15
Views
34
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Caspase 3-Mediated Inactivation of Rac GTPases Promotes Drug-Induced Apoptosis in Human Lymphoma Cells

, &
Pages 5716-5725 | Received 14 Mar 2003, Accepted 13 May 2003, Published online: 27 Mar 2023

REFERENCES

  • Archer, H., and D. Bar-Sagi. 2002. Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol. Biol. 189: 67–73.
  • Aznar, S., and J. C. Lacal. 2001. Rho signals to cell growth and apoptosis. Cancer Lett. 165: 1–10.
  • Benard, V., B. P. Bohl, and G. M. Bokoch. 1999. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils with a novel assay for active GTPases. J. Biol. Chem. 274: 13198–13204.
  • Boehm, J. E., O. V. Chaika, and R. E. Lewis. 1999. Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain. J. Biol. Chem. 274: 28632–28636.
  • Bokoch, G. M. 2000. Regulation of cell function by Rho family GTPases. Immunol. Res. 21: 139–148.
  • Boulares, A. H., A. G. Yakovlev, V. Ivanova, B. A. Stoica, G. Wang, S. Iyer, and M. Smulson. 1999. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J. Biol. Chem. 274: 22932–22940.
  • Cohen, G. M. 1997. Caspases: the executioners of apoptosis. Biochem. J. 326: 1–16.
  • Coleman, M. L., and M. F. Olson. 2002. Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ. 9: 493–504.
  • Deshpande, S. S., P. Angkeow, J. Huang, M. Ozaki, and K. Irani. 2000. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J. 14: 1705–1714.
  • Droin, N., L. Dubrez, B. Eymin, C. Renvoize, J. Breard, M. T. Dimanche-Boitrel, and E. Solary. 1998. Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Oncogene 16: 2885–2894.
  • Embade, N., P. F. Valeron, S. Aznar, E. Lopez-Collazo, and J. C. Lacal. 2000. Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramide production. Mol. Biol. Cell 11: 4347–4358.
  • Esteve, P., N. Embade, R. Perona, B. Jimenez, L. del Peso, J. Leon, M. Arends, T. Miki, and J. C. Lacal. 1998. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but BclII dependent pathway. Oncogene 17: 1855–1869.
  • Fiorentini, C., P. Matarrese, E. Straface, L. Falzano, G. Donelli, P. Boquet, and W. Malorni. 1998. Rho-dependent cell spreading activated by E. coli cytotoxic necrotizing factor 1 hinders apoptosis in epithelial cells. Cell Death Differ. 5: 921–929.
  • Flygare, J., D. Hellgren, and A. Wennborg. 2000. Caspase-3 mediated cleavage of HsRad51 at an unconventional site. Eur. J. Biochem. 267: 5977–5982.
  • Gescher, A. 2000. Staurosporine analogues—pharmacological toys or useful antitumour agents? Crit. Rev. Oncol. Hematol. 34: 127–135.
  • Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science 279: 509–514.
  • Harrington, A. W., J. Y. Kim, and S. O. Yoon. 2002. Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis. J. Neurosci. 22: 156–166.
  • Hirshberg, M., R. W. Stockley, G. Dodson, and M. R. Webb. 1997. The crystal structure of human Rac1, a member of the Rho-family complexed with a GTP analogue. Nat. Struct. Biol. 4: 147–152.
  • Jaffe, A. B., and A. Hall. 2002. Rho GTPases in transformation and metastasis. Adv. Cancer Res. 84: 57–80.
  • Jeong, H. G., H. J. Cho, I. Y. Chang, S. P. Yoon, Y. J. Jeon, M. H. Chung, and H. J. You. 2002. Rac1 prevents cisplatin-induced apoptosis through downregulation of p38 activation in NIH 3T3 cells. FEBS Lett. 518: 129–134.
  • Joneson, T., and D. Bar-Sagi. 1999. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell. Biol. 19: 5892–5901.
  • Kipp, M., B. L. Schwab, M. Przybylski, P. Nicotera, and F. O. Fackelmayer. 2000. Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase 3 occurs at a noncanonical cleavage site. J. Biol. Chem. 275: 5031–5036.
  • Krieser, R. J., and A. Eastman. 1999. Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-guanine nucleotide dissociation inhibitors, during apoptosis. Cell Death Differ. 6: 412–419.
  • Lee, Y., and E. Shacter. 1997. Bcl-2 does not protect Burkitt's lymphoma cells from oxidant-induced cell death. Blood 89: 4480–4492.
