REFERENCES
- Alpert, D., P. Schwenger, J. Han, and J. Vilcek. 1999. Cell stress and MKK6b-mediated p38 mitogen-activated protein kinase activation inhibit tumor necrosis factor-induced IκB phosphorylation and NF-κB activation. J. Biol. Chem. 274: 22176–22183.
- Altucci, L., A. Rossin, W. Raffelsberger, A. Reitmair, C. Chomienne, and H. Gronemeyer. 2001. Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. Nat. Med. 7: 680–686.
- Arlt, A., J. Vorndamm, S. Muerkoster, H. Yu, W. E. Schmidt, U. R. Folsch, and H. Schafer. 2002. Autocrine production of interleukin 1 beta confers constitutive nuclear factor κB activity and chemoresistance in pancreatic carcinoma cell lines. Cancer Res. 62: 910–916.
- Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12: 141–179.
- Barkett, M., and T. D. Gilmore. 1999. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18: 6910–6924.
- Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336: 1066–1071.
- Beg, A. A., and D. Baltimore. 1999. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782–784.
- Bernard, A., J.-M. Bernardon, C. Delescluse, B. Martin, M.-C. Lenoir, J. maignan, B. Charpentier, W. R. Pilgrim, U. Reichert, and B. Shroot. 1992. Identification of synthetic retinoids with selectivity for human nuclear RAR γ. Biochem. Biophys. Res. Commun. 186: 977–983.
- Biswas, D. K., A. P. Cruz, E. Gansberger, and A. B. Pardee. 2000. Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc. Natl. Acad. Sci. USA 97: 8542–8547.
- Biswas, D. K., S. C. Dai, A. Cruz, B. Weiser, E. Graner, and A. B. Pardee. 2001. The nuclear factor κB (NF-κB): a potential therapeutic target for estrogen receptor negative breast cancers. Proc. Natl. Acad. Sci. USA 98: 10386–10391.
- Bond, M., A. J. Chase, A. H. Baker, and A. C. Newby. 2001. Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc. Res. 50: 556–565.
- Chen, Z., J. Hagler, V. J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9: 1586–1597.
- Chu, Z. L., T. A. McKinsey, L. Liu, J. J. Gentry, M. H. Malim, and D. W. Ballard. 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. USA 94: 10057–10062.
- Cogswell, P. C., D. C. Guttridge, W. K. Funkhouser, and A. S. Baldwin, Jr. 2000. Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3. Oncogene 19: 1123–1131.
- Deveraux, Q. L., and J. C. Reed. 1999. IAP family proteins—suppressors of apoptosis. Genes Dev. 13: 239–252.
- DiDonato, J., F. Mercurio, C. Rosette, J. Wu-Li, H. Suyang, S. Ghosh, and M. Karin. 1996. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16: 1295–1304.
- DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388: 548–554.
- Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475–1489.
- Donjerkovic, D., C. M. Mueller, and D. W. Scott. 2000. Steroid- and retinoid-mediated growth arrest and apoptosis in WEHI-231 cells: role of NF-κB, c-Myc and CKI p27(Kip1). Eur. J. Immunol. 30: 1154–1161.
- Fanjul, A., P. D. Hobbs, L. Jong, J. F. Cameron, E. Harlev, G. Graupner, X.-P. Lu, M. I. Dawson, and M. Pfahl. 1994. A novel class of retinoids with selective anti-AP-1 activity exhibit anti-proliferative activity. Nature 372: 107–111.
- Fanjul, A. N., F. J. Piedrafita, H. Al-Shamma, and M. Pfahl. 1998. Apoptosis induction and potent antiestrogen receptor-negative breast cancer activity in vivo by a retinoid antagonist. Cancer Res. 58: 4607–4610.
- Feinman, R., K. O. Clarke, and L. E. Harrison. 2002. Phenylbutyrate-induced apoptosis is associated with inactivation of NF-κB in HT-29 colon cancer cells. Cancer Chemother. Pharmacol. 49: 27–34.
- Gerritsen, M. E., A. J. Williams, A. S. Neish, S. Moore, Y. Shi, and T. Collins. 1997. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA 94: 2927–2932.
- Grumont, R. J., I. J. Rourke, and S. Gerondakis. 1999. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. 13: 400–411.
- Guttridge, D. C., C. Albanese, J. Y. Reuther, R. G. Pestell, and A. S. Baldwin, Jr. 1999. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19: 5785–5799.
- Holmes-McNary, M., and A. S. Baldwin, Jr. 2000. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase. Cancer Res. 60: 3477–3483.
- Holmes, W. F., M. I. Dawson, R. D. Soprano, and K. J. Soprano. 2000. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by RARs. J. Cell. Physiol. 185: 61–67.
- Hsu, C. A., A. K. Rishi, X. Su-Li, T. M. Gerald, M. I. Dawson, C. Schiffer, U. Reichert, B. Shroot, G. C. Poirer, and J. A. Fontana. 1997. Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway. Blood 89: 4470–4479.
