61
Views
259
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa2

, , , , , , & show all
Pages 6921-6929 | Received 28 Jan 2002, Accepted 09 Jul 2002, Published online: 27 Mar 2023

REFERENCES

  • Allard, J., S. Barrón, J. Diaz, C. Lubetzki, B. Zalc, J. C. Schwartz, and P. Sokoloff. 1998. A rat G protein-coupled receptor selectively expressed in myelin-forming cells. Eur. J. Neurosci. 10: 1045–1053.
  • Allard, J., S. Barrón, S. Trottier, P. Cervera, C. Daumus-Duport, E. Leguern, A. Brice, J. C. Schwartz, and P. Sokoloff. 1999. Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth disease. Glia 26: 176–185.
  • An, S., T. Bleu, O. G. Hallmark, and E. J. Goetzl. 1998. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273: 7906–7910.
  • An, S., T. Bleu, Y. Zheng, and E. J. Goetzl. 1998. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol. Pharmacol. 54: 881–888.
  • An, S., M. A. Dickens, T. Bleu, O. G. Hallmark, and E. J. Goetzl. 1997. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun. 231: 619–622.
  • Balazs, L., J. Okolicany, M. Ferrebee, B. Tolley, and G. Tigyi. 2001. Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R466–R472.
  • Bandoh, K., J. Aoki, H. Hosono, S. Kobayashi, T. Kobayashi, K. Murakami-Murofushi, M. Tsujimoto, H. Arai, and K. Inoue. 1999. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274: 27776–27785.
  • Blaschke, A. J., K. Staley, and J. Chun. 1996. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 122: 1165–1174.
  • Chun, J. 1999. Lysophospholipid receptors: implications for neural signaling. Crit. Rev. Neurobiol. 13: 151–168.
  • Chun, J., E. J. Goetzl, T. Hla, Y. Igarashi, K. R. Lynch, W. Moolenaar, S. Pyne, and G. Tigyi. 2002. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54: 265–269.
  • Contos, J. J., and J. Chun. 1998. Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lp A1/vzg-1/Gpcr26. Genomics 51: 364–378.
  • Contos, J. J., and J. Chun. 2000. Genomic characterization of the lysophosphatidic acid receptor gene, lp A2/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. Genomics 64: 155–169.
  • Contos, J. J., and J. Chun. 2001. The mouse lp A3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267: 243–253.
  • Contos, J. J. A., N. Fukushima, J. A. Weiner, D. Kaushal, and J. Chun. 2000. Requirement for the lp A1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. USA 97: 13384–13389.
  • Contos, J. J. A., I. Ishii, and J. Chun. 2000. Lysophosphatidic acid receptors. Mol. Pharmacol. 58: 1188–1196.
  • Demoyer, J. S., T. C. Skalak, and M. E. Durieux. 2000. Lysophosphatidic acid enhances healing of acute cutaneous wounds in the mouse. Wound Repair Regen. 8: 530–537.
  • Eichholtz, T., K. Jalink, I. Fahrenfort, and W. H. Moolenaar. 1993. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem. J. 291: 677–680.
  • Fang, X., S. Yu, R. LaPushin, Y. Lu, T. Furui, L. Z. Penn, D. Stokoe, J. R. Erickson, R. C. Bast, Jr., and G. B. Mills. 2000. Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase. Biochem. J. 352(Pt. 1): 135–143.
  • Fukushima, N., J. Weiner, and J. Chun. 2000. Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev. Biol. 228: 6–18.
  • Fukushima, N., I. Ishii, J. J. Contos, J. A. Weiner, and J. Chun. 2001. Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 41: 507–534.
  • Fukushima, N., I. Ishii, Y. Habara, C. B. Allen, and J. Chun. Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines. Mol. Biol. Cell, in press.
  • Fukushima, N., Y. Kimura, and J. Chun. 1998. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl. Acad. Sci. USA 95: 6151–6156.
  • Fukushima, N., J. A. Weiner, D. Kaushal, J. J. Contos, K. Y. Kim, and J. Chun. 2002. Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol. Cell. Neurosci. 20: 271–282.
  • Hecht, J. H., J. A. Weiner, S. R. Post, and J. Chun. 1996. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135: 1071–1083.
  • Hordijk, P. L., I. Verlaan, E. J. van Corven, and W. H. Moolenaar. 1994. Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of MAP kinase is mediated by the Gi-p21ras pathway. J. Biol. Chem. 269: 645–651.
  • Im, D. S., C. E. Heise, M. A. Harding, S. R. George, B. F. O'Dowd, D. Theodorescu, and K. R. Lynch. 2000. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol. Pharmacol. 57: 753–759.
  • Ishii, I., J. J. A. Contos, N. Fukushima, and J. Chun. 2000. Functional comparisons of the lysophosphatidic acid receptors, LPA1/Vzg-1/Edg2, LPA2/Edg4, and LPA3/Edg7 in neuronal cell lines using a retrovirus expression system. Mol. Pharmacol. 58: 895–902.
  • Ishii, I., B. Friedman, X. Ye, S. Kawamura, C. McGiffert, J. J. Contos, M. A. Kingsbury, G. Zhang, J. H. Brown, and J. Chun. 2001. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3. J. Biol. Chem. 276: 33697–33704.
  • Ishii, I., X. Ye, B. Friedman, S. Kawamura, J. J. Contos, M. A. Kingsbury, A. H. Yang, G. Zhang, J. H. Brown, and J. Chun. 2002. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors: S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3. J. Biol. Chem. 277: 25152–25159.
  • Jalink, K., T. Eichholtz, F. R. Postma, E. J. van Corven, and W. H. Moolenaar. 1993. Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action. Cell Growth Differ. 4: 247–255.
  • Kimura, Y., A. Schmitt, N. Fukushima, I. Ishii, H. Kimura, A. R. Nebreda, and J. Chun. 2001. Two novel Xenopus homologs of mammalian LPA1/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J. Biol. Chem. 276: 15208–15215.
  • Lee, M. J., S. Thangada, C. H. Liu, B. D. Thompson, and T. Hla. 1998. Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J. Biol. Chem. 273: 22105–22112.
  • Moolenaar, W. H., O. Kranenburg, F. R. Postma, and G. C. Zondag. 1997. Lysophosphatidic acid: G-protein signalling and cellular responses. Curr. Opin. Cell Biol. 9: 168–173.
  • Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389–399.
  • Sasaki, T., T. Maehama, T. Yamamoto, S. Takasuga, S. Hoshino, H. Nishina, O. Hazeki, and T. Katada. 1998. Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. J. Biochem. (Tokyo) 124: 934–939.
  • Seufferlein, T., D. J. Withers, D. Mann, and E. Rozengurt. 1996. Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor. Mol. Biol. Cell 7: 1865–1875.
  • van Corven, E. J., A. Groenink, K. Jalink, T. Eichholtz, and W. H. Moolenaar. 1989. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell 59: 45–54.
  • Weiner, J. A., and J. Chun. 1999. Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc. Natl. Acad. Sci. USA 96: 5233–5238.
  • Weiner, J. A., J. H. Hecht, and J. Chun. 1998. Lysophosphatidic acid receptor gene vzg-1/lp A1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J. Comp. Neurol. 398: 587–598.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.