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Cell Growth and Development

PIM3 Proto-Oncogene Kinase Is a Common Transcriptional Target of Divergent EWS/ETS Oncoproteins

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Pages 3897-3908 | Received 19 Nov 2002, Accepted 03 Mar 2003, Published online: 27 Mar 2023

REFERENCES

  • Arvand, A., and C. T. Denny. 2001. Biology of EWS/ETS fusions in Ewings family tumors. Oncogene 20: 5747–5754.
  • Arvand, A., H. Bastians, S. M. Welford, A. D. Thompson, J. V. Ruderman, and C. T. Denny. 1998. EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction. Oncogene 17: 2039–2045.
  • Attwooll, C., M. Tariq, M. Harris, J. D. Coyne, N. Telford, and J. M. Varley. 1999. Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. Oncogene 18: 7599–7601.
  • Bastians, H., L. M. Topper, G. L. Gorbsky, and J. V. Ruderman. 1999. Cell cycle-regulated proteolysis of mitotic target proteins. Mol. Biol. Cell 10: 3927–3941.
  • Berns, A., H. Mikkers, P. Krimpenfort, J. Allen, B. Scheijen, and J. Jonkers. 1999. Identification and characterization of collaborating oncogenes in compound mutant mice. Cancer Res. 59: 1773–1777.
  • Bertolotti, A., Y. Lutz, D. J. Heard, P. Chambon, and L. Tora. 1996. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. EMBO J. 15: 5022–5031.
  • Braun, B. S., R. Frieden, S. L. Lessnick, W. A. May, and C. T. Denny. 1995. Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis. Mol. Cell. Biol. 15: 4623–4630.
  • Breuer, M., R. Slebos, S. Verbeek, M. van Lohuizen, E. Weintjens, and A. Berns. 1989. Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature 340: 61–63.
  • Calvio, C., G. Neubauer, M. Mann, and A. I. Lamond. 1995. Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry. RNA 1: 724–733.
  • Coller, H. A., C. Grandori, P. Tamayo, T. Colbert, E. S. Lander, R. N. Eisenman, and T. R. Golub. 2000. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc. Natl. Acad. Sci. USA 97: 3260–3265.
  • de Alava, E., and W. L. Gerald. 2000. Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family. J. Clin. Oncol. 18: 204–213.
  • Feldman, J. D., L. Vician, M. Crispino, G. Tocco, M. Baudry, and H. R. Herschman. 1998. Seizure activity induces PIM-1 expression in brain. J. Neurosci. Res. 53: 502–509.
  • Feldman, J. D., L. Vician, M. Crispino, G. Tocco, V. L. Marcheselli, N. G. Bazan, M. Baudry, and H. R. Herschman. 1998. KID-1, a protein kinase induced by depolarization in brain. J. Biol. Chem. 273: 16535–16543.
  • Fukada, T., Y. Yoshida, K. Nishida, T. Ohtani, T. Shirogane, M. Hibi, and T. Hirano. 1999. Signaling through Gp130: toward a general scenario of cytokine action. Growth Factors 17: 81–91.
  • Ginsberg, J. P., E. de Alava, M. Ladanyi, L. H. Wexler, H. Kovar, M. Paulussen, A. Zoubek, B. Dockhorn-Dworniczak, H. Juergens, J. S. Wunder, I. L. Andrulis, R. Malik, P. H. Sorensen, R. B. Womer, and F. G. Barr. 1999. EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J. Clin. Oncol. 17: 112–123.
  • Graves, B. J., and J. M. Petersen. 1998. Specificity within the ets family of transcription factors. Adv. Cancer Res. 75: 1–55.
  • Ichikawa, H., K. Shimizu, Y. Hayashi, and M. Ohki. 1994. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res. 54: 2865–2868.
  • Ishitsuka, H., M. M. Takemoto, K. Kukouka, A. Itoga, and H. B. Marruyama. 1980. Role of uridine phosphorylase for antitumor activity of 5′-deoxy-5-fluorouridine. Jpn. J. Cancer Res. 71: 112–123.
  • Kallio, M., J. Weinstein, J. R. Daum, D. J. Burke, and G. J. Gorbsky. 1998. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141: 1393–1406.
  • Lessnick, S., C. S. Dacwag, and T. R. Golub. 2002. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 4: 393–401.
  • Mastrangelo, T., P. Modena, S. Tornielli, F. Bullrich, M. A. Testi, A. Mezzelani, P. Radice, A. Azzarelli, S. Pilotti, C. M. Croce, M. A. Pierotti, and G. Sozzi. 2000. A novel zinc finger gene is fused to EWS in small round cell tumor. Oncogene 19: 3799–3804.
  • May, W. A., A. Arvand, A. D. Thompson, B. S. Braun, M. Wright, and C. T. Denny. 1997. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic. Nat. Genet. 17: 495–497.
  • Mochizuki, T., C. Kitanaka, K. Noguchi, T. Muramatsu, A. Asai, and Y. Kuchino. 1999. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J. Biol. Chem. 274: 18659–18666.
  • Mochizuki, T., K. C. Noguchi, A. Sugiyama, S. Kagaya, S. Chi, A. Asai, and Y. Kuchino. 1997. Pim-1 kinase stimulates c-Myc mediated death signaling upstream of caspase 3 (CPP32)-like protease activation. Oncogene 15: 1471–1480.
  • Panagopoulos, I., M. Hoglund, F. Mertens, N. Mandahl, F. Mitelman, and P. Aman. 1996. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene 12: 489–494.
  • Panagopoulos, I., M. Mencinger, C. U. Dietrich, B. Bjerkehagen, G. Saeter, F. Mertens, N. Mandahl, and S. Heim. 1999. Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation. Oncogene 18: 7594–7598.
  • Roshak, A. K., E. A. Capper, C. Imburgia, J. Fornwald, G. Scott, and L. A. Marshall. 2000. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal. 12: 405–411.
  • Shirogane, T., T. Fukada, J. M. Muller, D. T. Shima, M. Hibi, and T. Hirano. 1999. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 11: 709–719.
  • Tamayo, P., D. Slonim, J. Mesirov, Q. Zhu, S. Kitareewan, E. Dmitrovsky, E. S. Lander, and T. R. Golub. 1999. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc. Natl. Acad. Sci. USA 96: 2907–2912.
  • Thompson, A. D., M. A. Teitell, A. Arvand, and C. T. Denny. 1999. Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic pheno-type on NIH3T3 cells. Oncogene 18: 5506–5513.
  • Van Maanen, M., P. A. Fournier, T. N. Palmer, and L. J. Abraham. 1999. Characterization of mouse glycogenin-1 cDNA and promoter region. Biochim. Biophys. Acta 1447: 284–290.
  • Weighardt, F., G. Biamonti, and S. Riva. 1996. The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism. BioEssays 18: 747–756.
  • Welford, S. M., S. P. Hebert, B. Deneen, A. Arvand, and C. T. Denny. 2001. DNA binding domain-independent pathways are involved in EWS/FLI1 mediated oncogenesis. J. Biol. Chem. 276: 41977–41984.
  • Yang, L., L. J. Embree, S. Tsai, and D. D. Hickstein. 1998. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J. Biol. Chem. 273: 27761–27764.
  • Zinszner, H., J. Sok, D. Immanuel, Y. Yin, and D. Ron. 1997. TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling. J. Cell Sci. 110: 1741–1750.
  • Zwerner, J. A., and W. A. May. 2001. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing's family of tumors. Oncogene 20: 626–633.

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