Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase Cγ1 Phosphorylation

REFERENCES

• Asada, H., N. Ishii, Y. Sasaki, K. Endo, H. Kasai, N. Tanaka, T. Takeshita, S. Tsuchiya, T. Konno, and K. Sugamura. 1999. Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. J. Exp. Med. 189:1383–1390.
   PubMedGoogle Scholar
• Ashwell, J. D., and U. D'Oro. 1999. CD45 and Src-family kinases: and now for something completely different. Immunol. Today 20:412–416.
   PubMedGoogle Scholar
• Carpenter, G., and Q. Ji. 1999. Phospholipase C-gamma as a signal-transducing element. Exp. Cell Res. 253:15–24.
   PubMed Web of Science ®Google Scholar
• Clements, J. L., B. Yang, S. E. Ross-Barta, S. L. Eliason, R. F. Hrstka, R. A. Williamson, and G. A. Koretzky. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281:416–419.
   PubMedGoogle Scholar
• D'Ambrosio, D., D. A. Cantrell, L. Frati, A. Santoni, and R. Testi. 1994. Involvement of p21ras activation in T cell CD69 expression. Eur. J. Immunol. 24:616–620.
   PubMed Web of Science ®Google Scholar
• da Silva, A. J., Z. Li, C. de Vera, E. Canto, P. Findell, and C. E. Rudd. 1997. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc. Natl. Acad. Sci. USA 94:7493–7498.
   PubMedGoogle Scholar
• Desai, D. M., M. E. Newton, T. Kadlecek, and A. Weiss. 1990. Stimulation of the phosphatidylinositol pathway can induce T-cell activation. Nature 348:66–69.
   PubMedGoogle Scholar
• D'Oro, U., and J. D. Ashwell. 1999. The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. J. Immunol. 162:1879–1883.
   PubMedGoogle Scholar
• Dower, N. A., S. L. Stang, D. A. Bottorff, J. O. Ebinu, P. Oikie, H. L. Ostergaard, and J. C. Stone. 2000. Ras GRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1:317–321.
   PubMedGoogle Scholar
• Durand, D. B., J. P. Shaw, M. R. Bush, R. E. Replogle, R. Belagaje, and G. R. Crabtree. 1988. Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol. Cell. Biol. 8:1715–1724.
   PubMed Web of Science ®Google Scholar
• Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 9:617–626.
   PubMed Web of Science ®Google Scholar
• Flint, A. J., T. Tiganis, D. Barford, and N. K. Tonks. 1997. Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases. Proc. Natl. Acad. Sci. USA 94:1680–1685.
   PubMed Web of Science ®Google Scholar
• Goldsmith, A. M., D. M. Desai, T. Schultz, and A. Weiss. 1989. Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants. J. Biol. Chem. 264:17190–17197.
   PubMedGoogle Scholar
• Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547–5551.
   PubMed Web of Science ®Google Scholar
• Gossen, M., S. Freundlieb, G. Bender, G. Müller, W. Hillen, and H. Bujard. 1995. Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766–1769.
   PubMed Web of Science ®Google Scholar
• Graber, M., C. H. June, L. E. Samelson, and A. Weiss. 1992. The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor. Int. Immunol. 4:1201–1210.
   PubMedGoogle Scholar
• Grynkiewicz, G., M. Poenie, and R. Y. Tsien. 1985. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440–3450.
   PubMed Web of Science ®Google Scholar
• Hara, T., L. K. Jung, J. M. Bjorndahl, and S. M. Fu. 1986. Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens. J. Exp. Med. 164:1988–2005.
   PubMed Web of Science ®Google Scholar
• Hardwick, J. S., and B. M. Sefton. 1997. The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505. J. Biol. Chem. 272:25429–25432.
   PubMed Web of Science ®Google Scholar
• Imboden, J. B., and J. D. Stobo. 1985. Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J. Exp. Med. 161:446–456.
   PubMed Web of Science ®Google Scholar
• Izquierdo, M., S. J. Leevers, C. J. Marshall, and D. Cantrell. 1993. p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J. Exp. Med. 178:1199–1208.
   PubMedGoogle Scholar
• Jallal, B., K. Mossie, G. Vasiloudis, P. Knyazev, J. Zachwieja, F. Clairvoyant, J. Schilling, and A. Ullrich. 1997. The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase. J. Biol. Chem. 272:12158–12163.
   PubMedGoogle Scholar
• Jiang, G., J. den Hertog, J. Su, J. Noel, J. Sap, and T. Hunter. 1999. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. Nature 401:606–610.
   PubMedGoogle Scholar
• Keane, M. M., G. A. Lowrey, S. A. Ettenberg, M. A. Dayton, and S. Lipkowitz. 1996. The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells. Cancer Res. 56:4236–4243.
   PubMed Web of Science ®Google Scholar
• Kim, H. K., J. W. Kim, A. Zilberstein, B. Margolis, J. G. Kim, J. Schlessinger, and S. G. Rhee. 1991. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Cell 65:435–441.
   PubMed Web of Science ®Google Scholar
• Kovalenko, M., K. Denner, J. Sandström, C. Persson, S. Gross, E. Jandt, R. Vilella, F. Böhmer, and A. Ostman. 2000. Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. J. Biol. Chem. 275:16219–16226.
   PubMedGoogle Scholar
• Law, C. L., M. K. Ewings, P. M. Chaudhary, S. A. Solow, T. J. Yun, A. J. Marshall, L. Hood, and E. A. Clark. 1999. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. J. Exp. Med. 189:1243–1253.
