The Human Candidate Tumor Suppressor Gene HIC1 Recruits CtBP through a Degenerate GLDLSKK Motif

REFERENCES

• Ahmad, K. F., C. K. Engel, and G. G. Privé. 1998. Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. USA 95: 12123–12128.
   PubMed Web of Science ®Google Scholar
• Albagli, O., P. Dhordain, C. Deweindt, G. Lecocq, and D. Leprince. 1995. The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. Cell Growth Differ. 6: 1193–1198.
   PubMedGoogle Scholar
• Bardwell, V. J., and R. Treisman. 1994. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8: 1664–1677.
   PubMed Web of Science ®Google Scholar
• Boyd, J. M., T. Subramanian, U. Schaeper, M. La Regina, S. Bayley, and G. Chinnadurai. 1993. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J. 12: 469–478.
   PubMed Web of Science ®Google Scholar
• Brannon, M., J. D. Brown, R. Bates, D. Kimelman, and R. T. Moon. 1999. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development 126: 3159–3170.
   PubMed Web of Science ®Google Scholar
• Carter, M. G., M. A. Johns, X. Zeng, L. Zhou, M. C. Zink, J. L. Mankowski, D. M. Donovan, and S. B. Baylin. 2000. Mice deficient in the candidate tumor suppressor gene HIC1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum. Mol. Genet. 9: 413–419.
   PubMedGoogle Scholar
• Chen, G., and A. J. Courey. 2000. Groucho/TLE family proteins and transcriptional repression. Gene 249: 1–16.
   PubMed Web of Science ®Google Scholar
• Cohen, R. N., S. Brzostek, B. Kim, M. Chorev, F. E. Wondisford, and A. N. Hollenberg. 2001. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol. Endocrinol. 15: 1049–1061.
   PubMedGoogle Scholar
• Criqui-Filipe, P., C. Ducret, S. M. Maira, and B. Wasylyk. 1999. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J. 18: 3392–3403.
   PubMedGoogle Scholar
• Deltour, S., C. Guérardel, and D. Leprince. 1999. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC1 and γFBP-B. Proc. Natl. Acad. Sci. USA 96: 14831–14836.
   PubMedGoogle Scholar
• Deltour, S., S. Pinte, C. Guérardel, and D. Leprince. 2001. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. Biochem. Biophys. Res. Commun. 287: 427–434.
   PubMedGoogle Scholar
• Dhordain, P., O. Albagli, R. J. Lin, S. Ansieau, S. Quief, A. Leutz, J. P. Kerckaert, R. M. Evans, and D. Leprince. 1997. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. USA 94: 10762–10769.
   PubMed Web of Science ®Google Scholar
• Dobyns, W. B., and C. L. Truwit. 1995. Lissencephaly and other malformations of cortical development: 1995 update. Neuropediatrics 26: 132–147.
   PubMedGoogle Scholar
• Emiliani, S., W. Fischle, C. Van Lint, Y. Al-Abed, and E. Verdin. 1998. Characterization of a human RPD3 ortholog, HDAC3. Proc. Natl. Acad. Sci. USA 95: 2795–2800.
   PubMed Web of Science ®Google Scholar
• Fox, A. H., C. Liew, M. Holmes, K. Kowalski, J. MacKay, and M. Crossley. 1999. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. EMBO J. 18: 2812–2822.
   PubMedGoogle Scholar
• Furusawa, T., H. Moribe, H. Kondoh, and Y. Higashi. 1999. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor δEF-1. Mol. Cell. Biol. 19: 8581–8590.
   PubMedGoogle Scholar
• Ghosh, D., T. I. Gerasimova, and V. Corces. 2001. Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function. EMBO J. 20: 2518–2527.
   PubMedGoogle Scholar
• Guérardel, C., S. Deltour, S. Pinte, D. Monté, A. Bègue, A. K. Godwin, and D. Leprince. 2001. Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. J. Biol. Chem. 276: 3078–3089.
   PubMedGoogle Scholar
• Grimm, C., R. Spörle, T. E. Schmid, I.-D. Adler, A. Adamski, K. Schughart, and J. Graw. 1999. Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Hum. Mol. Genet. 8: 697–710.
   PubMedGoogle Scholar
• Holmes, M., J. Turner, A. Fox, O. Chisholm, M. Crossley, and B. Chong. 1999. hFOG-2, a novel zinc finger protein binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J. Biol. Chem. 274: 23491–23498.
   PubMedGoogle Scholar
• Huynh, K. D., and V. J. Bardwell. 1998. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 17: 2473–2484.
