Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes

REFERENCES

• Bell, A., L. Grunder, and A. Sorisky. 2000. Rapamycin inhibits human adipocyte differentiation in primary culture. Obes. Res. 8:249–254.
   PubMedGoogle Scholar
• Bradford, M. M.. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
   PubMed Web of Science ®Google Scholar
• Brüning, J. C., J. Winnay, B. Cheatham, and C. R. Kahn. 1997. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol. Cell. Biol. 17:1513–1521.
   PubMed Web of Science ®Google Scholar
• Cheatham, B., and C. R. Kahn. 1995. Insulin action and the insulin signaling network. Endocr. Rev. 16:117–142.
   PubMed Web of Science ®Google Scholar
• Christy, R. J., V. W. Yang, J. M. Ntambi, D. E. Geiman, W. H. Landschulz, A. D. Friedman, Y. Nakabeppu, T. J. Kelly, and M. D. Lane. 1989. Differentiation-induced gene expression in 3T3–L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1323–1335.
   PubMedGoogle Scholar
• Curtis, S. E., M. D. Michael, B. E. Crute, S. R. Keller, and G. E. Lienhard. 2000. Double knockout of IRS proteins reveals critical roles of IRS-1 and IRS-3 in the maintenance of glucose homeostasis. Diabetes Suppl. 49:A5
   Web of Science ®Google Scholar
• Fasshauer, M., J. Klein, K. Ueki, K. M. Kriauciunas, M. Benito, M. F. White, and C. R. Kahn. 2000. Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J. Biol. Chem. 275:25494–25501.
   PubMed Web of Science ®Google Scholar
• Font de Mora, J., A. Porras, N. Ahn, and E. Santos. 1997. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3–L1 adipocytic differentiation. Mol. Cell. Biol. 17:6068–6075.
   PubMedGoogle Scholar
• Force, W. R., T. C. Cheung, and C. F. Ware. 1997. Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. J. Biol. Chem. 272:30835–30840.
   PubMedGoogle Scholar
• Freytag, S. O., D. L. Paielli, and J. D. Gilbert. 1994. Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8:1654–1663.
   PubMed Web of Science ®Google Scholar
• Hu, E., J. B. Kim, P. Sarraf, and B. M. Spiegelman. 1996. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274:2100–2103.
   PubMed Web of Science ®Google Scholar
• Hwang, C. S., T. M. Loftus, S. Mandrup, and M. D. Lane. 1997. Adipocyte differentiation and leptin expression. Annu. Rev. Cell Dev. Biol. 13:231–259.
   PubMed Web of Science ®Google Scholar
• Jiang, B. H., M. Aoki, J. Z. Zheng, J. Li, and P. K. Vogt. 1999. Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B. Proc. Natl. Acad. Sci. USA 96:2077–2081.
   PubMed Web of Science ®Google Scholar
• Kaestner, K. H., R. J. Christy, and M. D. Lane. 1993. Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein. Proc. Natl. Acad. Sci. USA 87:251–255.
   Google Scholar
• Kaliman, P., F. Vinals, X. Testar, M. Palacin, and A. Zorzano. 1996. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. J. Biol. Chem. 271:19146–19151.
   PubMed Web of Science ®Google Scholar
• Klein, J., M. Fasshauer, M. Ito, B. B. Lowell, M. Benito, and C. R. Kahn. 1999. Beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin induced glucose uptake in brown adipocytes. J. Biol. Chem. 274:34795–34802.
   PubMed Web of Science ®Google Scholar
• Kohn, A. D., S. A. Summers, M. J. Birnbaum, and R. A. Roth. 1996. Expression of a constitutively active Akt Ser/Thr kinase in 3T3/L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271:31372–31378.
   PubMed Web of Science ®Google Scholar
• Kraus, S.. 1996. Functional differentiation of white and brown adipocytes. Bioessays 19:215–223.
   Google Scholar
• Lowell, B. B., and J. S. Flier. 1997. Brown adipose tissue, β3-adrenergic receptors, and obesity. Annu. Rev. Med. 48:307–316.
   PubMed Web of Science ®Google Scholar
• Morgenstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587–3596.
