ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival

REFERENCES

• Altiok, N., J. L. Bessereau, and J. P. Changeux. 1995. ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate. EMBO J. 14: 4258–4266.
   PubMedGoogle Scholar
• Andrechek, E. R., W. R. Hardy, P. M. Siegel, M. A. Rudnicki, R. D. Cardiff, and W. J. Muller. 2000. Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc. Natl. Acad. Sci. USA 97: 3444–3449.
   PubMed Web of Science ®Google Scholar
• Anton, M., and F. L. Graham. 1995. Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J. Virol. 69: 4600–4606.
   PubMed Web of Science ®Google Scholar
• Bargmann, C. I., M. C. Hung, and R. A. Weinberg. 1986. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 319: 226–230.
   PubMed Web of Science ®Google Scholar
• Britsch, S., L. Li, S. Kirchhoff, F. Theuring, V. Brinkmann, C. Birchmeier, and D. Riethmacher. 1998. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12: 1825–1836.
   PubMed Web of Science ®Google Scholar
• Bruning, J. C., M. D. Michael, J. N. Winnay, T. Hayashi, D. Horsch, D. Accili, L. J. Goodyear, and C. R. Kahn. 1998. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 2: 559–569.
   PubMed Web of Science ®Google Scholar
• Burden, S., and Y. Yarden. 1997. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18: 847–855.
   PubMed Web of Science ®Google Scholar
• Burgering, B. M., and P. J. Coffer. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599–602.
   PubMed Web of Science ®Google Scholar
• Butler, R. 1979. A new grouping of intrafusal muscle fibers based on developmental studies of muscle spindles in the cat. Am. J. Anat. 156: 115–120.
   PubMedGoogle Scholar
• Chamberlain, J. S., J. B. Jaynes, and S. D. Hauschka. 1985. Regulation of creatine kinase induction in differentiating mouse myoblasts. Mol. Cell. Biol. 5: 484–492.
   PubMed Web of Science ®Google Scholar
• Chan, R., W. R. Hardy, M. A. Laing, S. E. Hardy, and W. J. Muller. 2002. The catalytic activity of the ErbB-2 receptor tyrosine kinase is essential for embryonic development. Mol. Cell. Biol. 22: 1073–1078.
   PubMed Web of Science ®Google Scholar
• Coussens, L., T. L. Yang-Feng, Y. C. Liao, E. Chen, A. Gray, J. McGrath, P. H. Seeburg, T. A. Libermann, J. Schlessinger, U. Francke, et al. 1985. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230: 1132–1139.
   PubMed Web of Science ®Google Scholar
• Dougall, W. C., X. Qian, N. C. Peterson, M. J. Miller, A. Samanta, and M. I. Greene. 1994. The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies. Oncogene 9: 2109–2123.
   PubMed Web of Science ®Google Scholar
• Erickson, S. L., K. S. O'Shea, N. Ghaboosi, L. Loverro, G. Frantz, M. Bauer, L. H. Lu, and M. W. Moore. 1997. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124: 4999–5011.
   PubMed Web of Science ®Google Scholar
• Ernfors, P., K. F. Lee, J. Kucera, and R. Jaenisch. 1994. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77: 503–512.
   PubMed Web of Science ®Google Scholar
• Franke, T. F., S. I. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, and P. N. Tsichlis. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727–736.
   PubMed Web of Science ®Google Scholar
• Garratt, A. N., S. Britsch, and C. Birchmeier. 2000. Neuregulin, a factor with many functions in the life of a Schwann cell. Bioessays 22: 987–996.
   PubMed Web of Science ®Google Scholar
• Garratt, A. N., O. Voiculescu, P. Topilko, P. Charnay, and C. Birchmeier. 2000. A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool. J. Cell Biol. 148: 1035–1046.
   PubMedGoogle Scholar
• Gassmann, M., F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein, and G. Lemke. 1995. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378: 390–394.
