REFERENCES
- Boriack-Sjodin, P. A., S. M. Margarit, D. Bar-Sagi, and J. Kuriyan. 1998. The structural basis of the activation of Ras by Sos. Nature 394:337–343.
- Cantor, S., T. Urano, and L. A. Feig. 1995. Identification and characterization of RalBP1, a potential downstream target of Ral GTPases. Mol. Cell. Biol. 15:4578–4584.
- Damon, D. H., P. A. D'Amore, and J. A. Wagner. 1990. Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms. J. Cell Biol. 110:1333–1339.
- Downward, J., J. D. Graves, P. H. Warne, S. Rayter, and D. A. Cantrell. 1990. Stimulation of p21 ras upon T-cell activation. Nature 346:719–723.
- Exton, J. H.. 1999. Regulation of phospholipase D. Biochim. Biophys. Acta 1439:121–133.
- Goi, T., G. Rusanescu, T. Urano, and L. A. Feig. 1999. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol. Cell. Biol. 19:1731–1741.
- Goi, T., M. Shipistin, Z. Lu, D. A. Foster, S. Klinz, and L. A. Feig. 2000. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. EMBO J. 19:623–630.
- Gotoh, T., D. Cai, X. Tian, L. A. Feig, and A. Lerner. 2000. p130Cas regulates the activity of AND-34, a novel ral, rap1, and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275:30118–30123.
- Hagemann, C., and U. R. Rapp. 1999. Isotype-specific functions of Raf kinases. Exp. Cell Res. 253:34–46.
- Hall, F. L., P. Fernyhough, D. N. Ishii, and P. R. Vulliet. 1988. Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C. J. Biol. Chem. 263:4460–4466.
- Jiang, H., J. Q. Luo, T. Urano, P. Frankel, Z. Lu, D. A. Foster, and L. A. Feig. 1995. Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature 378:409–412.
- Jullien-Flores, V., O. Dorseuil, F. Romero, F. Letourneur, S. Saragosti, R. Berger, A. Tavitian, G. Gacon, and J. H. Camonis. 1995. Bridging Ral GTPase to Rho pathways. J. Biol. Chem. 270:22473–22477.
- Kariya, K., S. Koyama, S. Nakashima, T. Oshiro, K. Morinaka, and A. Kikuchi. 2000. Regulation of complex formation of POB1/Epsin/AP-2 by mitotic phosphorylation. J. Biol. Chem. 275:18399–18406.
- Lowenstein, E. J., R. J. Daly, A. G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431–442.
- Luo, J. Q., X. Liu, S. M. Hammond, W. C. Colley, L. A. Feig, M. A. Frohman, A. J. Morris, and D. A. Foster. 1997. RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem. Biophys. Res. Commun. 235:854–859.
- Marais, R., Y. Light, C. Mason, H. Paterson, M. F. Olson, and C. J. Marshall. 1998. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280:109–112 (Erratum, 280:987.)
- Matsubara, K., S. Kishida, Y. Matsuura, H. Kitayama, M. Noda, and A. Kikuchi. 1999. Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation. Oncogene 18:1303–1312.
- McCormick, F.. 1994. Activators and effectors of Ras p21 proteins. Curr. Opin. Genet. Dev. 4:71–76.
- Nakae, J., B. C. Park, and D. Accili. 1999. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway. J. Biol. Chem. 274:15982–15985.
- Nakashima, S., K. Morinaka, S. Koyama, M. Ikeda, M. Kishida, K. Okawa, A. Iwamatsu, S. Kishida, and A. Kikuchi. 1999. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 18:3629–3642.
- Ohta, Y., N. Suzuki, S. Nakamura, J. H. Hartwig, and T. P. Stossel. 1999. The small GTPase RalA targets filamin to induce filopodia. Proc. Natl. Acad. Sci. USA 96:2122–2128.
- Park, S. H., and R. A. Weinberg. 1995. A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene 11:2349–2355.
- Quaroni, A., and E. C. Paul. 1999. Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatus. J. Cell Sci. 112:707–718.
- Rameh, L. E., and L. C. Cantley. 1999. The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274:8347–8350.
- Rebhun, J. F., H. Chen, and L. A. Quilliam. 2000. Identification and characterization of a new family of guanine nucleotide exchange factors for the Ras-related GTPase Ral. J. Biol. Chem. 275:13406–13410.
- Schonwasser, D. C., R. M. Marais, C. J. Marshall, and P. J. Parker. 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18:790–798.
- Shields, J. M., K. Pruitt, A. McFall, A. Shaub, and C. J. Der. 2000. Understanding Ras: ‘it ain’t over ‘til it’s over.'. Trends Cell Biol. 10:147–154.
- Toker, A.. 1998. Signaling through protein kinase C. Front. Biosci. 3:D1134–D1147.
- Urano, T., R. Emkey, and L. A. Feig. 1996. Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J. 16:810–816.
- Voss, M., P. A. Weernink, S. Haupenthal, U. Moller, R. H. Cool, B. Bauer, J. H. Camonis, K. H. Jakobs, and M. Schmidt. 1999. Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade. J. Biol. Chem. 274:34691–34698.
- Wolthuis, R. M., N. D. de Ruiter, R. H. Cool, and J. L. Bos. 1997. Stimulation of gene induction and cell growth by the Ras effector Rlf. EMBO J. 16:6748–6761.