley, T.. 1998. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12:1046–1057
  • Katakura, Y., Seto, P., Ohashi, H., Teruya, K., and Shirahata, S.. Cytotechnology 31:103–109
  • Kidd, S., Baylies, M. K., Gasic, G. P., and Young, M. W.. 1989. 1999. Structure and distribution of the Notch protein in developing Drosophila. Genes Dev. 3:1113–1129
  • Kidd, S., Lieber, T., and Young, M. W.. 1998. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev. 12:3728–3740
  • Klein, T., and Arias, A. M.. 1998. Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development. Development 125:2951–2962
  • Kopan, R., Nye, J. S., and Weintraub, H.. 1994. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120:2385–2396
  • Kopan, R., and Weintraub, H.. 1993. Mouse notch: expression in hair follicles correlates with cell fate determination. J. Cell. Biol. 121:631–641
  • Kopczynski, C. C., Alton, A. K., Fechtel, K., Kooh, P. J., and Muskavitch, M. A.. 1988. Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes Dev. 2:1723–1735
  • Kuroda, K., Tani, S., Tamura, K., Minoguchi, S., Kurooka, H., and Honjo, T.. 1999. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J. Biol. Chem. 274:7238–7244
  • Lardelli, M., Williams, R., Mitsiadis, T., and Lendahl, U.. 1996. Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mech. Dev. 59:177–190
  • Lewis, A. K., Frantz, G. D., Carpenter, D. A., de Sauvage, F. J., and Gao, W. Q.. 1998. Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear. Mech. Dev. 78:159–163
  • Li, L., Milner, L. A., Deng, Y., Iwata, M., Banta, A., Graf, L., Marcovina, S., Friedman, C., Trask, B. J., Hood, L., and Torok, S. B.. 1998. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity 8:43–55
  • Lieber, T., Kidd, S., Alcamo, E., Corbin, V., and Young, M. W.. 1993. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7:1949–1965
  • Lin, A., Frost, J., Deng, T., Smeal, T., al-Alawi, N., Kikkawa, U., Hunter, T., Brenner, D., and Karin, M.. 1992. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1. Cell 70:777–789
  • Lindsell, C. E., Boulter, J., diSibio, G., Gossler, A., and Weinmaster, G.. 1996. Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. Mol. Cell. Neurosci. 8:14–27
  • Lindsell, C. E., Shawber, C. J., Boulter, J., and Weinmaster, G.. 1995. Jagged: a mammalian ligand that activates Notch1. Cell 80:909–917
  • Luo, B., Aster, J. C., Hasserjian, R. P., Kuo, F., and Sklar, J.. 1997. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17:6057–6067
  • Manak, J. R., de Bisschop, N., Kris, R. M., and Prywes, R.. 1990. Casein kinase II enhances the DNA binding activity of serum response factor. Genes Dev. 4:955–967
  • Milner, L. A., Bigas, A., Kopan, R., Brashem, S. C., Bernstein, I. D., and Martin, D. I.. 1996. Inhibition of granulocytic differentiation by mNotch1. Proc. Natl. Acad. Sci. USA 93:13014–13019
  • Minoguchi, S., Taniguchi, Y., Kato, H., Okazaki, T., Strobl, L. J., Zimber-Strobl, U., Bornkamm, G. W., and Honjo, T.. 1997. RBP-L, a transcription factor related to RBP-Jkappa. Mol. Cell. Biol. 17:2679–2687
  • Nofziger, D., Miyamoto, A., Lyons, K. M., and Weinmaster, G.. 1999. Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development 126:1689–1702
  • Nye, J. S., Kopan, R., and Axel, R.. 1994. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 120:2421–2430
  • Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F., and Kageyama, R.. 1999. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 18:2196–2207
