8
Views
36
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Transcriptional Repression by Drosophila Methyl-CpG-Binding Proteins

, , , , , , & show all
Pages 7401-7409 | Received 06 Jan 2000, Accepted 06 Jul 2000, Published online: 28 Mar 2023

REFERENCES

  • Baylin, S. B.. 1997. Tying it all together: epigenetics, genetics, cell cycle, and cancer. Science 277:1948–1949
  • Bestor, T. H., and Verdine, G. L.. 1994. DNA methyltransferases. Curr. Opin. Cell Biol. 6:380–389
  • Bhattacharya, S. K., Ramchandani, S., Cervoni, N., and Szyf, M.. 1999. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 397:579–583
  • Bird, A., and Wolffe, A. P.. 1999. Methylation-induced repression—belts, braces, and chromatin. Cell 99:451–454
  • Chen, G., Fernandez, J., Mische, S., and Courey, A. J.. 1999. A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development. Genes Dev. 13:2218–2230
  • Courey, A. J., and Tjian, R.. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887–898
  • Fujita, N., Takebayashi, S.-I., Okumura, K., Kudo, S., Chiba, T., Saya, H., and Nakao, M.. 1999. Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms. Mol. Cell. Biol. 19:6415–6426
  • Hendrich, B., and Bird, A.. 1998. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18:6538–6547
  • Hung, M. S., Karthikeyan, N., Huang, B., Koo, H.-C., Kiger, J., and Shen, C.-K. J.. 1999. Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases. Proc. Natl. Acad. Sci. USA 96:11940–11945
  • Imai, S.-I., Armstrong, C. M., Kaeberlein, M., and Guarente, L.. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795–800
  • Jin, S., and Scotto, K. W.. 1998. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol. Cell. Biol. 18:4377–4384
  • Jones, P. A., and Gonzalgo, M. L.. 1997. Altered DNA methylation and genome instability—a new pathway to cancer? Proc. Natl. Acad. Sci. USA 94:2103–2105
  • Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., and Wolffe, A. P.. 1998. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 19:187–191
  • Jost, J. P., and Saluz, H. P.. 1993. DNA methylation: molecular and biological significance. Birkhäuser Verlag, Basel, Switzerland
  • Kudo, S.. 1998. Methyl-CpG-binding protein MeCP2 represses SP1-activated transcription of the human leukosialin gene when the promoter is methylated. Mol. Cell. Biol. 18:5492–5499
  • Laird, P. W., and Jaenisch, R.. 1996. The role of DNA methylation in cancer genetic and epigenetics. Annu. Rev. Genet. 30:441–464
  • Luo, R. X., Postigo, A. A., and Dean, D. C.. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92:463–473
  • Lyko, F., Ramsahoye, B. H., Kashevsky, H., Tudor, M., Mastrangelo, M.-A., Orr-Weaver, T. L., and Jaenisch, R.. 1999. Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat. Genet. 23:363–366
  • MacGregor, G. R., and Caskey, C. T.. 1989. Construction of plasmids that express E. coli beta-galactosidase in mammalian cells. Nucleic Acids Res. 17: 2365
  • Mertineit, C., Yoder, J. A., Taketo, T., Laird, D. W., Trasler, J. M., and Bestor, T. H.. 1998. Sex-specific exons control DNA methyltransferase in mammalian germ cells. Development 125:889–897
  • Nan, X., Campoy, F. J., and Bird, A.. 1987. MeCp2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88:471–481
  • Nan, X., Meehan, R. R., and Bird, A.. 1993. Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucleic Acids Res. 21:4886–4892
  • Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., and Bird, A.. 1998. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386–389
  • Ng, H.-H., Zhang, Y., Hendrich, B., Johnson, C. A., Turner, B. M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., and Bird, A.. 1999. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat. Genet. 23:58–61
  • Ng, H.-H., Jeppesen, P., and Bird, A.. 2000. Active repression of methylated genes by the chromosomal protein MBD1. Mol. Cell. Biol. 20:1394–1406
  • Okano, M., Xie, S., and Li, E.. 1998. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 26:2536–2540
  • Okano, M., Bell, D. W., Haber, D. A., and Li, E.. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247–257
  • Patel, C. V., and Gopinathan, K. P.. 1987. Determination of trace amounts of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography. Anal. Biochem. 164:164–169
  • Sadowski, I., and Ptashne, M.. 1989. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17: 7539
  • Sambrook, J., Fritsch, E. F., and Maniatis, T.. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
  • Tweedie, S., Ng, H.-H., Barlow, A. L., Turner, B. M., Hendrich, B., and Bird, A.. 1989. 1999. Vestiges of a DNA methylation system in Drosophila melanogaster? Nat. Genet. 23:389–390
  • Urieli-Shoval, S., Gruenbaum, Y., Sedat, J., and Razin, A.. 1982. The absence of detectable methylated bases in Drosophila melanogaster DNA. FEBS Lett. 146:148–152
  • Van Lint, C., Emiliani, S., and Verdin, E.. 1996. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr. 5:245–253
  • Wade, P. A., Gegonne, A., Jones, P. L., Ballestar, E., Aubry, F., and Wolffe, A. P.. 1999. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat. Genet. 23:62–66
  • Walsh, C. P., and Bestor, T. H.. 1999. Cytosine methylation and mammalian development. Genes Dev. 13:26–34
  • Xiao, H., Hasegawa, T., and Isobe, K.-I.. 1999. Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells. J. Cell. Biochem. 73:291–302
  • Yu, F., Thiesen, J., and Stratling, W. H.. 2000. Histone-deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res. 28:2201–2206

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.