- Hu, Y., V. Baud, T. Oga, K. I. Kim, K. Yoshida, and M. Karin. 2001. IKKα controls formation of the epidermis independently of NF-κB. Nature 410: 710–714.
- Huang, S., A. DeGuzman, C. D. Bucana, and I. J. Fidler. 2000. Nuclear factor-κB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin. Cancer Res. 6: 2573–2581.
- Huang, S., C. A. Pettaway, H. Uehara, C. D. Bucana, and I. J. Fidler. 2001. Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20: 4188–4197.
- Huang, S., J. B. Robinson, A. DeGuzman, C. D. Bucana, and I. J. Fidler. 2000. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 60: 5334–5339.
- Kapahi, P., T. Takahashi, G. Natoli, S. R. Adams, Y. Chen, R. Y. Tsien, and M. Karin. 2000. Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase. J. Biol. Chem. 275: 36062–36066.
- Karin, M. 1999. The beginning of the end: IκB kinase (IKK) and NF-κB activation. J. Biol. Chem. 274: 27339–27342.
- Karin, M., Y. Cao, F. R. Greten, and Z. W. Li. 2002. NF-κB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2: 301–310.
- Koch, A. E., P. J. Polverini, S. L. Kunkel, L. A. Harlow, L. A. DiPietro, V. M. Elner, S. G. Elner, and R. M. Strieter. 1992. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258: 1798–1801.
- Lee, F. S., R. T. Peters, L. C. Dang, and T. Maniatis. 1998. MEKK1 activates both IκB kinase alpha and IκB kinase beta. Proc. Natl. Acad. Sci. USA 95: 9319–9324.
- Li, Q., Q. Lu, J. Y. Hwang, D. Buscher, K. F. Lee, J. C. Izpisua-Belmonte, and I. M. Verma. 1999. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 13: 1322–1328.
- Li, Q., D. Van Antwerp, F. Mercurio, K. F. Lee, and I. M. Verma. 1999. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284: 321–325.
- Li, Z. W., W. Chu, Y. Hu, M. Delhase, T. Deerinck, M. Ellisman, R. Johnson, and M. Karin. 1999. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J. Exp. Med. 189: 1839–1845.
- Lind, D. S., S. N. Hochwald, J. Malaty, S. Rekkas, P. Hebig, G. Mishra, L. L. Moldawer, E. M. Copeland III, and S. Mackay. 2001. Nuclear factor-κB is upregulated in colorectal cancer. Surgery 130: 363–369.
- Liu, Z. G., H. Hsu, D. V. Goeddel, and M. Karin. 1996. Dissection of TNF- receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87: 565–576.
- Lu, X. P., A. N. Fanjul, N. Picard, M. Pfahl, D. Rungta, K. Nared-Hood, B. Carter, F. J. Piedrafita, S. Tang, E. Fabbrizio, and M. Pfahl. 1997. Novel RRMs as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo. Nat. Med. 3: 686–690.
- Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF-, CD95 and interleukin-1. Nature 385: 540–544.
- Marchetti, P., N. Zamzami, B. Joseph, S. Schraen-Maschke, C. Mereau-Richard, P. Costantini, D. Metivier, S. A. Susin, G. Kroemer, and P. Formstecher. 1999. The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus. Cancer Res. 59: 6257–6266.
- Mayo, M. W., and A. S. Baldwin. 2000. The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance. Biochim. Biophys. Acta 1470: M55–M62.
- Micheau, O., S. Lens, O. Gaide, K. Alevizopoulos, and J. Tschopp. 2001. NF-κB signals induce the expression of c-FLIP. Mol. Cell. Biol. 21: 5299–5305.
- Miura, M., H. Zhu, R. Rotello, E. A. Hartwieg, and J. Yuan. 1993. Induction of apoptosis in fibroblasts by interleukin-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75: 653–660.
- Na, S. Y., B. Y. Kang, S. W. Chung, S. J. Han, X. Ma, G. Trinchieri, S. Y. Im, J. W. Lee, and T. S. Kim. 1999. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NF-κB. J. Biol. Chem. 274: 7674–7680.
- Na, S. Y., S. K. Lee, S. J. Han, H. S. Choi, S. Y. Im, and J. W. Lee. 1998. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor κB-mediated transactivations. J. Biol. Chem. 273: 10831–10834.
- Nakshatri, H., P. Bhat-Nakshatri, D. A. Martin, R. J. J. Goulet, and G. W. J. Sledge. 1997. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 17: 3629–3639.
- Olson, N. E., J. Kozlowski, and M. A. Reidy. 2000. Proliferation of intimal smooth muscle cells. Attenuation of basic fibroblast growth factor 2-stimulated proliferation is associated with increased expression of cell cycle inhibitors. J. Biol. Chem. 275: 11270–11277.
- Oridate, N., M. Higuchi, S. Suzuki, B. Shroot, W. K. Hong, and R. Lotan. 1997. Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl)hydroxyphenyl]-2-naphtalene carboxylic acid (CD437). Int. J. Cancer 70: 484–487.
