21
Views
67
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Role for Cdk1 (Cdc2)/Cyclin A in Preventing the Mammalian Origin Recognition Complex's Largest Subunit (Orc1) from Binding to Chromatin during Mitosis

, &
Pages 5875-5886 | Received 10 Sep 2003, Accepted 23 Mar 2004, Published online: 27 Mar 2023

REFERENCES

  • Abdurashidova, G., Danailov M. B., Ochem A., Triolo G., Djeliova V., Radulescu S., Vindigni A., Riva S., and Falaschi A.. 2003. Localization of proteins bound to a replication origin of human DNA along the cell cycle. EMBO J. 22:4294–4303.
  • Abdurashidova, G., Deganuto M., Klima R., Riva S., Biamonti G., Giacca M., and Falaschi A.. 2000. Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Science 287:2023–2026.
  • Abdurashidova, G., Riva S., Biamonti G., Giacca M., and Falaschi A.. 1998. Cell cycle modulation of protein-DNA interactions at a human replication origin. EMBO J. 17:2961–2969.
  • Adamczewski, J. P., Gannon J. V., and Hunt T.. 1993. Simian virus 40 large T antigen associates with cyclin A and p33cdk2. J. Virol. 67:6551–6557.
  • Arooz, T., Yam C. H., Siu W. Y., Lau A., Li K. K., and Poon R. Y.. 2000. On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells. Biochemistry 39:9494–9501.
  • Bell, S. P. 2002. The origin recognition complex: from simple origins to complex functions. Genes Dev. 16:659–672.
  • Bell, S. P., and Dutta A.. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:333–374.
  • Bogan, J. A., Natale D. A., and DePamphilis M. L.. 2000. Initiation of eukaryotic DNA replication: conservative or liberal? J. Cell. Physiol. 184:139–150.
  • Carpenter, P. B., and Dunphy W. G.. 1998. Identification of a novel 81-kDa component of the Xenopus origin recognition complex. J. Biol. Chem. 273:24891–24897.
  • Clute, P., and Pines J.. 1999. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat. Cell Biol. 1:82–87.
  • Coleman, T. R., Carpenter P. B., and Dunphy W. G.. 1996. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87:53–63.
  • Costanzo, V., Avvedimento E. V., Gottesman M. E., Gautier J., and Grieco D.. 1999. Protein kinase A is required for chromosomal DNA replication. Curr. Biol. 9:903–906.
  • Coverley, D., Laman H., and Laskey R. A.. 2002. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat. Cell Biol. 4:523–528.
  • den Elzen, N., and Pines J.. 2001. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. J. Cell Biol. 153:121–136.
  • DePamphilis, M. L. 1993. Eukaryotic DNA replication: anatomy of an origin. Annu. Rev. Biochem. 62:29–63.
  • DePamphilis, M. L. 2003. The “ORC cycle”: a novel pathway for regulating eukaryotic DNA replication. Gene 310:1–15.
  • Dhar, S. K., Delmolino L., and Dutta A.. 2001. Architecture of the human origin recognition complex. J. Biol. Chem. 276:29067–29071.
  • Dulic, V., Lees E., and Reed S. I.. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958–1961.
  • Erlandsson, F., Linnman C., Ekholm S., Bengtsson E., and Zetterberg A.. 2000. A detailed analysis of cyclin A accumulation at the G(1)/S border in normal and transformed cells. Exp. Cell Res. 259:86–95.
  • Findeisen, M., El-Denary M., Kapitza T., Graf R., and Strausfeld U.. 1999. Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis. Eur. J. Biochem. 264:415–426.
  • Fujita, M., Ishimi Y., Nakamura H., Kiyono T., and Tsurumi T.. 2002. Nuclear organization of DNA replication initiation proteins in mammalian cells. J. Biol. Chem. 277:10354–10361.
  • Geley, S., Kramer E., Gieffers C., Gannon J., Peters J. M., and Hunt T.. 2001. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J. Cell Biol. 153:137–148.
  • Gilbert, D. M., Miyazawa H., and DePamphilis M. L.. 1995. Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure. Mol. Cell. Biol. 15:2942–2954.
  • Goodger, N. M., Gannon J., Hunt T., and Morgan P. R.. 1996. The localization of p34cdc2 in the cells of normal, hyperplastic, and malignant epithelial and lymphoid tissues of the oral cavity. J. Pathol. 178:422–428.
  • Hamaguchi, J. R., Tobey R. A., Pines J., Crissman H. A., Hunter T., and Bradbury E. M.. 1992. Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210. J. Cell Biol. 117:1041–1053.
  • Hua, X. H., and Newport J.. 1998. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J. Cell Biol. 140:271–281.
  • Itzhaki, J. E., Gilbert C. S., and Porter A. C.. 1997. Construction by gene targeting in human cells of a “conditional” CDC2 mutant that rereplicates its DNA. Nat. Genet. 15:258–265.
  • Jackman, M., Lindon C., Nigg E. A., and Pines J.. 2003. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5:143–148.
  • Jiang, W., Wells N. J., and Hunter T.. 1999. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA 96:6193–6198.
  • Knockaert, M., Greengard P., and Meijer L.. 2002. Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol. Sci. 23:417–425.
  • Kobayashi, T., Rein T., and DePamphilis M. L.. 1998. Identification of primary initiation sites for DNA replication in the hamster dihydrofolate reductase gene initiation zone. Mol. Cell. Biol. 18:3266–3277.
  • Kong, D., Coleman T. R., and DePamphilis M. L.. 2003. Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC. EMBO J. 22:3441–3450.
  • Kreitz, S., Ritzi M., Baack M., and Knippers R.. 2001. The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells. J. Biol. Chem. 276:6337–6342.
