The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest

REFERENCES

• Antonetti, D. A., P, Algenstaedt, and C. R. Kahn. 1996. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell. Biol. 16: 2195–2203.
   PubMedGoogle Scholar
• Bacus, S. S., A. V. Gudkov, C. R. Zelnick, D. Chin, R. Stern, I. Stancovski, E. Peles, N. Ben-Baruch, H. Farbstein, R. Lupu, D. Wen, M. Sela, and Y. Yarden. 1993. Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumors. Cancer Res. 53: 5251–5261.
   PubMed Web of Science ®Google Scholar
• Bondeva, T., L. Pirola, G. Bulgarelli-Leva, I. Rubio, R. Wetzker, and M. P. Wymann. 1998. Bifurcation of lipid and protein kinase signals of PI-3K to the protein kinases PKB and MAPK. Science 282: 293–296.
   PubMedGoogle Scholar
• Brehm, A., E. A. Miska, D. J. McCance, J. L. Reid, A. J. Bannister, and T. Kouzarides. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391: 597–601.
   PubMed Web of Science ®Google Scholar
• Brennan, P., J. W. Babbage, B. M. T. Burgering, B. Gronder, K. Reif, and D. A. Cantrell. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7: 679–689.
   PubMed Web of Science ®Google Scholar
• Brennan, P., J. W. Babbage, G. Thomas, and D. A. Cantrell. 1999. p70S6k integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol. Cell. Biol. 19: 4729–4738.
   PubMed Web of Science ®Google Scholar
• Downward, J. 1998. Lipid-regulated kinases: some common theme at last. Science 279: 673–674.
   PubMedGoogle Scholar
• Fruman, D. A., R. E. Meyers, and L. C. Cantley. 1998. Phosphoinositide kinases. Annu. Rev. Biochem. 67: 481–507.
   PubMed Web of Science ®Google Scholar
• Herrera, R. E., V. P. Sah, B. O. Williams, T. P. Makela, R. A. Weinberg, and T. Jacks. 1996. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16: 2402–2407.
   PubMedGoogle Scholar
• Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6: 177–185.
   PubMed Web of Science ®Google Scholar
• Inukai, K., M. E. Anai, T. Van Breda, H. Hosaka, M. Katagiri, Y. Funaki, T. Fukushima, Y. Ogihara, M. Yazaki, Y. Kikuchi, Y. Oka, and T. Asano. 1996. A novel 55KDa regulatory subunit for phosphatidyl inositol 3-kinase structurally similar to p55γ is generated by alternative splicing of the p85α gene. J. Biol. Chem. 271: 5317–5320.
   PubMedGoogle Scholar
• Kaelin, W. G. 1999. Functions of the retinoblastoma proteins. Bioessays 21: 950–958.
   PubMed Web of Science ®Google Scholar
• Kraus, M. H., N. C. Popescu, S. C. Amsbaugh, and C. R. King. 1987. Overexpression of the EGF receptor-related proto-oncogene ErbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 6: 605–610.
   PubMed Web of Science ®Google Scholar
• Pons, S., T. Osano, E. Glasheen, M. Miralpeix, Y. Zhang, T. L. Fisher, M. G. Myers, X.-J. Sun, and M. White. 1995. The structure and function of p55γ reveals a new regulatory subunit for phosphatidylinositol 3-kinase. Mol. Cell. Biol. 15: 4453–4465.
   PubMed Web of Science ®Google Scholar
• Ramsby, M. L., and G. S. Makowski. 1997. Differential detergent fractionation of eukaryotic cells. Methods Mol. Biol. 112: 53–67.
   Google Scholar
• Rodriquez-Viciana, P., P. H. Wanre, B. Vanhaesebroeck, and M. D. Waterfield. 1996. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutants. EMBO J. 15: 2442–2451.
   PubMedGoogle Scholar
• Sellers, W. R., and W. Kaelin. 1996. Rb as a modulator of transcription. Biochim. Biophys. Acta 1288: M1–M5.
   PubMedGoogle Scholar
• Sherr, C. J., and J. M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13: 1501–1512.
   PubMed Web of Science ®Google Scholar
• Stephens, L. R., T. R. Jackson, and P. T. Hawkins. 1993. Agonist-stimulated synthesis of phosphatidylinositol (3,4,5)-triphosphate: a new intracellular signaling system? Biochim. Biophys. Acta 1179: 27–75.
   PubMed Web of Science ®Google Scholar
• Takuwa, N., Y. Fukui, and Y. Takuwa. 1999. Cyclin D1 expression is mediated by phosphatidylinositol 3-kinase through mTOR-p70S6K-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts. Mol. Cell. Biol. 19: 1346–1358.
   PubMed Web of Science ®Google Scholar
• Vanhaesebroeck, B., S. J. Leevers, G. Panayotou, and M. D. Waterfield. 1997. Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22: 267–272.
   PubMed Web of Science ®Google Scholar
• Watanabe, G., C. Albanese, R. J. Lee, R. J. A. Reutens, G. Vairo, B. Henglein, and R. G. Pestell. 1998. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol. Cell. Biol. 18: 3212–3222.
   PubMed Web of Science ®Google Scholar
• Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323–330.
   PubMed Web of Science ®Google Scholar
• Xia, X., and G. Serrero. 1999. Multiple forms of p55, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation. Biochem. J. 341: 831–837.
   PubMedGoogle Scholar
• Xia, X., A. Cheng, T. Lessor, Y. Zhang, and A. W. Hamburger. 2001. Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. J. Cell. Physiol. 187: 209–217.
   PubMed Web of Science ®Google Scholar
• Zacksenhaus, E., Z. Jiang, D. Chung, J. D. Marth, R. A. Phillips, and B. L. Gallie. 1996. pRb controls proliferation, differentiation and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10: 3051–3064.
   PubMed Web of Science ®Google Scholar
• Zarkowska, T., and S. Mittnacht. 1997. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272: 12738–12746.
   PubMed Web of Science ®Google Scholar