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Cell Growth and Development

Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding

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Pages 4544-4555 | Received 04 Feb 2002, Accepted 03 Apr 2002, Published online: 27 Mar 2023

REFERENCES

  • Alessi, D. R., Y. Saito, D. G. Campbell, P. Cohen, G. Sithanandam, U. Rapp, A. Ashworth, C. J. Marshall, and S. Cowley. 1994. Identification of the sites in MAP kinase kinase-1 phosphorylation by p74raf-1. EMBO J. 13: 1610–1619.
  • Boguslawski, G. 1992. PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae. J. Gen. Microbiol. 138: 2425–2432.
  • Brewster, J. L., T. de Valoir, N. D. Dwyer, E. Winter, and M. C. Gustin. 1993. An osmosensing signal transduction pathway in yeast. Science 259: 1760–1763.
  • Cairns, B. R., S. W. Ramer, and R. D. Kornberg. 1992. Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes Dev. 6: 1305–1318.
  • Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and S. M. Frisch. 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90: 315–323.
  • Chang, H. Y., H. Nishitoh, X. Yang, H. Ichijo, and D. Baltimore. 1998. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281: 1860–1863.
  • Chang, L., and M. Karin. 2001. Mammalian MAP kinase signalling cascades. Nature 410: 37–40.
  • Chen, Z., T. B. Gibson, F. Robinson, L. Silvestro, G. Pearson, B. Xu, A. Wright, C. Vanderbilt, and M. H. Cobb. 2001. MAP kinases. Chem. Rev. 101: 2449–2476.
  • Christianson, T. W., R. S. Sikorski, M. Dante, J. H. Shero, and P. Hieter. 1992. Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119–122.
  • Coleman, K. G., B. S. Wautlet, D. Morrissey, J. Mulheron, S. A. Sedman, P. Brinkley, S. Price, and K. R. Webster. 1997. Identification of CDK4 sequences involved in cyclin D1 and p16 binding. J. Biol. Chem. 272: 18869–18874.
  • Deak, J. C., J. V. Cross, M. Lewis, Y. Qian, L. A. Parrott, C. W. Distelhorst, and D. J. Templeton. 1998. Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc. Natl. Acad. Sci. USA 95: 5595–5600.
  • Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A. E. Kilburn, W.-H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7: 555–569.
  • Fornace, A. J., Jr. 1992. Mammalian genes induced by radiation; activation of genes associated with growth control. Annu. Rev. Genet. 26: 507–526.
  • Fornace, A. J., Jr., I. Alamo, Jr., and M. C. Hollander. 1988. DNA damage-inducible transcripts in mammalian cells. Proc. Natl. Acad. Sci. USA 85: 8800–8804.
  • Gartner, A., K. Nasmyth, and G. Ammerer. 1992. Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1. Genes Dev. 6: 1280–1292.
  • Gerwins, P., J. L. Blank, and G. L. Johnson. 1997. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 272: 8288–8295.
  • Goldfarb, D. S., J. Gariepy, G. Schoolnik, and R. D. Kornberg. 1986. Synthetic peptides as nuclear localization signals. Nature 322: 641–644.
  • King, A. J., H. Sun, B. Diaz, D. Barnard, W. Miao, S. Bagrodia, and M. S. Marshall. 1998. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396: 180–183.
  • Lei, M., W. Lu, W. Meng, M.-C. Parrini, M. J. Eck, B. J. Mayer, and S. C. Harrison. 2000. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102: 387–397.
  • Li, L., S. J. Elledge, C. A. Peterson, E. S. Bales, and R. J. Legerski. 1994. Specific association between the human DNA repair proteins XPA and ERCC1. Proc. Natl. Acad. Sci. USA 91: 5012–5016.
  • Lu, B., H. Yu, C. Chow, B. Li, W. Zheng, R. J. Davis, and R. A. Flavell. 2001. GADD45γ mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector Th1 cells. Immunity 14: 583–590.
  • Maeda, T., M. Takekawa, and H. Saito. 1995. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269: 554–558.
  • Maeda, T., S. M. Wurgler-Murphy, and H. Saito. 1994. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369: 242–245.
  • Mumberg, D., R. Müller, and M. Funk. 1995. Yeast vectors for the controlled expression of heterologous proteins in different genetic background. Gene 156: 119–122.
  • Ninomiya-Tsuji, J., S. Nomoto, H. Yasuda, S. I. Reed, and K. Matsumoto. 1991. Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proc. Natl. Acad. Sci. USA 88: 9006–9010.
  • Nishitoh, H., M. Saitoh, Y. Mochida, K. Takeda, H. Nakano, M. Rothe, K. Miyazono, and H. Ichijo. 1998. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell 2: 389–395.
  • Papathanasiou, M. A., N. C. Kerr, J. H. Robbins, O. W. McBride, I. Alamo, Jr., S. F. Barrett, I. D. Hickson, and A. J. Fornace, Jr. 1991. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol. Cell. Biol. 11: 1009–1016.
  • Payne, D. M., A. J. Rossomando, P. Martino, A. K. Erickson, J.-H. Her, J. Shabanowitz, D. F. Hunt, M. J. Weber, and T. W. Sturgill. 1991. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 10: 885–892.
  • Polverino, A., J. Frost, P. Yang, M. Hutchison, A. M. Neiman, M. H. Cobb, and S. Marcus. 1995. Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. J. Biol. Chem. 270: 26067–26070.
  • Posas, F., and H. Saito. 1998. Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J. 17: 1385–1394.
  • Posas, F., and H. Saito. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276: 1702–1705.
  • Posas, F., S. M. Wurgler-Murphy, T. Maeda, E. A. Witten, T. C. Thai, and H. Saito. 1996. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 “two-component” osmosensor. Cell 86: 865–875.
  • Rose, M. D., and J. R. Broach. 1991. Cloning genes by complementation in yeast. Methods Enzymol. 194: 195–230.
  • Shaulian, E., and M. Karin. 1999. Stress-induced JNK activation is independent of Gadd45 induction. J. Biol. Chem. 274: 29595–29598.
  • Sheikh, M. S., M. C. Hollander, and A. J. Fornace, Jr. 2000. Role of Gadd45 in apoptosis. Biochem. Pharmacol. 59: 43–45.
  • Takekawa, M., F. Posas, and H. Saito. 1997. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16: 4973–4982.
  • Takekawa, M., and H. Saito. 1998. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95: 521–530.
  • Takekawa, M., and H. Saito. 1998. Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J. 17: 4744–4752.
  • Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74: 205–214.
  • Wang, X., M. Gorospe, and N. J. Holbrook. 1999. Gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress. J. Biol. Chem. 274: 29599–29602.
  • Wölfel, T., M. Hauer, J. Schneider, M. Serrano, C. Wölfel, E. Klehmann-Hieb, E. De Plaen, T. Hankeln, K.-H. M. zum Büschenfelde, and D. Beach. 1995. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269: 1281–1284.
  • Xu, S., D. Robbins, J. Frost, A. Dang, C. Lange-Carter, and M. H. Cobb. 1995. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 92: 6808–6812.
  • Yamaguchi, K., K. Shirakabe, H. Shibuya, K. Irie, I. Oishi, N. Ueno, T. Taniguchi, E. Nishida, and K. Matsumoto. 1995. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270: 2008–2011.
  • Yang, J., H. Zhu, T. L. Murphy, W. Ouyang, and K. M. Murphy. 2001. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat. Immunol. 2: 157–164.
  • Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and G. M. Bokoch. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270: 23934–23936.

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