16
Views
34
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Distinct Activities of the α-Catenin Family, α-Catulin and α-Catenin, on β-Catenin-Mediated Signaling

, &
Pages 2410-2422 | Received 03 Sep 2003, Accepted 17 Dec 2003, Published online: 27 Mar 2023

REFERENCE

  • Aberle, H., Butz S., Stappert J., Weissig H., Kemler R., and Hoschuetzky H.. 1994. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J. Cell Sci. 107:3655–3663.
  • Bienz, M., and Clevers H.. 2000. Linking colorectal cancer to Wnt signaling. Cell 103:311–320.
  • Bullions, L. C., Notterman D. A., Chung L. S., and Levine A. J.. 1997. Expression of wild-type alpha-catenin protein in cells with a mutant alpha-catenin gene restores both growth regulation and tumor suppressor activities. Mol. Cell. Biol. 17:4501–4508.
  • Cadigan, K. M., and Nusse R.. 1997. Wnt signaling: a common theme in animal development. Genes Dev. 11:3286–3305.
  • Downward, J. 2003. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3:11–22.
  • Geiger, B., Yehuda-Levenberg S., and Bershadsky A. D.. 1995. Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions. Acta Anat. 154:46–62.
  • Giannini, A. L., Vivanco M., and Kypta R. M.. 2000. Alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex. J. Biol. Chem. 275:21883–21888.
  • Giannini, A. L., Vivanco M. M., and Kypta R. M.. 2000. Analysis of beta-catenin aggregation and localization using GFP fusion proteins: nuclear import of alpha-catenin by the beta-catenin/Tcf complex. Exp. Cell Res. 255:207–220.
  • Gottardi, C. J., and Gumbiner B. M.. 2001. Adhesion signaling: how beta-catenin interacts with its partners. Curr. Biol. 11:R792–R794.
  • Hagenbuchle, O., and Wellauer P. K.. 1992. A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture. Nucleic Acids Res. 20:3555–3559.
  • Hazan, R. B., Kang L., Roe S., Borgen P. I., and Rimm D. L.. 1997. Vinculin is associated with the E-cadherin adhesion complex. J. Biol. Chem. 272:32448–32453.
  • He, T. C., Sparks A. B., Rago C., Hermeking H., Zawel L., da Costa L. T., Morin P. J., Vogelstein B., and Kinzler K. W.. 1998. Identification of c-MYC as a target of the APC pathway. Science 281:1509–1512.
  • Huber, O., Krohn M., and Kemler R.. 1997. A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin. J. Cell Sci. 110:1759–1765.
  • Hunter, T., and Pines J.. 1994. Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell 79:573–582.
  • Ilan, N., Mahooti S., Rimm D. L., and Madri J. A.. 1999. PECAM-1 (CD31) functions as a reservoir for and a modulator of tyrosine-phosphorylated beta-catenin. J. Cell Sci. 112:3005–3014.
  • Imamura, Y., Itoh M., Maeno Y., Tsukita S., and Nagafuchi A.. 1999. Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion. J. Cell Biol. 144:1311–1322.
  • Janssens, B., Staes K., and van Roy F.. 1999. Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. Biochim. Biophys. Acta 1447:341–347.
  • Jou, T. S., Stewart D. B., Stappert J., Nelson W. J., and Marrs J. A.. 1995. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA 92:5067–5071.
  • Kemler, R. 1993. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet. 9:317–321.
  • Kikuchi, A. 2000. Regulation of beta-catenin signaling in the Wnt pathway. Biochem. Biophys. Res. Commun. 268:243–248.
  • Kikuchi, A. 2003. Tumor formation by genetic mutations in the components of the Wnt signaling pathway. Cancer Sci. 94:225–229.
  • Kim, K., and Lee K. Y.. 2001. Tyrosine phosphorylation translocates beta-catenin from cell→cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. Cell Biol. Int. 25:421–427.
  • Klein, P. S., and Melton D. A.. 1996. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93:8455–8459.
  • Liberto, M., Cobrinik D., and Minden A.. 2002. Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells. Oncogene 21:1590–1599.
