Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia

REFERENCES

• Abu-Shaar, M., H. D. Ryoo, and R. S. Mann. 1999. Control of the nuclear localization of extradenticle by competing nuclear import and export signals. Genes Dev. 13:935–945.
   PubMedGoogle Scholar
• Azpiazu, N., and G. Morata. 1998. Functional and regulatory interactions between Hox and extradenticle genes. Genes Dev. 12:261–273.
   PubMedGoogle Scholar
• Berthelsen, J., C. Kilstrup-Nielsen, F. Blasi, F. Mavilio, and V. Zappavigna. 1999. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev. 13:946–953.
   PubMed Web of Science ®Google Scholar
• Berthelsen, J., V. Zappavigna, E. Feretti, F. Mavilio, and F. Blasi. 1998. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 17:1434–1445.
   PubMedGoogle Scholar
• Berthelsen, J., V. Zappavigna, F. Mavilio, and F. Blasi. 1998. Prep1, a novel functional partner of Pbx proteins. EMBO J. 17:1423–1433.
   PubMedGoogle Scholar
• Borrow, J., A. M. Shearman, V. P. Stanton, R. Becher, T. Collins, A. J. Williams, I. D. Dubé, F. Katz, Y. L. Kwong, C. Morris, K. Ohyashiki, K. Toyama, J. Rowley, and D. E. Housman. 1996. The t(7;11)(p15;p15) translocation in acute myeloid leukemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat. Genet. 12:159–167.
   PubMed Web of Science ®Google Scholar
• Calvo, K. R., D. B. Sykes, M. Pasillas, and M. P. Kamps. 2000. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced Meis expression. Mol. Cell. Biol. 20:3274–3285.
   PubMed Web of Science ®Google Scholar
• Chang, C. P., Y. Jacobs, T. Nakamura, N. A. Jenkins, N. G. Copeland, and M. L. Cleary. 1997. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17:5679–5687.
   PubMed Web of Science ®Google Scholar
• Ferreti, E., H. Marshall, H. Pöpperl, H. Maconochie, R. Krumlauf, F. Blasi, and J. Berthelsen. 2000. Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Development 127:155–166.
   PubMedGoogle Scholar
• Ferreti, E., H. Schulz, D. Talarico, and F. Blasi. 1999. The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech. Dev. 83:53–64.
   PubMedGoogle Scholar
• Giampaolo, A., P. Sterpetti, D. Bulocrini, P. Samoggia, P. Pelosi, F. Valtieri, and C. Peschle. 1994. Key functional role and lineage-specific expression of HOXB cluster genes in purified hematopoietic progenitor differentiation. Blood 84:3637–3647.
   PubMed Web of Science ®Google Scholar
• Golub, T. R., D. K. Slonim, P. Tamayo, C. Huard, M. Gaasenbeek, J. P. Mesirov, H. Coller, M. L. Loh, J. R. Downing, M. A. Caligiuri, C. D. Bloomfield, and E. S. Lander. 1999. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286:531–537.
   PubMed Web of Science ®Google Scholar
• Hawley, R. G., A. Z. Fong, M. D. Reis, N. Zhang, M. Lu, and T. S. Hawley. 1997. Transforming function of the HOX11/TCL3 homeobox gene. Cancer Res. 57:337–345.
   PubMed Web of Science ®Google Scholar
• Jacobs, Y., C. A. Schnabel, and M. L. Cleary. 1999. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol. Cell. Biol. 19:5134–5142.
   PubMed Web of Science ®Google Scholar
• Jaw, T. J., L.-R. You, P. S. Knoepfler, L.-C. Yao, C.-Y. Pai, C.-Y. Tang, L.-P. Chang, J. Berthelsen, F. Blasi, M. P. Kamps, and Y. H. Sun. 2000. Direct interaction of two homeoproteins, Homothorax and Extradenticle, is essential for EXD nuclear localization and function. Mech. Dev. 91:279–291.
   PubMedGoogle Scholar
• Kamps, M. P., C. Murre, X. H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547–555.
   PubMed Web of Science ®Google Scholar
• Kroon, E., J. Krosl, U. Thorsteinsdottir, S. Baban, A. M. Buchberg, and G. Sauvageau. 1998. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 17:3714–3725.
   PubMed Web of Science ®Google Scholar
• Krosl, J., S. Baban, G. Krosl, S. Rozenfeld, C. Largman, and G. Sauvageau. 1998. Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1. Oncogene 16:3403–3412.
   PubMed Web of Science ®Google Scholar
• Look, A. T.. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278:1059–1064.
   PubMed Web of Science ®Google Scholar
• Mann, R. S.. 1995. The specificity of homeotic gene function. Bioessays 17:855–863.
