DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

REFERENCES

• Badie, C., G. Iliakis, N. Foray, G. Alsbeih, B. Cedervall, N. Chavaudra, G. Pantelias, C. Arlett, and E. P. Malaise. 1995. Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines. Radiat. Res. 144:26–35.
   PubMed Web of Science ®Google Scholar
• Badie, C., G. Iliakis, N. Foray, G. Alsbeih, G. E. Pantellias, R. Okayasu, N. Cheong, N. S. Russell, A. C. Begg, C. F. Arlett, et al.. 1995. Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient. Cancer Res. 55:1232–1234.
   PubMed Web of Science ®Google Scholar
• Baumann, P., and S. C. West. 1998. DNA end-joining catalyzed by human cell-free extracts. Proc. Natl. Acad. Sci. USA 95:14066–14070.
   PubMed Web of Science ®Google Scholar
• Bishop, D. K., U. Ear, A. Bhattacharyya, C. Calderone, M. Beckett, R. R. Weichselbaum, and A. Shinohara. 1998. Xrcc3 is required for assembly of Rad51 complexes in vivo. J. Biol. Chem. 273:21482–21488.
   PubMed Web of Science ®Google Scholar
• Boulton, S. J., and S. P. Jackson. 1996. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15:5093–5103.
   PubMed Web of Science ®Google Scholar
• Bravo, R., and H. Macdonald-Bravo. 1987. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J. Cell Biol. 105:1549–1554.
   PubMed Web of Science ®Google Scholar
• Bressan, D. A., B. K. Baxter, and J. H. J. Petrini. 1999. The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:7681–7687.
   PubMedGoogle Scholar
• Brown, J. M., J. W. Evans, and M. S. Kovacs. 1993. Mechanism of chromosome exchange formation in human fibroblasts: insights from “chromosome painting.”. Environ. Mol. Mutagen. 22:218–224.
   PubMedGoogle Scholar
• Carney, J. P., R. S. Maser, H. Olivares, E. M. Davis, M. Le Beau, J. R. Yates 3rd, L. Hays, W. F. Morgan, and J. H. J. Petrini. 1998. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93:477–486.
   PubMed Web of Science ®Google Scholar
• Critchlow, S. E., and S. P. Jackson. 1998. DNA end-joining: from yeast to man. Trends Biochem. Sci. 23:394–398.
   PubMed Web of Science ®Google Scholar
• Difilippantonio, M. J., J. Zhu, H. T. Chen, E. Meffre, M. C. Nussenzweig, E. E. Max, T. Ried, and A. Nussenzweig. 2000. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404:510–514.
   PubMed Web of Science ®Google Scholar
• Dimitrova, D. S., I. T. Todorov, T. Melendy, and D. M. Gilbert. 1999. Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex. J. Cell Biol. 146:709–722.
   PubMed Web of Science ®Google Scholar
• Dolganov, G. M., R. S. Maser, A. Novikov, L. Tosto, S. Chong, D. A. Bressan, and J. H. J. Petrini. 1996. Human Rad50 is physically associated with hMre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol. 16:4832–4841.
   PubMed Web of Science ®Google Scholar
• Dong, Z., Q. Zhong, and P. L. Chen. 1999. The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J. Biol. Chem. 274:19513–19516.
   PubMedGoogle Scholar
• Featherstone, C., and S. P. Jackson. 1999. DNA double-strand break repair. Curr. Biol. 9:R759–R761.
   PubMed Web of Science ®Google Scholar
• Featherstone, C., and S. P. Jackson. 1999. Ku, a DNA repair protein with multiple cellular functions?. Mutat. Res. 434:3–15.
   PubMedGoogle Scholar
• Flygare, J., F. Benson, and D. Hellgren. 1996. Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes. Biochim. Biophys. Acta 1312:231–236.
   PubMedGoogle Scholar
• Gao, Y., Y. Sun, K. M. Frank, P. Dikkes, Y. Fujiwara, K. J. Seidl, J. M. Sekiguchi, G. A. Rathbun, W. Swat, J. Wang, R. T. Bronson, B. A. Malynn, M. Bryans, C. Zhu, J. Chaudhuri, L. Davidson, R. Ferrini, T. Stamato, S. H. Orkin, M. E. Greenberg, and F. W. Alt. 1998. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95:891–902.
   PubMed Web of Science ®Google Scholar
• Gatei, M., D. Young, K. M. Cerosaletti, A. Desai-Mehta, K. Spring, S. Kozlov, M. F. Lavin, R. A. Gatti, P. Concannon, and K. Khanna. 2000. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25:115–119.