  • Lores, P., L. Morin, R. Luna, and G. Gacon. 1997. Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase. Oncogene 15: 601–605.
  • Meriane, M., S. Charrasse, F. Comunale, A. Mery, P. Fort, P. Roux, and C. Gauthier-Rouviere. 2002. Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation. Oncogene 21: 2901–2907.
  • Mira, J. P., V. Benard, J. Groffen, L. C. Sanders, and U. G. Knaus. 2000. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc. Natl. Acad. Sci. USA 97: 185–189.
  • Mow, B. M., A. L. Blajeski, J. Chandra, and S. H. Kaufmann. 2001. Apoptosis and the response to anticancer therapy. Curr. Opin. Oncol. 13: 453–462.
  • Murga, C., M. Zohar, H. Teramoto, and J. S. Gutkind. 2002. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB. Oncogene 21: 207–216.
  • Na, S., T. H. Chuang, A. Cunningham, T. G. Turi, J. H. Hanke, G. M. Bokoch, and D. E. Danley. 1996. D4-guanine nucleotide dissociation inhibitors, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem. 271: 11209–11213.
  • Nicholson, D. W., and N. A. Thornberry. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22: 299–306.
  • Nishida, K., Y. Kaziro, and T. Satoh. 1999. Anti-apoptotic function of Rac in hematopoietic cells. Oncogene 18: 407–415.
  • Pervaiz, S., J. Cao, O. S. Chao, Y. Y. Chin, and M. V. Clement. 2001. Activation of the RacGTPase inhibits apoptosis in human tumor cells. Oncogene 20: 6263–6268.
  • Philips, A., P. Roux, V. Coulon, J. M. Bellanger, A. Vie, M. L. Vignais, and J. M. Blanchard. 2000. Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts. J. Biol. Chem. 275: 5911–5917.
  • Qi, H., P. Juo, J. Masuda-Robens, M. J. Caloca, H. Zhou, N. Stone, M. G. Kazanietz, and M. M. Chou. 2001. Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Cell Growth Differ. 12: 603–611.
  • Rudel, T., and G. M. Bokoch. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276: 1571–1574.
  • Ruggieri, R., Y. Y. Chuang, and M. Symons. 2001. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts. Mol. Med. 7: 293–300.
  • Samejima, K., P. A. Svingen, G. S. Basi, T. Kottke, P. W. Mesner, Jr., L. Stewart, F. Durrieu, G. G. Poirier, E. S. Alnemri, J. J. Champoux, S. H. Kaufmann, and W. C. Earnshaw. 1999. Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis. J. Biol. Chem. 274: 4335–4340.
  • Schnelzer, A., D. Prechtel, U. Knaus, K. Dehne, M. Gerhard, H. Graeff, N. Harbeck, M. Schmitt, and E. Lengyel. 2000. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19: 3013–3020.
  • Schurmann, A., A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed, and G. M. Bokoch. 2000. p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis. Mol. Cell. Biol. 20: 453–461.
  • Senturker, S., R. Tschirret-Guth, J. Morrow, R. Levine, and E. Shacter. 2002. Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species. Arch. Biochem. Biophys. 397: 262–272.
  • Subauste, M. C., M. Von Herrath, V. Benard, C. E. Chamberlain, T. H. Chuang, K. Chu, G. M. Bokoch, and K. M. Hahn. 2000. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J. Biol. Chem. 275: 9725–9733.
  • Takahashi, M., H. Mukai, M. Toshimori, M. Miyamoto, and Y. Ono. 1998. Proteolytic activation of PKN by caspase 3 or related protease during apoptosis. Proc. Natl. Acad. Sci. USA 95: 11566–11571.
  • Tu, S., and R. A. Cerione. 2001. Cdc42 is a substrate for caspases and influences Fas-induced apoptosis. J. Biol. Chem. 276: 19656–19663.
  • Zhang, B., J. Chernoff, and Y. Zheng. 1998. Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J. Biol. Chem. 273: 8776–8782.
  • Zhang, B., Y. Gao, S. Y. Moon, Y. Zhang, and Y. Zheng. 2001. Oligomerization of Rac1 GTPase mediated by the carboxyl-terminal polybasic domain. J. Biol. Chem. 276: 8958–8967.
  • Zhang, B., Z. X. Wang, and Y. Zheng. 1997. Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains. J. Biol. Chem. 272: 21999–22007.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.