   PubMedGoogle Scholar
• Liu, K. Q., S. C. Bunnell, C. B. Gurniak, and L. J. Berg. 1998. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J. Exp. Med. 187:1721–1727.
   PubMed Web of Science ®Google Scholar
• Liu, S. K., N. Fang, G. A. Koretzky, and C. J. McGlade. 1999. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9:67–75.
   PubMedGoogle Scholar
• Majeti, R., A. M. Bilwes, J. P. Noel, T. Hunter, and A. Weiss. 1998. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science 279:88–91.
   PubMed Web of Science ®Google Scholar
• Motto, D. G., S. E. Ross, J. Wu, L. R. Hendricks-Taylor, and G. A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J. Exp. Med. 183:1937–1943.
   PubMedGoogle Scholar
• Musci, M. A., L. R. Hendricks-Taylor, D. G. Motto, M. Paskind, J. Kamens, C. W. Turck, and G. A. Koretzky. 1997. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J. Biol. Chem. 272:11674–11677.
   PubMed Web of Science ®Google Scholar
• Nishibe, S., M. I. Wahl, S. M. Hernández-Sotomayor, N. K. Tonks, S. G. Rhee, and G. Carpenter. 1990. Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation. Science 250:1253–1256.
   PubMed Web of Science ®Google Scholar
• Ostman, A., Q. Yang, and N. K. Tonks. 1994. Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proc. Natl. Acad. Sci. USA 91:9680–9684.
   PubMed Web of Science ®Google Scholar
• Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F. W. Alt, and R. S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94:229–238.
   PubMed Web of Science ®Google Scholar
• Qian, D., S. Lev, N. S. van Oers, I. Dikic, J. Schlessinger, and A. Weiss. 1997. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med. 185:1253–1259.
   PubMedGoogle Scholar
• Rao, A., C. Luo, and P. G. Hogan. 1997. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15:707–747.
   PubMed Web of Science ®Google Scholar
• Shapiro, V. S., M. N. Mollenauer, W. C. Greene, and A. Weiss. 1996. c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1. J. Exp. Med. 184:1663–1669.
   PubMedGoogle Scholar
• Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31–40.
   PubMed Web of Science ®Google Scholar
• Su, Y. W., Y. Zhang, J. Schweikert, G. A. Koretzky, M. Reth, and J. Wienands. 1999. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur. J. Immunol. 29:3702–3711.
   PubMed Web of Science ®Google Scholar
• Tangye, S. G., J. H. Phillips, L. L. Lanier, J. E. de Vries, and G. Aversa. 1998. CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation. J. Immunol. 161:3249–3255.
   PubMed Web of Science ®Google Scholar
• Tangye, S. G., J. Wu, G. Aversa, J. E. de Vries, L. L. Lanier, and J. H. Phillips. 1998. Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148. J. Immunol. 161:3803–3807.
   PubMed Web of Science ®Google Scholar
• Thomas, M. L., and E. J. Brown. 1999. Positive and negative regulation of Src-family membrane kinases by CD45. Immunol. Today 20:406–411.
   PubMedGoogle Scholar
• Tomlinson, G. M., T. Kurosaki, A. E. Berson, G. H. Fujii, J. A. Johnston, and J. B. Bolen. 1999. Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk. J. Biol. Chem. 274:13577–13585.
   PubMedGoogle Scholar
• Tomlinson, G. M., J. Lin, and A. Weiss. 2000. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunol. Today 21:584–591.
   PubMedGoogle Scholar
• van Oers, N. S., H. von Boehmer, and A. Weiss. 1995. The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit. J. Exp. Med. 182:1585–1590.
   PubMed Web of Science ®Google Scholar
• Weiss, A., G. Koretzky, R. C. Schatzman, and T. Kadlecek. 1991. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc. Natl. Acad. Sci. USA 88:5484–5488.
   PubMedGoogle Scholar
• Weiss, A., and J. D. Stobo. 1984. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J. Exp. Med. 160:1284–1299.
   PubMed Web of Science ®Google Scholar
• Woodrow, M., N. A. Clipstone, and D. Cantrell. 1993. p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178:1517–1522.
   PubMedGoogle Scholar
• Woodrow, A. M., S. Rayter, J. Downward, and D. A. Cantrell. 1993. p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells. J. Immunol. 150:3853–3861.
   PubMedGoogle Scholar
• Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science 281:413–416.
   PubMedGoogle Scholar
• Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, H. C. Tsay, H. M. Jacobs, C. M. Kessler, E. O. Long, P. E. Love, and L. E. Samelson. 1999. Essential role of LAT in T cell development. Immunity 10:323–332.
   PubMed Web of Science ®Google Scholar
• Zhang, W., R. P. Trible, and L. E. Samelson. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9:239–246.
   PubMed Web of Science ®Google Scholar
• Zhang, W., R. P. Trible, M. Zhu, S. K. Liu, C. J. McGlade, and L. E. Samelson. 2000. Association of Grb2, Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues. J. Biol. Chem. 275:23355–23361.
   PubMed Web of Science ®Google Scholar
• Zhao, Q., and A. Weiss. 1996. Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70. Mol. Cell. Biol. 16:6765–6774.
   PubMedGoogle Scholar
• Zheng, X. M., R. J. Resnick, and D. Shalloway. 2000. A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J. 19:964–978.
   PubMed Web of Science ®Google Scholar