   PubMed Web of Science ®Google Scholar
• Huynh, K. D., W. Fischle, E. Verdin, and V. J. Bardwell. 2000. BcoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 14: 1810–1823.
   PubMed Web of Science ®Google Scholar
• Izutsu, K., M. Kurokawa, Y. Imai, K. Maki, and H. Hirai. 2001. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signalling. Blood 97: 2815–2821.
   PubMed Web of Science ®Google Scholar
• Keller, S. A., Y. Mao, P. Struffi, C. Margulies, C. E. Yurk, A. R. Anderson, R. L. Amey, S. Moore, J. Ebels, K. Foley, M. Corado, and D. N. Arnosti. 2000. dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein. Mol. Cell. Biol. 20: 7247–7258.
   PubMedGoogle Scholar
• Knoepfler, P. S., and R. N. Eisenmann. 1999. Sin meets NURD and other tails of repression. Cell 99: 447–450.
   PubMed Web of Science ®Google Scholar
• Koipally, J., and K. Georgopoulos. 2000. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J. Biol. Chem. 275: 19594–19602.
   PubMedGoogle Scholar
• Kouzarides, T. 2000. Acetylation: a regulatory modification to rival phosphorylation? EMBO J. 19: 1176–1179.
   PubMed Web of Science ®Google Scholar
• Li, S., P.-L. Chen, T. Subramanian, G. Chinnudarrai, G. Tomlinson, C. K. Osborne, Z. D. Sharp, and W.-H. Lee. 1999. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J. Biol. Chem. 274: 11334–11338.
   PubMed Web of Science ®Google Scholar
• Liu, Q., F. Shalaby, M. C. Puri, S. Tang, and M. L. Breitman. 1994. Novel zinc finger proteins that interact with the mouse γF-crystallin promoter and are expressed in the sclerotome during early embryogenesis. Dev. Biol. 165: 165–177.
   PubMedGoogle Scholar
• Makos-Wales, M., M. Biel, W. El Deiry, B. D. Nelkin, J. P. Issa, W. K. Cavenee, S. J. Kuerbitz, and S. B. Baylin. 1995. p53 activates expression of HIC1, a new candidate tumor suppressor gene on 17p13.3. Nat. Med. 1: 570–577.
   PubMedGoogle Scholar
• Melhuish, T. A., and D. Wotton. 2000. The interaction of the carboxyl-terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275: 39762–39766.
   PubMed Web of Science ®Google Scholar
• Melnick, A., K. F. Ahmad, S. Arai, A. Polinger, H. Ball, K. L. Borden, G. W. Carlile, G. G. Privé, and J. D. Licht. 2000. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Mol. Cell. Biol. 20: 6550–6567.
   PubMedGoogle Scholar
• Meloni, A. R., E. J. Smith, and J. R. Nevins. 1999. A mechanism of Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. USA 96: 9574–9579.
   PubMedGoogle Scholar
• Miska, E. A., C. Karlsson, E. Langley, S. J. Nielsen, J. Pines, and T. Kouzarides. 1999. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 18: 5099–5107.
   PubMed Web of Science ®Google Scholar
• Molloy, D. P., A. E. Milner, I. K. Yakub, G. Chinnadurai, P. H. Gallimore, and R. J. A. Grand. 1998. Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins. J. Biol. Chem. 273: 20867–20876.
   PubMedGoogle Scholar
• Molloy, D. P., P. M. Barral, K. H. Brenner, P. H. Gallimore, and R. J. A. Grand. 2001. Structural determinants outside the PXDLS sequence affect the interaction of adenovirus E1A, C-terminal interacting protein and Drosophila repressors with C-terminal binding protein. Biochim. Biophys. Acta 1546: 55–70.
   PubMedGoogle Scholar
• Morel, V., M. Lecourtois, O. Massiani, D. Maier, A. Preiss, and F. Schweisguth. 2001. Transcriptional repression by Suppressor of Hairy involves the binding of a Hairless-dCtBP complex in Drosophila. Curr. Biol. 11: 789–792.
   PubMed Web of Science ®Google Scholar
• Murakami, A., S. Ishida, J. Thurlow, J. M. Revest, and C. Dickson. 2001. Sox6 binds CtBP2 to repress transcription from the Fgf-3 promoter. Nucleic Acids Res. 29: 3347–3355.
   PubMedGoogle Scholar
• Nibu, Y., H. Zhang, and M. Levine. 1998. Interaction of short-range repressors with Drosophila CtBP in the embryo. Science 280: 101–104.
