23
Views
55
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Generation and Analysis of Siah2 Mutant Mice

, , , , , , , , , , , , , & show all
Pages 9150-9161 | Received 08 May 2003, Accepted 03 Sep 2003, Published online: 27 Mar 2023

REFERENCES

  • Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732–738.
  • Barr, T. A., and A. W. Heath. 1999. Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation. Infect. Immun. 67: 3637–3640.
  • Beg, A. A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782–784.
  • Boehm, J., Y. He, A. Greiner, L. Staudt, and T. Wirth. 2001. Regulation of BOB.1/OBF.1 stability by SIAH. EMBO J. 20: 4153–4162.
  • Bogdan, S., S. Senkel, F. Esser, G. U. Ryffel, and E. Pogge v. Strandmann. 2001. Misexpression of Xsiah-2 induces a small eye phenotype in Xenopus. Mech. Dev. 103: 61–69.
  • Carthew, R. W., and G. M. Rubin. 1990. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63: 561–577.
  • Della, N. G., D. D. Bowtell, and F. Beck. 1995. Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis. Cell Tissue Res. 279: 411–419.
  • Della, N. G., P. V. Senior, and D. D. Bowtell. 1993. Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Development 117: 1333–1343.
  • Dickins, R. A., I. J. Frew, C. M. House, M. K. O'Bryan, A. J. Holloway, I. Haviv, N. Traficante, D. M. de Kretser, and D. D. Bowtell. 2002. The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol. Cell. Biol. 22: 2294–2303.
  • Fazeli, A., S. L. Dickinson, M. L. Hermiston, R. V. Tighe, R. G. Steen, C. G. Small, E. T. Stoeckli, K. Keino-Masu, M. Masu, H. Rayburn, J. Simons, R. T. Bronson, J. I. Gordon, M. Tessier-Lavigne, and R. A. Weinberg. 1997. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386: 796–804.
  • Fischer, K. D., Y. Y. Kong, H. Nishina, K. Tedford, L. E. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, M. P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, and J. M. Penninger. 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8: 554–562.
  • Frew, I. J., R. A. Dickins, A. R. Cuddihy, M. Del Rosario, C. Reinhard, M. J. O'Connell, and D. D. Bowtell. 2002. Normal p53 function in primary cells deficient for Siah genes. Mol. Cell. Biol. 22: 8155–8164.
  • Germani, A., H. Bruzzoni-Giovanelli, A. Fellous, S. Gisselbrecht, N. Varin-Blank, and F. Calvo. 2000. SIAH-1 interacts withα -tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Oncogene 19: 5997–6006.
  • Germani, A., F. Romero, M. Houlard, J. Camonis, S. Gisselbrecht, S. Fischer, and N. Varin-Blank. 1999. hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. Mol. Cell. Biol. 19: 3798–3807.
  • Graziadei, G. A., R. S. Stanley, and P. P. Graziadei. 1980. The olfactory marker protein in the olfactory system of the mouse during development. Neuroscience 5: 1239–1252.
  • Grumont, R. J., I. B. Richardson, C. Gaff, and S. Gerondakis. 1993. rel/NF-κB nuclear complexes that bind κB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells. Cell Growth Differ. 4: 731–743.
  • Habelhah, H., I. J. Frew, A. Laine, P. W. Janes, F. Relaix, D. Sassoon, D. D. Bowtell, and Z. Ronai. 2002. Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J. 21: 5756–5765.
  • Hamilton, J. A., G. A. Whitty, I. Kola, and P. J. Hertzog. 1996. Endogenous IFN-αβ suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-α. J. Immunol. 156: 2553–2557.
  • Hu, G., Y. L. Chung, T. Glover, V. Valentine, A. T. Look, and E. R. Fearon. 1997. Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Genomics 46: 103–111.
  • Hu, G., and E. R. Fearon. 1999. Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol. Cell. Biol. 19: 724–732.
