32
Views
75
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn

, &
Pages 1426-1435 | Received 25 Jun 1999, Accepted 16 Nov 1999, Published online: 28 Mar 2023

REFERENCES

  • Abraham, N., Miceli, M. C., Parnes, J. R., and Veillette, A.. 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature 350:62–66
  • Appleby, M. W., Gross, J. A., Cooke, M. P., Levin, S. D., Qian, X., and Perlmutter, R. M.. 1992. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70:751–763
  • Boussiotis, V. A., Barber, D. L., Lee, B. J., Gribben, J. G., Freeman, G. J., and Nadler, L. M.. 1996. Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J. Exp. Med. 184:365–376
  • Cantrell, D.. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14:259–274
  • Chan, A. C., Dalton, M., Johnson, R., Kong, G. H., Wang, T., Thoma, R., and Kurosaki, T.. 1995. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14:2499–2508
  • Chan, A. C., Iwashima, M., Turck, C. W., and Weiss, A.. 1992. ZAP-70: a 70-kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71:649–662
  • Clements, J. L., Yang, B., Ross-Barta, S. E., Eliason, S. L., Hrstka, R. F., Williamson, R. A., and Koretzky, G. A.. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281:416–419
  • Cooke, M. P., Abraham, K. M., Forbush, K. A., and Perlmutter, R. M.. 1991. Regulation of thymocyte signal transduction by a non-receptor protein tyrosine kinase, p59fyn(T). Cell 65:281–292
  • Cooke, M. P., and Perlmutter, R. M.. 1989. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. New Biol. 1:66–74
  • Denny, M. F., Kaufman, H. C., Chan, A. C., and Straus, D. B.. 1999. The Lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling. J. Biol. Chem. 274:5146–5152
  • Duplay, P., Thome, M., Herve, F., and Acuto, O.. 1994. p56lck interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp. Med. 179:1163–1172
  • Fang, N., Motto, D. G., Ross, S. E., and Koretzky, G. A.. 1996. Tyrosines 113, 118, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. J. Immunol. 157:3769–3773
  • Finco, T. S., Kadlecek, T., Zhang, W., Samelson, L. E., and Weiss, A.. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 9:617–626
  • Gauen, L. K., Kong, A.-N., Samelson, L. E., and Shaw, A. S.. 1992. p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain. Mol. Cell. Biol. 12:5438–5446
  • Gossen, M., and Bujard, H.. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547–5551
  • Groves, T., Smiley, P., Cooke, M., Forbush, K., Perlmutter, R., and Guidos, C.. 1996. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5:417–428
  • Grynkiewicz, G., Poenie, M., and Tsien, R. Y.. 1985. A new generation of Ca++ indicators with greatly improved fluorescent properties. J. Biol. Chem. 260:3440–3448
  • Hampl, J., Chien, Y.-H., and Davis, M. M.. 1997. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7:379–385
  • Haughn, L., Gratton, S., Caron, L., Sekaly, R., Veillette, A., and Julius, M.. 1992. Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the αβ T-cell receptor. Nature 358:328–331
  • Hemmer, B., Stefanova, I., Vergelli, M., Germain, R. N., and Martin, R.. 1998. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J. Immunol. 160:5807–5814
  • Irving, B. A., Chan, A. C., and Weiss, A.. 1993. Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain. J. Exp. Med. 177:1093–1103
  • Iwashima, M., Irving, B. A., van Oers, N., Chan, A., and Weiss, A.. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136–1139
  • Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M., and Schwartz, R. H.. 1987. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc. Natl. Acad. Sci. USA 84:5409–5413
  • Katagiri, T., Urakawa, K., Yamanashi, Y., Semba, K., Takahashi, T., Toyoshima, K., Yamamoto, T., and Kano, K.. 1989. Overexpression of src family gene for tyrosine-kinase p59fyn in CD4−CD8− T cells of mice with a lymphoproliferative disorder. Proc. Natl. Acad. Sci. USA 86:10064–10068
  • Kersh, E. N., Shaw, A. S., and Allen, P. M.. 1998. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 281:572–575
  • Kolanus, W., Romeo, C., and Seed, B.. 1993. T cell activation by clustered tyrosine kinases. Cell 74:171–183
  • Kong, G., Dalton, M., Wardenburg, J. B., Straus, D., Kurosaki, T., and Chan, A. C.. 1996. Distinct tyrosine phosphorylation sites within ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol. Cell. Biol. 16:5026–5035
  • Liu, J., Kang, H., Raab, M., da Silva, A. J., Kraeft, S.-K., and Rudd, C. E.. 1998. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc. Natl. Acad. Sci. USA 95:8779–8784
  • Luo, K., and Sefton, B. M.. 1992. Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells. Mol. Cell. Biol. 12:4724–4732
  • Madrenas, J., Chau, L. A., Smith, J., Bluestone, J. A., and Germain, R. N.. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185:219–229
  • Madrenas, J., Wange, R. L., Wang, J. L., Isakov, N., Samelson, L., and Germain, R. N.. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515–518
  • Marie-Cardine, A., Bruyns, E., Eckerskorn, C., Kirchgessner, H., Meuer, S. C., and Schraven, B.. 1997. Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J. Biol. Chem. 272:16077–16080
