Increased p300 Expression Inhibits Glucocorticoid Receptor-T-Cell Receptor Antagonism but Does Not Affect Thymocyte Positive Selection

REFERENCES

• Ashwell, J. D., F. Lu, and M. S. Vacchio. 2000. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 18: 309–346.
   PubMed Web of Science ®Google Scholar
• Avots, A., M. Buttmann, S. Chuvpilo, C. Escher, U. Smola, A. J. Bannister, U. R. Rapp, T. Kouzarides, and E. Serfling. 1999. CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation. Immunity 10: 515–524.
   PubMedGoogle Scholar
• Barton, K., N. Muthusamy, M. Chanyanggam, C. Fischer, C. Cledenin, and J. M. Leiden. 1996. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379: 81–85.
   PubMedGoogle Scholar
• Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and R. H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175: 731–742.
   PubMed Web of Science ®Google Scholar
• Blobel, G. A. 2000. CREB-binding protein and p300: molecular integrators of hematopoietic transcription. Blood 95: 745–755.
   PubMed Web of Science ®Google Scholar
• Boothby, M. R., A. L. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard. 1997. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of NF-κB. J. Exp. Med. 185: 1897–1907.
   PubMed Web of Science ®Google Scholar
• Brandle, D., S. Muller, C. Muller, H. Hengartner, and H. Pircher. 1994. Regulation of Rag-1 and CD69 expression in the thymus during positive and negative selection. Eur. J. Immunol. 24: 145–151.
   PubMedGoogle Scholar
• Chakravarti, D., V. J. LaMorte, M. C. Nelson, T. Nakajima, I. G. Schulman, H. Juguilon, M. Montminy, and R. M. Evans. 1996. Role of CBP/P300 in nuclear receptor signalling. Nature 383: 99–103.
   PubMed Web of Science ®Google Scholar
• Chrivia, J. C., R. P. S. Kowk, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855–859.
   PubMed Web of Science ®Google Scholar
• De Bosscher, K., W. Vanden Berghe, L. Vermeulen, S. Plaisance, E. Boone, and G. Haegeman. 2000. Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc. Natl. Acad. Sci. USA 97: 3919–3924.
   PubMed Web of Science ®Google Scholar
• De Bosscher, K., W. Vanden Berghe, and G. Haegeman. 2001. Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators. Mol. Endocrinol. 15: 219–227.
   PubMed Web of Science ®Google Scholar
• Garcia-Rodriguez, C., and A. Rao. 1998. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J. Exp. Med. 187: 2031–2036.
   PubMedGoogle Scholar
• Gerritsen, M. E., A. J. Williams, A. S. Neish, S. Moore, Y. Shi, and T. Collins. 1997. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA 94: 2927–2932.
   PubMed Web of Science ®Google Scholar
• Godfrey, D. I., J. F. Purton, R. L. Boyd, and T. J. Cole. 2000. Stress-free T-cell development: glucocorticoids are not obligatory. Immunol. Today 21: 606–611.
   PubMedGoogle Scholar
• Goodman, R. H., and S. Smolik. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14: 1553–1577.
   PubMed Web of Science ®Google Scholar
• Greaves, D. R., F. D. Wilson, G. Lang, and D. Kioussis. 1989. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 56: 979–986.
   PubMed Web of Science ®Google Scholar
• Hsueh, Y.-P., H.-E. Liang, S.-Y. Ng, and M.-Z. Lai. 1997. CD28-costimulation activates cyclic AMP-responsive element binding protein in T lymphocytes. J. Immunol. 158: 85–93.
   PubMedGoogle Scholar
• Iwata, M., S. Hanaoka, and K. Sato. 1991. Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21: 643–648.
   PubMed Web of Science ®Google Scholar
• Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7: 333–342.
   PubMed Web of Science ®Google Scholar
• Jamieson, C. A. M., and K. R. Yamamoto. 2000. Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling. Proc. Natl. Acad. Sci. USA 97: 7319–7324.
   PubMed Web of Science ®Google Scholar
• Jenkinson, E. J., S. Parnell, J. Shuttleworth, J. Owen, and G. Anderson. 1999. Specialized ability of thymic epithelial cells to mediate positive selection does not require expression of the steroidogenic enzyme P450scc. J. Immunol. 163: 5781–5785.
   PubMedGoogle Scholar
• Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S. C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403–414.
   PubMed Web of Science ®Google Scholar
• Kaye, J., M. Hsu, M. Sauron, S. Jameson, N. Gascoigne, and S. Hedrick. 1989. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341: 746–749.
   PubMed Web of Science ®Google Scholar
• Kearse, K. P., Y. Takahama, J. A. Punt, S. O. Sharrow, and A. Singer. 1995. Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+CD8+ thymocytes: increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-α instability, improves TCR assembly, and parallels other indicators of positive selection. J. Exp. Med. 181: 193–202.
   PubMedGoogle Scholar
• King, L. B., M. S. Vacchio, K. Dixon, R. Hunziker, D. H. Margulies, and J. D. Ashwell. 1995. A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 3: 647–656.
   PubMed Web of Science ®Google Scholar
• Kowk, R. P. S., J. R. Lundblad, J. C. Chrivia, J. P. Richards, H. P. Bachinger, R. G. Brennan, S. G. E. Roberts, M. R. Green, and R. H. Goodman. 1994. Nuclear factor CBP is a coactivator for the transcription factor CREB. Nature 370: 223–226.