   PubMed Web of Science ®Google Scholar
• Grounds, M. D., and Z. Yablonka-Reuveni. 1993. Molecular and cell biology of skeletal muscle regeneration. Mol. Cell. Biol. Hum. Dis. Ser. 3: 210–256.
   PubMedGoogle Scholar
• Hansen, L. A., N. Alexander, M. E. Hogan, J. P. Sundberg, A. Dlugosz, D. W. Threadgill, T. Magnuson, and S. H. Yuspa. 1997. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am. J. Pathol. 150: 1959–1975.
   PubMed Web of Science ®Google Scholar
• Harari, D., and Y. Yarden. 2000. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene 19: 6102–6114.
   PubMed Web of Science ®Google Scholar
• Hynes, N. E., and D. F. Stern. 1994. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim. Biophys. Acta 1198: 165–184.
   PubMed Web of Science ®Google Scholar
• Jo, S. A., X. Zhu, M. A. Marchionni, and S. J. Burden. 1995. Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature 373: 158–161.
   PubMed Web of Science ®Google Scholar
• Kita, Y. A., J. Barff, Y. Luo, D. Wen, D. Brankow, S. Hu, N. Liu, S. A. Prigent, W. J. Gullick, and M. Nicolson. 1994. NDF/heregulin stimulates the phosphorylation of Her3/erbB3. FEBS Lett. 349: 139–143.
   PubMedGoogle Scholar
• Klein, R., I. Silos-Santiago, R. J. Smeyne, S. A. Lira, R. Brambilla, S. Bryant, L. Zhang, W. D. Snider, and M. Barbacid. 1994. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature 368: 249–251.
   PubMed Web of Science ®Google Scholar
• Kraus, M. H., W. Issing, T. Miki, N. C. Popescu, and S. A. Aaronson. 1989. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. USA 86: 9193–9197.
   PubMed Web of Science ®Google Scholar
• Lee, K. F., H. Simon, H. Chen, B. Bates, M. C. Hung, and C. Hauser. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394–398.
   PubMed Web of Science ®Google Scholar
• Lin, W., H. B. Sanchez, T. Deerinck, J. K. Morris, M. Ellisman, and K. F. Lee. 2000. Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc. Natl. Acad. Sci. USA 97: 1299–1304.
   PubMedGoogle Scholar
• Loeb, J. A., and G. D. Fischbach. 1997. Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons. J. Neurosci. 17: 1416–1424.
   PubMed Web of Science ®Google Scholar
• Megeney, L. A., B. Kablar, K. Garrett, J. E. Anderson, and M. A. Rudnicki. 1996. MyoD is required for myogenic stem cell function in adult skeletal muscle. Genes Dev. 10: 1173–1183.
   PubMed Web of Science ®Google Scholar
• Mittal, S. K., A. J. Bett, L. Prevec, and F. L. Graham. 1995. Foreign gene expression by human adenovirus type 5-based vectors studied using firefly luciferase and bacterial beta-galactosidase genes as reporters. Virology 210: 226–230.
   PubMed Web of Science ®Google Scholar
• Morris, J. K., W. Lin, C. Hauser, Y. Marchuk, D. Getman, and K. F. Lee. 1999. Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron 23: 273–283.
   PubMedGoogle Scholar
• Moscoso, L. M., G. C. Chu, M. Gautam, P. G. Noakes, J. P. Merlie, and J. R. Sanes. 1995. Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev. Biol. 172: 158–169.
   PubMed Web of Science ®Google Scholar
• Plowman, G. D., J. M. Culouscou, G. S. Whitney, J. M. Green, G. W. Carlton, L. Foy, M. G. Neubauer, and M. Shoyab. 1993. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc. Natl. Acad. Sci. USA 90: 1746–1750.
   PubMed Web of Science ®Google Scholar
• Plowman, G. D., G. S. Whitney, M. G. Neubauer, J. M. Green, V. L. McDonald, G. J. Todaro, and M. Shoyab. 1990. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc. Natl. Acad. Sci. USA 87: 4905–4909.
