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Cell Growth and Development

Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation

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Pages 4573-4585 | Received 13 Sep 2002, Accepted 19 Mar 2003, Published online: 27 Mar 2023

REFERENCES

  • Brown, D., S. Kogan, E. Lagasse, I. Weissman, M. Alcalay, P. G. Pelicci, S. Atwater, and J. M. Bishop. 1997. A PMLRAR alpha transgene initiates murine acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 94: 2551–2556.
  • Chang, J. M., D. Metcalf, R. A. Lang, T. J. Gonda, and G. R. Johnson. 1989. Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression. Blood 73: 1487–1497.
  • Cline, M. J. 1994. The molecular basis of leukemia. N. Engl. J. Med. 330: 328–336.
  • Cuenco, G. M., and R. Ren. 2001. Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia. Oncogene 20: 8236–8248.
  • D'Andrea, R. J., and T. J. Gonda. 2000. A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: insights from activated mutants of the common beta subunit. Exp. Hematol. 28: 231–243.
  • Dash, A. B., I. R. Williams, J. L. Kutok, M. H. Tomasson, E. Anastasiadou, K. Lindahl, S. Li, R. A. Van Etten, J. Borrow, D. Housman, B. Druker, and D. G. Gilliland. 2002. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc. Natl. Acad. Sci. USA 99: 7622–7627.
  • de Groot, R. P., P. J. Coffer, and L. Koenderman. 1998. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell. Signal. 10: 619–628.
  • Di Croce, L., V. A. Raker, M. Corsaro, F. Fazi, M. Fanelli, M. Faretta, F. Fuks, F. Lo Coco, T. Kouzarides, C. Nervi, S. Minucci, and P. G. Pelicci. 2002. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295: 1079–1082.
  • Dubois, C., M. H. Schlageter, A. Degentile, F. Guidez, N. Balitrand, M. E. Toubert, I. Krawice, P. Fenaux, S. Castaigne, Y. Najean, L. Degos, and C. Chomienne. 1994. Hematopoietic growth factor expression and ATRA sensitivity in acute promyelocytic blast cells. Blood 83: 3264–3270.
  • Durstin, M., R. C. Inhorn, and J. D. Griffin. 1996. Tyrosine phosphorylation of Shc is not required for proliferation or viability signaling by granulocyte-macrophage colony-stimulating factor in hematopoietic cell lines. J. Immunol. 157: 534–540.
  • Freeburn, R. W., R. E. Gale, H. M. Wagner, and D. C. Linch. 1996. The beta subunit common to the GM-CSF, IL-3 and IL-5 receptors is highly polymorphic but pathogenic point mutations in patients with acute myeloid leukemia (AML) are rare. Leukemia 10: 123–129.
  • Grignani, F., P. F. Ferrucci, U. Testa, G. Talamo, M. Fagioli, M. Alcalay, A. Mencarelli, F. Grignani, C. Peschle, I. Nicoletti, and P. G. Pelicci. 1993. The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74: 423–431.
  • Grignani, F., U. Testa, M. Fagioli, T. Barberi, R. Masciulli, G. Mariani, C. Peschle, and P. G. Pelicci. 1995. Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. Cancer Res. 55: 440–443.
  • Grignani, F., M. Valtieri, M. Gabbianelli, V. Gelmetti, R. Botta, L. Luchetti, B. Masella, O. Morsilli, E. Pelosi, P. Samoggia, P. G. Pelicci, and C. Peschle. 2000. PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype. Blood 96: 1531–1537.
  • Grisolano, J. L., R. L. Wesselschmidt, P. G. Pelicci, and T. J. Ley. 1997. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood 89: 376–387.
  • Guthridge, M. A., F. C. Stomski, D. Thomas, J. M. Woodcock, C. J. Bagley, M. C. Berndt, and A. F. Lopez. 1998. Mechanism of activation of the GM-CSF IL-3, and IL-5 family of receptors. Stem Cells 16: 301–313.
  • He, L. Z., C. Tribioli, R. Rivi, D. Peruzzi, P. G. Pelicci, V. Soares, G. Cattoretti, and P. P. Pandolfi. 1997. Acute leukemia with promyelocytic features in PML/RARα transgenic mice. Proc. Natl. Acad. Sci. USA 94: 5302–5307.
  • Higuchi, M., D. O'Brien, P. Kumaravelu, N. Lenny, E. J. Yeoh, and J. R. Downing. 2002. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1: 63–74.
  • Itoh, T., R. Liu, T. Yokota, K. Arai, and S. Watanabe. 1998. Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor. Mol. Cell. Biol. 18: 742–752.