   PubMed Web of Science ®Google Scholar
• Getts, R. C., and T. D. Stamato. 1994. Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J. Biol. Chem. 269:15981–15984.
   PubMed Web of Science ®Google Scholar
• Goedecke, W., M. Eijpe, H. H. Offenberg, M. van Aalderen, and C. Heyting. 1999. Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat. Genet. 23:194–198.
   PubMedGoogle Scholar
• Gu, Y., K. J. Seidl, G. A. Rathbun, C. Zhu, J. P. Manis, N. van der Stoep, L. Davidson, H. L. Cheng, J. M. Sekiguchi, K. Frank, P. Stanhope-Baker, M. S. Schlissel, D. B. Roth, and F. W. Alt. 1997. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7:653–665.
   PubMed Web of Science ®Google Scholar
• Gu, Y., J. Sekiguchi, Y. Gao, P. Dikkes, K. Frank, D. Ferguson, P. Hasty, J. Chun, and F. W. Alt. 2000. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc. Natl. Acad. Sci. USA 97:2668–2673.
   PubMedGoogle Scholar
• Haaf, T., E. I. Golub, G. Reddy, C. M. Radding, and D. C. Ward. 1995. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc. Natl. Acad. Sci. USA 92:2298–2302.
   PubMed Web of Science ®Google Scholar
• Haber, J. E.. 1998. The many interfaces of Mre11. Cell 95:583–586.
   PubMed Web of Science ®Google Scholar
• Ito, A., H. Tauchi, J. Kobayashi, K. Morishima, A. Nakamura, Y. Hirokawa, S. Matsuura, K. Ito, and K. Komatsu. 1999. Expression of full-length NBS1 protein restores normal radiation responses in cells from Nijmegen breakage syndrome patients. Biochem. Biophys. Res. Commun. 265:716–721.
   PubMedGoogle Scholar
• Jin, S., and D. T. Weaver. 1997. Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J. 16:6874–6885.
   PubMed Web of Science ®Google Scholar
• Jorgensen, T. J., and Y. Shiloh. 1996. The ATM gene and the radiobiology of ataxia-telangiectasia. Int. J. Radiat. Biol. 69:527–537.
   PubMed Web of Science ®Google Scholar
• Kanaar, R., J. H. Hoeijmakers, and D. C. van Gent. 1998. Molecular mechanisms of DNA double strand break repair. Trends Cell Biol. 8:483–489.
   PubMed Web of Science ®Google Scholar
• Kanaar, R., and J. H. J. Hoeijmakers. 1997. Recombination and joining: different means to the same ends. Genes Funct. 1:165–174.
   PubMedGoogle Scholar
• Kodym, R., and E. Hurth. 1995. Determination of radiation-induced DNA strand breaks in individual cells by non-radioactive labelling of 3′ OH ends. Int. J. Radiat. Biol. 68:133–139.
   PubMed Web of Science ®Google Scholar
• Kretz-Remy, C., and R. M. Tanguay. 1999. SUMO/sentrin: protein modifiers regulating important cellular functions. Biochem. Cell Biol. 77:299–309.
   PubMedGoogle Scholar
• Lee, S. E., J. K. Moore, A. Holmes, K. Umezu, R. D. Kolodner, and J. E. Haber. 1998. Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94:399–409.
   PubMed Web of Science ®Google Scholar
• Lim, D. S., S. T. Kim, B. Xu, R. S. Maser, J. Lin, J. H. J. Petrini, and M. B. Kastan. 2000. ATM phosphorylates p95/Nbs1 in an S-phase checkpoint pathway. Nature 404:613–617.
   PubMed Web of Science ®Google Scholar
• Liu, Y., M. Li, E. Y. Lee, and N. Maizels. 1999. Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage. Curr. Biol. 9:975–978.
   PubMedGoogle Scholar
• Lombard, D. B., and L. Guarente. 2000. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60:2331–2334.
   PubMedGoogle Scholar
• Maser, R. S., K. J. Monsen, B. E. Nelms, and J. H. J. Petrini. 1997. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell. Biol. 17:6087–6096.
   PubMed Web of Science ®Google Scholar
• Maul, G. G., D. Negorev, P. Bell, and A. M. Ishov. 2000. Review: properties and assembly mechanisms of ND10, PML bodies, or PODs. J. Struct. Biol. 129:278–287.
   PubMed Web of Science ®Google Scholar
• Mittnacht, S., and R. A. Weinberg. 1991. G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell 65:381–393.
   PubMed Web of Science ®Google Scholar
• Moore, J. K., and J. E. Haber. 1996. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:2164–2173.
