Induction of Apoptosis by Sphingoid Long-Chain Bases in Aspergillus nidulans

REFERENCES

• Adrain, C., and S. J. Martin. 2001. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem. Sci. 26: 390–397.
   PubMed Web of Science ®Google Scholar
• Alvarez, M. E., R. I. Pennell, P. J. Meijer, A. Ishikawa, R. A. Dixon, and C. Lamb. 1998. Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity. Cell 92: 773–784.
   PubMed Web of Science ®Google Scholar
• Arnult, D., I. Tatischeff, J. Estaquier, M. Girard, F. Sureau, J. P. Tissier, A. Grodet, M. Dellinger, F. Traincard, A. Kahn, J. C. Ameisen, and P. X. Petit. 2001. On the evolutionary conservation of the cell death pathway: mitochondrial release of an apoptosis-inducing factor during Dictystelium discoideum cell death. Mol. Biol. Cell 12: 3016–3030.
   PubMedGoogle Scholar
• Bokoch, G. M., A. M. Reilly, R. H. Daniels, C. C. King, A. Olivera, S. Spiegel, and U. G. Knaus. 1998. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J. Biol. Chem. 273: 8137–8144.
   PubMedGoogle Scholar
• Budihardjo, I., H. Oliver, M. Lutter, X. Luo, and X. Wang. 1999. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 15: 269–290.
   PubMed Web of Science ®Google Scholar
• Cheng, J. J., T. S. Park, A. S. Fischl, and X. S. Ye. 2001. Cell cycle progression and cell polarity require sphingolipid biosynthesis in Aspergillus nidulans. Mol. Cell. Biol. 21: 6198–6209.
   PubMed Web of Science ®Google Scholar
• Chung, N., G. Jenkins, Y. A. Hannun, J. Heitman, and L. M. Obeid. 2000. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J. Biol. Chem. 275: 17229–17232.
   PubMed Web of Science ®Google Scholar
• Chung, N., C. Mao, J. Heitman, Y. A. Hannun, and L. M. Obeid. 2001. Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J. Biol. Chem. 276: 35614–35621.
   PubMedGoogle Scholar
• Cuvillier, O., L. Edsall, and S. Spiegel. 2000. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J. Biol. Chem. 275: 15691–15700.
   PubMedGoogle Scholar
• Dalla Libera, L., R. Sabbadini, C. Renken, B. Ravara, M. Sandri, R. Betto, A. Angelini, and G. Vescovo. 2001. Apoptosis in the skeletal muscle of rats with heart failure is associated with increased serum levels of TNF-alpha and sphingosine. J. Mol. Cell Cardiol. 33: 1871–1878.
   PubMedGoogle Scholar
• deHart, A. K. A., J. D. Schnell, D. A. Allen, and L. Hicke. 2002. The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J. Cell Biol. 156: 241–248.
   PubMedGoogle Scholar
• Del Carratore, R., C. Della Croce, M. Simili, E. Taccini, M. Scavuzzo, and S. Sbrana. 2002. Cell cycle and morphological alterations as indicative of apoptosis promoted by UV irradiation in S. cerevisiae. Mutat. Res. 513: 183–191.
   PubMed Web of Science ®Google Scholar
• Denning, D. W., K. V. Clemons, L. A. Hanson, and D. A. Stevens. 1990. Restriction endonuclease analysis of total cellular DNA of Aspergillus fumigatus isolates of geographically and epidemiologically diverse origin. J. Infect. Dis. 162: 1151–1158.
   PubMed Web of Science ®Google Scholar
• De Souza, C. P., A. H. Osmani, L. P. Wu, J. L. Spotts, and S. A. Osmani. 2000. Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans. Cell 102: 293–302.
   PubMed Web of Science ®Google Scholar
• Dickson, R. C. 1998. Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals. Annu. Rev. Biochem. 67: 27–48.
   PubMed Web of Science ®Google Scholar
• Gobe, G. C., B. Harmon, J. Leighton, and D. J. Allan. 1999. Radiation-induced apoptosis and gene expression in neonatal kidney and testis with and without protein synthesis inhibition. Int. J. Radiat. Biol. 75: 973–983.
   PubMed Web of Science ®Google Scholar
• Green, D. R. 2000. Apoptosis and sphingomyelin hydrolysis: the flip side. J. Cell Biol. 150: F5–F7.
