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Mammalian Genetic Models with Minimal or Complex Phenotypes

Six4, a Putative myogeninGene Regulator, Is Not Essential for Mouse Embryonal Development

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Pages 3343-3350 | Received 27 Nov 2000, Accepted 21 Feb 2001, Published online: 28 Mar 2023

REFERENCES

  • Abdelhak, S., V. Kalatzis, R. Heilig, S. Compain, D. Samson, C. Vincent, D. Weil, C. Cruaud, I. Sahly, M. Leibovici, M. Bitner-Glindzicz, M. Francis, D. Lacombe, J. Vigneron, R. Charachon, K. Boven, P. Bedbeder, N. Van Regemorter, J. Weissenbach, and C. Petit. 1997. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat. Genet. 15:157–164.
  • Boucher, C. A., N. Carey, Y. H. Edwards, M. J. Siciliano, and K. J. Johnson. 1996. Cloning of the human SIX1 gene and its assignment to chromosome 14. Genomics 33:140–142.
  • Boucher, C. A., S. K. King, N. Carey, R. Krahe, C. L. Winchester, S. Rahman, T. Creavin, P. Meghji, M. E. Bailey, F. L. Chartier, S. D. Brown, M. J. Siciliano, and K. J. Johnson. 1995. A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. Hum. Mol. Genet. 4:1919–1925.
  • Boucher, C. A., C. L. Winchester, G. M. Hamilton, A. D. Winter, K. J. Johnson, and M. E. Bailey. 2000. Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. Gene 247:145–151.
  • Cheyette, B. N., P. J. Green, K. Martin, H. Garren, V. Hartenstein, and S. L. Zipursky. 1994. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12:977–996.
  • Esteve, P., and P. Bovolenta. 1999. cSix4, a member of the six gene family of transcription factors, is expressed during placode and somite development. Mech. Dev. 85:161–165.
  • Gallardo, M. E., J. Lopez-Rios, I. Fernaud-Espinosa, B. Granadino, R. Sanz, C. Ramos, C. Ayuso, M. J. Seller, H. G. Brunner, P. Bovolenta, and S. Rodriguez de Cordoba. 1999. Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies. Genomics 61:82–91.
  • Granadino, B., M. E. Gallardo, J. Lopez-Rios, R. Sanz, C. Ramos, C. Ayuso, P. Bovolenta, and S. Rodriguez de Cordoba. 1999. Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene. Genomics 55:100–105.
  • Hara, Y., O. Urayama, K. Kawakami, H. Nojima, H. Nagamune, T. Kojima, T. Ohta, K. Nagano, and M. Nakao. 1987. Primary structures of two types of alpha-subunit of rat brain Na+,K+-ATPase deduced from cDNA sequences. J. Biochem. 102:43–58.
  • Jean, D., G. Bernier, and P. Gruss. 1999. Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk. Mech. Dev. 84:31–40.
  • Kalatzis, V., I. Sahly, A. El-Amraoui, and C. Petit. 1998. Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of branchio-oto-renal (BOR) syndrome. Dev. Dyn. 213:486–499.
  • Kawakami, K., H. Ohto, K. Ikeda, and R. G. Roeder. 1996. Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 24:303–310.
  • Kawakami, K., H. Ohto, T. Takizawa, and T. Saito. 1996. Identification and expression of six family genes in mouse retina. FEBS Lett. 393:259–263.
  • Kawakami, K., S. Sato, H. Ozaki, and K. Ikeda. 2000. Six family genes—structure and function as transcription factors and their roles in development. Bioessays 22:616–626.
  • Klesert, T. R., D. H. Cho, J. I. Clark, J. Maylie, J. Adelman, L. Snider, E. C. Yuen, P. Soriano, and S. J. Tapscott. 2000. Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Nat. Genet. 25:105–109.
  • Klesert, T. R., A. D. Otten, T. D. Bird, and S. J. Tapscott. 1997. Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP. Nat. Genet. 16:402–406.
  • Kobayashi, M., H. Osanai, K. Kawakami, and M. Yamamoto. 2000. Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites. Mech. Dev. 98:151–155.
  • Kobayashi, M., R. Toyama, H. Takeda, I. B. Dawid, and K. Kawakami. 1998. Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development 125:2973–2982.
  • Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707–710.
  • Lee, J. K., J. H. Cho, W. S. Hwang, Y. D. Lee, D. S. Reu, and H. Suh-Kim. 2000. Expression of neuroD/BETA2 in mitotic and postmitotic neuronal cells during the development of nervous system. Dev. Dyn. 217:361–367.
  • Loosli, F., S. Winkler, and J. Wittbrodt. 1999. Six3 overexpression initiates the formation of ectopic retina. Genes Dev. 13:649–654.
  • Lopez-Rios, J., M. E. Gallardo, S. Rodriguez de Cordoba, and P. Bovolenta. 1999. Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development. Mech. Dev. 83:155–159.