  • Moiseyeva, E. P., Weller P. A., Zhidkova N. I., Corben E. B., Patel B., Jasinska I., Koteliansky V. E., and Critchley D. R.. 1993. Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter. J. Biol. Chem. 268:4318–4325.
  • Molenaar, M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., Godsave S., Korinek V., Roose J., Destree O., and Clevers H.. 1996. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 86:391–399.
  • Morin, P. J. 1999. Beta-catenin signaling and cancer. Bioessays 21:1021–1030.
  • Morin, P. J., Sparks A. B., Korinek V., Barker N., Clevers H., Vogelstein B., and Kinzler K. W.. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:1787–1790.
  • Motokura, T., and Arnold A.. 1993. PRAD1/cyclin D1 proto-oncogene: genomic organization, 5′ DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosomes Cancer 7:89–95.
  • Nieset, J. E., Redfield A. R., Jin F., Knudsen K. A., Johnson K. R., and Wheelock M. J.. 1997. Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin. J. Cell Sci. 110:1013–1022.
  • Obama, H., and Ozawa M.. 1997. Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin). J. Biol. Chem. 272:11017–11020.
  • Park, B., Nguyen N. T., Dutt P., Merdek K. D., Bashar M., Sterpetti P., Tosolini A., Testa J. R., and Toksoz D.. 2002. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. J. Biol. Chem. 277:45361–45370.
  • Prendergast, G. C., Khosravi-Far R., Solski P. A., Kurzawa H., Lebowitz P. F., and Der C. J.. 1995. Critical role of Rho in cell transformation by oncogenic Ras. Oncogene 10:2289–2296.
  • Qiu, R. G., Chen J., McCormick F., and Symons M.. 1995. A role for Rho in Ras transformation. Proc. Natl. Acad. Sci. USA 92:11781–11785.
  • Quelle, D. E., Ashmun R. A., Shurtleff S. A., Kato J. Y., Bar-Sagi D., Roussel M. F., and Sherr C. J.. 1993. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev. 7:1559–1571.
  • Resnitzky, D., Gossen M., Bujard H., and Reed S. I.. 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14:1669–1679.
  • Sehgal, R. N., Gumbiner B. M., and Reichardt L. F.. 1997. Antagonism of cell adhesion by an alpha-catenin mutant, and of the Wnt-signaling pathway by alpha-catenin in Xenopus embryos. J. Cell Biol. 139:1033–1046.
  • Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551–555.
  • Shtutman, M., Zhurinsky J., Simcha I., Albanese C., D'Amico M., Pestell R., and Ben-Ze'ev A.. 1999. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA 96:5522–5527.
  • Simcha, I., Shtutman M., Salomon D., Zhurinsky J., Sadot E., Geiger B., and Ben-Ze'ev A.. 1998. Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. J. Cell Biol. 141:1433–1448.
  • Sunaga, N., Kohno T., Kolligs F. T., Fearon E. R., Saito R., and Yokota J.. 2001. Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. Genes Chromosomes Cancer 30:316–321.
  • Sutter, T., Doi S., Carnevale K. A., Arber N., and Weinstein I. B.. 1997. Expression of cyclins D1 and E in human colon adenocarcinomas. J. Med. 28:285–309.
  • Tetsu, O., and McCormick F.. 1999. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398:422–426.
  • Vermeulen, S. J., Bruyneel E. A., Bracke M. E., De Bruyne G. K., Vennekens K. M., Vleminckx K. L., Berx G. J., van Roy F. M., and Mareel M. M.. 1995. Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells. Cancer Res. 55:4722–4728.
  • Westwick, J. K., Lee R. J., Lambert Q. T., Symons M., Pestell R. G., Der C. J., and Whitehead I. P.. 1998. Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J. Biol. Chem. 273:16739–16747.
  • Zhang, J. S., Nelson M., Wang L., Liu W., Qian C. P., Shridhar V., Urrutia R., and Smith D. I.. 1998. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. Genomics 54:149–154.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.