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Cell Growth and Development

Protein Kinase B/Akt Binds and Phosphorylates PED/PEA-15, Stabilizing Its Antiapoptotic Action

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Pages 4511-4521 | Received 08 Nov 2002, Accepted 08 Apr 2003, Published online: 27 Mar 2023

REFERENCES

  • Alessi, D. R., F. B. Caudwell, M. Andjelkovic, B. A. Hemmings, and P. Cohen. 1996. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 399: 333–338.
  • Araujo, H., N. Danzinger, J. Cordier, J. Glowinski, and H. Chneiweiss. 1993. Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268: 5911–5920.
  • Brunet, A., A. Bonni, M. J. Zigmond, M. Z. Lin, P. Juo, L. S. Hu, M. J. Anderson, K. C. Arden, J. Blenis, and M. E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857–868.
  • Cardone, M. H., N. Roy, H. R. Stennicke, G. S. Salvesen, T. F. Franke, E. Stanbridge, S. Fricsh, and J. C. Reed. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318–1321.
  • Condorelli, G., A. Trencia, G. Vigliotta, A. Perfetti, U. Goglia, E. Autori, A. Cassese, A. Musti, C. Miele, S. Santopietro, P. Formisano, and F. Beguinot. 2002. Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function. J. Biol. Chem. 277: 11013–11018.
  • Condorelli, G., G. Vigliotta, C. Iavarone, M. Caruso, C. G. Tocchetti, F. Andreozzi, M. F. Tecce, A. Cafieri, P. Formisano, L. Beguinot, and F. Beguinot. 1998. PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. EMBO J. 17: 3858–3865.
  • Condorelli, G., G. Vigliotta, C. Iavarone, A. Trencia, P. Andalò, F. Oriente, C. Miele, M. Caruso, P. Formisano, and F. Beguinot. 1999. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. Oncogene 18: 4409–4415.
  • Danzinger, N., M. Yokohama, T. Jay, J. Cordier, J. Glowinski, and H. Chneiweiss. 1995. Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate. J. Neurochem. 64: 1016–1025.
  • Del Bufalo, D., V. Di Castro, A. Biroccio, M. Varmi, D. Salani, L. Rosano, D. Trisciuoglio, F. Spinella, and A. Bagnato. 2002. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation. Mol. Pharmacol. 61: 524–532.
  • Du, K., and M. Montminy. 1998. CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 273: 32377–32379.
  • Dudek, H., S. R. Datta, T. F. Franke, M. Brinbaum, R. Yao, G. M. Cooper, R. A. Segal, D. R. Kaplan, and M. E. Greenberg. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661–665.
  • Dudek, H., S. R. Datta, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231–241.
  • Eves, E. M., W. Xiong, A. Bellacosa, S. G. Kennedy, P. N. Tsichlis, M. R. Rosner, and N. Hay. 1998. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol. Cell. Biol. 18: 2143–2152.
  • Formstecher, E., J. W. Ramos, M. Fauquet, D. A. Calderwood, J. C. Hsieh, B. Canton, X. T. Nguyen, J. V. Barnier, J. Camonis, M. H. Ginsberg, and H. Chneiweiss. 2001. PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev. Cell 1: 239–250.
  • Franke, T. F., D. R. Kaplan, L. C. Cantly, and A. Toker. 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275: 665–668.
  • Hao, C., F. Beguinot, G. Condorelli, A. Trencia, H. T. Chen, E. G. Van Meir, V. W. Yong, I. F. Parney, W. H. Roa, and K. C. Petruk. 2001. Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apoptosis in human malignant glioma cells. Cancer Res. 61: 1–9.
  • Hill, J. M., H. Vaidyanathan, J. W. Ramos, M. H. Ginsberg, and M. H. Werner. 2002. Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J. 21: 6494–6504.
  • Hoeffler, J. P., T. E. Meyer, Y. Yun, J. L. Jameson, and J. F. Habener. 1988. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242: 1430–1433.
  • Honda, R., Y. Ohba, and H. Yasuda. 1997. 14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase. Biochem. Biophys. Res. Commun. 230: 262–265.
  • Hwang, S., W. Kuo, J. F. Cochron, R. C. Gurman, T. Tsukamoto, G. Bandyopadhyay, K. Mambo, and C. C. Collins. 1997. Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers. Genomics 42: 540–542.
  • Khwaja, A., S. Rodriguez-Viciana Wennstrom, P. H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16: 2783–2793.
  • Kitsberg, D., E. Formstecher, M. Fauquet, M. Kubes, J. Cordier, B. Canton, G. Pan, M. Rolli, J. Glowinski, and H. Chneiweiss. 1999. Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. J. Neurosci. 19: 8244–8251.
  • Kubes, M., J. Cordier, J. Glowinski, J. A. Girault, and H. Chneiweiss. 1998. Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro. J. Neurochem. 71: 1303–1314.
  • Li, Y., D. Dowbenko, and L. A. Lasky. 2002. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J. Biol. Chem. 277: 11352–11361.
  • Marte, B. M., and J. Downward. 1997. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22: 355–358.
  • Nicholson, K. M., and N. G. Anderson. 2002. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14: 381–395.
  • Powell, D. W., M. J. Rane, Q. Chen, S. Singh, and K. R. McLeish. 2002. Identification of 14-3-3zeta as a protein kinase B/Akt substrate. J. Biol. Chem. 277: 21639–21642.
  • Testa, J. R., and A. Bellacosa. 2001. AKT plays a central role in tumorigenesis. Proc. Natl. Acad. Sci. USA 98: 10983–10985.
  • Vivano, I., and C. L. Sawyers. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2: 489–502.
  • Wang, H. G., U. R. Rapp, and J. C. Reed. 1996. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 629–638.
  • Xiao, C., B. F. Yang, N. Asadi, F. Beguinot, and C. Hao. 2002. Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J. Biol. Chem. 277: 25020–25025.

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