  • Hu, G., S. Zhang, M. Vidal, J. L. Baer, T. Xu, and E. R. Fearon. 1997. Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev. 11: 2701–2714.
  • Hwang, S. Y., P. J. Hertzog, K. A. Holland, S. H. Sumarsono, M. J. Tymms, J. A. Hamilton, G. Whitty, I. Bertoncello, and I. Kola. 1995. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc. Natl. Acad. Sci. USA 92: 11284–11288.
  • Inoue, J., T. Ishida, N. Tsukamoto, N. Kobayashi, A. Naito, S. Azuma, and T. Yamamoto. 2000. Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp. Cell Res. 254: 14–24.
  • Johnsen, S. A., M. Subramaniam, D. G. Monroe, R. Janknecht, and T. C. Spelsberg. 2002. Modulation of TGFβ/Smad transcriptional responses through targeted degradation of the TGFβ inducible early gene-1 by the human seven in absentia homologue. J. Biol. Chem. 277: 30754–30759.
  • Li, E., T. H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915–926.
  • Li, S., Y. Li, R. W. Carthew, and Z. C. Lai. 1997. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell. 90: 469–478.
  • Li, S., C. Xu, and R. W. Carthew. 2002. Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol. Cell. Biol. 22: 6854–6865.
  • Liu, J., J. Stevens, C. A. Rote, H. J. Yost, Y. Hu, K. L. Neufeld, R. L. White, and N. Matsunami. 2001. Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell 7: 927–936.
  • Locksley, R. M., N. Killeen, and M. J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104: 487–501.
  • Lomaga, M. A., W. C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, A. van der Heiden, A. Itie, A. Wakeham, W. Khoo, T. Sasaki, Z. Cao, J. M. Penninger, C. J. Paige, D. L. Lacey, C. R. Dunstan, W. J. Boyle, D. V. Goeddel, and T. W. Mak. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13: 1015–1024.
  • Matsuzawa, S., and J. C. Reed. 2001. Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol. Cell 7: 915–926.
  • McLeod, M. J. 1980. Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22: 299–301.
  • Michaelidis, T. M., M. Sendtner, J. D. Cooper, M. S. Airaksinen, B. Holtmann, M. Meyer, and H. Thoenen. 1996. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 17: 75–89.
  • Nakano, H., S. Sakon, H. Koseki, T. Takemori, K. Tada, M. Matsumoto, E. Munechika, T. Sakai, T. Shirasawa, H. Akiba, T. Kobata, S. M. Santee, C. F. Ware, P. D. Rennert, M. Taniguchi, H. Yagita, and K. Okumura. 1999. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc. Natl. Acad. Sci. USA 96: 9803–9808.
  • Nguyen, L. T., G. S. Duncan, C. Mirtsos, M. Ng, D. E. Speiser, A. Shahinian, M. W. Marino, T. W. Mak, P. S. Ohashi, and W. C. Yeh. 1999. TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. Immunity 11: 379–389.
  • Polekhina, G., C. M. House, N. Traficante, J. P. Mackay, F. Relaix, D. A. Sassoon, M. W. Parker, and D. D. Bowtell. 2002. Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat. Struct. Biol. 9: 68–75.
  • Quinn, J. M., G. A. Whitty, R. J. Byrne, M. T. Gillespie, and J. A. Hamilton. 2002. The generation of highly enriched osteoclast-lineage cell populations. Bone 30: 164–170.
  • Sarin, A., M. Conan-Cibotti, and P. A. Henkart. 1995. Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts. J. Immunol. 155: 3716–3718.
  • Sims, N. A., P. Clement-Lacroix, F. Da Ponte, Y. Bouali, N. Binart, R. Moriggl, V. Goffin, K. Coschigano, M. Gaillard-Kelly, J. Kopchick, R. Baron, and P. A. Kelly. 2000. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J. Clin. Investig. 106: 1095–1103.
  • Smith, K. G., A. Light, G. J. Nossal, and D. M. Tarlinton. 1997. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J. 16: 2996–3006.
