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DNA Dynamics and Chromosome Structure

The T-Cell Receptor β Variable Gene Promoter Is Required for Efficient Vβ Rearrangement but Not Allelic Exclusion

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Pages 7015-7023 | Received 04 Feb 2004, Accepted 19 May 2004, Published online: 27 Mar 2023

REFERENCES

  • Alt, F., Blackwell T. K., and Yancopoulos G.. 1987. Development of the primary antibody repertoire. Science 238:1079–1087.
  • Anderson, S. J., Chou H. S., and Loh D. Y.. 1988. A conserved sequence in the T-cell receptor β-chain promoter region. Proc. Natl. Acad. Sci. USA 85:3551–3554.
  • Baker, J. E., Cado D., and Raulet D. H.. 1998. Developmentally programmed rearrangement of T cell receptor Vγ genes is controlled by sequences immediately upstream of the Vγ genes. Immunity 9:159–168.
  • Bories, J.-C., Demengeot J., Davidson L., and Alt F. W.. 1996. Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl. Acad. Sci. USA 93:7871–7876.
  • Bouvier, G., Watrin F., Naspetti M., Verthuy C., Naquet P., and Ferrier P.. 1996. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc. Natl. Acad. Sci. USA 93:7877–7881.
  • Chattopadhyay, S., Whitehurst C., Schwenk F., and Chen J.. 1998. Biochemical and functional analyses of chromatin changes at the TCRβ locus during CD4− CD8− to CD4+ CD8+ thymocyte differentiation. J. Immunol. 160:1256–1267.
  • Chen, J., Young F., Bottaro A., Stewart V., Smith R., and Alt F.. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 12:4635–4645.
  • Eastman, Q. M., Leu T. M. J., and Schatz D. G.. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380:85–88.
  • Fugmann, S. D., Lee A. I., Shockett P. E., Villey I. J., and Schatz D. G.. 2000. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18:495–527.
  • Gellert, M. 2002. V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71:101–132.
  • Gorman, J. R., van der Stoep N., Monroe R., Cogne M., Davidson L., and Alt F. W.. 1996. The Igκ 3′ enhancer influences the ration of Igκ versus Igλ B lymphocytes. Immunity 5:241–252.
  • Halle, J.-P., Seuffert P.-H., Woltering C., Stelzer G., and Meisterernst M.. 1997. A conserved tissue-specific structure at a human T-cell receptor β-chain core promoter. Mol. Cell. Biol. 17:4220–4229.
  • Hempel, W. M., Leduc I., Mathieu N., Tripathi R. K., and Ferrier P.. 1998. Accessibility control of V(D)J recombination: lessons from gene targeting. Adv. Immunol. 69:309–352.
  • Hernandez-Munain, C., Sleckman B. P., and Krangel M. S.. 1999. A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. Immunity 10:723–733.
  • Krangel, M. S. 2001. V(D)J recombination becomes accessible. J. Exp. Med. 193:F27–F30.
  • Levelt, C. N., and Eichmann K.. 1995. Receptors and signals in early thymic selection. Immunity 3:667–672.
  • Mathieu, N., Hempel W. M., Spicuglia S., Verthuy C., and Ferrier P.. 2000. Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: implications for the control of TCR-beta locus recombination. J. Exp. Med. 192:625–636.
  • Mathieu, N., Spicuglai S., Gorbatch S., Cabaud O., Fernex C., Verthuy C., Hempel W. M., Huber A.-O., and Ferrier P.. 2003. Assessing the role of the T cell receptor β gene enhancer in regulating coding joint formation during V(D)J recombination. J. Biol. Chem. 278:18101–18109.
  • McBlane, J. F., van Gent D. C., Ramsden D. A., Romeo C., Cuomo C. A., Gellert M., and Oettinger M. A.. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387–395.
  • Neiditch, M. B., Lee G. S., Huye L. E., Brandt V. L., and Roth D. B.. 2002. The V(D)J recombinase efficiently cleaves and transposes signal joints. Mol. Cell 9:871–878.
  • Okada, C. Y., and Weissman I. L.. 1989. Relative Vβ transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. J. Exp. Med. 169:1703–1719.
  • Rowen, L., Koop B. F., and Hood L.. 1996. The complete 685-kilobase DNA sequence of the human β T cell receptor locus. Science 272:1755–1762.
  • Schlissel, M., Constantinescu A., Morrow T., Baxter M., and Peng A.. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent and cell cycle regulated. Genes Dev. 7:2520–2532.
  • Schlissel, M. S., and Stanhope-Baker P.. 1997. Accessibility and the developmental regulation of V(D)J recombination. Semin. Immunol. 9:161–170.
  • Schwenk, F., Baron U., and Rajewsky K.. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:5080–5081.
  • Senoo, M., and Shinkai Y.. 1998. Regulation of Vβ germline transcription in RAG-deficient mice by the CD3ε-mediated signals: implication of Vβ transcriptional regulation in TCRβ allelic exclusion. Int. Immunol. 10:553–560.
  • Serwe, M., and Sablitzky F.. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321–2327.
  • Sha, W. C., Nelson C. A., Newberry R. D., Kranz D. M., Russell J. H., and Loh D. Y.. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271–274.
  • Sieh, P., and Chen J.. 2001. Distinct control of the frequency and allelic exclusion of the Vβ gene rearrangement at the TCRβ locus. J. Immunol. 167:2121–2129.
  • Sikes, M. L., Meade A., Tripathi R., Krangel M. S., and Oltz E. M.. 2002. Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. Proc. Natl. Acad. Sci. USA 99:12309–12314.
  • Sleckman, B. P., Bardon C. G., Ferrini R., Davidson L., and Alt F. W.. 1997. Function of the TCRα enhancer in αβ and γδ T cells. Immunity 7:505–515.
  • Sleckman, B. P., Gorman J. R., and Alt F. W.. 1996. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 14:459–481.
  • Stanhope-Baker, P., Hudson K. M., Shaffer A. L., Constantinescu A., and Schlissel M. S.. 1996. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85:887–897.
  • Steen, S. B., Gomelsky L., and Roth D. B.. 1996. The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1:543–553.
  • Tripathi, R., Jackson A., and Krangel M. S.. 2002. A change in the structure of Vβ chromatin associated with TCR beta allelic exclusion. J. Immunol. 168:2316–2324.
  • Tycko, B., and Sklar J.. 1990. Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model. Cancer Cells 2:1–8.
  • van Gent, D. C., McBlane J. F., Ransden D. A., Sadofsky M. J., Hesse J. E., and Gellert M.. 1995. Initiation of V(D)J recombination in a cell-free system. Cell 81:925–934.
  • van Gent, D. C., Ramsden D. A., and Gellert M.. 1996. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85:107–113.
  • von Boehmer, H., and Fehling H. J.. 1997. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15:433–452.
  • Whitehurst, C., Chattopadhyay S., and Chen J.. 1999. Control of V(D)J recombination accessibility of the Dβ1 gene segment at the TCRβ locus by a germline promoter. Immunity 10:313–322.
  • Whitehurst, C. E., Schlissel M. S., and Chen J.. 2000. Deletion of germline promoter PDβ1 from the TCRβ locus causes hypermethylation that impairs Dβ1 recombination by multiple mechanisms. Immunity 13:703–714.
  • Xu, Y., Davidson L., Alt F. W., and Baltimore D.. 1996. Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish VκJκ rearrangement. Immunity 4:377–385.

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