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DNA Dynamics and Chromosome Structure

Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins

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Pages 5539-5553 | Received 14 Mar 2002, Accepted 25 Apr 2002, Published online: 27 Mar 2023

REFERENCES

  • Aagaard, L., G. Laible, P. Selenko, M. Schmid, R. Dorn, G. Schotta, S. Kuhfittig, A. Wolf, A. Lebersorger, P. B. Singh, G. Reuter, and T. Jenuwein. 1999. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18: 1923–1938.
  • Aasland, R., and A. F. Stewart. 1995. The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1. Nucleic Acids Res. 23: 3168–3174.
  • Bannister, A. J., P. Zegerman, J. F. Partridge, E. A. Miska, J. O. Thomas, R. C. Allshire, and T. Kouzarides. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410: 120–124.
  • Breiling, A., E. Bonte, S. Ferrari, P. B. Becker, and R. Paro. 1999. The Drosophila Polycomb protein interacts with nucleosomal core particles in vitro via its repression domain. Mol. Cell. Biol. 19: 8451–8460.
  • Bunker, C. A., and R. E. Kingston. 1994. Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells. Mol. Cell. Biol. 14: 1721–1732.
  • Cheung, P., C. D. Allis, and P. Sassone-Corsi. 2000. Signaling to chromatin through histone modifications. Cell 103: 263–271.
  • Cooke, H. J., and J. Hindley. 1979. Cloning of human satellite III DNA: different components are on different chromosomes. Nucleic Acids Res. 6: 3177–3197.
  • DeCamillis, M., N. S. Cheng, D. Pierre, and H. W. Brock. 1992. The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. Genes Dev. 6: 223–232.
  • De Rubertis, F., D. Kadosh, S. Henchoz, D. Pauli, G. Reuter, K. Struhl, and P. Spierer. 1996. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384: 589–591.
  • Franke, A., M. DeCamillis, D. Zink, N. Cheng, H. W. Brock, and R. Paro. 1992. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11: 2941–2950.
  • Gould, A. 1997. Functions of mammalian Polycomb group and trithorax group related genes. Curr. Opin. Genet. Dev. 7: 488–494.
  • Gunster, M. J., D. P. Satijn, K. M. Hamer, J. L. den Blaauwen, D. de Bruijn, M. J. Alkema, M. van Lohuizen, R. van Driel, and A. P. Otte. 1997. Identification and characterization of interactions between the vertebrate Polycomb-group protein BMI1 and human homologs of Polyhomeotic. Mol. Cell Biol. 17: 2326–2335.
  • Hamvas, R. M., W. Reik, S. J. Gaunt, S. D. Brown, and P. B. Singh. 1992. Mapping of a mouse homolog of a heterochromatin protein gene to the X chromosome. Mamm. Genome 2: 72–75.
  • Horard, B., C. Tatout, S. Poux, and V. Pirrotta. 2000. Structure of a Polycomb response element and in vitro binding of Polycomb group complexes containing GAGA factor. Mol. Cell. Biol. 20: 3187–3197.
  • Jenuwein, T. 2001. Re-SET-ting heterochromatin by histone methyltransferases. Trends Cell Biol. 11: 266–273.
  • Jenuwein, T., and C. D. Allis. 2001. Translating the histone code. Science 293: 1074–1080.
  • Jurgens, G. 1985. A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316: 153–155.
  • Kingston, R. E., C. A. Bunker, and A. N. Imbalzano. 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10: 905–920.
  • Koonin, E. V., S. Zhou, and J. C. Lucchesi. 1995. The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin. Nucleic Acids Res. 23: 4229–4233.
  • Lachner, M., D. O'Carroll, S. Rea, K. Mechtler, and T. Jenuwein. 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410: 116–120.
  • Lonie, A., R. D'Andrea, R. Paro, and R. Saint. 1994. Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Development 120: 2629–2636.
  • Melcher, M., M. Schmid, L. Aagaard, P. Selenko, G. Laible, and T. Jenuwein. 2000. Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Mol. Cell. Biol. 20: 3728–3741.
  • Messmer, S., A. Franke, and R. Paro. 1992. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev. 6: 1241–1254.
  • Muller, J. 1995. Transcriptional silencing by the Polycomb protein in Drosophila embryos. EMBO J. 14: 1209–1220.
  • Ng, J., C. M. Hart, K. Morgan, and J. A. Simon. 2000. A Drosophila ESC-E(Z) protein complex is distinct from other Polycomb group complexes and contains covalently modified ESC. Mol. Cell. Biol. 20: 3069–3078.
  • Paro, R. 1990. Imprinting a determined state into the chromatin of Drosophila. Trends Genet. 6: 416–421.
  • Paro, R., and D. S. Hogness. 1991. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc. Natl. Acad. Sci. USA 88: 263–267.
  • Pearce, J. J., P. B. Singh, and S. J. Gaunt. 1992. The mouse has a Polycomb-like chromobox gene. Development 114: 921–929.
  • Peters, A. H., D. O'Carroll, H. Scherthan, K. Mechtler, S. Sauer, C. Schofer, K. Weipoltshammer, M. Pagani, M. Lachner, A. Kohlmaier, S. Opravil, M. Doyle, M. Sibilia, and T. Jenuwein. 2001. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107: 323–337.
  • Pirrotta, V. 1997. PcG complexes and chromatin silencing. Curr. Opin. Genet. Dev. 7: 249–258.
