11
Views
28
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Different Domains of the Essential GTPase Cdc42p Required for Growth and Development of Saccharomyces cerevisiae

, &
Pages 235-248 | Received 21 Aug 2000, Accepted 03 Oct 2000, Published online: 28 Mar 2023

REFERENCES

  • Adams, A. E., and J. R. Pringle. 1991. Staining of actin with fluorochrome-conjugated phalloidin. Methods Enzymol. 194:729–731.
  • Benton, B. K., A. Tinkelenberg, I. Gonzalez, and F. R. Cross. 1997. Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol. Cell. Biol. 17:5067–5076.
  • Bi, E., J. B. Chiavetta, H. Chen, G. C. Chen, C. S. Chan, and J. R. Pringle. 2000. Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Mol. Biol. Cell 11:773–793.
  • Brown, J. L., M. Jaquenoud, M. P. Gulli, J. Chant, and M. Peter. 1997. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev. 11:2972–2982.
  • Cali, B. M., T. C. Doyle, D. Botstein, and G. R. Fink. 1998. Multiple functions for actin during filamentous growth of Saccharomyces cerevisiae. Mol. Biol. Cell 9:1873–1889.
  • Chen, G. C., Y. J. Kim, and C. S. Chan. 1997. The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae. Genes Dev. 11:2958–2971.
  • Chen, G. C., L. Zheng, and C. S. Chan. 1996. The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:1376–1390.
  • Cross, F. R., and A. H. Tinkelenberg. 1991. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell 65:875–883.
  • Cvrckova, F., C. De Virgilio, E. Manser, J. R. Pringle, and K. Nasmyth. 1995. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev. 9:1817–1830.
  • Davis, C. R., T. J. Richman, S. B. Deliduka, J. O. Blaisdell, C. C. Collins, and D. I. Johnson. 1998. Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant lethal cdc42G12V and dominant negative cdc42D118A mutations. J. Biol. Chem. 273:849–858.
  • Eby, J. J., S. P. Holly, F. van Drogen, A. V. Grishin, M. Peter, D. G. Drubin, and K. J. Blumer. 1998. Actin cytoskeleton organization regulated by the PAK family of protein kinases. Curr. Biol. 8:967–970.
  • Epp, J. A., and J. Chant. 1997. An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast. Curr. Biol. 7:921–929.
  • Evangelista, M., K. Blundell, M. S. Longtine, C. J. Chow, N. Adames, J. R. Pringle, M. Peter, and C. Boone. 1997. Bni1p, a yeast formin linking Cdc42p and the actin cytoskeleton during polarized morphogenesis. Science 276:118–122.
  • Feltham, J. L., V. Dotsch, S. Raza, D. Manor, R. A. Cerione, M. J. Sutcliffe, G. Wagner, and R. E. Oswald. 1997. Definition of the switch surface in the solution structure of Cdc42Hs. Biochemistry 36:8755–8766.
  • Fujiwara, T., K. Tanaka, E. Inoue, M. Kikyo, and Y. Takai. 1999. Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:8016–8027.
  • Fujiwara, T., K. Tanaka, A. Mino, M. Kikyo, K. Takahashi, K. Shimizu, and Y. Takai. 1998. Rho1p-Bni1p-Spa2p interactions: implication in localization of Bni1p at the bud site and regulation of the actin cytoskeleton in Saccharomyces cerevisiae. Mol. Biol. Cell 9:1221–1233.
  • Gimeno, C. J., P. O. Ljungdahl, C. A. Styles, and G. R. Fink. 1992. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68:1077–1090.
  • Guarente, L.. 1983. Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. Methods Enzymol. 101:181–191.
  • Guex, N., and M. C. Peitsch. 1997. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18:2714–2723.
  • Guthrie, C., and G. R. Fink. 1991. Methods in enzymology 194. Guide to yeast genetics and molecular biology, Academic Press, San Diego, Calif
  • Gyuris, J., E. Golemis, H. Chertkov, and R. Brent. 1993. Cdi1, a Human G1 and S Phase Protein Phosphatase That Associates with Cdk2. Cell 75:791–803.
  • Imamura, H., K. Tanaka, T. Hihara, M. Umikawa, T. Kamei, K. Takahashi, T. Sasaki, and Y. Takai. 1997. Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J. 16:2745–2755.
  • Jansen, R.-P., C. Dowzer, C. Michaelis, M. Galova, and K. Nasmyth. 1996. Mother cell-specific HO expression in budding yeast depends on the unconventional Myo4p and other cytoplasmic proteins. Cell 84:687–697.
  • Johnson, D. I.. 1999. Cdc42: an essential rho-type GTPase controlling eukaryotic cell polarity. Microbiol. Mol. Biol. Rev. 63:54–105.
  • Kozminski, K. G., A. J. Chen, A. A. Rodal, and D. G. Drubin. 2000. Functions and functional domains of the GTPase Cdc42p. Mol. Biol. Cell 11:339–354.
  • Kübler, E., H.-U. Mösch, S. Rupp, and M. P. Lisanti. 1997. Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J. Biol. Chem. 272:20321–20323.
  • Leberer, E., C. Wu, T. Leeuw, A. Fourest-Lieuvin, J. E. Segall, and D. Y. Thomas. 1997. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16:83–97.
  • Li, R.. 1997. Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton. J. Cell Biol. 136:649–658.
  • Li, R., B. Debreceni, B. Jia, Y. Gao, G. Tigyi, and Y. Zheng. 1999. Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42. J. Biol. Chem. 274:29648–29654.
  • Lippincott, J., and R. Li. 1998. Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J. Cell Biol. 140:355–366.
  • Liu, H., C. A. Styles, and G. R. Fink. 1993. Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262:1741–1744.
  • Lo, W. S., and A. M. Dranginis. 1998. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae. Mol. Biol. Cell 9:161–171.