   PubMed Web of Science ®Google Scholar
• Hannun, Y. A., C. R. Loomis, A. H. Merrill, and R. M. Bell. 1986. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261: 12604–12609.
   PubMed Web of Science ®Google Scholar
• Hannun, Y. A., and C. Luberto. 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10: 73–80.
   PubMed Web of Science ®Google Scholar
• Hannun, Y. A., C. Luberto, and K. M. Argraves. 2001. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40: 4893–4903.
   PubMed Web of Science ®Google Scholar
• Hanson, B. A., and R. L. Lester. 1980. The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa. J. Lipid Res. 21: 309–315.
   PubMed Web of Science ®Google Scholar
• Henson, P. M., D. L. Bratton, and V. A. Fadok. 2001. The phosphatidylserine receptor: crucial molecular switch? Nat. Rev. Mol. Cell Biol. 2: 627–633.
   PubMed Web of Science ®Google Scholar
• Hirano, T. 2000. Chromosome cohesion, condensation and separation. Annu. Rev. Biochem. 69: 115–144.
   PubMedGoogle Scholar
• Hoffmann, P. R., A. M. deCathelineau, C. A. Ogden, Y. Leverrier, D. L. Bratton, D. L. Daleke, A. J. Ridley, V. A. Fadok, and P. M. Henson. 2001. Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J. Cell Biol. 155: 649–659.
   PubMed Web of Science ®Google Scholar
• Hsu, J. Y., Z. W. Sun, X. Li, M. Reuben, K. Tatchell, D. K. Bishop, J. M. Grushcow, C. J. Brame, J. A. Caldwell, D. F. Hunt, R. Lin, M. M. Smith, and C. D. Allis. 2000. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102: 279–291.
   PubMed Web of Science ®Google Scholar
• Jacobson, M. D., and M. C. Raff. 1995. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374: 814–816.
   PubMed Web of Science ®Google Scholar
• Jenkins, G. M., and Y. A. Hannun. 2001. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J. Biol. Chem. 276: 8574–8581.
   PubMedGoogle Scholar
• Jenkins, G. M., A. Richards, T. Wahl, C. Mao, L. M. Obeid, and Y. A. Hannun. 1997. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J. Biol. Chem. 272: 32566–32572.
   PubMed Web of Science ®Google Scholar
• Joza, N., S. A. Susin, E. Daugas, W. L. Stanford, S. K. Cho, C. Y. J. Li, T. Sasaki, A. J. Elia, H. Y. M. Cheng, L. Ravagnan, K. F. Ferri, A. Wakeham, R. Hakem, H. Yoshida, Y. Y. Kong, T. W. Mak, J. C. Zuniga-Pflucker, G. Kroemer, and J. M. Penninger. 2001. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410: 549–554.
   PubMed Web of Science ®Google Scholar
• Kagedal, K., M. Zhao, I. Svensson, and U. T. Brunk. 2001. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem. J. 359: 335–343.
   PubMed Web of Science ®Google Scholar
• Kim, S., H. Fyrst, and J. Saba. 2000. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics 156: 1519–1529.
   PubMed Web of Science ®Google Scholar
• King, C. C., F. T. Zenke, P. E. Dawson, E. M. Dutil, A. C. Newton, B. A. Hemmings, and G. M. Bokoch. 2000. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J. Biol. Chem. 275: 18108–18113.
   PubMed Web of Science ®Google Scholar
• Kolesnick, R. N., and M. Kronke. 1998. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60: 645–665.
   Google Scholar
• Lanterman, M. M., and J. D. Saba. 1998. Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem. J. 332: 525–531.
   PubMedGoogle Scholar
• Laun, P., A. Pichova, F. Madeo, J. Fuchs, A. Ellinger, S. Kohlwein, I. Dawes, K. U. Frohlich, and M. Breitenbach. 2001. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol. Microbiol. 39: 1166–1173.
   PubMed Web of Science ®Google Scholar
• Lee, J. S., D. S. Min, C. Park, C. S. Park, and N. J. Cho. 2001. Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor. FEBS Lett. 499: 82–86.
