Neuronal Differentiation and Protection from Nitric Oxide-Induced Apoptosis Require c-Jun-Dependent Expression of NCAM140

REFERENCES

• Amoureux, M. C., B. A. Cunningham, G. M. Edelman, and K. L. Crossin. 2000. N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neuronal phenotype. J. Neurosci. 20: 3631–3640.
   PubMedGoogle Scholar
• Ankarcrona, M., J. M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S. A. Lipton, and P. Nicotera. 1995. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961–973.
   PubMed Web of Science ®Google Scholar
• Azizeh, B. Y., D. H. Cribbs, V. M. Kreng, and C. W. Cotman. 1998. Cross-linking of NCAM receptors on neurons induces programmed cell death. Brain Res. 796: 20–26.
   PubMedGoogle Scholar
• Barthels, D., M. J. Santoni, W. Wille, C. Ruppert, J. C. Chaix, M. R. Hirsch, J. C. Fontecilla-Camps, and C. Goridis. 1987. Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning region. EMBO J. 6: 907–914.
   PubMed Web of Science ®Google Scholar
• Beggs, H. E., S. C. Baragona, J. Hemperly, and P. F. Maness. 1997. NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn). J. Biol. Chem. 272: 8310–8319.
   PubMed Web of Science ®Google Scholar
• Beggs, H. E., P. Soriano, and P. F. Maness. 1994. NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice. J. Cell Biol. 127: 825–833.
   PubMed Web of Science ®Google Scholar
• Bogdan, C. 2001. Nitric oxide and the regulation of gene expression. Trends Cell Biol. 11: 66–75.
   PubMed Web of Science ®Google Scholar
• Brown, P. H., T. K. Chen, and M. J. Birrer. 1994. Mechanism of action of a dominant-negative mutant of c-Jun. Oncogene 9: 791–799.
   PubMed Web of Science ®Google Scholar
• Brüne, B., A. von Knethen, and K. B. Sandau. 1999. Nitric oxide (NO): an effector of apoptosis. Cell Death Differ. 6: 969–975.
   PubMed Web of Science ®Google Scholar
• Cary, L. A., and J. L. Guan. 1999. Focal adhesion kinase in integrin-mediated signaling. Front. Biosci. 4: D102–D113.
   PubMedGoogle Scholar
• Cavallaro, U., J. Niedermeyer, M. Fuxa, and G. Christofori. 2001. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signaling. Nat. Cell Biol. 3: 650–657.
   PubMed Web of Science ®Google Scholar
• Chabot, B. 1996. Directing alternative splicing: cast and scenarios. Trends Genet. 12: 472–478.
   PubMedGoogle Scholar
• Colwell, G., B. Li, D. Forrest, and R. Brackenbury. 1992. Conserved regulatory elements in the promoter region of the N-CAM gene. Genomics 14: 875–882.
   PubMedGoogle Scholar
• Côté, J., M. J. Simard, and B. Chabot. 1999. An element in the 5′ common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5′ splice site selection. Nucleic Acids Res. 27: 2529–2537.
   PubMedGoogle Scholar
• Coyle, J. T., and P. Puttfarcken. 1993. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689–695.
   PubMed Web of Science ®Google Scholar
• Crossin, K. L., and L. A. Krushel. 2000. Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily. Dev. Dyn. 218: 260–279.
   PubMed Web of Science ®Google Scholar
• Doherty, P., G. Rimon, D. A. Mann, and F. S. Walsh. 1992. Alternative splicing of the cytoplasmic domain of neural cell adhesion molecule alters its ability to act as a substrate for neurite outgrowth. J. Neurochem. 58: 2338–2341.
   PubMed Web of Science ®Google Scholar
• Doherty, P., and F. S. Walsh. 1992. Cell adhesion molecules, second messengers and axonal growth. Curr. Opin. Neurobiol. 2: 595–601.
   PubMedGoogle Scholar
• Dragunow, M., R. Xu, M. Walton, A. Woodgate, P. Lawlor, G. A. MacGibbon, D. Young, H. Gibbons, J. Lipski, A. Muravlev, A. Pearson, and M. During. 2000. c-Jun promotes neurite outgrowth and survival in PC12 cells. Brain Res. Mol. Brain Res. 83: 20–33.
   PubMedGoogle Scholar
• Estus, S., W. J. Zaks, R. S. Freeman, M. Gruda, R. Bravo, and E. M. Johnson, Jr. 1994. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127: 1717–1727.
   PubMed Web of Science ®Google Scholar
• Feng, Z., and A. G. Porter. 1999. NF-kappaB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells. J. Biol. Chem. 274: 30341–30344.