   PubMed Web of Science ®Google Scholar
• Murnane, J. P.. 1995. Cell cycle regulation in response to DNA damage in mammalian cells: a historical perspective. Cancer Metastasis Rev. 14:17–29.
   PubMed Web of Science ®Google Scholar
• Nelms, B. E., R. S. Maser, J. F. MacKay, M. G. Lagally, and J. H. J. Petrini. 1998. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 280:590–592.
   PubMed Web of Science ®Google Scholar
• Nickerson, J. A., G. Krockmalnic, D. C. He, and S. Penman. 1990. Immunolocalization in three dimensions: immunogold staining of cytoskeletal and nuclear matrix proteins in resinless electron microscopy sections. Proc. Natl. Acad. Sci. USA 87:2259–2263.
   PubMedGoogle Scholar
• Nugent, C. I., G. Bosco, L. O. Ross, S. K. Evans, A. P. Salinger, J. K. Moore, J. E. Haber, and V. Lundblad. 1998. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 8:657–660.
   PubMed Web of Science ®Google Scholar
• Nussenzweig, A., C. Chen, V. da Costa Soares, M. Sanchez, K. Sokol, M. C. Nussenzweig, and G. C. Li. 1996. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382:551–555.
   PubMed Web of Science ®Google Scholar
• Petrini, J. H.. 1999. The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am. J. Hum. Genet. 64:1264–1269.
   PubMed Web of Science ®Google Scholar
• Petrini, J. H.. 2000. The mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12:293–296.
   PubMedGoogle Scholar
• Riballo, E., S. E. Critchlow, S. H. Teo, A. J. Doherty, A. Priestley, B. Broughton, B. Kysela, H. Beamish, N. Plowman, C. F. Arlett, A. R. Lehmann, S. P. Jackson, and P. A. Jeggo. 1999. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr. Biol. 9:699–702.
   PubMed Web of Science ®Google Scholar
• Shiloh, Y.. 1997. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31:635–662.
   PubMed Web of Science ®Google Scholar
• Smith, G. C., and S. P. Jackson. 1999. The DNA-dependent protein kinase. Genes Dev. 13:916–934.
   PubMed Web of Science ®Google Scholar
• Stewart, G., R. S. Maser, T. Stankovic, D. A. Bressan, M. I. Kaplan, N. G. J. Jaspers, P. J. Byrd, J. H. J. Petrini, and A. M. R. Taylor. 1999. The DNA double strand break repair gene hMre11 is mutated in individuals with a new ataxia telangiectasia like disorder (ATLD). Cell 99:577–587.
   PubMed Web of Science ®Google Scholar
• Wang, Y., D. Cortez, P. Yazdi, N. Neff, S. J. Elledge, and J. Qin. 2000. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14:927–939.
   PubMed Web of Science ®Google Scholar
• Weaver, D. T.. 1995. What to do at an end: DNA double-strand break repair. Trends Genet. 11:388–392.
   PubMedGoogle Scholar
• Wu, X., V. Ranganathan, D. S. Weisman, W. F. Heine, D. N. Ciccone, T. B. O'Neill, K. E. Crick, K. A. Pierce, W. S. Lane, G. Rathbun, D. M. Livingston, and D. T. Weaver. 2000. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 405:477–482.
   PubMed Web of Science ®Google Scholar
• Yamamoto, A., T. Taki, H. Yagi, T. Habu, K. Yoshida, Y. Yoshimura, K. Yamamoto, A. Matsushiro, Y. Nishimune, and T. Morita. 1996. Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol. Gen. Genet. 251:1–12.
   PubMedGoogle Scholar
• Zhao, S., Y. C. Weng, S. S. Yuan, Y. T. Lin, H. C. Hsu, S. C. Lin, E. Gerbino, M. H. Song, M. Z. Zdzienicka, R. A. Gatti, J. W. Shay, Y. Ziv, Y. Shiloh, and E. Y. Lee. 2000. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 405:473–477.
   PubMed Web of Science ®Google Scholar
• Zhong, Q., C. F. Chen, S. Li, Y. Chen, C. C. Wang, J. Xiao, P. L. Chen, Z. D. Sharp, and W. H. Lee. 1999. Association of BRCA1 with the hRad50-hMre11–p95 complex and the DNA damage response. Science 285:747–750.
   PubMed Web of Science ®Google Scholar
• Zhu, X.-D., B. Kuster, M. Mann, J. H. J. Petrini, and T. de Lange. 2000. Cell cycle regulated association of Rad50/Mre11/Nbs1 with TRF2 and human telomeres. Nat. Genet. 25:347–352.
   PubMed Web of Science ®Google Scholar