   PubMedGoogle Scholar
• Ligr, M., I. Velten, E. Frohlich, F. Madeo, M. Ledig, K. U. Frohlich, D. H. Wolf, and W. Hilt. 2001. The proteasomal substrate Stm1 participates in apoptosis-like cell death in yeast. Mol. Biol. Cell 12: 2422–2432.
   PubMedGoogle Scholar
• Lorenzo, H. K., S. A. Susin, J. Penninger, and G. Kroemer. 1999. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 6: 516–524.
   PubMed Web of Science ®Google Scholar
• Ludovico, P., M. J. Sousa, M. T. Silva, C. Leao, and M. Corte-Real. 2001. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology 147: 2409–2415.
   PubMed Web of Science ®Google Scholar
• Madeo, F., E. Frohlich, and K. U. Frohlich. 1997. A yeast mutant showing diagnostic markers of early and late apoptosis. J. Cell Biol. 139: 729–734.
   PubMed Web of Science ®Google Scholar
• Madeo, F., E. Frohlich, M. Ligr, M. Grey, S. Sigrist, D. H. Wolf, and K. U. Frohlich. 1999. Oxygen stress: a regulator of apoptosis in yeast. J. Cell Biol. 145: 757–767.
   PubMed Web of Science ®Google Scholar
• Madeo, F., E. Herker, C. Maldener, S. Wissing, S. Lachelt, M. Herlan, M. Fehr, K. Lauber, S. J. Sigrist, S. Wesselborg, and K. U. Frohlich. 2002. A caspase-related protease regulates apoptosis in yeast. Mol. Cell 9: 911–917.
   PubMed Web of Science ®Google Scholar
• Mandala, S. M., R. Thornton, Z. Tu, M. B. Kurtz, J. Nickels, J. Broach, R. Menzeleev, and S. Spiegel. 1998. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. USA 95: 150–155.
   PubMed Web of Science ®Google Scholar
• Mao, C., J. Saba, and L. M. Obeid. 1999. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem. J. 342: 667–675.
   PubMedGoogle Scholar
• Mao, C., M. Wadleigh, G. M. Jenkins, Y. A. Hannun, and L. M. Obeid. 1997. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272: 28690–28694.
   PubMed Web of Science ®Google Scholar
• Matsuyama, S., O. Xu, J. Velours, and J. C. Reed. 1998. The mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell 1: 327–336.
   PubMed Web of Science ®Google Scholar
• McNabb, T. J., A. E. Cremesti, P. R. Brown, and A. S. Fischl. 1999. The separation and direct detection of ceramides and sphingoid bases by normal-phase high-performance liquid chromatography and evaporative light-scattering detection. Anal. Biochem. 276: 242–250.
   PubMedGoogle Scholar
• Morris, N. R. 1975. Mitotic mutants of Aspergillus nidulans. Genet. Res. 26: 237–254.
   PubMedGoogle Scholar
• Oakley, B. R., and S. A. Osmani. 1993. Cell cycle analysis using the filamentous fungus Aspergillus nidulans, p. 127–142. In P. Fantes and R. Brooks (ed.), The cell cycle, a practical approach. IRL Press, Oxford, United Kingdom.
   Google Scholar
• Oberhammer, F. A., K. Hochegger, G. Froschl, R. Tiefenacher, and M. Pavelka. 1994. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126: 827–837.
   PubMed Web of Science ®Google Scholar
• Oh, C. S., D. A. Toke, S. Mandala, and C. E. Martin. 1997. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J. Biol. Chem. 272: 17376–17384.
   PubMed Web of Science ®Google Scholar
• Olivera, A., and S. Spiegel. 1993. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365: 557–560.
   PubMed Web of Science ®Google Scholar
• Osmani, S. A., R. T. Pu, and N. R. Morris. 1988. Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase. Cell 53: 237–244.
   PubMedGoogle Scholar
• Osmani, S. A., and X. S. Ye. 1996. Cell cycle regulation in Aspergillus by two protein kinases. Biochem. J. 317: 633–641.
   PubMed Web of Science ®Google Scholar
• Patton, J. L., B. Srinivasan, R. C. Dickson, and R. L. Lester. 1992. Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J. Bacteriol. 174: 7180–7184.
   PubMedGoogle Scholar
• Rao, L., D. Perez, and E. White. 1996. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135: 1441–1455.