   PubMedGoogle Scholar
• Monica, K., D. P. LeBrun, D. A. Dedera, R. Brown, and M. L. Cleary. 1994. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol. Cell. Biol. 14:8304–8314.
   PubMed Web of Science ®Google Scholar
• Moskow, J. J., F. Bullrich, K. Huebner, I. O. Daar, and A. M. Buchberg. 1995. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell. Biol. 15:5434–5443.
   PubMed Web of Science ®Google Scholar
• Nakamura, T., N. A. Jenkins, and N. G. Copeland. 1996. Identification of a new family of Pbx-related homeobox genes. Oncogene 15:2235–2242.
   Google Scholar
• Nakamura, T., D. A. Largaespada, M. P. Lee, L. A. Johnson, K. Ohyashiki, K. Toyama, S. J. Chen, C. L. Willman, I. M. Chen, A. P. Feinberg, N. A. Jenkins, N. G. Copeland, and J. D. Shaughnessy. 1996. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15; p15) in human myeloid leukaemia. Nat. Genet. 12:154–158.
   PubMed Web of Science ®Google Scholar
• Nakamura, T., D. A. Largaespada, J. D. Shaughnessy, N. A. Jenkins, and N. G. Copeland. 1996. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat. Genet. 12:149–153.
   PubMed Web of Science ®Google Scholar
• Nourse, J., J. D. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, S. D. Smith, and M. C. Cleary. 1990. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535–546.
   PubMed Web of Science ®Google Scholar
• Pai, C. Y., T. S. Kuo, T. J. Jaw, E. Kurant, C. T. Chen, D. A. Bessarab, A. Salzberg, and Y. H. Sun. 1998. The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila. Genes Dev. 12:446
   Google Scholar
• Perkins, A. C., and S. Cory. 1993. Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. EMBO J. 12:3835–3846.
   PubMedGoogle Scholar
• Pöpperl, H., M. Bienz, M. Studer, S.-K. Chan, S. Aparicio, R. S. Mann, and R. Krumlauf. 1995. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell 81:1031–1042.
   PubMed Web of Science ®Google Scholar
• Rieckhof, G. E., F. Casares, H. D. Ryoo, M. Abu-Shaar, and R. S. Mann. 1997. Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell 91:171–183.
   PubMedGoogle Scholar
• Ryoo, H. D., T. Marty, F. Casares, M. Affolter, and R. S. Mann. 1999. Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. Development 126:5137–5148.
   PubMedGoogle Scholar
• Sauvageau, G., P. M. Lansdorp, C. J. Eaves, D. E. Hogge, W. H. Dragowska, D. S. Reid, C. Largman, H. J. Lawrence, and R. K. Humphries. 1994. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc. Natl. Acad. Sci. USA 91:12223–12227.
   PubMed Web of Science ®Google Scholar
• Sauvageau, G., U. Thorsteinsdottir, C. J. Eaves, H. J. Lawrence, C. Largman, P. M. Lansdorp, and R. K. Humphries. 1995. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev. 9:1753–1765.
   PubMed Web of Science ®Google Scholar
• Sauvageau, G., U. Thorsteinsdottir, M. R. Hough, P. Hugo, H. J. Lawrence, C. Largman, and R. K. Humphries. 1997. Over-expression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. Immunity 6:13–22.
   PubMed Web of Science ®Google Scholar
• Schnabel, C. A., Y. Jacobs, and M. L. Cleary. 2000. HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis. Oncogene 19:608–616.
   PubMed Web of Science ®Google Scholar
• Shen, W. F., J. C. Montgomery, S. Rozenfeld, J. J. Moskow, H. J. Lawrence, A. M. Buchberg, and C. Largman. 1997. The AbdB-like proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol. Cell. Biol. 17:6448–6458.
   PubMed Web of Science ®Google Scholar
• Shen, W.-F., S. Rozenfeld, A. Kwong, L. G. Kömüves, H. J. Lawrence, and C. Largman. 1999. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Mol. Cell. Biol. 19:3051–3061.
   PubMed Web of Science ®Google Scholar
• Thorsteinsdottir, U., J. Krosl, E. Kroon, A. Haman, T. Hoang, and G. Sauvageau. 1999. The oncogene E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells. Mol. Cell. Biol. 19:6355–6366.
   PubMedGoogle Scholar
• Thorsteinsdottir, U., G. Sauvageau, M. R. Hough, H. J. Lawrence, C. Largman, and R. K. Humphries. 1997. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol. Cell. Biol. 17:495–505.
   PubMed Web of Science ®Google Scholar
• Thorsteinsdottir, U., G. Sauvageau, and R. K. Humphries. 1997. Hox homeobox genes as regulators of normal and leukemic hematopoiesis. Hematol. Oncol. Clin. N. Am. 11:1221–1237.
   PubMed Web of Science ®Google Scholar