Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism

REFERENCES

• Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J., and Ronai, Z.. 1999. Regulation of JNK signaling by GSTp. EMBO J. 18:1321–1334
   PubMed Web of Science ®Google Scholar
• Alvarez, M. E., Pennell, R. I., Meijer, P. J., Ishikawa, A., Dixon, R. A., and Lamb, C.. 1998. Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity. Cell 92:773–784
   PubMed Web of Science ®Google Scholar
• Auer, K. L., Contessa, J., Brenz-Verca, S., Pirola, L., Rusconi, S., Cooper, G., Abo, A., Wymann, M. P., Davis, R. J., Birrer, M., and Dent, P.. 1998. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell 9:561–573
   PubMedGoogle Scholar
• Avruch, J.. 1998. Insulin signal transduction through protein kinase cascades. Mol. Cell. Biochem. 182:31–48
   PubMed Web of Science ®Google Scholar
• Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I. C., Tekle, E., Chock, P. B., and Rhee, S. G.. 1997. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J. Biol. Chem. 272:217–221
   PubMed Web of Science ®Google Scholar
• Bae, G. U., Seo, D. W., Kwon, H. K., Lee, H. Y., Hong, S., Lee, Z. W., Ha, K. S., Lee, H. W., and Han, J. W.. 1999. Hydrogen peroxide activates p70(S6k) signaling pathway. J. Biol. Chem. 274:32596–32602
   PubMed Web of Science ®Google Scholar
• Banfi, B., Maturana, A., Jaconi, S., Arnaudeau, S., Laforge, T., Sinha, B., Ligeti, E., Demaurex, N., and Krause, K. H.. 2000. A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287:138–142
   PubMed Web of Science ®Google Scholar
• Beckman, K. B., and Ames, B. N.. 1998. The free radical theory of aging matures. Physiol. Rev. 78:547–581
   PubMed Web of Science ®Google Scholar
• Biaglow, J. E., Cerniglia, G., Tuttle, S., Bakanauskas, V., Stevens, C., and McKenna, G.. 1997. Effect of oncogene transformation of rat embryo cells on cellular oxygen consumption and glycolysis. Biochem. Biophys. Res. Commun. 235:739–742
   PubMedGoogle Scholar
• Boveris, A., and Chance, B.. 1973. The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem. J. 134:707–716
   PubMed Web of Science ®Google Scholar
• Cai, J., and Jones, D. P.. 1998. Superoxide in apoptosis: mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 273:11401–11404
   PubMed Web of Science ®Google Scholar
• Carter, H., Jones, A. M., and Doust, J. H.. 2000. Changes in blood lactate and pyruvate concentrations and the lactate-to-pyruvate ratio during the lactate minimum speed test. J. Sports Sci. 18:213–225
   PubMed Web of Science ®Google Scholar
• De Bleser, P. J., Xu, G., Rombouts, K., Rogiers, V., and Geerts, A.. 1999. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J. Biol. Chem. 274:33881–33887
   PubMed Web of Science ®Google Scholar
• Finkel, T.. 1998. Oxygen radicals and signaling. Curr. Opin. Cell Biol. 10:248–253
   PubMed Web of Science ®Google Scholar
• Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., and Alexander, R. W.. 1994. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res. 74:1141–1148
   PubMed Web of Science ®Google Scholar
• Guidarelli, A., Brambilla, L., Clementi, E., Sciorati, C., and Cantoni, O.. 1997. Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tertbutylhydroperoxide-induced DNA single-strand breaks. Exp. Cell Res. 237:176–185
   PubMed Web of Science ®Google Scholar
• Guinovart, J. J., Salavert, A., Massague, J., Ciudad, C. J., Salsas, E., and Itarte, E.. 1979. Glycogen synthase: a new activity ratio assay expressing a high sensitivity to the phosphorylation state. FEBS Lett. 106:284–288
   PubMed Web of Science ®Google Scholar
• Haring, H.. 1995. Pathophysiology of insulin resistance. Herz 20:5–15
   PubMedGoogle Scholar
• Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P. J.. 1997. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275:1649–1652
   PubMed Web of Science ®Google Scholar
• Joneson, T., and Bar-Sagi, D.. 1998. A Rac1 effector site controlling mitogenesis through superoxide production. J. Biol. Chem. 273:17991–17994
   PubMed Web of Science ®Google Scholar