  • Marie-Cardine, A., Hendricks-Taylor, L. R., Boerth, N. J., Zhao, H., Schraven, B., and Koretzky, G. A.. 1998. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP130. J. Biol. Chem. 273:25789–25795
  • Marth, J. D., Lewis, D. B., Wilson, C. B., Gearn, M. E., Krebs, E. G., and Perlmutter, R. M.. 1987. Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J. 6:2727–2734
  • Molina, T. J., Kishihara, K., Siderovski, D. P., van Ewijk, W., Narendran, A., Timms, E., Wakeham, A., Paige, C. J., Hartmann, K. U., Veillette, A., Davidson, D., and Mak, T. W.. 1992. Profound block in thymocyte development in mice lacking p56lck. Nature 357:161–164
  • Musci, M. A., Hendricks-Taylor, L. R., Motto, D. G., Paskind, M., Kamens, J., Turck, C. W., and Koretzky, G. A.. 1997. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J. Biol. Chem. 272:11674–11677
  • Negishi, I., Motoyama, N., Nakayama, K. I., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A. C., and Loh, D. Y.. 1995. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376:435–438
  • Olszowy, M. W., Leuchtmann, P. L., Veillette, A., and Shaw, A. S.. 1995. Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines. J. Immunol. 155:4236–4240
  • Pivniouk, V., Tsitsikov, E., Swinton, P., Rathburn, G., and Alt, F. W.. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94:229–238
  • Posner, B., Faure, R., Burgess, J., Bevan, P., Lachance, D., Zhang-Sun, G., Fantus, G., Ng, J., Hall, D., Lum, B., and Shaver, A.. 1994. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J. Biol. Chem. 269:4596–4604
  • Qian, D., Lev, S., van Oers, N., Dikic, I., Schlessinger, J., and Weiss, A.. 1997. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med. 185:1253–1259
  • Qian, D., and Weiss, A.. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205–212
  • Quill, H., Riley, M., Cho, E., Casnellie, J., Reed, J., and Torigoe, T.. 1992. Anergic Th1 cells express altered levels of the protein tyrosine kinases p56Lck and p59Fyn. J. Immunol. 149:2887–2893
  • Raab, M., da Silva, A. J., Findell, P. R., and Rudd, C. E.. 1997. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCRζ/CD3 induction. Immunity 6:155–164
  • Raab, M., Kang, H., da Silva, A., Zhu, X., and Rudd, C. E.. 1999. FYN-T-FYB-SLP-76 interactions define a T-cell receptor ζ/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells. J. Biol. Chem. 274:21170–21179
  • Samelson, L. E., Phillips, A. F., Luong, E. T., and Klausner, R. D.. 1990. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87:4358–4362
  • Sloan-Lancaster, J., Evavold, B. D., and Allen, P. M.. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156–159
  • Sloan-Lancaster, J., Shaw, A. S., Rothbard, J. B., and Allen, P. M.. 1994. Partial T cell signaling: altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy. Cell 79:913–922
  • Stein, P. L., Lee, H.-M., Rich, S., and Soriano, P.. 1992. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741–750
  • Straus, D., and Weiss, A.. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585–593
  • Straus, D. B., Chan, A. C., Patai, B., and Weiss, A.. 1996. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271:9976–9981
  • Taylor, S. J., and Shalloway, D.. 1996. Cell cycle-dependent activation of Ras. Curr. Biol. 6:1621–1627
  • van Oers, N., Killeen, N., and Weiss, A.. 1996. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183:1053–1062
  • van Oers, N., Lowin-Kropf, B., Finlay, D., Connolly, K., and Weiss, A.. 1996. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5:429–436
  • Wange, R., and Samelson, L.. 1996. Complex complexes: signaling at the TCR. Immunity 5:197–205
  • Wange, R. L., Guitian, R., Isakov, N., Watts, J. D., Aebersold, R., and Samelson, L. E.. 1995. Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270:18730–18733
  • Wange, R. L., Malek, S. N., Desiderio, S., and Samelson, L. E.. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3ɛ from activated Jurkat T cells. J. Biol. Chem. 268:19797–19801
  • Wardenburg, J., Fu, C., Jackman, J., Flotow, H., Wilkinson, S., Williams, D., Johnson, R., Kong, G., Chan, A., and Findell, P.. 1996. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J. Biol. Chem. 271:19641–19644
  • Weiss, A., and Stobo, J. D.. 1984. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J. Exp. Med. 160:1284–1299
  • Williams, B. L., Schreiber, K. L., Zhang, W., Wange, R. L., Samelson, L. E., Leibson, P. J., and Abraham, R. T.. 1998. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol. Cell. Biol. 18:1388–1399
  • Yablonski, D., Kuhne, M. R., Kadlecek, T., and Weiss, A.. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76 deficient T cell. Science 281:413–416
  • Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, J., and Samelson, L. E.. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83–92
  • Zhang, W., Sommers, C. L., Burshtyn, D. N., Stebbins, C. C., DeJarnette, J. B., Trible, R. P., Grinberg, A., Tsay, H. C., Jabobs, H. M., Kessler, C. M., Long, E. O., Love, P. E., and Samelson, L. E.. 1999. Essential role of LAT in T cell development. Immunity 10:323–332

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.