Bone-Specific Transcription Factor Runx2 Interacts with the 1α,25-Dihydroxyvitamin D₃ Receptor To Up-Regulate Rat Osteocalcin Gene Expression in Osteoblastic Cells

REFERENCES

• Banerjee, C., McCabe L. R., Choi J. Y., Hiebert S. W., Stein J. L., Stein G. S., and Lian J. B.. 1997. Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J. Cell Biochem. 66:1–8.
   PubMed Web of Science ®Google Scholar
• Breen, E. C., van Wijnen A. J., Lian J. B., Stein G. S., and Stein J. L.. 1994. In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells. Proc. Natl. Acad. Sci. USA 91:12902–12906.
   PubMedGoogle Scholar
• Christakos, S., Dhawan P., Liu Y., Peng X., and Porta A.. 2003. New insights into the mechanisms of vitamin D action. J. Cell Biochem. 88:695–705.
   PubMed Web of Science ®Google Scholar
• Ducy, P., Zhang R., Geoffroy V., Ridall A. L., and Karsenty G.. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747–754.
   PubMed Web of Science ®Google Scholar
• Gutierrez, J., Sierra J., Medina R., Puchi M., Imschenetzky M., van Wijnen A., Lian J., Stein G., Stein J., and Montecino M.. 2000. Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site. Biochemistry 39:13565–13574.
   PubMed Web of Science ®Google Scholar
• Gutierrez, S., Javed A., Tennant D. K., van Rees M., Montecino M., Stein G. S., Stein J. L., and Lian J. B.. 2002. CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J. Biol. Chem. 277:1316–1323.
   PubMed Web of Science ®Google Scholar
• Hsieh, J. C., Jurutka P. W., Nakajima S., Galligan M. A., Haussler C. A., Shimizu Y., Shimizu N., Whitfield G. K., and Haussler M. R.. 1993. Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site. J. Biol. Chem. 268:15118–15126.
   PubMed Web of Science ®Google Scholar
• Javed, A., Gutierrez S., Montecino M., van Wijnen A. J., Stein J. L., Stein G. S., and Lian J. B.. 1999. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Mol. Cell. Biol. 19:7491–7500.
   PubMed Web of Science ®Google Scholar
• Kitagawa, H., Fujiki R., Yoshimura K., Mezaki Y., Uematsu Y., Matsui D., Ogawa S., Unno K., Okubo M., Tokita A., Nakagawa T., Ito T., Ishimi Y., Nagasawa H., Matsumoto T., Yanagisawa J., and Kato S.. 2003. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell 113:905–917.
   PubMed Web of Science ®Google Scholar
• Komori, T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R. T., Gao Y. H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., and Kishimoto T.. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755–764.
   PubMed Web of Science ®Google Scholar
• Lian, J. B., Stein J. L., Stein G. S., Montecino M., van Wijnen A. J., Javed A., and Gutierrez S.. 2001. Contributions of nuclear architecture and chromatin to vitamin D-dependent transcriptional control of the rat osteocalcin gene. Steroids 66:159–170.
   PubMed Web of Science ®Google Scholar
• Majeska, R. J., Rodan S. B., and Rodan G. A.. 1980. Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. Endocrinology. 107:1494–1503.
   PubMed Web of Science ®Google Scholar
• Metivier, R., Penot G., Hubner M., Reid G., Brand H., Kos M., and Gannon F.. 2003. Estrogen receptor-α direct ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115:751–763.
   PubMed Web of Science ®Google Scholar
• Montecino, M., Lian J., Stein G., and Stein J.. 1996. Changes in chromatin structure support constitutive and developmentally regulated transcription of the bone-specific osteocalcin gene in osteoblastic cells. Biochemistry 35:5093–5102.
   PubMed Web of Science ®Google Scholar
• Montecino, M., Frenkel B., van Wijnen A. J., Lian J. B., Stein G. S., and Stein J. L.. 1999. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry. 26:1338–1345.
   Google Scholar
• Otto, F., Thornell A. P., Crompton T., Denzel A., Gilmour K. C., Rosewell I. R., Stamp G. W. H., Beddington R. S. P., Mundlos S., Olsen B. R., Selby P. B., and Owen M. J.. 1997. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765–771.
   PubMed Web of Science ®Google Scholar
• Owen, T. A., Aronow M., Shalhoub V., Barone L. M., Wilming L., Tassinari M. S., Kennedy M. B., Pockwinse S., Lian J. B., and Stein G. S.. 1990. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J. Cell Physiol. 143:420–430.
   PubMed Web of Science ®Google Scholar
• Paredes, R., Gutierrez J., Gutierrez S., Allison L., Puchi M., Imschenetzky M., van Wijnen A., Lian J., Stein G., Stein J., and Montecino M.. 2002. Interaction of the 1α,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Biochem. J. 363:667–676.
   PubMed Web of Science ®Google Scholar
• Rachez, C., and Freedman L. P.. 2000. Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions. Gene 246:9–21.
   PubMed Web of Science ®Google Scholar
• Rachez, C., Gamble M., Chang C. P. B., Atkins G. B., Lazar M. A., and Freedman L. P.. 2000. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol. Cell. Biol. 20:2718–2726.
   PubMed Web of Science ®Google Scholar
• Rachez, C., Lemon B. D., Suldan Z., Bromleigh V., Gamble M., Naar A. M., Erdjument-Bromage H., Tempst P., and Freedman L. P.. 1999. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398:824–828.
   PubMed Web of Science ®Google Scholar
• Rachez, C., Suldan Z., Ward J., Chang C. P., Burakov D., Erdjument-Bromage H., Tempst P., and Freedman L. P.. 1998. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev. 12:1787–1800.
   PubMedGoogle Scholar
• Shen, J., Montecino M., Lian L. B., Stein G. S., Van Wijnen A. J., and Stein J. L.. 2002. Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. J. Biol. Chem. 277:20284–20292.
   PubMed Web of Science ®Google Scholar
• Sierra, J., Villagra A., Paredes R., Cruzat F., Gutierrez S., Javed A., Arriagada G., Olate J., Imschenetzky M., van Wijnen A. J., Lian J. B., Stein G. S., Stein J. L., and Montecino M.. 2003. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol. Cell. Biol. 23:3339–3351.
   PubMedGoogle Scholar
• Soutoglou, E., and Talianidis I.. 2002. Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation. Science 295:1901–1904.
   PubMed Web of Science ®Google Scholar
• Staal, A., vanWijnen A. J., Birkenhager J. C., Pols H. A. P., Prahl J., DeLuca H., Gaub M. P., Lian J. B., Stein G. S., vanLeeuwen J. P. T. M., and Stein J. L.. 1996. Distinct conformations of vitamin D receptor retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. Mol. Endocrinol. 10:1444–1456.
   PubMedGoogle Scholar
• Thompson, P. D., Jurutka P. W., Haussler C. A., Whitfield G. K., and Haussler M. R.. 1998. Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions. J. Biol. Chem. 273:8483–8491.
   PubMedGoogle Scholar
• Zeng, C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J. B., Stein G. S., and Hiebert S. W.. 1997. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc. Natl. Acad. Sci. USA 94:6746–6751.
   PubMedGoogle Scholar
• Zhang, Y. W., Yasui N., Ito K., Huang G., Fujii M., Hanai J., Nogami H., Ochi T., Miyazono K., and Ito Y.. 2000. A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc. Natl. Acad. Sci. USA 97:10549–10554.
   PubMed Web of Science ®Google Scholar