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Cell Growth and Development

NF-κB1 Can Inhibit v-Abl-Induced Lymphoid Transformation by Functioning as a Negative Regulator of Cyclin D1 Expression

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Pages 5563-5574 | Received 11 Oct 2001, Accepted 16 Apr 2002, Published online: 27 Mar 2023

REFERENCES

  • Afar, D. E. H., J. McLaughlin, C. J. Sherr, O. N. Witte, and M. F. Roussel. 1995. Signaling by ABL oncogenes through cyclin D1. Proc. Natl. Acad. Sci. USA 92: 9540–9544.
  • Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649–681.
  • Beg, A. A., W. C. Sha, R. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the relA component of NF-κB. Nature 376: 167–170.
  • Bodrug, S. E., B. J. Warner, M. L. Bath, G. J. Lindeman, A. W. Harris, and J. M. Adams. 1994. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J. 13: 2124–2130.
  • Carlesso, N., D. A. Frank, and J. D. Griffin. 1996. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 183: 811–820.
  • Chen, Y. Y., and N. Rosenberg. 1992. Lymphoid cells transformed by Abelson virus require the v-Abl protein tyrosine kinase only during early G1. Proc. Natl. Acad. Sci. USA 89: 6683–6697.
  • Coutts, S. M., X. Zou, and K. Calame. 2000. v-Abl utilizes multiple mechanisms to drive G1/S progression in fibroblasts. Oncogene 19: 801–809.
  • Danial, N. N., A. Pernis, and P. B. Rothman. 1995. Jak-STAT signaling induced by the v-abl oncogene. Science 269: 1875–1877.
  • Danial, N. N., J. A. Losman, T. Lu, N. Yip, K. Krishnan, J. Krolewski, S. P. Goff, J. Y. Wang, and P. B. Rothman. 1998. Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation. Mol. Cell. Biol. 18: 6795–6804.
  • Doi, T. S., T. Takahashi, O. Taguchi, T. Azuma, and Y. Obata. 1997. NF-κB RelA deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J. Exp. Med. 185: 953–961.
  • Dyall-Smith, D., and S. Cory. 1988. Transformation of bone marrow cells from Eμ-myc transgenic mice by Abelson murine leukemia virus and Harvey murine sarcoma virus. Oncogene Res. 2: 403–409.
  • Fantl, V., G. Stamp, A. Andrews, I. Rosewell, and C. Dickson. 1995. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 9: 2364–2372.
  • Gerondakis, S., R. Grumont, I. Rourke, and M. Grossmann. 1998. The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation. Curr. Opin. Immunol. 10: 353–359.
  • Gerondakis, S., M. Grossmann, Y. Nakamura, T. Pohl, and R. Grumont. 1999. Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts. Oncogene 18: 6888–6895.
  • Gilmore, T. D., M. Koedood, K. A. Piffat, and D. W. White. 1996. Rel/NF-κB/IκB proteins and cancer. Oncogene 13: 1367–1378.
  • Goff, S. P. 1985. The Abelson murine leukemia virus oncogene. Proc. Soc. Exp. Biol. Med. 179: 403–412.
  • Green, P. L., D. A. Kaehler, L. M. Bennett, and R. Risser. 1989. Multiple steps are required for the induction of tumors by Abelson murine leukemia virus. J. Virol. 63: 1989–1994.
  • Grossmann, M., L. A. O'Reilly, R. Gugasyan, A. Strasser, J. M. Adams, and S. Gerondakis. 2000. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19: 6351–6360.
  • Grumont, R. J., and S. Gerondakis. 1994. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ. 5: 1321–1331.
  • Grumont, R. J., I. J. Rourke, L. A. O'Reilly, A. Strasser, K. Miyake, W. Sha, and S. Gerondakis. 1998. B lymphocytes differentially use the Rel and nuclear factor κB1 (NF-κB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. J. Exp. Med. 187: 663–674.
  • Grumont, R. J., J. Fecondo, and S. Gerondakis. 1994. Alternate RNA splicing of murine nfkbl −/− generates a nuclear isoform of the p50 precursor NF-κB1 that can function as a transactivator of NF-κB-regulated transcription. Mol. Cell. Biol. 14: 8460–8470.
  • Gugasyan, R., R. J. Grumont, M. Grossmann, Y. Nakamura, T. Pohl, D. Nesic, and S. Gerondakis. 2000. Rel/NF-κB transcription factors: key mediators of B cell activation. Immunol. Rev. 176: 134–140.
  • Guttridge, D. C., C. Albanese, J. Y. Reuther, R. G. Pestell, and A. S. Baldwin, Jr. 1999. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19: 5785–5799.
  • Hinz, M., D. Krappmann, A. Eichten, A. Heder, C. Scheidereit, and M. Strauss. 1999. NF-κB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 19: 2690–2698.
  • Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extensions using the polymerase chain reaction. Gene 77: 51–59.
  • Horwitz, B. H., M. L. Scott, S. R. Cherry, R. T. Bronson, and D. Baltimore. 1997. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells. Immunity 6: 765–772.
  • Joyce, D., B. Bouzahzah, M. Fu, C. Albanese, M. DíAmico, J. Steer, J. U. Klein, R. J. Lee, J. E. Segall, J. K. Westwick, C. J. Der, and R. G. Pestell. 1999. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-κB-dependent pathway. J. Biol. Chem. 274: 25245–25249.