- Ortiz, M. A., F. J. Lopez-Hernandez, Y. Bayon, M. Pfahl, and F. J. Piedrafita. 2001. Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH2-terminal kinase/p38 mitogen-activated protein kinases. Cancer Res. 61: 8504–8512.
- Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523–527.
- Piedrafita, F. J., and M. Pfahl. 1997. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Mol. Cell. Biol. 17: 6348–6358.
- Reuther, J. Y., and A. S. J. Baldwin. 1999. Apoptosis promotes a caspase-induced amino-terminal truncation of IκBα that functions as a stable inhibitor of NF-κB. J. Biol. Chem. 274: 20664–20670.
- Rossi, A., P. Kapahi, G. Natoli, T. Takahashi, Y. Chen, M. Karin, and M. G. Santoro. 2000. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 403: 103–108.
- Sasaki, N., T. Morisaki, K. Hashizume, T. Yao, M. Tsuneyoshi, H. Noshiro, K. Nakamura, T. Yamanaka, A. Uchiyama, M. Tanaka, and M. Katano. 2001. Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clin. Cancer Res. 7: 4136–4142.
- Scheinman, R. I., A. Gualberto, C. M. Jewell, J. A. Cidlowski, and A. S. Baldwin, Jr. 1995. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol. Cell. Biol. 15: 943–953.
- Shao, Z.-M., M. I. Dawson, X. S. Li, A. K. Rishi, M. S. Sheikh, Q.-X. Han, V. Ordonez, B. Shroot, and J. A. Fontana. 1995. p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene 11: 493–504.
- Sovak, M. A., R. E. Bellas, D. W. Kim, G. J. Zanieski, A. E. Rogers, and A. M. Traish. 1997. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Investig. 100: 2952–2960.
- Stehlik, C., R. de Martin, I. Kumabashiri, J. A. Schmid, B. R. Binder, and J. Lipp. 1998. Nuclear factor (NF-)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J. Exp. Med. 188: 211–216.
- Stein, B., and M. X. Yang. 1995. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBP beta. Mol. Cell. Biol. 15: 4971–4979.
- Sudo, T., and M. Karin. 2000. Assays for JNK and p38 mitogen-activated protein kinases. Methods Enzymol. 322: 388–392.
- Sun, S. Y., P. Yue, R. A. Chandraratna, Y. Tesfaigzi, W. K. Hong, and R. Lotan. 2000. Dual mechanisms of action of the retinoid CD437: nuclear RAR-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells. Mol. Pharmacol. 58: 508–514.
- Sun, S. Y., P. Yue, and R. Lotan. 2000. Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells. Oncogene 19: 4513–4522.
- Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. 1996. Suppression of TNF-alpha-induced apoptosis by NF-κB. Science 274: 787–789.
- Wang, C. Y., J. C. J. Cusack, R. Liu, and A. S. J. Baldwin. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat. Med. 5: 412–417.
- Wang, C. Y., D. C. Guttridge, M. W. Mayo, and A. S. Baldwin. 1999. NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Moll. Cell. Biol. 19: 5923–5929.
- Wang, C. Y., M. W. Mayo, and A. S. J. Baldwin. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274: 784–787.
- Wang, C. Y., M. W. Mayo, R. G. Korneluk, D. V. Goeddel, and A. S. J. Baldwin. 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680–1683.
- Wang, W., J. L. Abbruzzese, D. B. Evans, and P. J. Chiao. 1999. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene 18: 4554–4563.
- Wang, W., J. L. Abbruzzese, D. B. Evans, L. Larry, K. R. Cleary, and P. J. Chiao. 1999. The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res. 5: 119–127.
- Wu, M., H. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. FitzGerald, T. L. Rothstein, D. H. Sherr, and G. E. Sonenshein. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15: 4682–4690.
- Yamamoto, Y., M. J. Yin, K. M. Lin, and R. B. Gaynor. 1999. Sulindac inhibits activation of the NF-κB pathway. J. Biol. Chem. 274: 27307–27314.
- Yang, J., and A. Richmond. 2001. Constitutive IκB kinase activity correlates with nuclear factor-κB activation in human melanoma cells. Cancer Res. 61: 4901–4909.
- Yin, M. J., Y. Yamamoto, and R. B. Gaynor. 1998. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-beta. Nature 396: 77–80.
- Yuan, M., N. Konstantopoulos, J. Lee, L. Hansen, Z. W. Li, M. Karin, and S. E. Shoelson. 2001. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ. Science 293: 1673–1677.
- Zandi, E., and M. Karin. 1999. Bridging the gap: composition, regulation, and physiological function of the IκB kinase complex. Mol. Cell. Biol. 19: 4547–4551.
- Zong, W. X., L. C. Edelstein, C. Chen, J. Bash, and C. Gelinas. 1999. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNF-α-induced apoptosis. Genes Dev. 13: 382–387.