   PubMed Web of Science ®Google Scholar
• Ghatan, S., S. Larner, Y. Kinoshita, M. Hetman, L. Patel, Z. Xia, R. J. Youle, and R. S. Morrison. 2000. p38 MAP kinase mediates Bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150: 335–347.
   PubMedGoogle Scholar
• Haby, C., F. Lisovoski, D. Aunis, and J. Zwiller. 1994. Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c-fos and junB in PC12 cells. J. Neurochem. 62: 496–501.
   PubMedGoogle Scholar
• Ham, J., C. Babij, J. L. Whitfield, C. M. Pfarr, D. Lallemand, M. Yani, and L. L. Rubin. 1995. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14: 927–939.
   PubMed Web of Science ®Google Scholar
• Herdegen, T., and V. Waetzig. 2001. AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration. Oncogene 20: 2424–2437.
   PubMed Web of Science ®Google Scholar
• Hilberg, F., A. Aguzzi, N. Howells, and E. Wagner. 1993. c-Jun is essential for normal mouse development and hepatogenesis. Nature 365: 179–181.
   PubMed Web of Science ®Google Scholar
• Hilton, M., G. Middleton, and A. M. Davies. 1997. Bcl-2 influences axonal growth rate in embryonic sensory neurons. Curr. Biol. 7: 798–800.
   PubMed Web of Science ®Google Scholar
• Jänicke, R. U., F. H. H. Lee, and A. G. Porter. 1994. Nuclear c-myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells. Mol. Cell. Biol. 14: 5661–5670.
   PubMedGoogle Scholar
• Jensen, L. M., Y. Zhang, and E. M. Shooter. 1995. Steady-state polypeptide modulations associated with nerve growth factor (NGF)-induced terminal differentiation and NGF deprivation-induced apoptosis in human neuroblastoma cells. J. Biol. Chem. 267: 19325–19333.
   Google Scholar
• Johnson, R. S., B. M. Spiegelman, and V. Papaionnu. 1992. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71: 577–586.
   PubMed Web of Science ®Google Scholar
• Katoh, S., Y. Mitsui, K. Kitani, and T. Suzuki. 1996. Nerve growth factor rescues PC12 cells from apoptosis by increasing amount of bcl-2. Biochem. Biophys. Res. Commun. 229: 653–657.
   PubMed Web of Science ®Google Scholar
• Kolkova, K., V. Novitskaya, N. Pedersen, V. Berezin, and E. Bock. 2000. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J. Neurosci. 20: 2238–2246.
   PubMed Web of Science ®Google Scholar
• Kolkova, K., N. Pedersen, V. Berezin, and E. Bock. 2000. Identification of an amino acid sequence motif in the cytoplasmic domain of the NCAM-140 kDa isoform essential for its neuritogenic activity. J. Neurochem. 75: 1274–1282.
   PubMed Web of Science ®Google Scholar
• Leist, M., and P. Nicotera. 1998. Apoptosis, excitotoxicity, and neuropathology. Exp. Cell Res. 239: 183–201.
   PubMed Web of Science ®Google Scholar
• Leppä, S., and D. Bohmann. 1999. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 18: 6158–6162.
   PubMedGoogle Scholar
• Leppä, S., R. Saffrich, W. Ansorge, and D. Bohmann. 1998. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J. 17: 4404–4413.
   PubMed Web of Science ®Google Scholar
• Leppä, S., M. Eriksson, R. Saffrich, W. Ansorge, and D. Bohmann. 2001. Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells. Mol. Cell. Biol. 21: 4369–4378.
   PubMedGoogle Scholar
• Liegermann, D. A., E. Gregory, and B. Hoffman. 1998. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int. J. Oncol. 12: 685–700.
   PubMedGoogle Scholar
• Oh-hashi, K., W. Maruyama, H. Yi, T. Takahashi, M. Naoi, and K. Isobe. 1999. Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells. Biochem. Biophys. Res. Commun. 263: 504–509.
   PubMed Web of Science ®Google Scholar
• Påhlman, S., J. C. Hoehner, E. Nanberg, F. Hedborg, S. Fagerstrom, C. Gestblom, I. Johansson, U. Larsson, E. Lavenius, and E. Ortoft. 1995. Differentiation and survival influences of growth factors in human neuroblastoma. Eur. J. Cancer 31: A453–A458.
   Google Scholar
• Park, T. U., L. Lucka, W. Reutter, and R. Hortkorte. 1997. Turnover studies of the neural cell adhesion molecule NCAM: degradation of NCAM in PC12 cells depends on the presence of NGF. Biochem. Biophys. Res. Commun. 234: 686–689.