  • Itoh, T., A. Muto, S. Watanabe, A. Miyajima, T. Yokota, and K. Arai. 1996. Granulocyte-macrophage colony-stimulating factor provokes Ras activation and transcription of C-Fos through different modes of signaling. J. Biol. Chem. 271: 7587–7592.
  • Jenkins, B. J., T. J. Blake, and T. J. Gonda. 1998. Saturation mutagenesis of the beta subunit of the human granulocyte-macrophage colony-stimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential beta subunit tyrosine phosphorylation. Blood 92: 1989–2002.
  • Jenkins, B. J., R. D'Andrea, and T. J. Gonda. 1995. Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling. EMBO J. 14: 4276–4287.
  • Jenkins, B. J., F. Le, and T. J. Gonda. 1999. A cell type-specific constitutive point mutant of the common beta-subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors requires the GM-CSF receptor alpha-subunit for activation. J. Biol. Chem. 274: 8669–8677.
  • Johnson, B. S., L. Mueller, J. Si, and S. J. Collins. 2002. The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood 99: 746–753.
  • Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18: 97–104.
  • Kastner, P., H. J. Lawrence, C. Waltzinger, N. B. Ghyselinck, P. Chambon, and S. Chan. 2001. Positive and negative regulation of granulopoiesis by endogenous RAR alpha. Blood 97: 1314–1320.
  • Kelly, L. M., J. L. Kutok, I. R. Williams, C. L. Boulton, S. M. Amaral, D. P. Curley, T. J. Ley, and D. G. Gilliland. 2002. PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model. Proc. Natl. Acad. Sci. USA 99: 8283–8288.
  • Kiyoi, H., T. Naoe, S. Yokota, M. Nakao, S. Minami, K. Kuriyama, A. Takeshita, K. Saito, S. Hasegawa, S. Shimodaira, J. Tamura, C. Shimazaki, K. Matsue, H. Kobayashi, N. Arima, R. Suzuki, H. Morishita, H. Saito, R. Ueda, and R. Ohno. 1997. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia 11: 1447–1452.
  • Kogan, S. C., D. E. Brown, D. B. Shultz, B. T. H. Truong, V. Lallemand-Breitenbach, M. C. Guillemin, E. Lagasse, I. L. Weissman, and J. M. Bishop. 2001. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PML-RARα) to block neutrophil differentiation and initiate acute leukemia. J. Exp. Med. 193: 531–543.
  • Kogan, S. C., S. H. Hong, D. B. Shultz, M. L. Privalsky, and J. M. Bishop. 2000. Leukemia initiated by PML-RARα: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable. Blood 95: 1541–1550.
  • Kogan, S. C., E. Lagasse, S. Atwater, S. C. Bae, I. Weissman, Y. Ito, and J. M. Bishop. 1998. The PEBP2βMYH11 fusion created by inv(16)(p13q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc. Natl. Acad. Sci. USA 95: 11863–11868.
  • Kogan, S. C., J. M. Ward, M. R. Anver, J. J. Berman, C. Brayton, R. D. Cardiff, J. S. Carter, S. de Coronado, J. R. Downing, T. N. Fredrickson, D. C. Haines, A. W. Harris, N. L. Harris, H. Hiai, E. S. Jaffe, I. C. MacLennan, P. P. Pandolfi, P. K. Pattengale, A. S. Perkins, R. M. Simpson, M. S. Tuttle, J. F. Wong, and H. C. Morse III. 2002. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 100: 238–245.
  • Kottaridis, P. D., R. E. Gale, M. E. Frew, G. Harrison, S. E. Langabeer, A. A. Belton, H. Walker, K. Wheatley, D. T. Bowen, A. K. Burnett, A. H. Goldstone, and D. C. Linch. 2001. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98: 1752–1759.
  • Kroon, E., J. Krosl, U. Thorsteinsdottir, S. Baban, A. M. Buchberg, and G. Sauvageau. 1998. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 17: 3714–3725.
  • Labrecque, J., D. Allan, P. Chambon, N. N. Iscove, D. Lohnes, and T. Hoang. 1998. Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors α1 and γ. Blood 92: 607–615.
  • Lallemand-Breitenbach, V., M. C. Guillemin, A. Janin, M. T. Daniel, L. Degos, S. C. Kogan, J. M. Bishop, and H. de The. 1999. Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia. J. Exp. Med. 189: 1043–1052.
  • Le Beau, M. M., S. Bitts, E. M. Davis, and S. C. Kogan. 2002. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia. Blood 99: 2985–2991.
  • Look, A. T. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278: 1059–1064.
  • McCormack, M. P., and T. J. Gonda. 1997. Expression of activated mutants of the human interleukin-3/interleukin-5/granulocyte-macrophage colony-stimulating factor receptor common beta subunit in primary hematopoietic cells induces factor-independent proliferation and differentiation. Blood 90: 1471–1481.