   PubMed Web of Science ®Google Scholar
• Ruchaud, S., N. Korfali, P. Villa, T. J. Kottke, C. Dingwall, S. H. Kaufmann, and W. C. Earnshaw. 2002. Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J. 21: 1967–1977.
   PubMed Web of Science ®Google Scholar
• Saka, Y., T. Sutani., Y. Yamashita, S. Saito, M. Takeuchi, Y. Nakaseko, and M. Yanagida. 1994. Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromsome condensation and segregation in mitosis. EMBO J. 13: 4936–4952.
   Google Scholar
• Skrzypek, M. S., M. M. Nagiec, R. L. Lester, and R. C. Dickson. 1998. Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J. Biol. Chem. 273: 2829–2834.
   PubMedGoogle Scholar
• Slater, A. F. G., C. Stefan, I. Nobel. D. J. van den Dobbelsteen, and S. Orrenius. 1995. Signaling mechanisms and oxidative stress in apoptosis. Toxicol. Lett. 82 /83: 149–153.
   PubMedGoogle Scholar
• Spiegel, S., and S. Milstien. 2000. Sphingosine-1-phosphate: signaling inside and out. FEBS Lett. 476: 55–57.
   PubMed Web of Science ®Google Scholar
• Strasser, A., L. O'Connor, and V. M. Dixit. 2000. Apoptosis signaling. Annu. Rev. Biochem. 69: 217–245.
   PubMed Web of Science ®Google Scholar
• Stunnikov, A. V., E. Hogan, and D. Koshland. 1995. SMC2, a Saccharomyces cerevisiae gene essential for chromsome segregation and condensation, defines a subgroup within the SMC family. Genes Dev. 9: 587–599.
   PubMedGoogle Scholar
• Susin, S. A., H. K Lorenzo, N. Zamzami, I. Marzo, B. E. Snow, G. M. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D. R. Goodlett, R. Aebersold, D. P. Siderovski, J. M. Penninger, and G. Kroemer. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441–446.
   PubMed Web of Science ®Google Scholar
• Sylvie, F., R. Lombardi, T. Schmelzle, M. N. Hall, and H. Riezman. 2001. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J. 20: 6783–6792.
   PubMedGoogle Scholar
• Tan, S., Y. Sagara, Y. Liu, P. Maher, and D. Schubert. 1998. The regulation of reactive oxygen species production during programmed cell death. J. Cell Biol. 141: 1423–1432.
   PubMed Web of Science ®Google Scholar
• Tepper, A. D., P. Ruurs, T. Wiedmer, P. J. Sims, J. Borst, and van W. J. Blitterswijk. 2000. Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipids scrambling and alters cell-surface morphology. J. Cell Biol. 150: 155–165.
   PubMed Web of Science ®Google Scholar
• Uren, A. G., K. O'Rourke, L. Aravind, M. T. Pisabarro, S. Seshagiri, S., E. V. Koonin, and V. M. Dixit. 2000. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol. Cell 5: 961–967.
   Google Scholar
• Waring, R. B., G. S. May, and N. R. Morris. 1989. Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin-coding genes. Gene 79: 119–130.
   PubMed Web of Science ®Google Scholar
• Webb, S. J., D. J. Harrison, and A. H. Wyllie. 1997. Apoptosis: an overview of the process and its relevance in disease. Adv. Pharmacol. 41: 1–34.
   PubMedGoogle Scholar
• Wells, G. B., R. C. Dickson, and R. L. Lester. 1998. Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J. Biol. Chem. 273: 7235–7243.
   PubMedGoogle Scholar
• Ye, X. S., X. Xu, R. T. Pu, R. R. Fincher, S. L. McGuire, A. H. Osmani, and S. A. Osmani. 1995. The NIMA protein kinase is hyperphosphorylated and activated downstream of p34 cdc2 /cyclin B: coordination of two mitosis promoting kinases. EMBO J. 14: 986–994.
   PubMedGoogle Scholar
• Ye, X. S., L. P. Wu, and S. A. Osmani. 2001. Signal transduction in filamentous fungi: regulation of protein kinases, p. 157–174. In N. Talbot (ed.), Molecular and cellular biology of filamentous fungi: a practical approach. Oxford University Press, Oxford, United Kingdom.
   Google Scholar