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Transcriptional Regulation

Transactivation by the p65 Subunit of NF-κB in Response to Interleukin-1 (IL-1) Involves MyD88, IL-1 Receptor-Associated Kinase 1, TRAF-6, and Rac1

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Pages 4544-4552 | Received 30 Aug 2000, Accepted 19 Apr 2001, Published online: 28 Mar 2023

REFERENCES

  • Arbibe, L., J. Mira, N. Teusch, L. Kline, M. Guha, N. Mackman, P. J. Godowski, R. J. Ulevitch, and U. G. Knaus. 2000. Toll-like receptor 2-mediated NF-kappaB activation requires a Rac1-dependent pathway. Nat. Immunol. 1:533–540.
  • Baud, V., Z.-G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin. 1999. Signalling by proinflammatory cytokines: oligomerisation of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 13:1297–1308.
  • Bergmann, M., L. Hart, M. Lindsay, P. J. Barnes, and R. Newton. 1998. IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription: requirement for an additional activation pathway. J. Biol. Chem. 273:6607–6610.
  • Bird, T. A., K. Schooley, S. K. Dower, H. Hagen, and G. D. Virca. 1997. Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase IL-mediated phosphorylation of the p65 subunit. J. Biol. Chem. 272:32606–32612.
  • Bonnert, T. P., K. E. Garka, P. Parnet, G. Sonoda, J. R. Testa, and J. E. Sims. 1997. The cloning and characterisation of human MyD88: a member of the IL-1 receptor related family. FEBS Lett. 402:81–84.
  • Bowie, A., E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower, and L. A. J. O'Neill. 2000. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 97:10162–10167.
  • Burns, K., J. Clatworthy, L. Martin, F. Martinon, C. Plumpton, B. Maschera, A. Lewis, K. Ray, J. Tschopp, and F. Volpe. 2000. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat. Cell Biol. 2:346–351.
  • Burns, K., F. Martinon, C. Esslinger, H. Pahl, P. Schneider, J. L. Bodmer, F. Di Marco, L. French, and J. Tschopp. 1998. MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273:12203–12209.
  • Cao, Z., W. J. Henzel, and X. Gao. 1996. IRAK: a kinase associated with the interleukin-1 receptor. Science 271:1128–1131.
  • Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D. V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383:443–446.
  • De Bosscher, K., M. L. Schmitz, W. Vanden Berghe, S. Plaisance, W. Fiers, and G. Haegeman. 1997. Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA 94:13504–13509.
  • DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388:548–554.
  • Genot, E., S. Cleverley, S. Henning, and D. Cantrell. 1996. Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 15:3923–3933.
  • Greene, C., and L. O'Neill. 1999. Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFκB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA. Biochim. Biophys. Acta 1451:109–121.
  • Hall, A.. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509–514.
  • Hultmark, D.. 1994. Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family. Biochem. Biophys. Res. Commun. 199:144–146.
  • Jefferies, C. A., and L. A. J. O'Neill. 2000. Rac1 regulates interleukin 1-induced nuclear factor κB activation in an inhibitory protein κBα-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression. J. Biol. Chem. 275:3114–3120.
  • Knop, J., H. Wesche, D. Lang, and M. U. Martin. 1998. Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4. Eur. J. Immunol. 28:3100–3109.
  • Kopp, E., R. Medzhitov, J. Carothers, C. Xiao, I. Douglas, C. A. Janeway, and S. Ghosh. 1999. ECSIT is a evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 13:2059–2071.
  • Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213–222.
  • Li, N., and M. Karin. 2000. Signalling pathways leading to nuclear factor-kappa B activation. Methods Enzymol. 319:273–279.
  • Li, X., M. Commane, C. Burns, K. Vithalani, Z. Cao, and G. R. Stark. 1999. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol. Cell. Biol. 19:4643–4652.
  • Ling, L., Z. Cao, and D. V. Goeddel. 1998. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 95:3792–3797.
  • MacGillivray, M. K., T. F. Cruz, and C. A. G. McCulloch. 2000. The recruitment of the interleukin-1 receptor-associated kinase (IRAK) into focal adhesion complexes is required for IL-1 beta-induced ERK activation. J. Biol. Chem. 275:23509–23515.
  • Medzhitov, R., P. Preston Hurlburt, and C. A. Janeway Jr.. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394–397.
  • Muzio, M., J. Ni, P. Feng, and V. M. Dixit. 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278:1612–1615.
  • O'Neill, L. A. J., and C. A. Dinarello. 2000. The interleukin 1/Toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol. Today 21:206–209.
  • Perkins, N. D.. 1997. Achieving transcriptional specificity with NF-kappa B. Int. J. Biochem. Cell Biol. 29:1433–1448.
  • Qwarnstrom, E. E., R. C. Page, S. Gillis, and S. K. Dower. 1988. Binding, internalization and intracellular localization of interleukin-1 beta in human diploid fibroblasts. J. Biol. Chem. 263:8261–8269.
  • Sakurai, H., H. Chiba, H. Miyoshi, T. Sugita, and W. Toriumi. 1999. IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 274:30353–30356.
  • Schmitz, M. L., and P. A. Baeuerie. 1991. The p65 subunit is responsible for the strong transactivating potential of NF-kappa B. EMBO J. 10:3805–3817.
  • Schnare, M., A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2000. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 10:1139–1142.
  • Singh, R., B. Wang, A. Shirvaikar, S. Khan, S. Kamat, J. R. Schelling, M. Konieczkowski, and J. R. Sedor. 1999. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation. J. Clin. Investig. 103:1561–1570.
  • Sizemore, N., S. Leung, and G. R. Stark. 1999. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19:4798–4805.
  • Vanden Berghe, W., S. Plaisance, E. Boone, K. De Bosscher, M. L. Schmitz, W. Fiers, and G. Haegeman. 1998. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:3285–3290.
  • Vanden Berghe, W., S. Plaisance, E. Boone, K. De Bosscher, M. L. Schmitz, W. Fiers, and G. Haegeman. 1998. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:3285–3290.
  • Wang, D., and A. S. Baldwin. 1998. Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529. J. Biol. Chem. 273:29411–29416.
  • Wang, D., S. D. Westerheide, J. L. Hanson, and A. S. Baldwin. 2000. TNFalpha-induced phosphorylation of RelA/p65 on serine 529 by casein kinase II. J. Biol. Chem. 275:38127–38130.
  • Wesche, H., W. J. Henzel, W. Shillinglaw, S. Li, and Z. Cao. 1997. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837–847.
  • Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91:243–252.
  • Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661–671.

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