Identification and Characterization of a Candida albicans Mating Pheromone

REFERENCES

• Bennett, R. J., and A. D. Johnson. 2003. Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains. EMBO J. 22: 2505–2515.
   PubMed Web of Science ®Google Scholar
• Braun, B. R., W. S. Head, M. X. Wang, and A. D. Johnson. 2000. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 156: 31–44.
   PubMed Web of Science ®Google Scholar
• Calderone, R. A., and W. A. Fonzi. 2001. Virulence factors of Candida albicans. Trends Microbiol. 9: 327–335.
   PubMed Web of Science ®Google Scholar
• Chang, F., and I. Herskowitz. 1990. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 63: 999–1011.
   PubMedGoogle Scholar
• Chen, J., J. Chen, S. Lane, and H. Liu. 2002. A conserved mitogen-activated protein kinase pathway is required for mating in Candida albicans. Mol. Microbiol. 46: 1335–1344.
   PubMed Web of Science ®Google Scholar
• Chen, Y. C., C. C. Wu, W. L. Chung, and F. J. Lee. 2002. Differential secretion of Sap4-6 proteins in Candida albicans during hyphae formation. Microbiology 148: 3743–3754.
   PubMed Web of Science ®Google Scholar
• Clark, K. L., P. J. Feldmann, D. Dignard, R. Larocque, A. J. Brown, M. G. Lee, D. Y. Thomas, and M. Whiteway. 1995. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol. Gen. Genet. 249: 609–621.
   PubMedGoogle Scholar
• DeRisi, J. L., V. R. Iyer, and P. O. Brown. 1997. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278: 680–686.
   PubMed Web of Science ®Google Scholar
• Edmond, M. B., S. E. Wallace, D. K. McClish, M. A. Pfaller, R. N. Jones, and R. P. Wenzel. 1999. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin. Infect. Dis. 29: 239–244.
   PubMed Web of Science ®Google Scholar
• Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95: 14863–14868.
   PubMed Web of Science ®Google Scholar
• Erdman, S., and M. Snyder. 2001. A filamentous growth response mediated by the yeast mating pathway. Genetics 159: 919–928.
   PubMedGoogle Scholar
• Felk, A., M. Kretschmar, A. Albrecht, M. Schaller, S. Beinhauer, T. Nichterlein, D. Sanglard, H. C. Korting, W. Schafer, and B. Hube. 2002. Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Infect. Immun. 70: 3689–3700.
   PubMed Web of Science ®Google Scholar
• Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717–728.
   PubMed Web of Science ®Google Scholar
• Guthrie, C., and G. R. Fink. 1991. Guide to yeast genetics and molecular biology. Academic Press, San Diego, Calif.
   Google Scholar
• Hartig, A., J. Holly, G. Saari, and V. L. MacKay. 1986. Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 6: 2106–2114.
   PubMed Web of Science ®Google Scholar
• Hazan, I., and H. Liu. 2002. Hyphal tip-associated localization of Cdc42 is F-actin dependent in Candida albicans. Eukaryot. Cell 1: 856–864.
   PubMedGoogle Scholar
• Hull, C. M., R. M. Raisner, and A. D. Johnson. 2000. Evidence for mating of the “asexual” yeast Candida albicans in a mammalian host. Science 289: 307–310.
   PubMed Web of Science ®Google Scholar
• Janbon, G., F. Sherman, and E. Rustchenko. 1998. Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans. Proc. Natl. Acad. Sci. USA 95: 5150–5155.
   PubMed Web of Science ®Google Scholar
• Jenness, D. D., A. C. Burholder, and L. H. Hartwell. 1983. Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor. Cell 35: 521–529.
   PubMed Web of Science ®Google Scholar
• Kohler, J. R., and G. R. Fink. 1996. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Proc. Natl. Acad. Sci. USA 93: 13223–13228.
   PubMed Web of Science ®Google Scholar
• Lan, C. Y., G. Newport, L. A. Murillo, T. Jones, S. Scherer, R. W. Davis, and N. Agabian. 2002. Metabolic specialization associated with phenotypic switching in Candida albicans. Proc. Natl. Acad. Sci. USA 99: 14907–14912.
   PubMed Web of Science ®Google Scholar
• Leberer, E., D. Harcus, I. D. Broadbent, K. L. Clark, D. Dignard, K. Ziegelbauer, A. Schmidt, N. A. Gow, A. J. Brown, and D. Y. Thomas. 1996. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. USA 93: 13217–13222.
   PubMed Web of Science ®Google Scholar
• Liu, H. 2002. Co-regulation of pathogenesis with dimorphism and phenotypic switching in Candida albicans, a commensal and a pathogen. Int. J. Med. Microbiol. 292: 299–311.
   PubMed Web of Science ®Google Scholar
• Liu, H., J. Kohler, and G. R. Fink. 1994. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723–1726.
