16
Views
114
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Human Mitochondrial Transcription Factor B1 Interacts with the C-Terminal Activation Region of h-mtTFA and Stimulates Transcription Independently of Its RNA Methyltransferase Activity

&
Pages 5816-5824 | Received 25 Feb 2003, Accepted 15 May 2003, Published online: 27 Mar 2023

REFERENCES

  • Antoshechkin, I., and D. F. Bogenhagen. 1995. Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA. Mol. Cell. Biol. 15: 7032–7042.
  • Bogenhagen, D. F. 1996. Interaction of mtTFB and mtRNA polymerase at core promoters for transcription of Xenopus laevis mtDNA. J. Biol. Chem. 271: 12036–12041.
  • Bussiere, D. E., S. W. Muchmore, C. G. Dealwis, G. Schluckebier, V. L. Nienaber, R. P. Edalji, K. A. Walter, U. S. Ladror, T. F. Holzman, and C. Abad-Zapatero. 1998. Crystal structure of ErmC′, an rRNA methyltransferase which mediates antibiotic resistance in bacteria. Biochemistry 37: 7103–7112.
  • Cliften, P. F., J. Y. Park, B. P. Davis, S. H. Jang, and J. A. Jaehning. 1997. Identification of three regions essential for interaction between a sigma-like factor and core RNA polymerase. Genes Dev. 11: 2897–2909.
  • Cliften, P. F., S. H. Jang, and J. A. Jaehning. 2000. Identifying a core RNA polymerase surface critical for interactions with a sigma-like specificity factor. Mol. Cell. Biol. 20: 7013–7023.
  • Dairaghi, D. J., G. S. Shadel, and D. A. Clayton. 1995. Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim. Biophys. Acta 1271: 127–134.
  • Dairaghi, D. J., G. S. Shadel, and D. A. Clayton. 1995. Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J. Mol. Biol. 249: 11–28.
  • DiMauro, S., K. Tanji, E. Bonilla, F. Pallotti, and E. A. Schon. 2002. Mitochondrial abnormalities in muscle and other aging cells: classification, causes, and effects. Muscle Nerve 26: 597–607.
  • Falkenberg, M., M. Gaspari, A. Rantanen, A. Trifunovic, N. G. Larsson, and C. M. Gustafsson. 2002. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat. Genet. 31: 289–294.
  • Fisher, R. P., and D. A. Clayton. 1985. A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. J. Biol. Chem. 260: 11330–11338.
  • Fisher, R. P., and D. A. Clayton. 1988. Purification and characterization of human mitochondrial transcription factor 1. Mol. Cell. Biol. 8: 3496–3509.
  • Fisher, R. P., T. Lisowsky, M. A. Parisi, and D. A. Clayton. 1992. DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J. Biol. Chem. 267: 3358–3367.
  • Fisher, R. P., J. N. Topper, and D. A. Clayton. 1987. Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell 50: 247–258.
  • Hager, D. A., and R. R. Burgess. 1980. Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes. Anal. Biochem. 109: 76–86.
  • Jang, S. H., and J. A. Jaehning. 1991. The yeast mitochondrial RNA polymerase specificity factor, MTF1, is similar to bacterial sigma factors. J. Biol. Chem. 266: 22671–22677.
  • Lisowsky, T., and G. Michaelis. 1988. A nuclear gene essential for mitochondrial replication suppresses a defect of mitochondrial transcription in Saccharomyces cerevisiae. Mol. Gen. Genet. 219: 125–128.
  • Malone, T., R. M. Blumenthal, and X. Cheng. 1995. Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes. J. Mol. Biol. 253: 618–632.
  • Masters, B. S., L. L. Stohl, and D. A. Clayton. 1987. Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell 51: 89–99.
  • McCulloch, V., B. L. Seidel-Rogol, and G. S. Shadel. 2002. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol. Cell. Biol. 22: 1116–1125.
  • Micol, V., P. Fernandez-Silva, and G. Attardi. 1996. Isolation and assay of mitochondrial transcription termination factor from human cells. Methods Enzymol. 264: 158–173.
  • Parisi, M. A., and D. A. Clayton. 1991. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 252: 965–969.
  • Schluckebier, G., P. Zhong, K. D. Stewart, T. J. Kavanaugh, and C. Abad-Zapatero. 1999. The 2.2 Å structure of the rRNA methyltransferase ErmC′ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. J. Mol. Biol. 289: 277–291.
  • Schubot, F. D., C. J. Chen, J. P. Rose, T. A. Dailey, H. A. Dailey, and B. C. Wang. 2001. Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci. 10: 1980–1988.
  • Seidel-Rogol, B. L., V. McCulloch, and G. S. Shadel. 2003. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. Nat. Genet. 33: 23–24.
  • Seidel-Rogol, B. L., and G. S. Shadel. 2002. Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res. 30: 1929–1934.
  • Shadel, G. S., and D. A. Clayton. 1993. Mitochondrial transcription initiation. Variation and conservation. J. Biol. Chem. 268: 16083–16086.
  • Shadel, G. S., and D. A. Clayton. 1995. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol. Cell. Biol. 15: 2101–2108.
  • Shadel, G. S., and D. A. Clayton. 1997. Mitochondrial DNA maintenance in vertebrates. Annu. Rev. Biochem. 66: 409–435.
  • Shoubridge, E. A. 2001. Nuclear genetic defects of oxidative phosphorylation. Hum. Mol. Genet. 10: 2277–2284.
  • Tiranti, V., A. Savoia, F. Forti, M. F. D'Apolito, M. Centra, M. Rocchi, and M. Zeviani. 1997. Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database. Hum. Mol. Genet. 6: 615–625.
  • Topper, J. N., and D. A. Clayton. 1989. Identification of transcriptional regulatory elements in human mitochondrial DNA by linker substitution analysis. Mol. Cell. Biol. 9: 1200–1211.
  • Wallace, D. C. 1999. Mitochondrial diseases in man and mouse. Science 283: 1482–1488.
  • Xu, B., and D. A. Clayton. 1992. Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res. 20: 1053–1059.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.