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Nucleocytoplasmic Communication

Nuclear Export of mRNA by TAP/NXF1 Requires Two Nucleoporin-Binding Sites but Not p15

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Pages 5405-5418 | Received 16 Jan 2002, Accepted 23 Apr 2002, Published online: 27 Mar 2023

REFERENCES

  • Bachi, A., I. C. Braun, J. P. Rodrigues, N. Panté, K. Ribbeck, C. von Kobbe, U. Kutay, M. Wilm, D. Görlich, M. Carmo-Fonseca, and E. Izaurralde. 2000. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA 6: 136–158.
  • Bayliss, R., K. Ribbeck, D. Akin, H. M. Kent, C. M. Feldherr, D. Görlich, and M. Stewart. 1999. Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. J. Mol. Biol. 293: 579–593.
  • Bayliss, R., T. Littlewood, and M. Stewart. 2000. Structural basis for the interaction between FxFG nucleoporin repeats and importin b in nuclear trafficking. Cell 102: 99–108.
  • Bear, J., W. Tan, A. S. Zolotukhin, C. Tabernero, E. A. Hudson, and B. K. Felber. 1999. Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs. Mol. Cell. Biol. 19: 6306–6317.
  • Black, B. E., L. Lévesque, J. M. Holaska, T. C. Wood, and B. Paschal. 1999. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. Mol. Cell. Biol. 19: 8616–8624.
  • Black, B. E., J. M. Holaska, L. Levesque, B. Ossareh-Nazari, C. Gwizdek, C. Dargemont, and B. M. Paschal. 2001. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export. J. Cell Biol. 152: 141–155.
  • Braun, I. C., E. Rohrbach, C. Schmitt, and E. Izaurralde. 1999. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. EMBO J. 18: 1953–1965.
  • Braun, I. C., A. Herold, M. Rode, E. Conti, and E. Izaurralde. 2001. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. J. Biol. Chem. 276: 20536–20543.
  • Conti, E., and E. Izaurralde. 2001. Nucleocytoplasmic transport enters the atomic age. Curr. Opin. Cell Biol. 3: 310–319.
  • Fribourg, S., I. C. Braun, E. Izaurralde, and E. Conti. 2001. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol. Cell 8: 645–656.
  • Grant, R. P., E. Hurt, D. Neuhaus, and M. Stewart. 2002. Structural basis for the interaction between the Tap C-terminal domain and FG repeat-containing nucleoporins. Nat. Struct. Biol. 9: 247–251.
  • Grüter, P., C. Tabernero, C. von Kobbe, C. Schmitt, C. Saavedra, A. Bachi, M. Wilm, B. K. Felber, and E. Izaurralde. 1998. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell 1: 649–659.
  • Guzik, B. W., L. Levesque, S. Prasad, Y.-C. Bor, B. E. Black, B. M. Paschal, D. Rekosh, and M.-L. Hammarskjöld. 2001. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. Mol. Cell. Biol. 21: 2545–2554.
  • Herold, A., M. Suyama, J. P. Rodrigues, I. C. Braun, U. Kutay, M. Carmo-Fonseca, P. Bork, and E. Izaurralde. 2000. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol. Cell. Biol. 20: 8996–9008.
  • Herold, A., T. Klimenko, and E. Izaurralde. 2001. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA 7: 1768–1780.
  • Huang, X., T. J. Hope, B. L. Bond, D. McDonald, K. Grahl, and T. G. Parslow. 1991. Minimal Rev-responsive element for type 1 human immunodeficiency virus. J. Virol. 65: 2131–2134.
  • Jarmolowski, A., W. C. Boelens, E. Izaurralde, and I. W. Mattaj. 1994. Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124: 627–635.
  • Jun, L., S. Frints, H. Duhamel, A. Herold, J. Abad-Rodrigues, C. Dotti, E. Izaurralde, P. Marynen, and G. Froyen. 2001. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Curr. Biol. 11: 1381–1391.
  • Kang, Y., and B. R. Cullen. 1999. The human TAP protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev. 13: 1126–1139.
  • Kang, Y., H. P. Bogerd, and B. R. Cullen. 2000. Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element. J. Virol. 74: 5863–5871.