   PubMed Web of Science ®Google Scholar
• Lockhart, S. R., K. J. Daniels, R. Zhao, D. Wessels, and D. R. Soll. 2003. Cell biology of mating in Candida albicans. Eukaryot. Cell 2: 49–61.
   PubMedGoogle Scholar
• Lockhart, S. R., C. Pujol, K. J. Daniels, M. G. Miller, A. D. Johnson, M. A. Pfaller, and D. R. Soll. 2002. In Candida albicans, white-opaque switchers are homozygous for mating type. Genetics 162: 737–745.
   PubMed Web of Science ®Google Scholar
• Madhani, H. D., and G. R. Fink. 1998. The control of filamentous differentiation and virulence in fungi. Trends Cell Biol. 8: 348–353.
   PubMed Web of Science ®Google Scholar
• Magee, B. B., M. Legrand, A. M. Alarco, M. Raymond, and P. T. Magee. 2002. Many of the genes required for mating in Saccharomyces cerevisiae are also required for mating in Candida albicans. Mol. Microbiol. 46: 1345–1351.
   PubMed Web of Science ®Google Scholar
• Magee, B. B., and P. T. Magee. 2000. Induction of mating in Candida albicans by construction of MTLa and MTLα strains. Science 289: 310–313.
   PubMed Web of Science ®Google Scholar
• Miller, M. G., and A. D. Johnson. 2002. White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110: 293–302.
   PubMed Web of Science ®Google Scholar
• Mitchell, A. P. 1998. Dimorphism and virulence in Candida albicans. Curr. Opin. Microbiol. 1: 687–692.
   PubMedGoogle Scholar
• Nantel, A., D. Dignard, C. Bachewich, D. Harcus, A. Marcil, A. P. Bouin, C. W. Sensen, H. Hogues, M. van het Hoog, P. Gordon, T. Rigby, F. Benoit, D. C. Tessier, D. Y. Thomas, and M. Whiteway. 2002. Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition. Mol. Biol. Cell 13: 3452–3465.
   PubMed Web of Science ®Google Scholar
• Navarro-Garcia, F., M. Sanchez, C. Nombela, and J. Pla. 2001. Virulence genes in the pathogenic yeast Candida albicans. FEMS Microbiol. Rev. 25: 245–268.
   PubMedGoogle Scholar
• Newport, G., A. Kuo, A. Flattery, C. Gill, J. J. Blake, M. B. Kurtz, G. K. Abruzzo, and N. Agabian. 2003. Inactivation of Kex2p diminishes the virulence of Candida albicans. J. Biol. Chem. 278: 1713–1720.
   PubMedGoogle Scholar
• Roberts, C. J., B. Nelson, M. J. Marton, R. Stoughton, M. R. Meyer, H. A. Bennett, Y. D. He, H. Dai, W. L. Walker, T. R. Hughes, M. Tyers, C. Boone, and S. H. Friend. 2000. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287: 873–880.
   PubMed Web of Science ®Google Scholar
• Singh, P., S. Ghosh, and A. Datta. 1997. A novel MAP-kinase kinase from Candida albicans. Gene 190: 99–104.
   PubMedGoogle Scholar
• Sprague, G. F. J., and J. T. Thorner. 1992. Pheromone response and signal transduction during the mating process of S. cerevisiae, p. 657–744. In J. R. Pringle, J. R. Broach, and E. W. Jones (ed.), Molecular and cellular biology of the yeast Saccharomyces. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Staab, J. F., S. D. Bradway, P. L. Fidel, and P. Sundstrom. 1999. Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283: 1535–1538.
   PubMed Web of Science ®Google Scholar
• Tzung, K. W., R. M. Williams, S. Scherer, N. Federspiel, T. Jones, N. Hansen, V. Bivolarevic, L. Huizar, C. Komp, R. Surzycki, R. Tamse, R. W. Davis, and N. Agabian. 2001. Genomic evidence for a complete sexual cycle in Candida albicans. Proc. Natl. Acad. Sci. USA 98: 3249–3253.
   PubMed Web of Science ®Google Scholar
• Uhl, M. A., M. Biery, C. Craig, and A. D. Johnson. 2003. Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J. 22: 2668–2678.
   PubMed Web of Science ®Google Scholar
• Whiteway, M. 2000. Transcriptional control of cell type and morphogenesis in Candida albicans. Curr. Opin. Microbiol. 3: 582–588.
   PubMed Web of Science ®Google Scholar
• Wilson, R. B., D. Davis, and A. P. Mitchell. 1999. Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol. 181: 1868–1874.
   PubMed Web of Science ®Google Scholar
• Ziman, M., D. Preuss, J. Mulholland, J. M. O'Brien, D. Botstein, and D. I. Johnson. 1993. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol. Biol. Cell 4: 1307–1316.
   PubMedGoogle Scholar