Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

REFERENCES

• Adams, B., P. Dorfler, A. Aguzzi, Z. Kozmik, P. Urbanek, I. Maurer-Fogy, and M. Busslinger. 1992. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and the adult testis. Genes Dev. 6: 1589–1607.
   PubMed Web of Science ®Google Scholar
• Angelin-Duclos, C., G. Cattoretti, D. Chang, K. Lin, Y. Lin, J. Yu, and K. Calame. 1999. The role of B lymphocyte-induced maturation protein-1 (BLIMP-1) in terminal differentiation of B cells and other cell lineages. Cold Spring Harbor Symp. Quant. Biol. 64: 61–70.
   PubMedGoogle Scholar
• Angelin-Duclos, C., G. Cattoretti, K.-I. Lin, and K. Calame. 2000. Commitment of B lymphocytes to a plasma cell fate is associated with blimp-1 expression in vivo. J. Immunol. 165: 5462–5471.
   PubMedGoogle Scholar
• Barberis, A., K. Widenhorn, L. Vitelli, and M. Busslinger. 1990. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 4: 849–859.
   PubMedGoogle Scholar
• Chang, D., C. Angelin-Duclos, and K. Calame. 2000. BLIMP-1: trigger for differentiation of myeloid lineage. Nat. Immunol. 1: 169–176.
   PubMed Web of Science ®Google Scholar
• Keller, A. D., and T. Maniatis. 1991. Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev. 5: 868–879.
   PubMed Web of Science ®Google Scholar
• Keller, A. D., and T. Maniatis. 1992. Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding. Mol. Cell. Biol. 12: 1940–1949.
   PubMed Web of Science ®Google Scholar
• Kozmik, Z., S. Wang, P. Dorfler, B. Adams, and M. Busslinger. 1992. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol. 12: 2662–2672.
   PubMed Web of Science ®Google Scholar
• Lin, K.-I., Y. Lin, and K. Calame. 2000. Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro. Mol. Cell. Biol. 20: 8684–8695.
   PubMedGoogle Scholar
• Lin, Y., K. Wong, and K. Calame. 1997. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276: 596–599.
   PubMed Web of Science ®Google Scholar
• Max, E. E., Y. Wakatsuki, M. F. Neurath, and W. Strober. 1995. The role of BSAP in immunoglobulin isotype switching and B-cell proliferation. Curr. Top. Microbiol. Immunol. 194: 449–458.
   PubMedGoogle Scholar
• Neurath, M. F., W. Strober, and Y. Wakatsuki. 1994. The murine Ig 3′ alpha enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP). J. Immunol. 153: 730–742.
   PubMed Web of Science ®Google Scholar
• Niu, H., B. H. Ye, and R. Dalla-Favera. 1998. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 12: 1953–1961.
   PubMed Web of Science ®Google Scholar
• Nutt, S. L., B. Heavey, A. G. Rolink, and M. Busslinger. 1999. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401: 556–562.
   PubMed Web of Science ®Google Scholar
• Nutt, S. L., A. M. Morrison, P. Dorfler, A. Rolink, and M. Busslinger. 1998. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J. 17: 2319–2333.
   PubMed Web of Science ®Google Scholar
• Nutt, S. L., P. Urbanek, A. Rolink, and M. Busslinger. 1997. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev. 11: 476–491.
   PubMed Web of Science ®Google Scholar
• Okabe, T., S. R. Bauer, and A. Kudo. 1992. Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene. Eur. J. Immunol. 22: 31–36.
   PubMed Web of Science ®Google Scholar
• O'Riordan, M., and R. Grosschedl. 1999. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 11: 21–31.
   PubMedGoogle Scholar
• Piskurich, J. F., K. I. Lin, Y. Lin, Y. Wang, J. P. Ting, and K. Calame. 2000. BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells. Nat. Immunol. 1: 526–532.
   PubMedGoogle Scholar
• Qiu, G., and J. Stavnezer. 1998. Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line. J. Immunol. 161: 2906–2918.
   PubMed Web of Science ®Google Scholar
• Reimold, A. M., N. N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E. M. Gravallese, D. Friend, M. J. Grusby, F. Alt, and L. H. Glimcher. 2001. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412: 300–307.
   PubMed Web of Science ®Google Scholar
• Reimold, A. M., P. D. Ponath, Y. S. Li, R. R. Hardy, C. S. David, J. L. Strominger, and L. H. Glimcher. 1996. Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J. Exp. Med. 183: 393–401.
   PubMed Web of Science ®Google Scholar
• Reljic, R., S. D. Wagner, L. J. Peakman, and D. T. Fearon. 2000. Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6. J. Exp. Med. 192: 1841–1848.
   PubMed Web of Science ®Google Scholar
• Ren, B., K. J. Chee, T. H. Kim, and T. Maniatis. 1999. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev. 13: 125–137.
   PubMed Web of Science ®Google Scholar
• Rinkenberger, J. L., J. J. Wallin, K. W. Johnson, and M. E. Koshland. 1996. An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. Immunity 5: 377–386.
   PubMed Web of Science ®Google Scholar
• Schliephake, D. E., and A. Schimpl. 1996. Blimp-1 overcomes the block in IgM secretion in lipopolysaccharide/anti-mu F(ab′)2-costimulated B lymphocytes. Eur. J. Immunol. 26: 268–271.
   PubMedGoogle Scholar
• Shaffer, A. L., X. Yu, Y. He, J. Boldrick, E. P. Chan, and L. M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13: 199–212.
   PubMed Web of Science ®Google Scholar
• Singh, M., and B. K. Birshtein. 1993. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3′ alpha enhancer at early stages of B-cell differentiation. Mol. Cell. Biol. 13: 3611–3622.
   PubMed Web of Science ®Google Scholar
• Turner, C. A., Jr., D. H. Mack, and M. M. Davis. 1994. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77: 297–306.
   PubMed Web of Science ®Google Scholar
• Urbanek, P., Z. Q. Wang, I. Fetka, E. F. Wagner, and M. Busslinger. 1994. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79: 901–912.
   PubMed Web of Science ®Google Scholar
• Usui, T., Y. Wakatsuki, Y. Matsunaga, S. Kaneko, H. Kosek, and T. Kita. 1997. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J. Immunol. 158: 3197–3204.
   PubMed Web of Science ®Google Scholar
• Wakatsuki, Y., M. F. Neurath, E. E. Max, and W. Strober. 1994. The B cell-specific transcription factor BSAP regulates B cell proliferation. J. Exp. Med. 179: 1099–1108.
   PubMed Web of Science ®Google Scholar
• Wallin, J. J., E. R. Gackstetter, and M. E. Koshland. 1998. Dependence of BSAP repressor and activator functions on BSAP concentration. Science 279: 1961–1964.
   PubMedGoogle Scholar
• Yu, J., C. Angelin-Duclos, J. Greenwood, J. Liao, and K. Calame. 2000. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol. Cell. Biol. 20: 2592–2603.
   PubMed Web of Science ®Google Scholar
• Zwollo, P., and S. Desiderio. 1994. Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein. J. Biol. Chem. 269: 15310–15317.
   PubMed Web of Science ®Google Scholar