  • Katahira, J., K. Sträβer, A. Podtelejnikov, M. Mann, J. U. Jung, and E. Hurt. 1999. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 18: 2593–2609.
  • Katahira, J., K. Sträβer, T. Saiwaki, Y. Yoneda, and E. Hurt. 2001. Complex formation between TAP and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling. J. Biol. Chem. 277: 9242–9246.
  • Lévesque, L., B. Guzik, T. Guan, J. Coyle, B. E. Black, D. Rekosh, M. L. Hammarskjold, and B. M. Paschal. 2001. RNA export mediated by Tap involves NXT1-dependent interactions with the nuclear pore complex. J. Biol. Chem. 276: 44953–44962.
  • Liker, E., E. Fernandez, E. Izaurralde, and E. Conti. 2000. The structure of the mRNA nuclear export factor TAP reveals a cis arrangement of a noncanonical RNP domain and a leucine-rich-repeat domain. EMBO J. 19: 5587–5598.
  • Luo, M.-J., and R. Reed. 1999. Splicing is required for rapid and efficient mRNA export in metazoans. Proc. Natl. Acad. Sci. USA 96: 14937–14942.
  • Mattaj, I. W., and L. Englmeier. 1998. Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67: 256–306.
  • Nakielny, S., and G. Dreyfuss. 1999. Transport of proteins and RNAs in and out of the nucleus. Cell 99: 677–690.
  • Ossareh-Nazari, B., C. Maison, B. E. Black, L. Lévesque, B. M. Paschal, and C. Dargemont. 2000. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro. Mol. Cell. Biol. 20: 4562–4571.
  • Pasquinelli, A. E., R. K. Ernst, E. Lund, C. Grimm, M. L. Zapp, D. Rekosh, M.-L. Hammarskjold, and J. E. Dahlberg. 1997. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses an RNA export pathway utilized by cellular messenger RNAs. EMBO J. 16: 7500–7510.
  • Ribbeck, K., and D. Görlich. 2001. Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 20: 1320–1330.
  • Ryan, K., and S. R. Wente. 2000. The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. Curr. Opin. Cell Biol. 12: 361–371.
  • Saavedra, C. A., B. K. Felber, and E. Izaurralde. 1997. The simian retrovirus-1 constitutive transport element CTE, unlike HIV-1 RRE, utilises factors required for cellular RNA export. Curr. Biol. 7: 619–628.
  • Segref, A., K. Sharma, V. Doye, A. Hellwig, J. Huber, R. Lührmann, and E. Hurt. 1997. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J. 16: 3256–3271.
  • Stewart, M., H. M. Kent, and A. J. McCoy. 1998. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. J. Mol. Biol. 277: 635–646.
  • Strässer, K., J. Bassler, and E. Hurt. 2000. Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export. J. Cell Biol. 150: 695–706.
  • Suyama, M., T. Doerks, I. C. Braun, M. Sattler, E. Izaurralde, and P. Bork. 2000. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. EMBO Rep. 1: 53–58.
  • Tan, W., A. S. Zolotukhin, J. Bear, D. J. Patenaude, and B. K. Felber. 2000. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF1, an ortholog of human TAP/NXF1 and Saccharomyces cerevisiae Mex67p. RNA 6: 1762–1772.
  • Vankan, P., C. McGuigan, and I. W. Mattaj. 1992. Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes. EMBO J. 11: 335–342.
  • Wiegand, H. L., G. A. Coburn, Y. Zeng, Y. Kang, H. P. Bogerd, and B. R. Cullen. 2002. Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol. Cell. Biol. 22: 245–256.
  • Wilkie, G. S., V. Zimyanin, R. Kirby, C. A. Korey, H. Francis-Lang, D. Van Vactor, and I. Davis. 2001. Small bristles, the Drosophila ortholog of human TAP/NXF1 and yeast Mex67p, is essential for mRNA nuclear export throughout development. RNA 7: 1781–1792.
  • Yang, J., H. P. Bogerd, P. J. Wang, D. C. Page, and B. R. Cullen. 2001. Two closely related human nuclear export factors utilize entirely distinct export pathways. Mol. Cell 8: 397–406.
  • Yoon, J. H., D. C. Love, A. Guhathakurta, J. A. Hanover, and R. Dhar. 2000. Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export. Mol. Cell. Biol. 20: 8767–8782.

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