  • Karin, M. 1999. The beginning of the end: IκB kinase (IKK) and NF-κB activation. J. Biol. Chem. 274: 27339–27342.
  • Klug, C. A., S. J. Gerety, P. C. Shah, Y.-Y. Chen, N. R. Rice, N. Rosenberg, and H. Singh. 1994. The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytes. Genes Dev. 8: 678–687.
  • Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression. Genes Dev. 9: 1965–1977.
  • Krek, W., and J. A. DeCaprio. 1995. Cell synchronization. Methods Enzymol. 254: 114–125.
  • Lovec, H., A. Grzeschiczek, M-B. Kowalski, and T. Màrày. 1994. Cyclin D1/bcl-l cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. EMBO J. 13: 3487–3495.
  • Malumbres, M., and M. Barbacid. 2001. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1: 222–231.
  • Mann, R., R. C. Mulligan, and D. Baltimore. 1983. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 33: 153–159.
  • May, M. J., and S. Ghosh. 1997. Rel/NF-κβ and Iκβ proteins: an overview. Semin. Cancer Biol. 8: 63–73.
  • Morgenstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18: 3587–3596.
  • Mullins, M. W., B. T. Pittner, and E. C. Snow. 1998. CD40-mediated induction of p21 accumulation in resting and cycling B cells. Mol. Immunol. 35: 567–580.
  • Niwa, H., K.-I. Yamamura, and J.-I. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193–200.
  • Ohtsubo, M., and J. M. Roberts. 1993. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259: 1908–1912.
  • Radfar, A., I. Unnikrishnan, H.-W. Lee, R. A. DePinho, and N. Rosenberg. 1998. p19Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation. Proc. Natl. Acad. Sci. USA 95: 13194–13199.
  • Rayet, B., and C. Gelinas. 1999. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938–6947.
  • Reuther, J. Y., G. W. Reuther, D. Cortez, A. M. Pendergast, and A. S. Baldwin, Jr. 1998. A requirement for NF-κB activation in Bcr-Abl-mediated transformation. Genes Dev. 12: 968–981.
  • Rosenberg, N., and O. Witte. 1988. The viral and cellular forms of Abelson (abl) oncogene. Adv. Virus Res. 35: 39–81.
  • Ryan, K. M., M. K. Ernst, N. R. Rice, and K. H. Vousden. 2000. Role of NF-κB in p53-mediated programmed cell death. Nature 404: 892–897.
  • Sawyers, C. L., W. Callahan, and O. N. Witte. 1992. Dominant negative MYC blocks transformation by ABL oncogene. Cell 70: 901–910.
  • Sha, W. C., H.-C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to muitifocal defects in immune responses. Cell 80: 321–330.
  • Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10: 405–455.
  • Smith, R., G. Peters, and C. Dickson. 1995. Genomic organization of the mouse cyclin D1 gene (Cyl-1). Genomics 25: 85–92.
  • Tidmarsh, G. F., S. Heimfeld, C. A. Whitlock, I. L. Weissman, and C. E. Müller-Sieburg. 1989. Identification of a novel bone marrow-derived B-cell progenitor population that coexpresses B220 and Thy-1 and is highly enriched for Abelson leukemia virus targets. Mol. Cell. Biol. 9: 2665–2671.
  • Unnikrishnan, I., A. Radfar, J. Jenab-Wolcott, and N. Rosenberg. 1999. p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells. Mol. Cell. Biol. 19: 4825–4831.
  • Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274: 787–789.
  • van Parijs, L., Y. Refaet, A. K. Abbas, and D. Baltimore. 1999. Autoimmunity as a consequence of retroviral mediated expression of c-FLIP in lymphocytes. Immunity 11: 763–770.
  • Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. V. Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9: 2723–2735.
  • Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274: 784–787.
  • Weissinger, E. M., C. Eissner, C. Grammer, S. Fackler, B. Haefner, L. S. Yoon, K. S. Lu, A. Bazarov, J. M. Sedivy, H. Mischak, and W. Kolch. 1997. Inhibition of the Raf-l kinase by cyclic AMP agonists causes apoptosis of v-Abl-transformed cells. Mol. Cell. Biol. 17: 3229–3241.
  • Whitehead, I. P., Q. T. Lambert, J. A. Glaven, K. Abe, K. L. Rossman, G. M. Mahon, J. M. Trzaskos, R. Kay, S. L. Campbell, and C. J. Der. 1999. Dependence of Dbl and Dbs transformation on MEK and NF-κB activation. Mol. Cell. Biol. 19: 7759–7770.
  • Whiteside, S. T., and A. Israël. 1997. IκB proteins: structure, function and regulation. Semin. Cancer Biol. 8: 75–82.
  • Whitlock, C. A., S. F. Ziegler, and O. N. Witte. 1983. Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes. Mol. Cell. Biol. 3: 596–604.
  • Wood, W. M., M. Y. Kao, D. F. Gordon, and E. C. Ridgway. 1989. Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes. J. Biol. Chem. 264: 14840–14847.
  • Zou, X., S. Rudchenko, K.-K. Wong, and K. Calame. 1997. Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases. Genes Dev. 11: 654–662.
  • Zou, X., and K. Calame. 1999. Signaling pathways activated by oncogenic forms of Abl tyrosine kinase. J. Biol. Chem. 274: 18141–18144.

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