  • Loh, A. P., W. Guo, L. K. Nicholson, and R. E. Oswald. 1999. Backbone dynamics of inactive, active, and effector-bound Cdc42Hs from measurements of 15N relaxation parameters at multiple field strengths. Biochemistry 38:12547–12557.
  • Lorenz, M. C., and J. Heitman. 1997. Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J. 16:7008–7018.
  • Mackay, D. J., and A. Hall. 1998. Rho GTPases. J. Biol. Chem. 273:20685–20688.
  • Martin, H., A. Mendoza, J. M. Rodriguez-Pachon, M. Molina, and C. Nombela. 1997. Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase. Mol. Microbiol. 23:431–444.
  • Miller, P. J., and D. I. Johnson. 1997. Characterization of the Saccharomyces cerevisiae cdc42–1ts allele and new temperature-conditional-lethal cdc42 alleles. Yeast 13:561–572.
  • Mösch, H.-U., and G. R. Fink. 1997. Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145:671–684.
  • Mösch, H.-U., R. Graf, and G. H. Braus. 1992. Sequence-specific initiator elements focus initiation of transcription to distinct sites in the yeast TRP4 promoter. EMBO J. 11:4583–4590.
  • Mösch, H.-U., E. Kübler, S. Krappmann, G. R. Fink, and G. H. Braus. 1999. Crosstalk between the Ras2p-controlled mitogen-activated protein kinase and cAMP pathways during invasive growth of Saccharomyces cerevisiae. Mol. Biol. Cell 10:1325–1335.
  • Mösch, H.-U., R. L. Roberts, and G. R. Fink. 1996. Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5352–5356.
  • Naqvi, S. N., R. Zahn, D. A. Mitchell, B. J. Stevenson, and A. L. Munn. 1998. The WASP homologue Las17p functions with the WIP homologue End5p/verprolin and is essential for endocytosis in yeast. Curr. Biol. 8:959–962.
  • Nassar, N., G. R. Hoffman, D. Manor, J. C. Clardy, and R. A. Cerione. 1998. Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat. Struct. Biol. 5:1047–1052.
  • Oehlen, L. J., and F. R. Cross. 1998. The role of Cdc42 in signal transduction and mating of the budding yeast Saccharomyces cerevisiae. J. Biol. Chem. 273:8556–8559.
  • Osman, M. A., and R. A. Cerione. 1998. Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates Cdc42p effects on the actin cytoskeleton. J. Cell Biol. 142:443–455.
  • Owen, D., H. R. Mott, E. D. Laue, and P. N. Lowe. 2000. Residues in Cdc42 that specify binding to individual CRIB effector proteins. Biochemistry 39:1243–1250.
  • Peter, M., A. M. Neiman, H. O. Park, H. van Lohuizen, and I. Herskowitz. 1996. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15:7046–7059.
  • Pringle, J. R.. 1991. Staining of bud scars and other cell wall chitin with calcofluor. Methods Enzymol. 194:732–735.
  • Richman, T. J., M. M. Sawyer, and D. I. Johnson. 1999. The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. J. Biol. Chem. 274:16861–16870.
  • Rittinger, K., P. A. Walker, J. F. Eccleston, K. Nurmahomed, D. Owen, E. Laue, S. J. Gamblin, and S. J. Smerdon. 1997. Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature 388:693–697.
  • Roberts, R. L., and G. R. Fink. 1994. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev. 8:2974–2985.
  • Roberts, R. L., H.-U. Mösch, and G. R. Fink. 1997. 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89:1055–1065.
  • Rudolph, M. G., A. Wittinghofer, and I. R. Vetter. 1999. Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal. Protein Sci. 8:778–787.
  • Rupp, S., E. Summers, H. J. Lo, H. Madhani, and G. R. Fink. 1999. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J. 18:1257–1269.
  • Shannon, K. B., and R. Li. 1999. The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. Mol. Biol. Cell 10:283–296.
  • Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27.
  • Simon, M. N., C. De Virgilio, B. Souza, J. R. Pringle, A. Abo, and S. I. Reed. 1995. Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Nature 376:702–705.
  • Sloat, B. F., A. Adams, and J. R. Pringle. 1981. Roles of the CDC24 gene product in cellular morphogenesis during the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 89:395–405.
  • Stevenson, B. J., B. Ferguson, C. De Virgilio, E. Bi, J. R. Pringle, G. Ammerer, and G. F. Sprague Jr.. 1995. Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev. 9:2949–2963.
  • Umikawa, M., K. Tanaka, T. Kamei, K. Shimizu, H. Imamura, T. Sasaki, and Y. Takai. 1998. Interaction of Rho1p target Bni1p with F-actin-binding elongation factor 1alpha: implication in Rho1p-regulated reorganization of the actin cytoskeleton in Saccharomyces cerevisiae. Oncogene 16:2011–2016.
  • Ward, M. P., C. J. Gimeno, G. R. Fink, and S. Garrett. 1995. SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Mol. Cell. Biol. 15:6854–6863.
  • Zahner, J. E., H. A. Harkins, and J. R. Pringle. 1996. Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 16:1857–1870.
  • Zhao, Z., T. Leung, E. Manser, and L. Lim. 1995. Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. Mol. Cell. Biol. 15:5246–5257.
  • Zheng, Y., R. Cerione, and A. Bender. 1994. Control of the yeast bud-site assembly GTPase Cdc42: catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3. J. Biol. Chem. 269:2369–2372.
  • Ziman, M., J. M. O'Brien, L. A. Ouellette, W. R. Church, and D. I. Johnson. 1991. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. Mol. Cell. Biol. 11:3537–3544.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.