61
Views
78
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

DR3 Regulates Negative Selection during Thymocyte Development

, , , , &
Pages 3451-3461 | Received 16 Oct 2000, Accepted 22 Feb 2001, Published online: 28 Mar 2023

REFERENCES

  • Acha-Orbea, H.. 1995. Superantigens and tolerance. T cell receptors.. J. I. Bell, M. I. Owen, and E. Simpson. 224–265. Oxford University Press, Oxford, United Kingdom
  • Amakawa, R., A. Hakem, T. M. Kundig, T. Matsuyama, J. J. L. Simard, E. Timms, A. Wakeham, H.-W. Mittruecker, H. Griesser, H. Takimoto, R. Schmits, A. Shahinian, P. S. Ohashi, J. M. Penninger, and T. W. Mak. 1996. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell 84:551–562.
  • Baker, S. J., and E. P. Reddy. 1998. Modulation of life and death by the TNF receptor superfamily. Oncogene 17:3261–3270.
  • Banner, D. W., A. D'Arey, W. Janes, R. Gentz, H. J. Schoenfeld, C. Broger, H. Loetscher, and W. Lesslauer. 1993. Crystal structure of the soluble human 55 kD TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 73:431–445.
  • Bodmer, J.-L., K. Burns, P. Schneider, K. Hoffman, V. Steiner, M. Thome, T. Bornand, M. Hahne, M. Schroter, K. Becker, A. Wilson, L. E. French, J. L. Browning, H. Robson Macdonald, and J. Tschopp. 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 6:79–88.
  • Boldin, M. P., E. E. Verfolomeev, C. Pancer, I. L. Mett, J. H. Carmonis, and D. Wallach. 1995. A novel protein that interacts with the death domain of Fas/Apo1 contains a sequence motif related to the death domain. J. Biol. Chem. 270:7795–7787.
  • Boldin, M. P., T. M. Goncharov, Y. V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85:803–815.
  • Bowen, M. A., R. K. Lee, G. Miraglilotta, S. Y. Nam, and E. R. Podack. 1996. Structure and expression of murine CD30 and its role in cytokine production. J. Immunol. 156:442–449.
  • Chiarle, R., A. Podda, G. Prolla, E. R. Podack, G. J. Thorbecke, and G. Inghirami. 1999. CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2 sensitive pathway. J. Immunol. 163:194–205.
  • Chicheportiche, Y., P. R. Bourdon, H. Xu, Y. M. Hsu, H. Scoyy, C. Hession, I. Garcia, and J. L. Browning. 1997. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 272:32401–32410.
  • Chinnaiyan, A. M., K. O'Rourke, G. L. Yu, R. H. Lyons, M. Garg, D. R. Duan, L. Xing, R. Gentz, J. Ni, and V. M. Dixit. 1996. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274:990–992.
  • Chinnaiyan, A. M., K. O'Rourke, M. Tewari, and V. M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505–512.
  • Dixit, V. M.. 1996. The cell-death machine. Curr. Biol. 6:555–562.
  • Doerfler, P., K. A. Forbush, and R. M. Perlmutter. 2000. Caspase enzyme activity is not essential for apoptosis during thymocyte development. J. Immunol. 164:4071–4079.
  • Duan, H., and V. M. Dixit. 1997. RAIDD is a new “death” adaptor molecule. Nature 385:86–89.
  • Grenet, J., V. Valentine, J. Kitson, H. Li, S. N. Farrow, and V. J. Kidd. 1998. Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma. Genomics 49:385–393.
  • Henkart, P. A.. 1996. ICE family proteases: mediators of all apoptotic cell death?. Immunity 4:195–201.
  • Hsu, H., S. B. Shu, M. G. Pan, and D. V. Goeddel. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299–308.
  • Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375–387.
  • Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233–243.
  • Izquierdo, M., A. Grandien, L. M. Criado, S. Robles, E. Leonardo, J. P. Albar, G. G. de-Buitrago, and A. C. Martinez. 1999. Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. EMBO J. 18:156–166.
  • Kieselow, P., H. Bluthmann, U. D. Staerz, M. Steinmetz, and H. von Boehmer. 1988. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333:742–746.
  • Kishimoto, H., and J. Sprent. 1999. Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190:65–73.
  • Kitson, J., T. Raven, Y. P. Jiang, D. V. Goeddel, K. M. Giles, K. T. Pun, C. J. Grinham, R. Brown, and S. N. Farrow. 1996. A death domain-containing receptor that mediates apoptosis. Nature 384:372–375.
  • Koni, P. A., and R. A. Flavell. 1998. A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin β. J. Exp. Med. 187:1977–1983.
  • Koni, P. A., R. Sacca, P. Lawton, J. L. Browning, N. H. Ruddle, and R. A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity 6:491–500.
  • Kumar, S.. 1996. ICE-like proteases in apoptosis. Trends Biochem. Sci. 20:198–202.
  • Lucas, B., F. Vasseur, and C. Penit. 1997. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse labeled thymocytes. J. Immunol. 151:4574–4582.