   PubMed Web of Science ®Google Scholar
• Moyers, J. S., P. J. Bilan, C. Reynet, and C. R. Kahn. 1996. Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells. J. Biol. Chem. 271:23111–23116.
   PubMed Web of Science ®Google Scholar
• Park, E. A., W. J. Roesler, J. Liu, D. J. Klemm, A. L. Gurney, J. D. Thatcher, J. Shuman, A. Friedman, and R. W. Hanson. 1990. The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol. Cell. Biol. 10:6264–6272.
   PubMedGoogle Scholar
• Ristow, M., D. Muller-Wieland, A. Pfeiffer, W. Krone, and C. R. Kahn. 1998. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl. J. Med. 339:953–959.
   PubMed Web of Science ®Google Scholar
• Rosen, E. D., P. Sarraf, A. E. Troy, G. Bradwin, K. Moore, D. S. Milstone, B. M. Spiegelman, and R. M. Mortensen. 1999. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4:611–617.
   PubMed Web of Science ®Google Scholar
• Sakaue, H., W. Ogawa, M. Matsumoto, S. Kuroda, M. Takata, T. Sugimoto, B. M. Spiegelman, and M. Kasuga. 1998. Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase. J. Biol. Chem. 273:28945–28952.
   PubMed Web of Science ®Google Scholar
• Schoonjans, K., J. Peinado-Onsurbe, A. M. Lefebvre, R. A. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx. 1996. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15:5336–5348.
   PubMed Web of Science ®Google Scholar
• Spiegelman, B. M., and J. S. Flier. 1996. Adipogenesis and obesity: rounding out the big picture. Cell 87:377–389.
   PubMed Web of Science ®Google Scholar
• Tai, T. A. C., C. Jennermann, K. K. Brown, B. B. Oliver, M. A. MacGinnitie, W. O. Wilkison, H. R. Brown, J. M. Lehmann, S. A. Kliewer, D. C. Morris, and R. A. Graves. 1996. Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation. J. Biol. Chem. 271:29909–29914.
   PubMed Web of Science ®Google Scholar
• Tanaka, T., N. Yoshida, T. Kishimoto, and S. Akira. 1997. Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J. 16:7432–7443.
   PubMed Web of Science ®Google Scholar
• Tontonoz, P., E. Hu, R. A. Granes, A. I. Budavari, and B. M. Spiegelman. 1994. MPPARχ: tissue specific regulator of an adipocyte enhancer. Genes Dev. 8:1224–1234.
   PubMed Web of Science ®Google Scholar
• Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79:1147–1156.
   PubMed Web of Science ®Google Scholar
• Valverde, A. M., C. R. Kahn, and M. Benito. 1999. Insulin signaling in insulin receptor substrate (IRS)-1-deficient adipocytes: requirement of IRS-1 for lipid synthesis. Diabetes 48:2122–2131.
   PubMed Web of Science ®Google Scholar
• White, M. F.. 1998. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 182:3–11.
   PubMed Web of Science ®Google Scholar
• Wu, Z., N. L. R. Bucher, and S. R. Farmer. 1996. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol. Cell. Biol. 16:4128–4136.
   PubMed Web of Science ®Google Scholar
• Wu, Z., E. D. Rosen, R. Brun, S. Hauser, G. Adelmant, A. E. Troy, C. McKeon, G. J. Darlington, and B. M. Spiegelman. 1999. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell 3:151–158.
   PubMed Web of Science ®Google Scholar
• Wu, Z., Y. Xie, N. L. Bucher, and S. R. Farmer. 1995. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 9:2350–2363.
   PubMed Web of Science ®Google Scholar
• Wu, Z., Y. Xie, R. F. Morrison, N. L. Bucher, and S. R. Farmer. 1998. PPARγ induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes. J. Clin. Investig. 101:22–32.
   PubMed Web of Science ®Google Scholar
• Yeh, W. C., B. E. Bierer, and S. L. McKnight. 1995. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3–L1 cells. Proc. Natl. Acad. Sci. USA 92:11086–11090.
   PubMed Web of Science ®Google Scholar
• Yeh, W. C., Z. Cao, M. Classon, and S. L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168–181.
   PubMed Web of Science ®Google Scholar