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DNA Dynamics and Chromosome Structure

Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans

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Pages 5606-5613 | Received 21 Feb 2003, Accepted 16 May 2003, Published online: 27 Mar 2023

REFERENCES

  • Autexier, C., and C. W. Greider. 1995. Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes Dev. 9: 2227–2239.
  • Autexier, C., and C. W. Greider. 1998. Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro. Nucleic Acids Res. 26: 787–795.
  • Bachand, F., I. Triki, and C. Autexier. 2001. Human telomerase RNA-protein interactions. Nucleic Acids Res. 29: 3385–3393.
  • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2000. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell 11: 3329–3340.
  • Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 1998. Reconstitution of human telomerase activity in vitro. Curr. Biol. 8: 177–180.
  • Bhattacharyya, A., and E. H. Blackburn. 1994. Architecture of telomerase RNA. EMBO J. 13: 5521–5531.
  • Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106: 661–673.
  • Blasco, M. A., W. Funk, B. Villeponteau, and C. W. Greider. 1995. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269: 1267–1270.
  • Bryan, T. M., and T. R. Cech. 1999. Telomerase and the maintenance of chromosome ends. Curr. Opin. Cell Biol. 11: 318–324.
  • Bryan, T. M., K. J. Goodrich, and T. R. Cech. 2000. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J. Biol. Chem. 31: 24199–24207.
  • Chen, J. L., M. A. Blasco, and C. W. Greider. 2000. Secondary structure of vertebrate telomerase RNA. Cell 100: 503–514.
  • Chen, J. L., K. K. Opperman, and C. W. Greider. 2002. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 30: 592–597.
  • Collins, K., and L. Gandhi. 1998. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc. Natl. Acad. Sci. USA 95: 8485–8490.
  • Collins, K., and C. W. Greider. 1993. Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev. 7: 1364–1376.
  • Feng, J., W. D. Funk, S.-S. Wang, S. L. Weinrich, A. A. Avilion, C.-P. Chiu, R. R. Adams, E. Chang, R. C. Allsopp, J. Yu, S. Le, M. D. West, C. B. Harley, W. H. Andrews, C. W. Greider, and B. Villeponteau. 1995. The RNA component of human telomerase. Science 269: 1236–1241.
  • Greider, C. W. 1991. Telomerase is processive. Mol. Cell. Biol. 11: 4572–4580.
  • Greider, C. W., and E. H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331–337.
  • Harrington, L., and M. O. Robinson. 2002. Telomere dysfunction: multiple paths to the same end. Oncogene 21: 592–597.
  • Harrington, L. A., and C. W. Greider. 1991. Telomerase primer specificity and chromosome healing. Nature 353: 451–454.
  • Lai, C. K., M. C. Miller, and K. Collins. 2002. Template boundary definition in Tetrahymena telomerase. Genes Dev. 16: 415–420.
  • Lai, C. K., J. R. Mitchell, and K. Collins. 2001. RNA binding domain of telomerase reverse transcriptase. Mol. Cell. Biol. 21: 990–1000.
  • Licht, J. D., and K. Collins. 1999. Telomerase RNA function in recombinant Tetrahymena telomerase. Genes Dev. 13: 1116–1125.
  • Lingner, J., L. L. Hendrick, and T. R. Cech. 1994. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev. 8: 1984–1998.
  • Lingner, J., T. R. Hughes, A. Shevchenko, M. Mann, V. Lundblad, and T. R. Cech. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276: 561–567.
  • Mason, D. X. 2002. Biochemical characterization of Tetrahymena telomerase. Ph. D. thesis. The Johns Hopkins University School of Medicine, Baltimore, Md.
  • McCormick-Graham, M., and D. P. Romero. 1995. Ciliate telomerase RNA structural features. Nucleic Acids Res. 23: 1091–1097.
  • McCormick-Graham, M., and D. P. Romero. 1996. A single telomerase RNA is sufficient for the synthesis of variable telomeric DNA repeats in ciliates of the genus Paramecium. Mol. Cell. Biol. 16: 1871–1879.
  • McEachern, M. J., and E. H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376: 403–409.
  • Miller, M. C., and K. Collins. 2002. Telomerase recognizes its template by using an adjacent RNA motif. Proc. Natl. Acad. Sci. USA 99: 6585–6590.
  • Mitchell, J. R., and K. Collins. 2000. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6: 361–371.
  • Romero, D. P., and E. H. Blackburn. 1991. A conserved secondary structure for telomerase RNA. Cell 67: 343–353.
  • Shippen-Lentz, D., and E. H. Blackburn. 1990. Functional evidence for an RNA template in telomerase. Science 247: 546–552.
  • Singer, M. S., and D. E. Gottschling. 1994. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266: 404–409.
  • Sperger, J. M., and T. R. Cech. 2001. A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry 40: 7005–7016.
  • Tesmer, V. M., L. P. Ford, S. E. Holt, B. C. Frank, X. Yi, D. L. Aisner, M. Ouellette, J. W. Shay, and W. E. Wright. 1999. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell. Biol. 19: 6207–6216.
  • Weinrich, S. L., R. Pruzan, L. Ma, M. Ouellette, V. M. Tesmer, S. E. Holt, A. G. Bodnar, S. Lichtsteiner, N. W. Kim, J. B. Trager, R. D. Taylor, R. Carlos, W. H. Andrews, W. E. Wright, J. W. Shay, C. B. Harley, and G. B. Morin. 1997. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17: 498–502.
  • Ye, A. J., and D. P. Romero. 2002. Phylogenetic relationships amongst tetrahymenine ciliates inferred by a comparison of telomerase RNAs. Int. J. Syst. Evol. Microbiol. 52: 2297–2302.
  • Zaug, A. J., and T. R. Cech. 1995. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, self-splicing rRNA and U2 snRNA. RNA 1: 363–374.

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