34
Views
90
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo

, , , , , & show all
Pages 7024-7031 | Received 16 Feb 2004, Accepted 12 May 2004, Published online: 27 Mar 2023

REFERENCES

  • Artandi, S. E., Alson S., Tietze M. K., Sharpless N. E., Ye S., Greenberg R. A., Castrillon D. H., Horner J. W., Weiler S. R., Carrasco R. D., and DePinho R. A.. 2002. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl. Acad. Sci. USA 99:8191–8196.
  • Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106:661–673.
  • Blackburn, E. H., Greider C. W., Henderson E., Lee M. S., Shampay J., and Shippen-Lentz D.. 1989. Recognition and elongation of telomeres by telomerase. Genome 31:553–560.
  • Blasco, M. A., Funk W., Villeponteau B., and Greider C. W.. 1995. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269:1267–1270.
  • Blasco, M. A., Lee H. W., Hande M. P., Samper E., Lansdorp P. M., DePinho R. A., and Greider C. W.. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25–34.
  • Blasco, M. A., Lee H. W., Rizen M., Hanahan D., DePinho R., and Greider C. W.. 1997. Mouse models for the study of telomerase. Ciba Found. Symp. 211:160–170.
  • Bryan, T. M., and Cech T. R.. 1999. Telomerase and the maintenance of chromosome ends. Curr. Opin. Cell Biol. 11:318–324.
  • Capecchi, M. R. 1989. The new mouse genetics: altering the genome by gene targeting. Trends Genet. 5:70–76.
  • Cech, T. R. 1994. Chromosome end games. Science 266:387–388.
  • Chiang, Y. J., Kole H. K., Brown K., Naramura M., Fukuhara S., Hu R. J., Jang I. K., Gutkind J. S., Shevach E., and Gu H.. 2000. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403:216–220.
  • Cong, Y.-S., Wright W. E., and Shay J. W.. 2002. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 66:407–425.
  • Erdmann, N., Liu Y., and Harrington L.. 2004. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc. Natl. Acad. Sci. USA 101:6080–6085.
  • González-Suárez, E., Flores J. M., and Blasco M. A.. 2002. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol. Cell. Biol. 22:7291–7301.
  • Gonzalez-Suarez, E., Samper E., Ramirez A., Flores J. M., Martin-Caballero J., Jorcano J. L., and Blasco M. A.. 2001. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20:2619–2630.
  • Greider, C. W. 1996. Telomere length regulation. Annu. Rev. Biochem. 65:337–365.
  • Hahn, W. C., Counter C. M., Lundberg A. S., Beijersbergen R. L., Brooks M. W., and Weinberg R. A.. 1999. Creation of human tumour cells with defined genetic elements. Nature 400:464–468.
  • Harley, C. B., Futcher A. B., and Greider C. W.. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458–460.
  • Hathcock, K. S., Hemann M. T., Opperman K. K., Strong M. A., Greider C. W., and Hodes R. J.. 2002. Haploinsufficiency of mTR results in defects in telomere elongation. Proc. Natl. Acad. Sci. USA 99:3591–3596.
  • Kim, N. W., Piatyszek M. A., Prowse K. R., Harley C. B., West M. D., Ho P. L., Coviello G. M., Wright W. E., Weinrich S. L., and Shay J. W.. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011–2015.
  • Lansdorp, P. M., Verwoerd N. P., van de Rijke F. M., Dragowska V., Little M. T., Dirks R. W., Raap A. K., and Tanke H. J.. 1996. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5:685–691.
  • Lee, H. W., Blasco M. A., Gottlieb G. J., Horner II J. W., Greider C. W., and DePinho R. A.. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392:569–574.
  • Lingner, J., and Cech T. R.. 1998. Telomerase and chromosome end maintenance. Curr. Opin. Genet. Dev. 8:226–232.
  • Liu, Y., Kha H., Ungrin M., Robinson M. O., and Harrington L.. 2002. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc. Natl. Acad. Sci. USA 99:3597–3602.
  • Liu, Y., Snow B. E., Hande M. P., Yeung D., Erdmann N. J., Wakeham A., Itie A., Siderovski D. P., Lansdorp P. M., Robinson M. O., and Harrington L.. 2000. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr. Biol. 10:1459–1462.
  • Mitchell, J. R., Wood E., and Collins K.. 1999. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402:551–555.
  • Oh, H., Taffet G. E., Youker K. A., Entman M. L., Overbeek P. A., Michael L. H., and Schneider M. D.. 2001. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc. Natl. Acad. Sci. USA 98:10308–10313.
  • Rudolph, K. L., Chang S., Lee H. W., Blasco M., Gottlieb G. J., Greider C., and DePinho R. A.. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96:701–712.
  • Schorpp, M., Jager R., Schellander K., Schenkel J., Wagner E. F., Weiher H., and Angel P.. 1996. The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res. 24:1787–1788.
  • Stewart, S. A., and Weinberg R. A.. 2002. Senescence: does it all happen at the ends? Oncogene 21:627–630.
  • Theimer, C. A., Finger L. D., Trantirek L., and Feigon J.. 2003. Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc. Natl. Acad. Sci. USA 100:449–454.
  • Vulliamy, T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P. J., and Dokal I.. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413:432–435.
  • Vulliamy, T. J., Knight S. W., Mason P. J., and Dokal I.. 2001. Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita. Blood Cells Mol. Dis. 27:353–357.
  • Wen, J., Cong Y. S., and Bacchetti S.. 1998. Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells. Hum. Mol. Genet. 7:1137–1141.
  • Weng, N. P., and Hodes R. J.. 2000. The role of telomerase expression and telomere length maintenance in human and mouse. J. Clin. Immunol. 20:257–267.
  • Yuan, X., Ishibashi S., Hatakeyama S., Saito M., Nakayama J., Nikaido R., Haruyama T., Watanabe Y., Iwata H., Iida M., Sugimura H., Yamada N., and Ishikawa F.. 1999. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice. Genes Cells 4:563–572.
  • Yudoh, K., Matsuno H., Nakazawa F., Katayama R., and Kimura T.. 2001. Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts. J. Bone Miner. Res. 16:1453–1464.
  • Zhu, L., Hathcock K. S., Hande P., Lansdorp P. M., Seldin M. F., and Hodes R. J.. 1998. Telomere length regulation in mice is linked to a novel chromosome locus. Proc. Natl. Acad. Sci. USA 95:8648–8653.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.