   PubMed Web of Science ®Google Scholar
• Rando, T. A., and H. M. Blau. 1994. Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J. Cell Biol. 125: 1275–1287.
   PubMed Web of Science ®Google Scholar
• Riethmacher, D., E. Sonnenberg-Riethmacher, V. Brinkmann, T. Yamaai, G. R. Lewin, and C. Birchmeier. 1997. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389: 725–730.
   PubMed Web of Science ®Google Scholar
• Schechter, A. L., D. F. Stern, L. Vaidyanathan, S. J. Decker, J. A. Drebin, M. I. Greene, and R. A. Weinberg. 1984. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 312: 513–516.
   PubMed Web of Science ®Google Scholar
• Si, J., Z. Luo, and L. Mei. 1996. Induction of acetylcholine receptor gene expression by ARIA requires activation of mitogen-activated protein kinase. J. Biol. Chem. 271: 19752–19759.
   PubMed Web of Science ®Google Scholar
• Sibilia, M., J. P. Steinbach, L. Stingl, A. Aguzzi, and E. F. Wagner. 1998. A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J. 17: 719–731.
   PubMedGoogle Scholar
• Siegel, P. M., D. L. Dankort, W. R. Hardy, and W. J. Muller. 1994. Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. Mol. Cell. Biol. 14: 7068–7077.
   PubMed Web of Science ®Google Scholar
• Soltoff, S. P., K. L. Carraway, 3rd, S. A. Prigent, W. G. Gullick, and L. C. Cantley. 1994. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol. Cell. Biol. 14: 3550–3558.
   PubMed Web of Science ®Google Scholar
• Sweeney, C., D. Fambrough, C. Huard, A. J. Diamonti, E. S. Lander, L. C. Cantley, and K. L. Carraway III. 2001. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J. Biol. Chem. 276: 22685–22698.
   PubMed Web of Science ®Google Scholar
• Tansey, M. G., G. C. Chu, and J. P. Merlie. 1996. ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway. J. Cell Biol. 134: 465–476.
   PubMed Web of Science ®Google Scholar
• Threadgill, D. W., A. A. Dlugosz, L. A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, R. C. Harris, et al. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269: 230–234.
   PubMed Web of Science ®Google Scholar
• Tourtellotte, W. G., and J. Milbrandt. 1998. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 20: 87–91.
   PubMed Web of Science ®Google Scholar
• Ullrich, A., L. Coussens, J. S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, et al. 1984. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309: 418–425.
   PubMed Web of Science ®Google Scholar
• Woldeyesus, M. T., S. Britsch, D. Riethmacher, L. Xu, E. Sonnenberg-Riethmacher, F. Abou-Rebyeh, R. Harvey, P. Caroni, and C. Birchmeier. 1999. Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 13: 2538–2548.
   PubMedGoogle Scholar
• Won, S., J. Si, M. Colledge, K. S. Ravichandran, S. C. Froehner, and L. Mei. 1999. Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc. J. Neurochem. 73: 2358–2368.
   PubMedGoogle Scholar
• Yamamoto, T., S. Ikawa, T. Akiyama, K. Semba, N. Nomura, N. Miyajima, T. Saito, and K. Toyoshima. 1986. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 319: 230–234.
   PubMed Web of Science ®Google Scholar
• Zhu, X., C. Lai, S. Thomas, and S. J. Burden. 1995. Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses. EMBO J. 14: 5842–5848.
   PubMed Web of Science ®Google Scholar
• Zisman, A., O. D. Peroni, E. D. Abel, M. D. Michael, F. Mauvais-Jarvis, B. B. Lowell, J. F. Wojtaszewski, M. F. Hirshman, A. Virkamaki, L. J. Goodyear, C. R. Kahn, and B. B. Kahn. 2000. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 6: 924–928.
   PubMed Web of Science ®Google Scholar