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DNA Dynamics and Chromosome Structure

DNA Interstrand Cross-Links Induce Futile Repair Synthesis in Mammalian Cell Extracts

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Pages 2446-2454 | Received 01 Dec 1999, Accepted 06 Jan 2000, Published online: 27 Mar 2023

REFERENCES

  • Bessho, T., Mu, D., and Sancar, A.. 1997. Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5′ to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand. Mol. Cell. Biol. 17:6822–6830
  • Bessho, T., Sancar, A., Thompson, L. H., and Thelen, M. P.. 1997. Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex. J. Biol. Chem. 272:3833–3837
  • Cheng, S. A., Sancar, A., and Hearst, J. E.. 1991. RecA-dependent incision of psoralen-DNA crosslinked DNA by (A)BC excinuclease. Nucleic Acids Res. 19:657–663
  • Cimino, G. D., Gamper, H. B., Isaacs, S. T., and Hearst, J. E.. 1985. Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry. Annu. Rev. Biochem. 54:1151–1193
  • Cole, R. S.. 1973. Repair of DNA containing interstrand cross-links in Escherichia coli: sequential excision and recombination. Proc. Natl. Acad. Sci. USA 70:1064–1068
  • Collins, A. R.. 1993. Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristics. Mutat. Res. 293:99–118
  • Dooley, P. A., Tsarouhtsis, D., Nechev, L. V., Kowaszyk, A., Stone, M. P., and Harris, T. M.. 1997. Synthesis and structural studies of the saturated analog of malondialdehyde crosslink in a synthetic oligonucleotide. Proc. Am. Assoc. Cancer Res. 38:334–335
  • Faruqi, A. F., Datta, H. J., Carroll, D., Seidman, M., and Glazer, P. M.. 2000. Triple-helix formation induces recombination in mammalian cells via a nucleotide excision repair-dependent pathway. Mol. Cell. Biol. 20:990–1000
  • Fink, S. P., Reddy, G. R., and Marnett, L. J.. 1997. Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde. Proc. Natl. Acad. Sci. USA 94:8652–8657
  • Fishman-Lobell, J., and Haber, J. E.. 1992. Removal of nonhomologous DNA ends in double-strand break recombination: the role of the yeast ultraviolet repair gene RAD1. Science 258:480–484
  • Hanawalt, P. C.. 1995. DNA repair comes of age. Mutat. Res. 336:101–113
  • Henricksen, L. A., Umbricht, G. B., and Wold, M. S.. 1994. Recombinant replication protein A: expression, complex formation, and functional characterization. J. Biol. Chem. 269:11121–11132
  • Hoy, C. A., Thompson, L. H., Mooney, C. L., and Salazar, E. P.. 1985. Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents. Cancer Res. 45:1737–1743
  • Huang, J. C., Svoboda, D. L., Reardon, J. T., and Sancar, A.. 1992. Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5′ and the 6th phosphodiester bond 3′ to the photodimer. Proc. Natl. Acad. Sci. USA 89:3664–3668
  • Jachymczyk, W. J., von Borstel, R. C., Mowat, M. R., and Hastings, P. J.. 1981. Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 system. Mol. Gen. Genet. 182:196–205
  • Johnson, R. D., Liu, N., and Jasin, M.. 1999. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature 401:397–399
  • Kohn, K. W.. 1996. Beyond DNA cross-linking: history and prospect of DNA-targeted cancer treatment. Cancer Res. 56:5533–5546
  • Li, L., Peterson, C. A., Lu, X., Wei, P., and Legerski, R. J.. 1999. Interstrand cross-links induced DNA synthesis in damaged and undamaged plasmids in mammalian cell extract. Mol. Cell. Biol. 19:5619–5630
  • Liu, N., Lamerdin, J. E., Tebbs, R. S., Schild, D., Tucker, J. D., Shen, M. R., Brookman, K. W., Siciliano, M. J., Walter, C. A., Fan, W., Narayana, L. S., Zhou, Z. Q., Adamson, A. W., Sorensen, K. J., Chen, D. J., Jones, N. J., and Thompson, L. H.. 1998. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol. Cell 1:783–793
  • Magana-Schwencke, N., Henriques, J. A., Chanet, R., and Moustacchi, E.. 1982. The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strains. Proc. Natl. Acad. Sci. USA 79:1722–1726
  • Matsunaga, T., Mu, D., Park, C.-H., Reardon, J. T., and Sancar, A.. 1995. Human DNA repair excision nuclease: analysis of the role of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies. J. Biol. Chem. 270:20862–20869
  • Matsunaga, T., Park, C.-H., Bessho, T., Mu, D., and Sancar, A.. 1996. Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease. J. Biol. Chem. 271:11047–11050
  • McCutchen-Maloney, S. L., Giannecchini, C. A., Hwang, M. H., and Thelen, M. P.. 1999. Domain mapping of the DNA binding, endonuclease, and ERCC1 binding properties of the human DNA repair protein XPF. Biochemistry 38:9417–9425
  • Michel, B., Ehrlich, S. D., and Uzest, M.. 1997. DNA double-strand breaks caused by replication arrest. EMBO J. 16:430–438
  • Modrich, P.. 1997. Strand-specific mismatch repair in mammalian cells. J. Biol. Chem. 272:24727–24730
  • Mu, D., Hsu, D. S., and Sancar, A.. 1996. Reaction mechanism of human DNA repair excision nuclease. J. Biol. Chem. 271:8285–8294
  • Mu, D., Tursun, M., Duckett, D. R., Drummond, J. T., Modrich, P., and Sancar, A.. 1997. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. Mol. Cell. Biol. 17:760–769
  • Mukai, F. H., and Goldstein, B. D.. 1976. Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids. Science 191:868–869
  • Pierce, A. J., Johnson, R. D., Thompson, L. H., and Jasin, M.. 1999. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 13:2633–2638
  • Reardon, J. T., Spielmann, H. P., Huang, J. C., Sastry, S., Hearst, J. E., and Sancar, A.. 1991. Removal of psoralen monoadduct and crosslinks by human cell free extracts. Nucleic Acids Res. 19:4623–4629
  • Russell, P.. 1998. Checkpoints on the road to mitosis. Trends Biochem. Sci. 24:399–402
  • Sladek, F. M., Munn, M. M., Rupp, W. D., and Howard-Flanders, P.. 1989. In vitro repair of psoralen-DNA cross-links by RecA, UvrABC, and the 5′-exonuclease of DNA polymerase I. J. Biol. Chem. 264:6755–6765
  • Spielmann, H. P., Sastry, S. S., and Hearst, J. E.. 1992. Methods for the large scale synthesis of psoralen furan-side monoadducted and diadducts. Proc. Natl. Acad. Sci. USA 89:4514–4518
  • Svoboda, D. L., Taylor, J. S., Hearst, J. E., and Sancar, A.. 1993. DNA repair by eukaryotic nucleotide excision nuclease: removal of thymine dimer and psoralen monoadduct by HeLa cell free extract and of thymine dimer by Xenopus oocytes. J. Biol. Chem. 268:1931–1936
  • Thompson, L. H.. 1996. Evidence that mammalian cells possess homologous recombinational repair pathway. Mutat. Res. 363:77–88
  • Thompson, L. H., and Schild, D.. 1999. The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81:87–105
  • Van Houten, B., Gamper, H., Holbrook, S. R., Hearst, J. E., and Sancar, A.. 1986. Action mechanism of ABC excision nuclease on a DNA substrate containing a psoralen crosslink at a defined position. Proc. Natl. Acad. Sci. USA. 83:8077–8081

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