  • Ma, Q., Z. Chen, I. del Barco Barrantes, J. L. de la Pompa, and D. J. Anderson. 1998. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20:469–482.
  • Ma, Q., L. Sommer, P. Cserjesi, and D. J. Anderson. 1997. Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands. J. Neurosci. 17:3644–3652.
  • McCormick, M. B., R. M. Tamimi, L. Snider, A. Asakura, D. Bergstrom, and S. J. Tapscott. 1996. neuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. Mol. Cell. Biol. 16:5792–5800.
  • Nagy, A., J. Rossant, R. Nagy, W. Abramow-Newerly, and J. C. Roder. 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90:8424–8428.
  • Niiya, A., H. Ohto, K. Kawakami, and M. Araki. 1998. Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development. Exp. Eye Res. 67:699–707.
  • Ohto, H., S. Kamada, K. Tago, S. Tominaga, H. Ozaki, S. Sato, and K. Kawakami. 1999. Cooperation of Six and Eya in activation of their target genes through nuclear translocation of Eya. Mol. Cell. Biol. 19:6815–6824.
  • Ohto, H., T. Takizawa, T. Saito, M. Kobayashi, K. Ikeda, and K. Kawakami. 1998. Tissue and developmental distribution of Six family gene products. Int. J. Dev. Biol. 42:141–148.
  • Oliver, G., F. Loosli, R. Koster, J. Wittbrodt, and P. Gruss. 1996. Ectopic lens induction in fish in response to the murine homeobox gene Six3. Mech. Dev. 60:233–239.
  • Oliver, G., A. Mailhos, R. Wehr, N. G. Copeland, N. A. Jenkins, and P. Gruss. 1995. Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development 121:4045–4055.
  • Oliver, G., R. Wehr, N. A. Jenkins, N. G. Copeland, B. N. Cheyette, V. Hartenstein, S. L. Zipursky, and P. Gruss. 1995. Homeobox genes and connective tissue patterning. Development 121:693–705.
  • Olson, E. N., and W. H. Klein. 1994. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev. 8:1–8.
  • Ozaki, H., K. Yamada, M. Kobayashi, S. Asakawa, S. Minoshima, N. Shimizu, M. Kajitani, and K. Kawakami. 1999. Structure and chromosomal mapping of human SIX4 and mouse Six4 genes. Cytogenet. Cell Genet. 87:108–112.
  • Sarkar, P. S., B. Appukuttan, J. Han, Y. Ito, C. Ai, W. Tsai, Y. Chai, J. T. Stout, and S. Reddy. 2000. Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat. Genet. 25:110–114.
  • Soriano, P., C. Montgomery, R. Geske, and A. Bradley. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693–702.
  • Spitz, F., J. Demignon, A. Porteu, A. Kahn, J. P. Concordet, D. Daegelen, and P. Maire. 1998. Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site. Proc. Natl. Acad. Sci. USA 95:14220–14225.
  • Suzuki-Yagawa, Y., K. Kawakami, and K. Nagano. 1992. Housekeeping Na,K-ATPase α1 subunit gene promoter is composed of multiple cis elements to which common and cell type-specific factors bind. Mol. Cell. Biol. 12:4046–4055.
  • Takahashi, K., N. Osawa, M. Ohmura, and K. Kitamura. 1999. Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami. Acta Otolaryngol. 119:767–772.
  • Toy, J., and O. H. Sundin. 1999. Expression of the optx2 homeobox gene during mouse development. Mech. Dev. 83:183–186.
  • Toy, J., J. M. Yang, G. S. Leppert, and O. H. Sundin. 1998. The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes. Proc. Natl. Acad. Sci. USA 95:10643–10648.
  • Wallis, D. E., E. Roessler, U. Hehr, L. Nanni, T. Wiltshire, A. Richieri-Costa, G. Gillessen-Kaesbach, E. H. Zackai, J. Rommens, and M. Muenke. 1999. Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly. Nat. Genet. 22:196–198.
  • Wilkinson, D. G.. 1992. Whole mount in situ hybridization of vertebrate embryos. In situ hybridization: a practical approach.. D. G. Wilkinson. 75–83. Oxford IRL Press, New York, N.Y
  • Winchester, C. L., R. K. Ferrier, A. Sermoni, B. J. Clark, and K. J. Johnson. 1999. Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. Hum. Mol. Genet. 8:481–492.
  • Wright, W. E., D. A. Sassoon, and V. K. Lin. 1989. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Cell 56:607–617.
  • Xu, P. X., J. Adams, H. Peters, M. C. Brown, S. Heaney, and R. Maas. 1999. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat. Genet. 23:113–117.
  • Yagi, T., S. Nada, N. Watanabe, H. Tamemoto, N. Kohmura, Y. Ikawa, and S. Aizawa. 1993. A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene. Anal. Biochem. 214:77–86.
  • Zuber, M. E., M. Perron, A. Philpott, A. Bang, and W. A. Harris. 1999. Giant eyes in Xenopus laevis by overexpression of XOptx2. Cell 98:341–352.

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