  • Panin, V. M., Papayannopoulos, V., Wilson, R., and Irvine, K. D.. 1997. Fringe modulates Notch-ligand interactions. Nature 387:908–912
  • Pui, J. C., Allman, D., Xu, L., DeRocco, S., Karnell, F. G., Bakkour, S., Lee, J. Y., Kadesch, T., Hardy, R. R., Aster, J. C., and Pear, W. S.. 1999. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11:299–308
  • Reaume, A. G., Conlon, R. A., Zirngibl, R., Yamaguchi, T. P., and Rossant, J.. 1992. Expression analysis of a Notch homologue in the mouse embryo. Dev. Biol. 154:377–387
  • Robey, E., Chang, D., Itano, A., Cado, D., Alexander, H., Lans, D., Weinmaster, G., and Salmon, P.. 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483–492
  • Schroeter, E. H., Kisslinger, J. A., and Kopan, R.. 1998. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382–386
  • Shawber, C., Boulter, J., Lindsell, C. E., and Weinmaster, G.. 1996. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev. Biol. 180:370–376
  • Shimizu, K., Chiba, S., Kumano, K., Hosoya, N., Takahashi, T., Kanda, Y., Hamada, Y., Yazaki, Y., and Hirai, H.. 1999. Mouse Jagged1 physically interacts with Notch2 and other notch receptors: assessment by quantitative methods. J. Biol. Chem. 274:32961–32969
  • Struhl, G., and Adachi, A.. 1998. Nuclear access and action of notch in vivo. Cell 93:649–660
  • Struhl, G., Fitzgerald, K., and Greenwald, I.. 1993. Intrinsic activity of the Lin-12 and Notch Intracellular domains in vivo. Cell 74:331–345
  • Swiatek, P. J., Lindsell, C. E., del Amo, F. F., Weinmaster, G., and Gridley, T.. 1994. Notch1 is essential for postimplantation development in mice. Genes Dev. 8:707–719
  • Takebayashi, K., Akazawa, C., Nakanishi, S., and Kageyama, R.. 1995. Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. J. Biol. Chem. 270:1342–1349
  • Takebayashi, K., Sasai, Y., Sakai, Y., Watanabe, T., Nakanishi, S., and Kageyama, R.. 1994. Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J. Biol. Chem. 269:5150–5156
  • Uyttendaele, H., Marazzi, G., Wu, G., Yan, Q., Sassoon, D., and Kitajewski, J.. 1996. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122:2251–2259
  • Valsecchi, C., Ghezzi, C., Ballabio, A., and Rugarli, E. I.. 1997. JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. Mech. Dev. 69:203–207
  • Vargesson, N., Patel, K., Lewis, J., and Tickle, C.. 1998. Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb. Mech. Dev. 77:197–199
  • Washburn, T., Schweighoffer, E., Gridley, T., Chang, D., Fowlkes, B. J., Cado, D., and Robey, E.. 1997. Notch activity influences the alphabeta versus gammadelta T cell lineage decision. Cell 88:833–843
  • Weinmaster, G.. 1997. The ins and outs of notch signaling. Mol. Cell. Neurosci. 9:91–102
  • Weinmaster, G., Roberts, V. J., and Lemke, G.. 1991. A homolog of Drosophila Notch expressed during mammalian development. Development 113:199–205
  • Weinmaster, G., Roberts, V. J., and Lemke, G.. 1992. Notch2: a second mammalian Notch gene. Development 116:931–941
  • Wharton, K. A., Johansen, K. M., Xu, T., and Artavanis-Tsakonas, S.. 1985. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43:567–581
  • Xue, Y., Gao, X., Lindsell, C. E., Norton, C. R., Chang, B., Hicks, C., Gendron-Maguire, M., Rand, E. B., Weinmaster, G., and Gridley, T.. 1999. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum. Mol. Genet. 8:723–730
  • Zagouras, P., Stifani, S., Blaumueller, C. M., Carcangiu, M. L., and Artavanis-Tsakonas, S.. 1995. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc. Natl. Acad. Sci. USA 92:6414–6418

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.