  • McCormack, M. P., and T. J. Gonda. 2000. Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the CM-CSF receptor beta subunit. Blood 95: 120–127.
  • Melnick, A., and J. D. Licht. 1999. Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93: 3167–3215.
  • Metcalf, D., C. G. Begley, G. R. Johnson, N. A. Nicola, A. F. Lopez, and D. J. Williamson. 1986. Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood 68: 46–57.
  • Okuda, K., L. Smith, J. D. Griffin, and R. Foster. 1997. Signaling functions of the tyrosine residues in the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. Blood 90: 4759–4766.
  • Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90: 8392–8396.
  • Pelengaris, S., M. Khan, and G. I. Evan. 2002. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109: 321–334.
  • Perkins, A., K. Kongsuwan, J. Visvader, J. M. Adams, and S. Cory. 1990. Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Proc. Natl. Acad. Sci. USA 87: 8398–8402.
  • Rego, E. M., Z. G. Wang, D. Peruzzi, L. Z. He, C. Cordon-Cardo, and P. P. Pandolfi. 2001. Role of promyelocytic leukemia (PML) protein in tumor suppression. J. Exp. Med. 193: 521–529.
  • Rousselot, P., B. Hardas, A. Patel, F. Guidez, J. Gaken, S. Castaigne, A. Dejean, H. de The, L. Degos, F. Farzaneh, and C. Chomienne. 1994. The PML-RAR alpha gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells. Oncogene 9: 545–551.
  • Rowley, J. D., G. Alimena, O. M. Garson, A. Hagemeijer, F. Mitelman, and E. L. Prigogina. 1982. A collaborative study of the relationship of the morphological type of acute nonlymphocytic leukemia with patient age and karyotype. Blood 59: 1013–1022.
  • Rowley, J. D., H. M. Golomb, and C. Dougherty. 1977. 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. Lancet i: 549–550.
  • Schnittger, S., C. Schoch, M. Dugas, W. Kern, P. Staib, C. Wuchter, H. Loffler, C. M. Sauerland, H. Serve, T. Buchner, T. Haferlach, and W. Hiddemann. 2002. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 100: 59–66.
  • Shimizu, T., and K. Takeda. 2000. Induction of retinoic acid receptor-alpha by granulocyte macrophage colony-stimulating factor in human myeloid leukemia cell lines. Cancer Res. 60: 4544–4549.
  • Sohal, J., V. T. Phan, P. V. Chan, E. M. Davis, B. Patel, L. M. Kelly, T. J. Abrams, A. M. O'Farrell, D. G. Gilliland, M. M. Le Beau, and S. C. Kogan. 2002. A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657. Blood 101: 3188–3197.
  • Testa, U., F. Grignani, H. J. Hassan, D. Rogaia, R. Masciulli, V. Gelmetti, R. Guerriero, G. Macioce, C. Liberatore, T. Barberi, G. Mariani, P. G. Pelicci, and C. Peschle. 1998. Terminal megakaryocytic differentiation of TF-1 cells is induced by phorbol esters and thrombopoietin and is blocked by expression of PML/RARalpha fusion protein. Leukemia 12: 563–570.
  • van Dijk, T. B., E. Caldenhoven, J. A. Raaijmakers, J. W. Lammers, L. Koenderman, and R. P. de Groot. 1997. Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5. FEBS Lett. 412: 161–164.
  • Vickers, M., G. Jackson, and P. Taylor. 2000. The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate-limiting mutation. Leukemia 14: 722–726.
  • Wong, P. M., S. W. Chung, C. E. Dunbar, D. M. Bodine, S. Ruscetti, and A. W. Nienhuis. 1989. Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder. Mol. Cell. Biol. 9: 798–808.
  • Yamamoto, Y., H. Kiyoi, Y. Nakano, R. Suzuki, Y. Kodera, S. Miyawaki, N. Asou, K. Kuriyama, F. Yagasaki, C. Shimazaki, H. Akiyama, K. Saito, M. Nishimura, T. Motoji, K. Shinagawa, A. Takeshita, H. Saito, R. Ueda, R. Ohno, and T. Naoe. 2001. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 97: 2434–2439.
  • Yokota, S., H. Kiyoi, M. Nakao, T. Iwai, S. Misawa, T. Okuda, Y. Sonoda, T. Abe, K. Kahsima, Y. Matsuo, and T. Naoe. 1997. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia 11: 1605–1609.
  • Zheng, R., A. D. Friedman, and D. Small. 2002. Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood 100: 4154–4161.

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