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Cell Growth and Development

Cdc42/Rac1-Mediated Activation Primes PAK2 for Superactivation by Tyrosine Phosphorylation

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Pages 6719-6725 | Received 18 Jan 2002, Accepted 05 Jul 2002, Published online: 27 Mar 2023

REFERENCES

  • Baccarini, M., D. M. Sabatini, H. App, U. R. Rapp, and E. R. Stanley. 1990. Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J. 9: 3649–3657.
  • Bagheri-Yarmand, R., M. Mandal, A. H. Taludker, R. A. Wang, R. K. Vadlamudi, H. J. Kung, and R. Kumar. 2001. Etk/bmx tyrosine kinase activates pak1 and regulates tumorigenicity of breast cancer cells. J. Biol. Chem. 276: 29403–29409.
  • Bagrodia, S., and R. A. Cerione. 1999. PAK to the future. Trends Cell Biol. 9: 350–355.
  • Bagrodia, S., S. J. Taylor, C. L. Creasy, J. Chernoff, and R. A. Cerione. 1995. Identification of a mouse p21Cdc42/Rac activated kinase. J. Biol. Chem. 270: 22731–22737.
  • Bagrodia, S., S. J. Taylor, K. A. Jordon, L. Van Aelst, and R. A. Cerione. 1998. A novel regulator of p21-activated kinases. J. Biol. Chem. 273: 23633–23636.
  • Boerner, J. L., A. J. Danielsen, M. J. McManus, and N. J. Maihle. 2001. Activation of Rho is required for ligand-independent oncogenic signaling by a mutant EGF receptor. J. Biol. Chem. 276: 3691–3695.
  • Bokoch, G. M., A. M. Reilly, R. H. Daniels, C. C. King, A. Olivera, S. Spiegel, and U. G. Knaus. 1998. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J. Biol. Chem. 273: 8137–8144.
  • Chong, C., L. Tan, L. Lim, and E. Manser. 2001. The mechanism of PAK activation. Auto-phosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276: 17347–17353.
  • Cutler, R. E., Jr., R. M. Stephens, M. R. Saracino, and D. K. Morrison. 1998. Autoregulation of the Raf-1 serine/threonine kinase. Proc. Natl. Acad. Sci. USA 95: 9214–9219.
  • Dan, I., N. M. Watanabe, and A. Kusumi. 2001. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11: 220–230.
  • Daniels, R. H., and G. M. Bokoch. 1999. p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem. Sci. 24: 350–355.
  • Gatti, A., Z. Huang, P. T. Tuazon, and J. A. Traugh. 1999. Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation. J. Biol. Chem. 274: 8022–8028.
  • Hallberg, B., S. I. Rayter, and J. Downward. 1994. Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J. Biol. Chem. 269: 3913–3916.
  • Hoffman, G. R., and R. A. Cerione. 2000. Flipping the switch: the structural basis for signaling through the CRIB motif. Cell 102: 403–406.
  • Jaffer, Z. M., and J. Chernoff. 2002. p21-activated kinases: three more join the Pak. Int. J. Biochem. Cell Biol. 34: 713–717.
  • Kamps, M. P., and B. M. Sefton. 1989. Acid and base hydrolysis of phosphoproteins bound to immobilon facilitates analysis of phosphoamino acids in gel-fractioned proteins. Anal. Biochem. 176: 22–27.
  • King, C. C., E. M. Gardiner, F. T. Zenke, B. P. Bohl, A. C. Newton, B. A. Hemmings, and G. M. Bokoch. 2000. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J. Biol. Chem. 275: 41201–41209.
  • Kovacina, K. S., K. Yonezawa, D. L. Brautigan, N. K. Tonks, U. R. Rapp, and R. A. Roth. 1990. Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation. J. Biol. Chem. 265: 12115–12118.
  • Lee, N., H. MacDonald, C. Reinhard, R. Halenbeck, A. Roulston, T. Shi, and L. T. Williams. 1997. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc. Natl. Acad. Sci. USA 94: 13642–13647.
  • Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369: 411–414.
  • Lei, M., W. Lu, W. Meng, M. C. Parrini, M. J. Eck, B. J. Mayer, and S. C. Harrison. 2000. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102: 387–397.
  • Lu, W., S. Katz, R. Gupta, and B. J. Mayer. 1997. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr. Biol. 7: 85–94.
  • Manser, E., H.-Y. Huang, T.-H. Loo, X.-Q. Chen, J.-M. Dong, T. Leung, and L. Lim. 1997. Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17: 1129–1143.
  • Manser, E., T. Leung, H. Salihuddin, Z. S. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367: 40–46.
  • Manser, E., T. H. Loo, C. G. Koh, Z. S. Zhao, X. Q. Chen, L. Tan, I. Tan, T. Leung, and L. Lim. 1998. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1: 183–192.
  • Marais, R., Y. Light, H. F. Paterson, and C. J. Marshall. 1995. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14: 3136–3145.
  • Mason, C. S., C. J. Springer, R. G. Cooper, G. Superti-Furga, C. J. Marshall, and R. Marais. 1999. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J. 18: 2137–2148.
  • McManus, M. J., J. L. Boerner, A. J. Danielsen, Z. Wang, F. Matsumura, and N. J. Maihle. 2000. An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex. J. Biol. Chem. 275: 35328–35334.
  • Morrison, D. K., and R. E. Cutler. 1997. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9: 174–179.
  • Parrini, M. C., M. Lei, S. C. Harrison, and B. J. Mayer. 2002. PAK1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol. Cell 9: 73–83.
  • Renkema, G. H., A. Manninen, D. A. Mann, M. Harris, and K. Saksela. 1999. Identification of the Nef-associated kinase as p21-activated kinase 2. Curr. Biol. 9: 1407–1410.
  • Renkema, G. H., A. Manninen, and K. Saksela. 2001. Human immunodeficiency virus type-1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or β-PIX. J. Virol. 75: 2154–2160.
  • Roig, J., Z. Huang, C. Lytle, and J. A. Traugh. 2000. p21-activated protein kinase gamma-PAK is translocated and activated in response to hyperosmolarity. J. Biol. Chem. 275: 16933–16940.
  • Roig, J., P. T. Tuazon, P. A. Zipfel, A. M. Pendergast, and J. A. Traugh. 2000. Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc. Natl. Acad. Sci. USA 97: 14346–14351.
  • Rudel, T., and G. M. Bokoch. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276: 1571–1574.
  • Tuazon, P. T., W. C. Spanos, E. L. Gump, C. A. Monnig, and J. A. Traugh. 1997. Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK). Biochemistry 36: 16059–16064.
  • Zenke, F. T., C. C. King, B. P. Bohl, and G. M. Bokoch. 1999. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J. Biol. Chem. 274: 32565–32573.
  • Zhao, Z.-S., E. Manser, and L. Lim. 2000. Interaction between PAK and Nck: a template for nck targets and role of PAK autophosphorylation. Mol. Cell. Biol. 20: 3906–3917.

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