   PubMedGoogle Scholar
• Li, W.-F., M.-D. Fan, C.-B. Pan, and M.-Z. Lai. 1992. T cell epitope selection: dominance may be determined by both affinity for major histocompatibility complex and stoichiometry of epitope. Eur. J. Immunol. 22: 943–949.
   PubMedGoogle Scholar
• Liang, H.-E., C.-C. Chen, D.-L. Chou, and M.-Z. Lai. 1994. Flexibility of the T cell receptor repertoire. Eur. J. Immunol. 24: 1604–1611.
   PubMedGoogle Scholar
• Lu, F. W. M., K. Yasutomo, G. B. Goodman, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams, R. N. Germain, and J. D. Ashwell. 2000. Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to “holes'' in the T cell repertoire. Immunity 12: 183–192.
   PubMed Web of Science ®Google Scholar
• Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271–279.
   PubMed Web of Science ®Google Scholar
• O'Reilly, L. A., D. C. S. Huang, and A. Strasser. 1998. The cell death inhibitor and its homologues influence control of cell cycle entry. EMBO J. 15: 6979–6990.
   Google Scholar
• Oukka, M., I.-C. Ho, F. C. de la Brousse, T. Hoey, M. J. Grusby, and L. H. Glimcher. 1998. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity 9: 295–304.
   PubMed Web of Science ®Google Scholar
• Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinase associated with the p300 coactivator. Science 275: 523–527.
   PubMed Web of Science ®Google Scholar
• Petrij, F., R. H. Giles, H. G. Dauwerse, J. J. Saris, R. C. M. Hennekam, M. Masuno, N. Tommerup, G. J. B. van Ommen, R. H. Goodman, D. J. M. Peters, et al. 1995. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376: 348–351.
   PubMed Web of Science ®Google Scholar
• Purton, J. F., R. L. Boyd, T. J. Cole, and D. I. Godfrey. 2000. Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 13: 179–186.
   PubMedGoogle Scholar
• Reichardt, H. M., K. H. Kaestner, J. Tuckermann, O. Kretz, O. Wessely, R. Bock, P. Gass, W. Schmid, P. Herrlich, P. Angel, and G. Schütz. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 531–541.
   PubMed Web of Science ®Google Scholar
• Reichardt, H. M., J. P. Tuckermann, M. Göttlicher, M. Vujic, F. Weih, P. Angel, P. Herrlich, and G. Schütz. 2001. Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J. 20: 7168–7173.
   PubMed Web of Science ®Google Scholar
• Rudolph, D., A. Tafuri, P. Gass, G. J. Hammerling, B. Arnold, and G. Schutz. 1998. Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc. Natl. Acad. Sci. USA 95: 4481–4886.
   PubMed Web of Science ®Google Scholar
• Scollay, R., and K. Shortman. 1983. Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers. Thymus 5: 245–295.
   PubMedGoogle Scholar
• Sheppard, K. A., K. M. Phelp, A. J. Williams, D. Thanos, C. K. Glass, M. G. Rosenfeld, M. E. Gerritsen, and T. Collins. 1998. Nuclear integration of glucocorticoid receptor and nuclear factor-κB signaling by CREB-binding protein and steroid receptor coactivator-1. J. Biol. Chem. 273: 29291–29294.
   PubMed Web of Science ®Google Scholar
• Shikama, N., J. Lyon, and N. B. La Thangue. 1997. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell. Biol. 7: 230–236.
   PubMedGoogle Scholar
• Vacchio, M. S., V. Papadopoulos, and J. D. Ashwell. 1994. Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 179: 1835–1846.
   PubMedGoogle Scholar
• Vacchio, M. S., and J. D. Ashwell. 1997. Thymus-derived glucocorticoids regulate antigen-specific positive selection. J. Exp. Med. 185: 2033–2038.
   PubMed Web of Science ®Google Scholar
• Van Laethem, F., E. Baus, L. A. Smyth, F. Andris, F. Bex, J. Urbain, D. Kioussis, and O. Leo. 2001. Glucocorticoids attenuate T cell receptor signaling. J. Exp. Med. 193: 803–814.
   PubMed Web of Science ®Google Scholar
• Vo, N., and R. H. Goodman. 2001. CREB-binding protein and p300 in transcriptional regulation. J. Biol. Chem. 276: 13505–13508.
   PubMed Web of Science ®Google Scholar
• Xue, Y., M. Murdjeva, S. Okret, D. McConkey, D. Kioussis, and M. Jondal. 1996. Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice. Eur. J. Immunol. 26: 428–434.
   PubMed Web of Science ®Google Scholar
• Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T. J. Schmidt, J. Drouin, and M. Karin. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62: 1205–1215.
   PubMed Web of Science ®Google Scholar
• Yu, C.-T., H.-M. Shih, and M.-Z. Lai. 2001. Multiple signals required for cyclic AMP-responsive element binding protein (CREB) binding protein interaction induced by CD3/CD28 costimulation. J. Immunol. 166: 284–292.
   PubMedGoogle Scholar
• Zacharchuk, C. M., M. Mercep, P. K. Chakraborti, S. S. Simons, and J. D. Ashwell. 1990. Programmed T lymphocyte death: cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 145: 4037–4045.
   PubMed Web of Science ®Google Scholar