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Transcriptional Regulation

Asymmetric Recognition of Nonconsensus AP-1 Sites by Fos-Jun and Jun-Jun Influences Transcriptional Cooperativity with NFAT1

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Pages 1737-1749 | Received 28 Aug 2002, Accepted 26 Nov 2002, Published online: 27 Mar 2023

REFERENCES

  • Abdel-Hafiz, H. A., L. E. Heasley, J. M. Kyriakis, J. Avruch, D. J. Kroll, G. L. Johnson, and J. P. Hoeffler. 1992. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol. Endocrinol. 6: 2079–2089.
  • Agarwal, S., O. Avni, and A. Rao. 2000. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12: 643–652.
  • Chen, L., J. N. Glover, P. G. Hogan, A. Rao, and S. C. Harrison. 1998. Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature 392: 42–48.
  • Chen, L., M. G. Oakley, J. N. Glover, J. Jain, P. B. Dervan, P. G. Hogan, A. Rao, and G. L. Verdine. 1995. Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp. Curr. Biol. 5: 882–889.
  • Chinenov, Y., and T. K. Kerppola. 2001. Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 20: 2438–2452.
  • Chytil, M., B. R. Peterson, D. A. Erlanson, and G. L. Verdine. 1998. The orientation of the AP-1 heterodimer on DNA strongly affects transcriptional potency. Proc. Natl. Acad. Sci. USA 95: 14076–14081.
  • Cleary, M. A., P. S. Pendergrast, and W. Herr. 1997. Structural flexibility in transcription complex formation revealed by protein-DNA photocrosslinking. Proc. Natl. Acad. Sci. USA 94: 8450–8455.
  • Diebold, R. J., N. Rajaram, D. A. Leonard, and T. K. Kerppola. 1998. Molecular basis of cooperative DNA bending and oriented heterodimer binding in the NFAT1-Fos-Jun-ARRE2 complex. Proc. Natl. Acad. Sci. USA 95: 7915–7920.
  • Dlakic, M., A. V. Grinberg, D. A. Leonard, and T. K. Kerppola. 2001. DNA sequence-dependent folding determines the divergence in binding specificities between Maf and other bZIP proteins. EMBO J. 20: 828–840.
  • Falvo, J. V., B. S. Parekh, C. H. Lin, E. Fraenkel, and T. Maniatis. 2000. Assembly of a functional beta interferon enhanceosome is dependent on ATF-2-c-Jun heterodimer orientation. Mol. Cell. Biol. 20: 4814–4825.
  • Falvo, J. V., A. M. Uglialoro, B. M. Brinkman, M. Merika, B. S. Parekh, E. Y. Tsai, H. C. King, A. D. Morielli, E. G. Peralta, T. Maniatis, D. Thanos, and A. E. Goldfeld. 2000. Stimulus-specific assembly of enhancer complexes on the tumor necrosis factor alpha gene promoter. Mol. Cell. Biol. 20: 2239–2247.
  • Fujii, Y., T. Shimizu, T. Toda, M. Yanagida, and T. Hakoshima. 2000. Structural basis for the diversity of DNA recognition by bZIP transcription factors. Nat. Struct. Biol. 7: 889–893.
  • Glover, J. N., and S. C. Harrison. 1995. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373: 257–261.
  • Hall, J. M., D. P. McDonnell, and K. S. Korach. 2002. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol. Endocrinol. 16: 469–486.
  • Hardwidge, P. R., J. Wu, S. L. Williams, K. M. Parkhurst, L. J. Parkhurst, and L. J. Maher. 2002. DNA bending by bZIP charge variants: a unified study using electrophoretic phasing and fluorescence resonance energy transfer. Biochemistry 41: 7732–7742.
  • Ho, I. C., M. R. Hodge, J. W. Rooney, and L. H. Glimcher. 1996. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85: 973–983.
  • Jain, J., P. G. McCaffrey, Z. Miner, T. K. Kerppola, J. N. Lambert, G. L. Verdine, T. Curran, and A. Rao. 1993. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365: 352–355.
  • Kamachi, Y., M. Uchikawa, A. Tanouchi, R. Sekido, and H. Kondoh. 2001. Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev. 15: 1272–1286.
  • Kerppola, T. K. 1996. Fos and Jun bend the AP-1 site: effects of probe geometry on the detection of protein-induced DNA bending. Proc. Natl. Acad. Sci. USA 93: 10117–10122.
  • Kerppola, T. K. 1997. Comparison of DNA bending by Fos-Jun and phased A tracts by multifactorial phasing analysis. Biochemistry 36: 10872–10884.
  • Kerppola, T. K., and T. Curran. 1991. Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell 66: 317–326.
  • Kerppola, T. K., and T. Curran. 1993. Selective DNA bending by a variety of bZIP proteins. Mol. Cell. Biol. 13: 5479–5489.