   PubMedGoogle Scholar
• Pollerberg, G. E., M. Schachner, and J. Davoust. 1986. Differentiation state-dependent surface mobilities of two forms of the neural cell adhesion molecule. Nature 324: 462–465.
   PubMed Web of Science ®Google Scholar
• Porter, A. G., P. Ng, and R. U. Jänicke. 1997. Death substrates come alive. Bioessays 19: 501–507.
   PubMedGoogle Scholar
• Potapova, O., S. Basu, D. Mercola, and N. J. Holbrook. 2001. Protective role for c-Jun in the cellular response to DNA damage. J. Biol. Chem. 276: 28546–28553.
   PubMedGoogle Scholar
• Reimold, A. M., M. J. Grusby, B. Kosaras, J. W. U. Fries, R. Mori, S. Maniwa, I. M. Clauss, T. Collins, R. L. Sidman, M. J. Glimcher, and L. H. Glimcher. 1996. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature 379: 262–265.
   PubMedGoogle Scholar
• Ronca, F., S.-L. Chan, and V. C. Yu. 1997. 1-(5-Isoquinolinesulfonyl)-2-methylpiperizine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway. J. Biol. Chem. 272: 4252–4260.
   PubMedGoogle Scholar
• Sassone-Corsi, P., C. J. Der, and I. M. Verma. 1989. ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol. Cell. Biol. 9: 3174–3183.
   PubMed Web of Science ®Google Scholar
• Schmid, R.-S., R. D. Graff, M. D. Schaller, S. Chen, M. Schachner, J. J. Hemperly, and P. F. Maness. 1999. NCAM stimulates the ras-MAPK pathway and CREB phosphorylation in neuronal cells. J. Neurobiol. 38: 542–558.
   PubMedGoogle Scholar
• Shaulian, E., M. Schreiber, F. Piu, M. Beeche, E. F. Wagner, and M. Karin. 2000. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103: 897–907.
   PubMed Web of Science ®Google Scholar
• Shaulian, E., and M. Karin. 2001. AP-1 in cell proliferation and survival. Oncogene 20: 2390–2400.
   PubMed Web of Science ®Google Scholar
• Skaper, S. D., S. E. Moore, and F. S. Walsh. 2001. Cell signaling cascades regulating neural growth-promoting and inhibitory cues. Prog. Neurobiol. (New York) 65: 593–608.
   PubMed Web of Science ®Google Scholar
• Sonoda, Y., S. Watanabe, Y. Matsumoto, E. Aizu-Yokota, and T. Kasahara. 1999. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J. Biol. Chem. 274: 10566–10570.
   PubMed Web of Science ®Google Scholar
• Tabuchi, A., E. Oh, A. Taoka, H. Sakurai, T. Tsuchiya, and M. Tsuda. 1996. Rapid attenuation of AP-1 transcriptional factors associated with nitric oxide (NO)-mediated neuronal cell death. J. Biol. Chem. 271: 31061–31067.
   PubMed Web of Science ®Google Scholar
• Tacke, R., and C. Goridis. 1991. Alternative splicing in the neural cell adhesion molecule pre-mRNA: regulation of exon 18 skipping depends on the 5′-splice site. Genes Dev. 5: 1416–1429.
   PubMedGoogle Scholar
• Tong, L., T. Toliver-Kinsky, G. Taglialatela, K. Werrback-Perez, T. Wood, and J. R. Perez-Polo. 1998. Signal transduction in neuronal death. J. Neurochem. 71: 447–459.
   PubMed Web of Science ®Google Scholar
• Torreilles, F., S. Salman-Tabcheh, M. Guérin, and J. Torreilles. 1999. Neurodegenerative disorders: the role of peroxynitrite. Brain Res. Rev. 33: 153–163.
   Google Scholar
• Uehara, T., Y. Kikuchi, and Y. Nomura. 1999. Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells. J. Neurochem. 72: 196–205.
   PubMedGoogle Scholar
• von Knethen, A. D., D. Callsen, and B. Brüne. 1999. NF-κB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages. Mol. Biol. Cell 10: 361–372.
   PubMed Web of Science ®Google Scholar
• Walsh, F. S., and P. Doherty. 1997. Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. Annu. Rev. Cell Dev. Biol. 13: 425–456.
   PubMed Web of Science ®Google Scholar
• Wisdom, R., S. J. Randall, and C. Moore. 1999. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18: 188–197.
   PubMed Web of Science ®Google Scholar
• Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326–1331.
   PubMed Web of Science ®Google Scholar