   PubMedGoogle Scholar
• Nibu, Y., and M. Levine. 2001. CtBP-dependent activities of the short-range Giant repressor in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 98: 6204–6208.
   PubMedGoogle Scholar
• Nielsen, A. L., J. A. Ortiz, J. You, M. Oulad-Abdelghani, R. Khechumian, A. Gansmuller, P. Chambon, and R. Losson. 1999. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 18: 6385–6395.
   PubMed Web of Science ®Google Scholar
• Palmer, S., J. P. Brouillet, A. Kilbey, R. Fulton, M. Walker, M. Crossley, and C. Bartholomew. 2001. Evi-1 transforming and repressing activities are mediated by CtBP co-repressor proteins. J. Biol. Chem. 276: 25834–25840.
   PubMedGoogle Scholar
• Phippen, T. M., A. L. Sweigart, M. Moniwa, A. Krumm, J. R. Davie, and S. M. Parkhurst. 2000. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both Mad and Groucho transcriptional repression. J. Biol. Chem. 275: 39628–39637.
   Google Scholar
• Poortinga, G., M. Watanabe, and S. M. Parkhurst. 1998. Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression. EMBO J. 17: 2067–2078.
   PubMedGoogle Scholar
• Postigo, A. A., and D. C. Dean. 1999. ZEB represses transcription through interaction with the corepressor CtBP. Proc. Natl. Acad. Sci. USA 96: 6683–6688.
   PubMedGoogle Scholar
• Schaeper, U., J. Boyd, S. Verma, E. Uhlmann, T. Subramanian, and G. Chinnadurai. 1995. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA 92: 10467–10471.
   PubMed Web of Science ®Google Scholar
• Sewalt, R. G. A. B., M. J. Gunster, J. van der Vlag, D. P. E. Satijn, and A. P. Otte. 1999. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol. 19: 777–787.
   PubMed Web of Science ®Google Scholar
• Strunk, B., P. Struffi, K. Wright, B. Pabst, J. Thomas, L. Qin, and D. N. Arnosti. 2001. Role of CtBP in transcriptional repression by the Drosophila giant protein. Dev. Biol. 239: 229–240.
   PubMedGoogle Scholar
• Sundqvist, A., K. Sollerbrant, and C. Svensson. 1998. The carboxy-terminal region of E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex. FEBS Lett. 429: 183–188.
   PubMed Web of Science ®Google Scholar
• Sundqvist, A., E. Bajak, S. D. Kurup, K. Sollerbrant, and C. Svensson. 2001. Functional knockout of the corepressor CtBP by the second exon of adenovirus E1A relieves repression of transcription. Exp. Cell Res. 268: 284–293.
   PubMedGoogle Scholar
• Touitou, R., M. Hickabottom, G. Parker, T. Crook, and M. J. Allday. 2001. Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C. J. Virol. 75: 7749–7755.
   PubMedGoogle Scholar
• Turner, J., and M. Crossley. 1998. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruüppel-like factor and other mammalian transcriptional regulators. EMBO J. 17: 5129–5140.
   PubMed Web of Science ®Google Scholar
• Turner, J., and M. Crossley. 2001. The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Bioessays 23: 683–690.
   PubMedGoogle Scholar
• Vo, N., C. Fjeld, and R. H. Goodman. 2001. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional repressor CtBP. Mol. Cell. Biol. 21: 6181–6188.
   PubMedGoogle Scholar
• Wen, J., D. Nguyen, Y. Li, and Z.-C. Lai. 2000. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye. Genetics 156: 195–203.
   PubMedGoogle Scholar
• Wolffe, A. P., F. D. Urnov, and D. Guschin. 2000. Co-repressor complexes and remodeling chromatin for repression. Biochem. Soc. Trans. 28: 379–386.
   PubMedGoogle Scholar
• Zhang, C. L., T. A. McKinsey, J.-R. Lu, and E. Olson. 2001. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to the transcriptional repression of the MEF2 transcription factor. J. Biol. Chem. 276: 35–39.
   PubMed Web of Science ®Google Scholar
• Zhang, H., and M. Levine. 1999. Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 96: 535–540.
   PubMedGoogle Scholar
• Zhang, Q., H. Yao, N. Vo, and R. H. Goodman. 2000. Acetylation of adenovirus E1A regulates binding of the transcriptional repressor CtBP. Proc. Natl. Acad. Sci. USA 97: 14323–14328.
   PubMed Web of Science ®Google Scholar