  • Marsters, S. A., J. P. Sheridan, C. J. Donahue, R. M. Pitti, C. L. Gray, A. D. Goddard, K. D. Bauer, and A. Ashkenazi. 1996. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB. Curr. Biol. 6:1669–1676.
  • Marsters, S. A., J. P. Sheridan, R. M. Pitti, J. Brush, A. Goddard, and A. Ashkenazi. 1998. Identification of a ligand for the death-domain-containing receptor Apo3. Curr. Biol. 8:525–528.
  • Muzio, M., A. M. Chinnaiyan, F. C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J. D. Bretz, M. Zhang, R. Gentz, M. Mann, P. H. Krammer, M. E. Peter, and V. M. Dixit. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95(Fas/APO-1) death-inducing signaling complex. Cell 85:817–827.
  • Neumann, B. A., K. Luz, K. Pfeffer, and B. Holzmann. 1996. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med. 184:259–264.
  • Newton, K., A. W. Harris, and A. Strasser. 2000. FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumor suppressor gene. EMBO J. 19:931–941.
  • Newton, K., A. W. Harris, M. L. Bath, K. C. G. Smith, and A. Strasser. 1998. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17:706–718.
  • Orlinick, J. R., and M. V. Chao. 1998. TNF-related ligands and their receptors. Cell Signal. 10:543–551.
  • Park, Y. C., V. Burkitt, A. R. Villa, L. Tong, and H. Wu. 1999. Structural basis for self-association and receptor recognition of human TRAF2. Nature 398:533–538.
  • Pasparakis, M., L. Alexopoulou, M. Grell, K. Pfizenmaier, H. Bleuthmann, and G. Kollias. 1997. Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc. Natl. Acad. Sci. USA 94:6319–6323.
  • Rivera, R. R., C. P. Johns, J. Quan, R. S. Johnson, and C. Murre. 2000. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity 12:17–26.
  • Roth, M., S. Wong, W. Henzel, and D. V. Goeddel. 1994. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681–692.
  • Schneider, P., R. Schwenzer, E. Haas, F. Muhlenbeck, G. Schubert, P. Scheurich, J. Tschopp, and H. Wajant. 1999. TWEAK can induce cell death via endogenous TNF and TNF receptor 1. Eur. J. Immunol. 29:1785–1792.
  • Screaton, G., and X.-N. Xu. 2000. T cell life and death signalling via TNF-receptor family members. Curr. Opin. Immunol. 12:316–322.
  • Screaton, G. R., X-N. Xu, A. L. Olsen, A. E. Cowper, R. Tan, A. J. McMichael, and J. I. Bell. 1997. LARD, a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 94:4615–4619.
  • Sentman, C. L., J. R. Shutter, D. Hockenbery, O. Kanagawa, and S. J. Korsmeyer. 1991. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879–888.
  • Smith, C. A., T. Farrah, and R. G. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation and death. Cell 76:958–962.
  • Strasser, A., A. W. Harris, H. von Boehmer, and S. Cory. 1994. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc. Natl. Acad. Sci. USA 91:1376–1380.
  • Takayama, E., T. Kina, Y. Katsura, and T. Tadakuma. 1998. Enhancement of activation-induced cell death by fibronectin in murine CD4+ CD8+ thymocytes. Immunology 95:553–558.
  • Tan, K. B., J. Harrop, M. Reddy, P. Young, J. Terrett, J. Emery, G. Moore, and A. Truneh. 1997. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoetic and non-hematopoietic cells. Gene 204:35–46.
  • Tartaglia, L. A., T. M. Ayers, G. H. W. Wong, and D. V. Goeddel. 1993. A novel domain within the 55 kd TNF receptor signals cell death. Cell 74:845–853.
  • Teh, H. S., P. Kisielow, B. Scott, H. Kishi, Y. Uematsu, H. Bluthmann, and H. von Boehmer. 1988. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335:229–233.
  • Walsh, C. M., B. G. Wen, A. M. Chinnaiyan, K. O'Rourke, V. M. Dixit, and S. M. Hedrick. 1998. A role for FADD in T cell activation and development. Immunity 8:439–449.
  • Wang, E. C., J. Kitson, A. Thern, J. Williamson, S. N. Farrow, and M. J. Owen. Genomic structure, expression and chromosome mapping of the murine homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics, in press.
  • Ware, C. F., S. Vanarsdale, and T. L. Vanarsdale. 1996. Apoptosis mediated by the TNF-related cytokine and receptor families. J. Cell Biochem. 60:47–55.
  • Warzocha, K., P. Ribeiro, C. Charlot, N. Renard, B. Coiffier, and G. Salles. 1998. A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. Biochem. Biophys. Res. Commun. 242:376–379.
  • Williams, O., T. Norton, M. Halligey, D. Kioussis, and H. J. M. Brady. 1998. The action of Bax and bcl-2 on T cell selection. J. Exp. Med. 188:1125–1133.
  • Yang, X., R. Khosravi-far, H. Y. Chang, and D. Baltimore. 1997. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89:1067–1076.
  • Zornig, M., A.-O. Huber, and G. Evan. 1998. p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice. Curr. Biol. 8:467–470.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.