  • Kerppola, T. K., and T. Curran. 1994. Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene 9: 675–684.
  • Kerppola, T. K., and T. Curran. 1994. A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins. Oncogene 9: 3149–3158.
  • Kerppola, T. K., and T. Curran. 1997. The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J. 16: 2907–2916.
  • Kurokawa, R., J. DiRenzo, M. Boehm, J. Sugarman, B. Gloss, M. G. Rosenfeld, R. A. Heyman, and C. K. Glass. 1994. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371: 528–531.
  • Kurokawa, R., M. Soderstrom, A. Horlein, S. Halachmi, M. Brown, M. G. Rosenfeld, and C. K. Glass. 1995. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377: 451–454.
  • Lefstin, J. A., and K. R. Yamamoto. 1998. Allosteric effects of DNA on transcriptional regulators. Nature 392: 885–888.
  • Leonard, D. A., and T. K. Kerppola. 1998. DNA bending determines Fos-Jun heterodimer orientation. Nat. Struct. Biol. 5: 877–881.
  • Leonard, D. A., N. Rajaram, and T. K. Kerppola. 1997. Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun. Proc. Natl. Acad. Sci. USA 94: 4913–4918.
  • Macian, F., C. Lopez-Rodriguez, and A. Rao. 2001. Partners in transcription: NFAT and AP-1. Oncogene 20: 2476–2489.
  • Misra, V., S. Walter, P. Yang, S. Hayes, and P. O'Hare. 1996. Conformational alteration of Oct-1 upon DNA binding dictates selectivity in differential interactions with related transcriptional coactivators. Mol. Cell. Biol. 16: 4404–4413.
  • Rajaram, N., and T. K. Kerppola. 1997. DNA bending by Fos-Jun and the orientation of heterodimer binding depend on the sequence of the AP-1 site. EMBO J. 16: 2917–2925.
  • Ramirez-Carrozzi, V. R., and T. K. Kerppola. 2001. Gel-based fluorescence resonance energy transfer (gelFRET) analysis of nucleoprotein complex architecture. Methods 25: 31–43.
  • Ramirez-Carrozzi, V. R., and T. K. Kerppola. 2001. Dynamics of Fos-Jun-NFAT1 complexes. Proc. Natl. Acad. Sci. USA 98: 4893–4898.
  • Ramirez-Carrozzi, V. R., and T. K. Kerppola. 2001. Control of the orientation of Fos-Jun binding and the transcriptional cooperativity of Fos-Jun-NFAT1 complexes. J. Biol. Chem. 276: 21797–21808.
  • Ramirez-Carrozzi, V. R., and T. K. Kerppola. 2001. Long-range electrostatic interactions influence the orientation of Fos-Jun binding at AP-1 sites. J. Mol. Biol. 305: 411–427.
  • Risse, G., K. Jooss, M. Neuberg, H. J. Bruller, and R. Muller. 1989. Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes. EMBO J. 8: 3825–3832.
  • Schrader, M., K. M. Muller, S. Nayeri, J. P. Kahlen, and C. Carlberg. 1994. Vitamin D3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation. Nature 370: 382–386.
  • Schrader, M., S. Nayeri, J. P. Kahlen, K. M. Muller, and C. Carlberg. 1995. Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation. Mol. Cell. Biol. 15: 1154–1161.
  • Scully, K. M., E. M. Jacobson, K. Jepsen, V. Lunyak, H. Viadiu, C. Carriere, D. W. Rose, F. Hooshmand, A. K. Aggarwal, and M. G. Rosenfeld. 2000. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 290: 1127–1131.
  • Sitlani, A., and D. M. Crothers. 1996. Fos and Jun do not bend the AP-1 recognition site. Proc. Natl. Acad. Sci. USA 93: 3248–3252.
  • Sitlani, A., and D. M. Crothers. 1998. DNA-binding domains of Fos and Jun do not induce DNA curvature: an investigation with solution and gel methods. Proc. Natl. Acad. Sci. USA 95: 1404–1409.
  • Staal, A., A. J. van Wijnen, J. C. Birkenhager, H. A. Pols, J. Prahl, H. DeLuca, M. P. Gaub, J. B. Lian, G. S. Stein, J. P. van Leeuwen, and J. L. Stein. 1996. Distinct conformations of vitamin D receptor/retinoid X receptor-α heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. Mol. Endocrinol. 10: 1444–1456.
  • Tomilin, A., A. Remenyi, K. Lins, H. Bak, S. Leidel, G. Vriend, M. Wilmanns, and H. R. Scholer. 2000. Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell 103: 853–864.
  • Tsai, E. Y., J. Jain, P. A. Pesavento, A. Rao, and A. E. Goldfeld. 1996. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol. Cell. Biol. 16: 459–467.

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