• Kheradmand, F., Werner, E., Tremble, P., Symons, M., and Werb, Z.. 1998. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science 280:898–902
   PubMed Web of Science ®Google Scholar
• Kwong, L. K., and Sohal, R. S.. 1998. Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria. Arch. Biochem. Biophys. 350:118–126
   PubMed Web of Science ®Google Scholar
• Lander, H. M.. 1997. An essential role for free radicals and derived species in signal transduction. FASEB J. 11:118–124
   PubMed Web of Science ®Google Scholar
• Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z. X., Ferrans, V. J., Howard, B. H., and Finkel, T.. 1999. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274:7936–7940
   PubMed Web of Science ®Google Scholar
• Lee, S. R., Kwon, K. S., Kim, S. R., and Rhee, S. G.. 1998. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J. Biol. Chem. 273:15366–15372
   PubMed Web of Science ®Google Scholar
• Mallet, R. T.. 2000. Pyruvate: metabolic protector of cardiac performance. Proc. Soc. Exp. Biol. Med. 223:136–148
   PubMed Web of Science ®Google Scholar
• Min, D. S., Kim, E. G., and Exton, J. H.. 1998. Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts. J. Biol. Chem. 273:29986–29994
   PubMedGoogle Scholar
• Moxham, C. M., Tabrizchi, A., Davis, R. J., and Malbon, C. C.. 1996. Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo. J. Biol. Chem. 271:30765–30773
   PubMedGoogle Scholar
• Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H. P., Giardino, I., and Brownlee, M.. 2000. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787–790
   PubMed Web of Science ®Google Scholar
• Nohl, H., and Hegner, D.. 1978. Do mitochondria produce oxygen radicals in vivo? Eur. J. Biochem. 82:563–567
   PubMedGoogle Scholar
• Pracyk, J. B., Tanaka, K., Hegland, D. D., Kim, K. S., Sethi, R., Rovira, I. I., Blazina, D. R., Lee, L., Bruder, J. T., Kovesdi, I., Goldschmidt-Clermont, P. J., Irani, K., and Finkel, T.. 1998. A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. J. Clin. Investig. 102:929–937
   PubMed Web of Science ®Google Scholar
• Rhee, S. G.. 1999. Redox signaling: hydrogen peroxide as intracellular messenger. Exp. Mol. Med. 31:53–59
   PubMed Web of Science ®Google Scholar
• Sohal, R. S., and Weindruch, R.. 1996. Oxidative stress, caloric restriction, and aging. Science 273:59–63
   PubMed Web of Science ®Google Scholar
• Standaert, M. L., Bandyopadhyay, G., Antwi, E. K., and Farese, R. V.. 1999. RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes: comparison to actions of insulin. Endocrinology 140:2145–2151
   PubMedGoogle Scholar
• Suh, Y. A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., and Lambeth, J. D.. 1999. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401:79–82
   PubMed Web of Science ®Google Scholar
• Sulciner, D. J., Irani, K., Yu, Z. X., Ferrans, V. J., Goldschmidt-Clermont, P., and Finkel, T.. 1996. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation. Mol. Cell. Biol. 16:7115–7121
   PubMedGoogle Scholar
• Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K., and Finkel, T.. 1995. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270:296–299
   PubMed Web of Science ®Google Scholar
• Sundaresan, M., Yu, Z. X., Ferrans, V. J., Sulciner, D. J., Gutkind, J. S., Irani, K., Goldschmidt-Clermont, P. J., and Finkel, T.. 1996. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem. J. 318Pt. 2379–382
   PubMedGoogle Scholar
• Trotti, D., Danbolt, N. C., and Volterra, A.. 1998. Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? Trends Pharmacol. Sci. 19:328–334
   PubMed Web of Science ®Google Scholar
• Ushio-Fukai, M., Alexander, R. W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., and Griendling, K. K.. 1999. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 274:22699–22704
   PubMed Web of Science ®Google Scholar
• Wallace, D. C., and Melov, S.. 1998. Radicals r'aging. Nat. Genet. 19:105–106
   PubMed Web of Science ®Google Scholar
• Zhao, Y., Bjorbaek, C., Weremowicz, S., Morton, C. C., and Moller, D. E.. 1995. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol. Cell. Biol. 15:4353–4363
   PubMed Web of Science ®Google Scholar