Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

REFERENCES

• Cho, R. J., M. J. Campbell, E. A. Winzeler, L. Steinmetz, A. Conway, L. Wodicka, T. G. Wolfsberg, A. E. Gabrielian, D. Landsman, D. J. Lockhart, and R. W. Davis. 1998. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol. Cell 2:65–73.
   PubMed Web of Science ®Google Scholar
• Cho, R. J., M. Huang, M. J. Campbell, H. Dong, L. Steinmetz, L. Sapinoso, G. Hampton, S. J. Elledge, R. W. Davis, and D. J. Lockhart. 2001. Transcriptional regulation and function during the human cell cycle. Nat. Genet. 27:48–54.
   PubMed Web of Science ®Google Scholar
• DeGregori, J., T. Kowalik, and J. R. Nevins. 1995. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis and G1/S regulatory genes. Mol. Cell. Biol. 15:4215–4224.
   PubMed Web of Science ®Google Scholar
• DeGregori, J., G. Leone, A. Miron, L. Jakoi, and J. R. Nevins. 1997. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94:7245–7250.
   PubMed Web of Science ®Google Scholar
• Dyson, N.. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245–2262.
   PubMed Web of Science ®Google Scholar
• Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95:14863–14868.
   PubMed Web of Science ®Google Scholar
• Fambrough, D., K. McClure, A. Kazlauskas, and E. S. Lander. 1999. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97:727–741.
   PubMed Web of Science ®Google Scholar
• Humbert, P. O., R. Verona, J. M. Trimarchi, C. Rogers, S. Dandapani, and J. A. Lees. 2000. E2f3 is critical for normal cellular proliferation. Genes Dev. 14:690–703.
   PubMed Web of Science ®Google Scholar
• Ikeda, M.-A., L. Jakoi, and J. R. Nevins. 1996. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA 93:3215–3220.
   PubMedGoogle Scholar
• Iyer, V. R., M. B. Eisen, D. T. Ross, G. Schuler, T. Moore, J. C. F. Lee, J. M. Trent, L. M. Staudt, J. Hudson Jr., M. S. Boguski, D. Lashkari, D. Shalon, D. Botstein, and P. O. Brown. 1999. The transcriptional program in the response of human fibroblasts to serum. Science 283:83–87.
   PubMed Web of Science ®Google Scholar
• Johnston, L. A., and B. A. Edgar. 1998. Wingless and notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394:82–84.
   PubMed Web of Science ®Google Scholar
• Leone, G., J. DeGregori, R. Sears, L. Jakoi, and J. R. Nevins. 1997. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387:422–426.
   PubMed Web of Science ®Google Scholar
• Leone, G., J. DeGregori, Z. Yan, L. Jakoi, S. Ishida, R. S. Williams, and J. R. Nevins. 1998. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 12:2120–2130.
   PubMed Web of Science ®Google Scholar
• Leone, G., F. Nuckolls, S. Ishida, M. Adams, R. Sears, L. Jakoi, A. Miron, and J. R. Nevins. 2000. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol. Cell. Biol. 20:3626–3632.
   PubMedGoogle Scholar
• Muller, H., A. P. Bracken, R. Vernell, M. C. Moroni, F. Christians, E. Grassilli, E. Prosperini, E. Vigo, J. D. Oliner, and K. Helin. 2000. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15:267–285.
   Google Scholar
• Neufeld, T. P., A. F. A. de la Cruz, L. A. Johnston, and B. A. Edgar. 1998. Coordination of growth and cell division in the Drosophila wing. Cell 93:1183–1193.
   PubMed Web of Science ®Google Scholar
• Nevins, J. R.. 1994. Cell cycle targets of the DNA tumor viruses. Curr. Opin. Gen. Dev. 4:130–134.
   PubMedGoogle Scholar
• Nevins, J. R.. 1998. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9:585–593.
   PubMedGoogle Scholar
• Nevins, J. R., J. DeGregori, L. Jakoi, and G. Leone. 1997. Functional analysis of E2F. Methods Enzymol. 283:205–219.
   PubMedGoogle Scholar
• Robertson, E. J.. 1987. Embryo-derived stem cells. Teratocarcinomas and embryonic stem cells: a practical approach.. E. J. Robertson. 104–108. IRL Press, Oxford, England
   Google Scholar
• Sherr, C. J.. 1996. Cancer cell cycles. Science 274:1672–1677.
   PubMed Web of Science ®Google Scholar
• Smith, E. J., G. Leone, J. DeGregori, L. Jakoi, and J. R. Nevins. 1996. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 from a G1 cell state. Mol. Cell. Biol. 16:6965–6976.
   PubMed Web of Science ®Google Scholar
• Spellman, P. T., G. Sherlock, M. Q. Zhnag, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein, and B. Futcher. 1998. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9:3273–3297.
   PubMed Web of Science ®Google Scholar
• Weinberg, R. A.. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323–330.
   PubMed Web of Science ®Google Scholar
• Zhang, H. S., M. Gavin, A. Dahiya, A. A. Postigo, D. Ma, R. X. Luo, J. W. Harbour, and D. C. Dean. 2000. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101:79–89.
   PubMed Web of Science ®Google Scholar