  • Ladenburger, E. M., Keller C., and Knippers R.. 2002. Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication. Mol. Cell. Biol. 22:1036–1048.
  • Li, C. J., Bogan J. A., Natale D. A., and DePamphilis M. L.. 2000. Selective activation of pre-replication complexes in vitro at specific sites in mammalian nuclei. J. Cell Sci. 113:887–898.
  • Li, C. J., and DePamphilis M. L.. 2002. Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Mol. Cell. Biol. 22:105–116.
  • Mendez, J., Zou-Yang X. H., Kim S. Y., Hidaka M., Tansey W. P., and Stillman B.. 2002. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol. Cell 9:481–491.
  • Mizushima, T., Takahashi N., and Stillman B.. 2000. Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev. 14:1631–1641.
  • Natale, D. A., Li C. J., Sun W. H., and DePamphilis M. L.. 2000. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. EMBO J. 19:2728–2738.
  • Nguyen, V. Q., Co C., and Li J. J.. 2001. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 411:1068–1073.
  • Ohtsubo, M., Theodoras A. M., Schumacher J., Roberts J. M., and Pagano M.. 1995. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15:2612–2624.
  • Okuno, Y., McNairn A. J., den Elzen N., Pines J., and Gilbert D. M.. 2001. Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle. EMBO J. 20:4263–4277.
  • Pagano, M., Pepperkok R., Verde F., Ansorge W., and Draetta G.. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11:961–971.
  • Petersen, B. O., Lukas J., Sorensen C. S., Bartek J., and Helin K.. 1999. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 18:396–410.
  • Pines, J., and Hunter T.. 1991. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell Biol. 115:1–17.
  • Ritzi, M., Tillack K., Gerhardt J., Ott E., Humme S., Kremmer E., Hammerschmidt W., and Schepers A.. 2003. Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. J. Cell Sci. 116:3971–3984.
  • Romanowski, P., Madine M. A., Rowles A., Blow J. J., and Laskey R. A.. 1996. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol. 6:1416–1425.
  • Romanowski, P., Marr J., Madine M. A., Rowles A., Blow J. J., Gautier J., and Laskey R. A.. 2000. Interaction of Xenopus Cdc2 cyclin A1 with the origin recognition complex. J. Biol. Chem. 275:4239–4243.
  • Rowles, A., Tada S., and Blow J. J.. 1999. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins. J. Cell Sci. 112:2011–2018.
  • Saha, P., Chen J., Thome K. C., Lawlis S. J., Hou Z. H., Hendricks M., Parvin J. D., and Dutta A.. 1998. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol. Cell. Biol. 18:2758–2767.
  • Sun, W. H., Coleman T. R., and DePamphilis M. L.. 2002. Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin. EMBO J. 21:1437–1446.
  • Tada, S., Li A., Maiorano D., Mechali M., and Blow J. J.. 2001. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat. Cell Biol. 3:107–113.
  • Tatsumi, Y., Ohta S., Kimura H., Tsurimoto T., and Obuse C.. 2003. The ORC1 cycle in human cells. I. Cell cycle-regulated oscillation of human ORC1. J. Biol. Chem. 278:41528–41534.
  • Tatsumi, Y., Tsurimoto T., Shirahige K., Yoshikawa H., and Obuse C.. 2000. Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures. J. Biol. Chem. 275:5904–5910.
  • Thome, K. C., Dhar S. K., Quintana D. G., Delmolino L., Shahsafaei A., and Dutta A.. 2000. Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins. J. Biol. Chem. 275:35233–35241.
  • Tugal, T., Zou-Yang X. H., Gavin K., Pappin D., Canas B., Kobayashi R., Hunt T., and Stillman B.. 1998. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J. Biol. Chem. 273:32421–32429.
  • Vas, A., Mok W., and Leatherwood J.. 2001. Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex. Mol. Cell. Biol. 21:5767–5777.
  • Vashee, S., Simancek P., Challberg M. D., and Kelly T. J.. 2001. Assembly of the human origin recognition complex. J. Biol. Chem. 276:26666–26673.
  • Vaziri, C., Saxena S., Jeon Y., Lee C., Murata K., Machida Y., Wagle N., Hwang D. S., and Dutta A.. 2003. A p53-dependent checkpoint pathway prevents rereplication. Mol. Cell 11:997–1008.
  • Welch, P. J., and Wang J. Y.. 1992. Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc. Natl. Acad. Sci. USA 89:3093–3097.
  • Wilkinson, K. D. 2000. Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin. Cell Dev. Biol. 11:141–148.
  • Wohlschlegel, J. A., Dhar S. K., Prokhorova T. A., Dutta A., and Walter J. C.. 2002. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol. Cell 9:233–240.
  • Wolf, D. A., Wu D., and McKeon F.. 1996. Disruption of re-replication control by overexpression of human ORC1 in fission yeast. J. Biol. Chem. 271:32503–32506.
  • Wu, J. R., and Gilbert D. M.. 1996. A distinct G1 step required to specify the Chinese hamster DHFR replication origin. Science 271:1270–1272.
  • Wuarin, J., Buck V., Nurse P., and Millar J. B.. 2002. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell 111:419–431.
  • Xu, H., Lu Z. H., and Leno G. H.. 2002. The binding of ORC2 to chromatin from terminally differentiated cells. Exp. Cell Res. 274:334–341.
  • You, Z., Harvey K., Kong L., and Newport J.. 2002. Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication. Genes Dev. 16:1182–1194.
  • Yu, G., Wu J. R., and Gilbert D. M.. 1998. Analysis of mammalian origin specification in ORC-depleted Xenopus egg extracts. Genes Cells 3:709–720.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.