  • Platero, J. S., T. Hartnett, and J. C. Eissenberg. 1995. Functional analysis of the chromo domain of HP1. EMBO J. 14: 3977–3986.
  • Rastelli, L., C. S. Chan, and V. Pirrotta. 1993. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J. 12: 1513–1522.
  • Rea, S., F. Eisenhaber, D. O'Carroll, B. D. Strahl, Z. W. Sun, M. Schmid, S. Opravil, K. Mechtler, C. P. Ponting, C. D. Allis, and T. Jenuwein. 2000. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406: 593–599.
  • Reijnen, M. J., K. M. Hamer, J. L. den Blaauwen, C. Lambrechts, I. Schoneveld, R. van Driel, and A. P. Otte. 1995. Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mech. Dev. 53: 35–46.
  • Satijn, D. P., M. J. Gunster, J. van der Vlag, K. M. Hamer, W. Schul, M. J. Alkema, A. J. Saurin, P. S. Freemont, R. van Driel, and A. P. Otte. 1997. RING1 is associated with the Polycomb group protein complex and acts as a transcriptional repressor. Mol. Cell. Biol. 17: 4105–4113.
  • Satijn, D. P., K. M. Hamer, J. den Blaauwen, and A. P. Otte. 2001. The Polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. Mol. Cell. Biol. 21: 1360–1369.
  • Satijn, D. P., D. J. Olson, J. van der Vlag, K. M. Hamer, C. Lambrechts, H. Masselink, M. J. Gunster, R. G. Sewalt, R. van Driel, and A. P. Otte. 1997. Interference with the expression of a novel human Polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol. Cell. Biol. 17: 6076–6086.
  • Satijn, D. P., and A. P. Otte. 1999. Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim. Biophys. Acta 1447: 1–16.
  • Saurin, A. J., C. Shiels, J. Williamson, D. P. Satijn, A. P. Otte, D. Sheer, and P. S. Freemont. 1998. The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J. Cell Biol. 142: 887–898.
  • Schoorlemmer, J., C. Marcos-Gutierrez, F. Were, R. Martinez, E. Garcia, D. P. Satijn, A. P. Otte, and M. Vidal. 1997. Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 16: 5930–5942.
  • Schumacher, A., and T. Magnuson. 1997. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13: 167–170.
  • Sewalt, R. G., M. J. Gunster, J. van der Vlag, D. P. Satijn, and A. P. Otte. 1999. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol. 19: 777–787.
  • Sewalt, R. G., J. van der Vlag, M. J. Gunster, K. M. Hamer, J. L. den Blaauwen, D. P. Satijn, T. Hendrix, R. van Driel, and A. P. Otte. 1998. Characterization of interactions between the mammalian Polycomb group proteins Enx1/EZH2 and EED suggests the existence of different mammalian Polycomb group protein complexes. Mol. Cell. Biol. 18: 3586–3595.
  • Simon, J. 1995. Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr. Opin. Cell Biol. 7: 376–385.
  • Simon, J., A. Chiang, and W. Bender. 1992. Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products. Development 114: 493–505.
  • Sinclair, D. A., N. J. Clegg, J. Antonchuk, T. A. Milne, K. Stankunas, C. Ruse, T. A. Grigliatti, J. A. Kassis, and H. W. Brock. 1998. Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster. Genetics 148: 211–220.
  • Strahl, B. D., and C. D. Allis. 2000. The language of covalent histone modifications. Nature 403: 41–45.
  • Strahl, B. D., S. D. Briggs, C. J. Brame, J. A. Caldwell, S. S. Koh, H. Ma, R. G. Cook, J. Shabanowitz, D. F. Hunt, M. R. Stallcup, and C. D. Allis. 2001. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11: 996–1000.
  • Strahl, B. D., R. Ohba, R. G. Cook, and C. D. Allis. 1999. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc. Natl. Acad. Sci. USA 96: 14967–14972.
  • Tachibana, M., K. Sugimoto, T. Fukushima, and Y. Shinkai. 2001. SET domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methylthansferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276: 25309–25317.
  • Tie, F., T. Furuyama, J. Prasad-Sinha, E. Jane, and P. J. Harte. 2001. The Drosophila Polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128: 275–286.
  • Turner, B. M. 2000. Histone acetylation and an epigenetic code. Bioessays 22: 836–845.
  • Vandel, L., and D. Trouche. 2001. Physical association between the histone acetyl transferase CBP and a histone methyl transferase. EMBO Rep. 2: 21–26.
  • van der Vlag, J., and A. P. Otte. 1999. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat. Genet. 23: 474–478.
  • van Lohuizen, M., M. Tijms, J. W. Voncken, A. Schumacher, T. Magnuson, and E. Wientjens. 1998. Interaction of mouse Polycomb group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol. Cell. Biol. 18: 3572–3579.
  • van Lohuizen, M., S. Verbeek, B. Scheijen, E. Wientjens, H. van der Gulden, and A. Berns. 1991. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65: 737–752.
  • Wu, J., and M. Grunstein. 2000. 25 years after the nucleosome model: chromatin modifications. Trends Biochem. Sci. 25: 619–623.
  • Zink, B., and R. Paro. 1989. In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster. Nature 337: 468–471.

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