  • Smith, K. G., U. Weiss, K. Rajewsky, G. J. Nossal, and D. M. Tarlinton. 1994. Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. Immunity 1: 803–813.
  • Sourisseau, T., C. Desbois, L. Debure, D. D. Bowtell, A. C. Cato, J. Schneikert, E. Moyse, and D. Michel. 2001. Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis. J. Cell Sci. 114: 1409–1416.
  • Stanley, E. R., and L. J. Guilbert. 1981. Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1). J. Immunol. Methods 42: 253–284.
  • Susini, L., B. J. Passer, N. Amzallag-Elbaz, T. Juven-Gershon, S. Prieur, N. Privat, M. Tuynder, M. C. Gendron, A. Israel, R. Amson, M. Oren, and A. Telerman. 2001. Siah-1 binds and regulates the function of Numb. Proc. Natl. Acad. Sci. USA 98: 15067–15072.
  • Sytwu, H. K., R. S. Liblau, and H. O. McDevitt. 1996. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 5: 17–30.
  • Tada, K., T. Okazaki, S. Sakon, T. Kobarai, K. Kurosawa, S. Yamaoka, H. Hashimoto, T. W. Mak, H. Yagita, K. Okumura, W. C. Yeh, and H. Nakano. 2001. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J. Biol. Chem. 276: 36530–36534.
  • Tang, A. H., T. P. Neufeld, E. Kwan, and G. M. Rubin. 1997. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90: 459–467.
  • Tanikawa, J., E. Ichikawa-Iwata, C. Kanei-Ishii, A. Nakai, S. Matsuzawa, J. C. Reed, and S. Ishii. 2000. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J. Biol. Chem. 275: 15578–15585.
  • Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and V. L. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374: 467–470.
  • Tarlinton, D. M., M. McLean, and G. J. Nossal. 1995. B1 and B2 cells differ in their potential to switch immunoglobulin isotype. Eur. J. Immunol. 25: 3388–3393.
  • Tartaglia, L. A., D. V. Goeddel, C. Reynolds, I. S. Figari, R. F. Weber, B. M. Fendly, and M. A. Palladino, Jr. 1993. Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor. J. Immunol. 151: 4637–4641.
  • Tartaglia, L. A., R. F. Weber, I. S. Figari, C. Reynolds, M. A. Palladino, Jr., and D. V. Goeddel. 1991. The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl. Acad. Sci. USA 88: 9292–9296.
  • Tiedt, R., B. A. Bartholdy, G. Matthias, J. W. Newell, and P. Matthias. 2001. The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. EMBO J. 20: 4143–4152.
  • Vadiveloo, P. K., E. Keramidaris, W. A. Morrison, and A. G. Stewart. 2001. Lipopolysaccharide-induced cell cycle arrest in macrophages occurs independently of nitric oxide synthase II induction. Biochim. Biophys. Acta 1539: 140–146.
  • Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274: 787–789.
  • Wheeler, T. C., L. S. Chin, Y. Li, F. L. Roudabush, and L. Li. 2002. Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J. Biol. Chem. 277: 10273–10282.
  • Xu, Y., G. Cheng, and D. Baltimore. 1996. Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity 5: 407–415.
  • Yamazaki, H., T. Kunisada, T. Yamane, and S. I. Hayashi. 2001. Presence of osteoclast precursors in colonies cloned in the presence of hematopoietic colony-stimulating factors. Exp. Hematol. 29: 68–76.
  • Yeh, W. C., A. Shahinian, D. Speiser, J. Kraunus, F. Billia, A. Wakeham, J. L. de la Pompa, D. Ferrick, B. Hum, N. Iscove, P. Ohashi, M. Rothe, D. V. Goeddel, and T. W. Mak. 1997. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7: 715–725.
  • Zhang, J., M. G. Guenther, R. W. Carthew, and M. A. Lazar. 1998. Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes Dev. 12: 1775–1780.
  • Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, and W. Swat. 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374: 470–473.
  • Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377: 348–351.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.